P Palozza


Affiliation: Catholic University
Country: Italy


  1. Palozza P, Simone R, Catalano A, Boninsegna A, Böhm V, Fröhlich K, et al. Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J Nutr Biochem. 2010;21:34-46 pubmed publisher
    ..Our study suggests that lycopene may act as a potential antiatherogenic agent by preventing 7-KC-induced oxidative stress and apoptosis in human macrophages. ..
  2. Palozza P, Parrone N, Catalano A, Simone R. Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications. Curr Med Chem. 2010;17:2547-63 pubmed
    ..A clear understanding of the molecular mechanisms of action of lycopene is crucial in the valuation of this molecule as a potential preventive and therapeutic agent. ..
  3. Palozza P, Parrone N, Simone R, Catalano A. Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention. Curr Med Chem. 2011;18:1846-60 pubmed
    ..Moreover, we speculate on the possible influence that lycopene may have as a redox agent in cancer. ..
  4. Palozza P, Simone R, Catalano A, Saraceni F, Celleno L, Mele M, et al. Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke. Inflamm Allergy Drug Targets. 2012;11:36-47 pubmed
    ..Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-?B are involved. ..
  5. Palozza P, Serini S, Di Nicuolo F, Boninsegna A, Torsello A, Maggiano N, et al. beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. Carcinogenesis. 2004;25:1315-25 pubmed
    ..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate. ..
  6. Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele M, et al. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009;283:108-17 pubmed publisher
    ..Growth-inhibitory effects by H. pluvialis were also observed in HT-29, LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer. ..
  7. Palozza P, Sheriff A, Serini S, Boninsegna A, Maggiano N, Ranelletti F, et al. Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad. Apoptosis. 2005;10:1445-56 pubmed
    ..This study suggests that lycopene, differently from beta-carotene, can exert protective effects against cigarette smoke condensate. ..
  8. Palozza P, Barone E, Mancuso C, Picci N. The protective role of carotenoids against 7-keto-cholesterol formation in solution. Mol Cell Biochem. 2008;309:61-8 pubmed
  9. Palozza P, Sestito R, Picci N, Lanza P, Monego G, Ranelletti F. The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cells. Carcinogenesis. 2008;29:2153-61 pubmed publisher
    ..All together, these data suggest that the modulation of cav-1 pathway by beta-carotene could be a novel mechanism by which the carotenoid acts as a potent growth-inhibitory agent in cancer cells. ..

More Information


  1. Palozza P, Colangelo M, Simone R, Catalano A, Boninsegna A, Lanza P, et al. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis. 2010;31:1813-21 pubmed publisher
    ..These findings provide a novel mechanistic insight into the growth-inhibitory effects of lycopene in cancer. ..
  2. Palozza P, Catalano A, Simone R, Cittadini A. Lycopene as a guardian of redox signalling. Acta Biochim Pol. 2012;59:21-5 pubmed
    ..Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-?B and AP-1, Nrf2. ..
  3. Palozza P, Simone R, Catalano A, Monego G, Barini A, Mele M, et al. Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-?B nuclear binding and increase in PPAR? expression. J Nutr Biochem. 2011;22:259-68 pubmed publisher
    ..Taken all together, these data bring new information on the anti-atherogenic properties of lycopene, and on its mechanisms of action in atherosclerosis prevention. ..
  4. Palozza P, Serini S, Currò D, Calviello G, Igarashi K, Mancuso C. beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth. Antioxid Redox Signal. 2006;8:1069-80 pubmed
  5. Palozza P, Simone R, Catalano A, Parrone N, Monego G, Ranelletti F. Lycopene regulation of cholesterol synthesis and efflux in human macrophages. J Nutr Biochem. 2011;22:971-8 pubmed publisher