Sergio Rutella

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint In vitro and in vivo modulation of MDR1/P-glycoprotein in HIV-infected patients administered highly active antiretroviral therapy and liposomal doxorubicin
    Mothanje Barbara Lucia
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr 30:369-78. 2002
  2. ncbi request reprint Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia
    Maria Teresa Voso
    Istituto di Ematologia, Universita Cattolica S Cuore and Dipartmento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Rome, Italy
    Blood 100:2703-7. 2002
  3. ncbi request reprint Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna and Stem Cell Center, S Orsola Malpighi Hospital, Bologna, Italy
    Blood 109:2871-7. 2007
  4. pmc Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes
    Sergio Rutella
    Department of Pediatric Hematology Oncology, IRCCS Bambino Gesù Children s Hospital, Piazza Sant Onofrio 4, 00165 Rome, Italy
    Clin Dev Immunol 2012:196063. 2012
  5. ncbi request reprint Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications
    Sergio Rutella
    Laboratory of Immunology, Department of Hematology, Catholic University Medical School, Largo Agostino Gemelli, 8, 00168 Rome, Italy
    Immunol Lett 94:11-26. 2004
  6. ncbi request reprint Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University School of Medicine, Rome, Italy
    J Immunol 175:7085-91. 2005
  7. ncbi request reprint Granulocyte colony-stimulating factor enhances the in vitro cytotoxicity of gemtuzumab ozogamicin against acute myeloid leukemia cell lines and primary blast cells
    Sergio Rutella
    Department of Hematology, Catholic University Medical School, Rome, Italy
    Exp Hematol 34:54-65. 2006
  8. ncbi request reprint Tolerogenic dendritic cells: cytokine modulation comes of age
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo Agostino Gemelli, 800168 Rome, Italy
    Blood 108:1435-40. 2006
  9. ncbi request reprint Granulocyte colony-stimulating factor for the induction of T-cell tolerance
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A Gemelli 8, 00168 Rome, Italy
    Transplantation 84:S26-30. 2007
  10. doi request reprint Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease
    Sergio Rutella
    Department of Hematology, Catholic University Medical School, Rome, Italy
    Am J Gastroenterol 106:762-70. 2011

Detail Information

Publications66

  1. ncbi request reprint In vitro and in vivo modulation of MDR1/P-glycoprotein in HIV-infected patients administered highly active antiretroviral therapy and liposomal doxorubicin
    Mothanje Barbara Lucia
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr 30:369-78. 2002
    ..Moreover, HIV PIs possess an inhibitory effect on P-gp function that may improve DOX sensitivity in KS spindle cells...
  2. ncbi request reprint Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia
    Maria Teresa Voso
    Istituto di Ematologia, Universita Cattolica S Cuore and Dipartmento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Rome, Italy
    Blood 100:2703-7. 2002
    ..003). In conclusion, individuals with GSTM1 or GSTT1 deletions (or deletions of both) may have an enhanced resistance to chemotherapy and a shorter survival...
  3. ncbi request reprint Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna and Stem Cell Center, S Orsola Malpighi Hospital, Bologna, Italy
    Blood 109:2871-7. 2007
    ..These data indicate that AML cells induce T-cell tolerance by directly converting CD4+CD25- T cells into CD4+CD25+ T(reg) cells through an IDO-dependent mechanism...
  4. pmc Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes
    Sergio Rutella
    Department of Pediatric Hematology Oncology, IRCCS Bambino Gesù Children s Hospital, Piazza Sant Onofrio 4, 00165 Rome, Italy
    Clin Dev Immunol 2012:196063. 2012
    ..This article summarizes our current knowledge on the molecular determinants of immune evasion in patients with MM and highlights how these pathways can be targeted to improve patients' clinical outcome...
  5. ncbi request reprint Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications
    Sergio Rutella
    Laboratory of Immunology, Department of Hematology, Catholic University Medical School, Largo Agostino Gemelli, 8, 00168 Rome, Italy
    Immunol Lett 94:11-26. 2004
    ..Furthermore, clinical implications of these studies for cellular therapy of immune-mediated pathologies are discussed...
