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Genomes and Genes | Dario PitoccoSummaryAffiliation: Catholic University Country: Italy Publications
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Publications
Six-month treatment with alendronate in acute Charcot neuroarthropathy: a randomized controlled trialDario Pitocco
Internal Medicine Institute, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy
Diabetes Care 28:1214-5. 2005
Oxidative stress, nitric oxide, and diabetesDario Pitocco
Institute of Internal Medicine, Catholic University of Rome, Largo Agostino Gemelli 8, 00168 Rome, Italy
Rev Diabet Stud 7:15-25. 2010..These are the two most relevant mechanisms in the pathophysiology of type 2 diabetes, and in the pathogenesis of diabetic vascular complications, the leading cause of death in diabetic patients...- The diabetic lung--a new target organ?Dario Pitocco
Diabetes Care Unit, Catholic University of Rome, Rome, Italy
Rev Diabet Stud 9:23-35. 2012..This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes... 
Association between reduced pulmonary diffusing capacity and cardiac autonomic dysfunction in Type 1 diabetesD Pitocco
Cardiology Institute, Catholic University, Rome, Italy
Diabet Med 25:1366-9. 2008..To our knowledge, no previous study has assessed whether cardiac sympatho-vagal balance is associated with lung diffusion capacity in diabetes...- Pioglitazone reduces monocyte activation in type 2 diabetesDario Pitocco
Internal Medicine Institute, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
Acta Diabetol 46:75-7. 2009..04 vs. baseline) while, in controls, did not change at 8 weeks (16.9 pg/mL, range 1.5-58.8). Treatment with pioglitazone, associated with metformin, showed a reduction of IL-6 monocyte production after their in vitro activation with LPS... - Interaction between IGF-1, inflammation, and neuropathy in the pathogenesis of acute charcot neuroarthropathy: lessons from alendronate therapy and future perspectives of medical therapyD Pitocco
Internal Medicine Institute, Catholic University, L. go A. Gemelli 8, Rome, Italy
Horm Metab Res 40:163-4. 2008 - Hypouricemia linked to an overproduction of nitric oxide is an early marker of oxidative stress in female subjects with type 1 diabetesDario Pitocco
Department of Internal Medicine, Catholic University, Rome, Italy
Diabetes Metab Res Rev 24:318-23. 2008.... - Association between osteoprotegerin G1181C and T245G polymorphisms and diabetic charcot neuroarthropathy: a case-control studyDario Pitocco
Institute of Internal Medicine, Policlinico A Gemelli, Rome, Italy
Diabetes Care 32:1694-7. 2009..Charcot neuroarthropathy is a disabling complication of diabetes. Although its pathogenesis remains unknown, we suppose that genetics may play a relevant role... - Role of asymmetric-dimethyl-L-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitusDario Pitocco
Diabetologia, Catholic University, Rome, Italy
Diabetes Res Clin Pract 86:173-6. 2009..To explore the role of asymmetric-dimethyl-L-arginine (ADMA), an endogenous nitric oxide synthetases (NOS) inhibitor, and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in early stages of type 1 diabetes mellitus... - Severe leucopenia associated with Sitagliptin useDario Pitocco
Department of Internal Medicine, Diabetes Care Unit, Catholic University School of Medicine, Rome, Italy
Diabetes Res Clin Pract 91:e30-2. 2011.... - Combined atherogenic effects of celiac disease and type 1 diabetes mellitusD Pitocco
Diabetes Care Unit, Internal Medicine, Catholic University, Rome, Italy
Atherosclerosis 217:531-5. 2011..The aim of our study was to assess carotid intima-media thickness (c-IMT), in patients with T1DM, CD or both (T1DM+CD) as compared with age- and sex-matched healthy individuals (H)... - Decline of neuroadrenergic bronchial innervation and respiratory function in type 1 diabetes mellitus: a longitudinal studyRaffaele Antonelli Incalzi
Department of Geriatrics Campus Biomedico University, Rome, Italy
Diabetes Metab Res Rev 23:311-6. 2007..We explored the effects of AN on the rate of decline of pulmonary sympathetic innervation and respiratory function during a 5-year follow-up... - Modifications in nasal function and nitric oxide serum level in type 1 diabetesWalter Di Nardo
Department of Otolaryngology, Catholic University of the Sacred Heart Rome, Rome, Italy
J Otolaryngol Head Neck Surg 37:611-5. 2008.... - Association between serum free IGF-I and IGFBP-3 levels in type-I diabetes patients affected with associated autoimmune diseases or diabetic complicationsEttore Capoluongo
Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
Eur Cytokine Netw 17:167-74. 2006..T1DM patients often present with associated autoimmune diseases such as thyroiditis or coeliac disease, and over time they frequently develop proliferative retinopathy, neuropathy or nephropathy in different combinations... - Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patientsRoberto Mollo
Department of Cardiovascular Medicine, Catholic University, Rome, Italy
Diabetes Care 35:196-7. 2012..Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients... - Reduced respiratory muscle strength and endurance in type 2 diabetes mellitusLeonello Fuso
Respiratory Disease Unit, Catholic University, Rome, Italy
Diabetes Metab Res Rev 28:370-5. 2012..We aimed to verify whether such a relationship applies also to type 2 DM patients... - No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trialCarla Bizzarri
Department of Endocrinology and Diabetes, Bambino Gesu Children s Hospital, Rome, Italy
Diabetes Care 33:1962-3. 2010..We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement... - The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic controlAntonio Petrone
Endocrinology, Department of Clinical Science, University Sapienza, Polo Pontino, Rome, Italy
Diabetes Care 31:1214-8. 2008.... - Glycemic risk factors of diabetic vascular complications: the role of glycemic variabilityFrancesco Zaccardi
Diabetologia, Catholic University, Rome, Italy
Diabetes Metab Res Rev 25:199-207. 2009..At last, we propose a simple model that summarizes the 'glucose triad' plus the 'new' risk factor glycemic variability (the 'Pyramid of the Risk')... - Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetesRoberto Nerla
Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
Acta Diabetol 47:117-22. 2010..This effect precedes those on metabolic and anthropometric parameters and is not associated with changes in cardiac autonomic function... - Inverse correlation between serum free IGF-I and IGFBP-3 levels and blood pressure in patients affected with type 1 diabetesEttore Capoluongo
Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
Cytokine 34:303-11. 2006..In addition, no information is available on type 1 diabetes patients... - The oxidative modification of von Willebrand factor is associated with thrombotic angiopathies in diabetes mellitusLaura Oggianu
Institute of Internal Medicine and Geriatrics and Haemostasis Research Centre, Catholic University School of Medicine, Rome, Italy
PLoS ONE 8:e55396. 2013..These findings may help identify diabetic patients particularly at risk for these complications and elucidate a new pathophysiological mechanism of thrombotic angiopathies in this clinical setting... - Glycaemic variability affects ischaemia-induced angiogenesis in diabetic miceFederico Biscetti
Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy
Clin Sci (Lond) 121:555-64. 2011.... - Comparison of nitrite/nitrate concentration in human plasma and serum samples measured by the enzymatic batch Griess assay, ion-pairing HPLC and ion-trap GC-MS: the importance of a correct removal of proteins in the Griess assayFederica Romitelli
Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 851:257-67. 2007.... - Early increase of oxidative stress and reduced antioxidant defenses in patients with uncomplicated type 1 diabetes: a case for gender differenceGiampiero Marra
Institute of Internal Medicine and Geriatrics, Catholic University School of Medicine, Largo Gemelli 8, 00168 Rome, Italy
Diabetes Care 25:370-5. 2002.... - Intraventricular conduction abnormalities in young patients with type 1 diabetes mellitusGiulio Coluzzi
Institute of Cardiology, Catholic University Medical School, Rome, Italy
J Cardiovasc Med (Hagerstown) 9:714-5. 2008 - A 2-year pilot trial of continuous subcutaneous insulin infusion versus intensive insulin therapy in patients with newly diagnosed type 1 diabetes (IMDIAB 8)Paolo Pozzilli
Department of Endocrinology and Diabetes, Università Campus Bio Medico, Rome, Italy
Diabetes Technol Ther 5:965-74. 2003..Both types of intensive insulin therapy combined with NA are able to preserve C-peptide secretion or even increase baseline levels for up to 2 years after diagnosis... - Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetesNicola Napoli
Department of Endocrinology and Diabetes, University Campus Bio Medico, Rome, Italy