  6. ncbi request reprint Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University School of Medicine, Rome, Italy
    J Immunol 175:7085-91. 2005
    ..This review summarizes the growing body of evidence that supports a critical role for G-CSF as a novel mediator of T cell tolerance...
  7. ncbi request reprint Granulocyte colony-stimulating factor enhances the in vitro cytotoxicity of gemtuzumab ozogamicin against acute myeloid leukemia cell lines and primary blast cells
    Sergio Rutella
    Department of Hematology, Catholic University Medical School, Rome, Italy
    Exp Hematol 34:54-65. 2006
    ..To evaluate the effects of granulocyte colony-stimulating factor (G-CSF) on the in vitro sensitivity of acute myeloid leukemia (AML) cell lines and primary AML blast cells to gemtuzumab ozogamicin (GO)...
  8. ncbi request reprint Tolerogenic dendritic cells: cytokine modulation comes of age
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo Agostino Gemelli, 800168 Rome, Italy
    Blood 108:1435-40. 2006
    ..From a therapeutic standpoint, cytokine-modulated TDCs might be beneficial for prevention and/or treatment of posttransplantation graft-versus-host disease (GVHD) and autoimmunity...
  9. ncbi request reprint Granulocyte colony-stimulating factor for the induction of T-cell tolerance
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A Gemelli 8, 00168 Rome, Italy
    Transplantation 84:S26-30. 2007
    ..The growing body of evidence supporting a novel role for G-CSF in the induction of T-cell tolerance is reviewed herein...
  10. doi request reprint Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease
    Sergio Rutella
    Department of Hematology, Catholic University Medical School, Rome, Italy
    Am J Gastroenterol 106:762-70. 2011
    ....
  11. ncbi request reprint Targeting indoleamine 2,3-dioxygenase (IDO) to counteract tumour-induced immune dysfunction: from biochemistry to clinical development
    S Rutella
    Department of Haematology, Catholic University Med School, 00168 Rome, Italy
    Endocr Metab Immune Disord Drug Targets 9:151-77. 2009
    ..Within the wider context of cancer immunotherapy, this Review also delineates how IDO could be exploited as a molecular target for therapeutic intervention in order to boost anti-cancer immunity...
  12. ncbi request reprint Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A Gemelli 8 00168 Rome, Italy
    Blood 108:218-27. 2006
    ..Collectively, our findings point to a novel role for HGF in the regulation of monocyte/DC functions that might be exploited therapeutically...
  13. ncbi request reprint Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors
    Sergio Rutella
    Department of Hematology and Department of Gynecology, Catholic University Medical School, USA
    Clin Cancer Res 15:4299-311. 2009
    ..The present study aimed to determine whether CD133 expression may identify cells with characteristics of cancer stem/progenitor cells in human endometrial tumors...
  14. ncbi request reprint Function and dysfunction of dendritic cells in autoimmune rheumatic diseases
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, and CdC San Raffaele Valletri, Rome, Italy
    Hum Immunol 70:360-73. 2009
    ..This article will review the current experimental evidence underpinning DC dysfunction in rheumatic autoimmune diseases and will discuss how the manipulation of DC and Treg number and function may control undesired T-cell responses...
  15. ncbi request reprint Human cord blood CD133+ cells immunoselected by a clinical-grade apparatus differentiate in vitro into endothelial- and cardiomyocyte-like cells
    Giuseppina Bonanno
    Department of Gynecology and Obstetrics, Catholic University Medical School, Rome, Italy
    Transfusion 47:280-9. 2007
    ..Recent findings on human hematopoietic stem cell (HSC) properties suggest a possible therapeutic role of human umbilical cord blood (UCB) HSC-based cellular therapies in the treatment of myocardial infarction...
  16. ncbi request reprint Identification of a novel subpopulation of human cord blood CD34-CD133-CD7-CD45+lineage- cells capable of lymphoid/NK cell differentiation after in vitro exposure to IL-15
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Rome, Italy
    J Immunol 171:2977-88. 2003
    ....
  17. ncbi request reprint Clinical isolation and functional characterization of cord blood CD133+ hematopoietic progenitor cells
    Giuseppina Bonanno
    Department of Gynecology and Obstetrics, and UNICATT Cord Blood Bank, Catholic University Medical School, Rome, Italy
    Transfusion 44:1087-97. 2004
    ..CD133+ HPCs isolated after large-scale processing were functionally characterized...
  18. ncbi request reprint The intracoelomic route: a new approach for in utero human cord blood stem cell transplantation
    Giuseppe Noia
    Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
    Fetal Diagn Ther 19:13-22. 2004
    ..This preliminary study indicates that intracoelomic transplantation of human hematopoietic stem cells in fetal lambs is feasible and effective in terms of hematopoietic engraftment...
  19. ncbi request reprint Granulocyte colony-stimulating factor promotes the generation of regulatory DC through induction of IL-10 and IFN-alpha
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Rome, Italy
    Eur J Immunol 34:1291-302. 2004
    ..This novel mechanism of immune regulation effected by G-CSF might be therapeutically exploited for tolerance induction in autoimmune disorders...
  20. ncbi request reprint Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells
    Sergio Rutella
    Departments of Hematology and Gynecology, Catholic University Medical School, Rome, and the Laboratory of Clinical Pathology and Microbiology, IRCCS San Gallicano, Rome, Italy
    Blood 100:2562-71. 2002
    ..Tr cells generated ex vivo after exposure to G-CSF might be clinically relevant for transplantation medicine and for the treatment of human immune-mediated diseases...
  21. ncbi request reprint Role of lymphocyte multidrug resistance protein 1 in HIV infection: expression, function, and consequences of inhibition
    Mothanje Barbara Lucia
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr 40:257-66. 2005
    ..Our results are consistent with a model wherein HIV replication is favored by the MRP1-related oxidative stress and inhibition of MRP1 may contribute to the antiviral activity of PIs...
  22. doi request reprint Effect of intensive vs standard statin therapy on endothelial progenitor cells and left ventricular function in patients with acute myocardial infarction: Statins for regeneration after acute myocardial infarction and PCI (STRAP) trial
    Antonio Maria Leone
    Institute of Cardiology and Institute of Haematology, Catholic University of the Sacred Heart, Rome, Italy
    Int J Cardiol 130:457-62. 2008
    ....
  23. pmc Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells
    Giuseppina Bonanno
    Department of Gynaecology, Catholic University Medical School, Rome, Italy
    BMC Immunol 10:46. 2009
    ..The present study was designed and conducted to address whether IL-21 might replace the stromal cell requirements and foster the IL-15-induced NK differentiation of human UCB CD34-lineage- cells...
  24. doi request reprint Enhanced platelet adhesion induces angiogenesis in intestinal inflammation and inflammatory bowel disease microvasculature
    Sergio Rutella
    Department of Hematology, Catholic University Medical School, Rome, Italy
    J Cell Mol Med 15:625-34. 2011
    ..These findings suggest that inflamed HIMEC may recruit PLT which, upon release of pro-angiogenic factors, actively contribute to inflammation-induced angiogenesis...
  25. ncbi request reprint Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction
    Antonio Maria Leone
    Institute of Cardiology, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Int J Cardiol 111:202-8. 2006
    ....
  26. pmc Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures
    Giuseppina Bonanno
    Department of Gynecology, Catholic University Med School, and Department of Blood Transfusion and Cell Therapy, Azienda Ospedaliera S Camillo Forlanini, Rome, Italy
    J Transl Med 8:129. 2010
    ....
  27. doi request reprint Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stress
    Stefano Lancellotti
    Institute of Internal Medicine and Geriatrics and Hemostasis Research Center, Catholic University School of Medicine, 00168 Rome, Italy
    Free Radic Biol Med 48:446-56. 2010
    ....
  28. doi request reprint Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells
    Maria Grazia Iachininoto
    Department of Haematology, Catholic University Medical School, Largo A Gemelli 8, 00168 Rome, Italy
    Molecules 18:10132-45. 2013
    ..Overall, these data point to COX-2 inhibition as a potential strategy to be pursued with the aim at circumventing leukaemia-induced, IDO-mediated immune dysfunction...
  29. pmc Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma
    Giuseppina Bonanno
    Department of Gynecology, Catholic University Med School, Rome, Italy
    J Transl Med 10:247. 2012
    ..It is presently unknown whether MM cells express IDO1 and whether IDO1 activity correlates with immune system impairment...