PLoS ONE 8:e56488. 2013..We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined... - Neuroadrenergic denervation of the lung in type I diabetes mellitus complicated by autonomic neuropathyRaffaele Antonelli Incalzi
Department of Internal Medicine, Catholic University, Rome, Italy
Chest 121:443-51. 2002..Further research is needed to identify clinical and prognostic implications of these findings... - Expansion of CD4+CD28null T-lymphocytes in diabetic patients: exploring new pathogenetic mechanisms of increased cardiovascular risk in diabetes mellitusSimona Giubilato
Institute of Cardiology, Catholic University, Largo A Gemelli, Rome, Italy
Eur Heart J 32:1214-26. 2011..We sought to investigate the role of CD4(+)CD28(null)T-lymphocytes, a rare long-lived subset of T-lymphocytes with proatherogenic and plaque-destabilizing properties, in the increased cardiovascular risk associated with DM... - Blue eyes as a risk factor for type 1 diabetesEnrico Di Stasio
Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Hearth, Rome, Italy
Diabetes Metab Res Rev 27:609-13. 2011..We determined whether iris colour and skin pigmentation are risk factors in a Caucasian population living in two Mediterranean regions located at the same latitude with higher ultraviolet B irradiance, but with different T1D incidence... - Inhaled insulin and the lungLeonello Fuso
Fisiopatologia Respiratoria, Universita Cattolica S Cuore, Largo A Gemelli 8, 00168 Roma, Italy
Curr Med Chem 14:1335-47. 2007..Clarifying these issues is mandatory in order to define the indications and safety of inhaled insulin... - Continuous subcutaneous insulin infusion (CSII) in inpatient setting: unmet needs and the proposal of a CSII unitLelio Morviducci
Diabetes Unit, San Camillo Forlanini Hospital, Rome, Italy
Diabetes Technol Ther 13:1071-4. 2011..We suggest that a CSII unit should be activated inside the hospital, in order to increase compliance with required procedures and to properly address the unmet needs of CSII in inpatient setting... - Slight association between type 1 diabetes and "ff" VDR FokI genotype in patients from the Italian Lazio Region. Lack of association with diabetes complicationsE Capoluongo
Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Largo A Gemelli 8, 00168 Rome, Italy
Clin Biochem 39:888-92. 2006..In addition, T1DM patients without complications were compared with those carrying three complications... - Severity of coronary atherosclerosis in patients with a first acute coronary event: a diabetes paradoxGiampaolo Niccoli
Institute of Cardiology, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
Eur Heart J 34:729-41. 2013..We aimed to compare coronary artery disease (CAD) at the time of a first acute coronary syndrome (ACS) in type II diabetic and non-diabetic patients by coronary angiography and by optical coherence tomography (OCT)... - Effect of ranolazine on arterial endothelial function in patients with type 2 diabetes mellitusPriscilla Lamendola
Institute of Cardiology, Universita Cattolica del Sacro Cuore, Rome, Italy
Atherosclerosis 226:157-60. 2013..To assess the effect of ranolazine on systemic vascular function in patients with type II diabetes mellitus (T2DM)... - Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stressStefano Lancellotti
Institute of Internal Medicine and Geriatrics and Hemostasis Research Center, Catholic University School of Medicine, 00168 Rome, Italy
Free Radic Biol Med 48:446-56. 2010.... - Effects of GLP-1 on forearm vasodilator function and glucose disposal during hyperinsulinemia in the metabolic syndromeManfredi Tesauro
Department of Internal Medicine, University of Tor Vergata, Rome, Italy
Diabetes Care 36:683-9. 2013..This study, therefore, aimed to assess whether GLP-1 affects insulin-stimulated vasodilator reactivity in patients with the MetS... - A novel MEN1 frameshift germline mutation in two Italian monozygotic twinsPaola Concolino
Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
Clin Chem Lab Med 46:824-6. 2008..This report describes clinical, biochemical and molecular findings regarding two Italian monozygotic twins carrying a novel multiple endocrine neoplasia type 1 (MEN1) mutation inherited from their mother... - Multinevritis of cranial nerves following inhalation of toxinsIrene Aprile
Institute of Neurology, Don C Gnocchi Foundation, Rome, Italy
Neurol Res 25:208-10. 2003..We believe physicians should be aware that multinevritis of the cranial nerves may be related to acute exposure to toxic substances. Missing this diagnosis could lead to a delay in therapy... - Small bowel bacterial overgrowth and type 1 diabetesV Ojetti
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
Eur Rev Med Pharmacol Sci 13:419-23. 2009..Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts... - Low glucose blood levels are associated with abnormal cardiac sympatho-vagal balance in type 2 diabetic patients with coronary artery diseaseF Infusino
Institute of Cardiology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
Eur Rev Med Pharmacol Sci 14:203-7. 2010..In our study we assessed whether blood glucose fluctuation may be related to variations in CAF during daily life in diabetic patients with coronary artery disease (CAD)... - Purine metabolites and malondialdehyde in platelets of diabetic patientsB Zappacosta
Lab Di Chimica Clinica Policlinico A Gemelli, Istituto di Chimica e Chimica Clinica and Centro CNR per lo Studio della Chimica dei Recettori e delle Sostanze Biologicamente Attive, Rome, Italy
Diabetes Res Clin Pract 46:127-34. 1999.... - [Role of Helicobacter pylori infection in insulin-dependent diabetes mellitus]V Ojetti
Policlinico Gemelli, Rome, Italy
Minerva Med 92:137-44. 2001..pylori re-infection was observed in IDDM patients when compared to not IDDM controls. The data suggest that vaccine development seems to be the only effective long run treatment for this subset of patients... - Computer use, free time activities and metabolic control in patients with type 1 diabetesD Benevento
University Campus Bio Medico, Rome, Italy
Diabetes Res Clin Pract 88:e32-4. 2010..Multiple linear regression showed that HbA1c% was not related to age, DM1 duration, TV watching or computer use but was independently and negatively related to the weekly hours spent on physical exercise... - Effect of carbohydrate counting and medical nutritional therapy on glycaemic control in Type 1 diabetic subjects: a pilot studyG Scavone
Diabetes Centre, Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy
Diabet Med 27:477-9. 2010..The effect of a balanced, carbohydrate-counting diet on glycaemic control in Type 1 diabetic subjects is unclear. Our aim was to determine its effect in a small, pilot trial... - Age at diagnosis of type 1 diabetes and the effect of immunomodulatory therapies on residual beta cell functionD Pitocco
, Rome, Italy
Horm Metab Res 40:66-8. 2008 - A case of chronic hepatitis C developing insulin-dependent diabetes, thyroid autoimmunity and stiff-person syndrome as complications of interferon therapyG Scavone
Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy
Diabetes Res Clin Pract 89:e36-8. 2010..This is the first reported case in which SPS has appeared as complication of IFNalpha therapy... - Peroxisome proliferator-activated receptors and angiogenesisF Biscetti
Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Catholic University School of Medicine, Largo F Vito, 8, 00168 Rome, Italy
Nutr Metab Cardiovasc Dis 19:751-9. 2009.... - The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI)D Pitocco
, Ospedale Pediatrico Bambino Ges, Rome, Italy
Diabet Med 23:920-3. 2006..CONCLUSIONS: At the dosage used, calcitriol has a modest effect on residual pancreatic beta-cell function and only temporarily reduces the insulin dose... - A two year observational study of nicotinamide and intensive insulin therapy in patients with recent onset type 1 diabetes mellitusA Crino
Department of Endocrinology and Diabetes, Clinica Medica, Universitá Catholica Sacro Cuore and Ospedale Pediatrico Bambino Gesu, Rome, Italy
J Pediatr Endocrinol Metab 18:749-54. 2005.... - IGF-1 and macrovascular complications of diabetes: alternative interpretations of recently published dataElena Conti
Diabetes Care 26:1653-4; author reply 1654-5. 2003 - High rate of helicobacter pylori re-infection in patients affected by type 1 diabetesVeronica Ojetti
Diabetes Care 25:1485. 2002 - Effect of sildenafil on diabetic gastropathyAlessandro Bianco
Diabetes Care 25:1888-9. 2002 - Association between cardiac autonomic dysfunction and inflammation in type 1 diabetic patients: effect of beta-blockadeGaetano Antono Lanza
Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8, 00168 Roma, Italy
Eur Heart J 28:814-20. 2007..To assess the relationship between cardiac autonomic dysfunction and inflammation in patients with type 1 diabetes and whether beta-blocker therapy might improve both abnormalities in these patients...