  30. pmc Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies
    Giuseppina Bonanno
    Department of Hematology, Catholic University Med, School, Rome, Italy
    J Transl Med 8:114. 2010
    ....
  31. ncbi request reprint Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function
    Antonio Maria Leone
    Institute of Cardiology, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Eur Heart J 26:1196-204. 2005
    ..The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+ after AMI and its relation to post-infarction remodelling...
  32. ncbi request reprint Transforming growth factor-beta1 causes transcriptional activation of CD34 and preserves haematopoietic stem/progenitor cell activity
    Luca Pierelli
    Istituto di Ematologia, Dipartimento per la Salute della Donna e della Vita Nascente, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Br J Haematol 118:627-37. 2002
    ....
  33. pmc FOXP3⁺ T regulatory cell modifications in inflammatory bowel disease patients treated with anti-TNFα agents
    Luisa Guidi
    Department of Internal Medicine, Inflammatory Bowel Disease Unit, Complesso Integrato Columbus, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Biomed Res Int 2013:286368. 2013
    ..Our data suggest the possibility that in IBD patients the treatment with anti-TNFα may affect Treg percentages and that Treg modifications may correlate with clinical response, but differently in early versus late disease...
  34. pmc Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease
    Sergio Rutella
    Department of Pediatric Hematology Oncology, IRCCS Children s Hospital Bambino Gesù 00165 Rome, Italy
    World J Gastroenterol 17:3761-75. 2011
    ..It also addresses the potential clinical benefit derived from DC targeting either in vivo or in vitro...
  35. ncbi request reprint Cell cycle regulation in human hematopoietic stem cells: from isolation to activation
    Maria Marone
    Department of Gynecology, Catholic University, Rome, Italy
    Leuk Lymphoma 43:493-501. 2002
    ....
  36. ncbi request reprint A novel route of transplantation of human cord blood stem cells in preimmune fetal sheep: the intracelomic cavity
    Giuseppe Noia
    Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
    Stem Cells 21:638-46. 2003
    ..This preliminary study indicates that intracelomic transplantation of human hematopoietic stem cells in fetal lambs is feasible and effective in terms of hematopoietic engraftment...
  37. ncbi request reprint TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease
    Silvio Danese
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Immunol 176:2617-24. 2006
    ..Thus, in addition to neutralizing TNF-alpha and inducing T cell death, the therapeutic effects of infliximab in CD appear to be also mediated by inhibition of vascular inflammation in the gut...
  38. ncbi request reprint Usefulness of granulocyte colony-stimulating factor in patients with a large anterior wall acute myocardial infarction to prevent left ventricular remodeling (the rigenera study)
    Antonio Maria Leone
    Institute of Cardiology, Catholic University of Sacred Heart, Rome, Italy
    Am J Cardiol 100:397-403. 2007
    ..In conclusion, G-CSF prevents unfavorable LV remodeling and improves LV function in patients with large anterior wall AMI and decreased LV ejection fraction after successful percutaneous coronary intervention...
  39. doi request reprint Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors
    Giovanna Petrucci
    Department of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy
    J Pharmacol Exp Ther 336:391-402. 2011
    ..PGE(2) through different EPs finely modulates human platelet responsiveness. These findings should inform the rational selection of novel antithrombotic strategies based on EP modulation...
  40. doi request reprint At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies
    Franco Locatelli
    1 Piazza Sant Onofrio 4, 00165 Rome, Italy
    J Leukoc Biol 94:1141-57. 2013
    ..Basic aspects of innate immunity relevant to the field will be covered by a companion review article. ..
  41. doi request reprint Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol
    Sergio Rutella
    Department of Pediatric Hematology Oncology, IRCCS Bambino Gesù Children s Hospital, Rome, Italy
    Cytotherapy 14:841-50. 2012
    ..It is presently unknown whether the infusion of autologous immune effector cells generated by TG, IFN-γ and IL-2 is feasible and safe...
  42. doi request reprint How I treat relapsed childhood acute lymphoblastic leukemia
    Franco Locatelli
    Department of Pediatric Hematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children s Hospital, Rome, Italy
    Blood 120:2807-16. 2012
    ..Innovative approaches, including new agents or strategies of immunotherapy, are under investigation in trials enrolling patients with resistant or more advanced disease...
  43. doi request reprint Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds
    Tiziana Di Pucchio
    Istituto Superiore di Sanita, Department of Cell Biology and Neurosciences, Rome, Italy
    Expert Opin Ther Pat 20:229-50. 2010
    ..Recently, IDO has been implicated in B-cell stimulation and autoantibody production in experimental models of autoimmune diseases...
  44. ncbi request reprint Lymphocyte recovery in advanced ovarian cancer patients after high-dose chemotherapy and peripheral blood stem cell plus growth factor support: clinical implications
    Gabriella Ferrandina
    Department of Gynecology, Catholic University of Rome, 00168 Rome, Italy
    Clin Cancer Res 9:195-200. 2003
    ....
  45. pmc Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors
    Stefano Lancellotti
    Institute of Internal Medicine and Geriatrics, and Haemostasis Research Centre, Catholic University School of Medicine, 00168 Rome, Italy
    J Biol Chem 283:30193-204. 2008
    ..In summary, fibrinogen gamma' chain binds with high affinity to thrombin and inhibits with combined mechanisms the platelet response to thrombin. Thus, its variations in vivo may affect the hemostatic balance in arterial circulation...
  46. ncbi request reprint Management of relapsed acute lymphoblastic leukemia in childhood with conventional and innovative approaches
    Franco Locatelli
    aDepartment of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children s Hospital, Rome bUniversity of Pavia, Pavia, Italy
    Curr Opin Oncol 25:707-15. 2013
    ....
  47. ncbi request reprint Adoptive immunotherapy with antigen-specific T cells during extracorporeal membrane oxygenation (ECMO) for adenovirus-related respiratory failure in a child given haploidentical stem cell transplantation
    Matteo Di Nardo
    Department of Pediatric Intensive Care, IRCCS Bambino Gesù Children s Hospital, Rome, Italy
    Pediatr Blood Cancer 61:376-9. 2014
    ..T-cell responses to HAdV antigens were documented after four weeks and were associated with viral clearance, immune reconstitution and clinical amelioration...
  48. ncbi request reprint Miniaturized and high-throughput assays for analysis of T-cell immunity specific for opportunistic pathogens and HIV
    Giuseppina Li Pira
    Bambino Gesu Children s Hospital, Rome, Italy
    Clin Vaccine Immunol 21:488-95. 2014
    ....
  49. ncbi request reprint Lymphocyte proliferation specific for recall, CMV and HIV antigens in miniaturized and automated format
    Giuseppina Li Pira
    Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children Hospital, Rome, Italy
    J Immunol Methods 384:135-42. 2012
    ..This procedure is consistent with our policy to miniaturize assays for specific T-cell immunity, as we have already established for cytokine secretion assays...
  50. ncbi request reprint Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21
    Maria Marone
    Department of Gynecology, Catholic University, Rome, Italy
    Leuk Lymphoma 43:51-7. 2002
    ....
  51. pmc MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle
    Roberta Morosetti
    Department of Neurosciences and Interdisciplinary Laboratory for Stem Cell Research and Cellular Therapy, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Proc Natl Acad Sci U S A 103:16995-7000. 2006
    ..Indeed, silencing this gene or overexpressing MyoD rescues the myogenic defect of IBM mesoangioblasts, opening novel cell-based therapeutic strategies for this crippling disorder...
  52. ncbi request reprint The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines
    Roberta Morosetti
    Division of Pediatric Oncology, Catholic University of Rome, 00168 Rome, Italy
    Int J Oncol 25:493-502. 2004
    ..By contrast, the modulation of differentiation-associated proteins by PGJ2, but not rosiglitazone, suggests that PGJ2 promotes differentiation of glioblastoma cells independently of PPARgamma activation...
  53. ncbi request reprint Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms
    Maria Teresa Voso
    German Cancer Research Center, Heidelberg, Germany
    Haematologica 87:918-25. 2002
    ..It was the objective of this study to define the contribution of the different mechanisms of action of rituximab on primary normal and malignant B-cells...
  54. ncbi request reprint Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia
    Valentina Folgiero
    Department of Pediatric Hematology Oncology and Transfusion Medicine, IRCCS Bambino Gesù Children s Hospital, Rome, Italy
    Oncotarget 5:2052-64. 2014
    ..Moreover, they speak in favor of the hypothesis that IDO can be targeted, in adjunct to current chemotherapy approaches, to improve the clinical outcome of children with AML. ..
  55. doi request reprint Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism
    Federico Biscetti
    Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy
    Int J Cardiol 167:910-6. 2013
    ..The aim of this work was to investigate the effects of cilostazol on angiogenic response in a murine model of peripheral ischemia and to clarify the underlying molecular mechanisms of that response...
  56. ncbi request reprint Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis
    Nicola Piccirillo
    Hematology Institute, Università Cattolica del Sarco Cuore, Rome, Italy
    Haematologica 88:192-200. 2003
    ....
  57. ncbi request reprint The Yin and Yang of non-neuronal α7-nicotinic receptors in inflammation and autoimmunity
    Perla Filippini
    System Approaches and Non Communicable Disease Lab, IRCCS San Raffaele Pisana, Rome, Italy
    Curr Drug Targets 13:644-55. 2012
    ..These data may portend favorable implications for the targeted treatment of chronic and debilitating human disorders, such as diabetes, arthritis, asthma and inflammatory bowel disease, with α7-selective ligands...
  58. doi request reprint Strategies to optimize the outcome of children given T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation
    Franco Locatelli
    Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S Onofrio, Rome, Italy
    Best Pract Res Clin Haematol 24:339-49. 2011
    ..Novel and effective strategies aimed at further augmenting the graft-versus-leukemia effect and at optimizing prevention/treatment of opportunistic/viral infections are warranted...
  59. ncbi request reprint The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan
    Angela Maria Di Francesco
    Division of Paediatric Oncology, Catholic University, Rome, Italy
    Biochem Pharmacol 70:1125-36. 2005
    ..We propose that DNA strand breaks efficiency as measured by the Comet assay might provide important information about the stability of the ternary complexes induced by camptothecin compounds...
  60. doi request reprint Analysis of genome-wide methylation and gene expression induced by 5-aza-2'-deoxycytidine identifies BCL2L10 as a frequent methylation target in acute myeloid leukemia
    Emiliano Fabiani
    Istituto di Ematologia, Universita Cattolica Sacro Cuore, Rome, Italy
    Leuk Lymphoma 51:2275-84. 2010
    ..The apoptotic gene BCL2L10 is a frequent target for aberrant promoter methylation in patients with acute leukemia, de novo and therapy-related...
  61. ncbi request reprint Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors
    Andrea Savarino
    Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Acquir Immune Defic Syndr 35:223-32. 2004
    ..We tested the effects of chloroquine (CQ) on glycosylation of HIV particles and in combination with protease inhibitors (PIs) on HIV replication and on P-glycoprotein (P-gp)/multidrug resistance protein-1 (MRP1)...
  62. ncbi request reprint The interplay between indoleamine 2,3-dioxygenase 1 (IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer
    A Cesario
    IRCCS San Raffaele Pisana, Rome, Italy
    Curr Med Chem 18:2263-71. 2011
    ..COX-2 inhibition might, in principle, be pursued in cancer-associated inflammation characterized by IDO1 hyper-activity, with the foreseeable aim at altering the immune response within the tumor microenvironment...
  63. ncbi request reprint Immunophenotypic analysis in 119 patients with acute myeloid leukemia following a previous malignancy: a comparison with the immunophenotype of 231 de novo AML
    Livio Pagano
    Haematologica 88:225-7. 2003
  64. ncbi request reprint In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study
    Giuseppe Leone
    Haematologica 89:634-6. 2004
    ..Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complete remission, 2 patients had a partial remission and the other 2 were resistant...
  65. ncbi request reprint Atazanavir inhibits P-glycoprotein and multidrug resistance-associated protein efflux activity
    Mothanje Barbara Lucia
    J Acquir Immune Defic Syndr 39:635-7. 2005
  66. ncbi request reprint Differential induction of P-glycoprotein and MRP by rifamycins in T lymphocytes from HIV-1/tuberculosis co-infected patients
    Mothanje B Lucia
    AIDS 16:1563-5. 2002