P Palozza

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi Effect of lycopene and tomato products on cholesterol metabolism
    P Palozza
    Institute of General Pathology, School of Medicine, Catholic University, Rome, Italy
    Ann Nutr Metab 61:126-34. 2012
  2. ncbi Lycopene modulation of molecular targets affected by smoking exposure
    P Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Curr Cancer Drug Targets 12:640-57. 2012
  3. ncbi Lycopene as a guardian of redox signalling
    Paola Palozza
    Institute of General Pathology, Catholic University, School of Medicine, Rome, Italy
    Acta Biochim Pol 59:21-5. 2012
  4. ncbi Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 100168 Rome, Italy
    Inflamm Allergy Drug Targets 11:36-47. 2012
  5. ncbi Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2
    P Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Carcinogenesis 27:2383-91. 2006
  6. ncbi beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 8:1069-80. 2006
  7. ncbi Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Free Radic Biol Med 42:1579-90. 2007
  8. ncbi Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168, Rome, Italy
    Mol Cell Biochem 287:21-32. 2006
  9. ncbi The protective role of carotenoids against 7-keto-cholesterol formation in solution
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, 00168 Rome, Italy
    Mol Cell Biochem 309:61-8. 2008
  10. doi Design, synthesis, and antioxidant potency of novel alpha-tocopherol analogues in isolated membranes and intact cells
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168 Rome, Italy
    Free Radic Biol Med 44:1452-64. 2008

Collaborators

Detail Information

Publications50

  1. ncbi Effect of lycopene and tomato products on cholesterol metabolism
    P Palozza
    Institute of General Pathology, School of Medicine, Catholic University, Rome, Italy
    Ann Nutr Metab 61:126-34. 2012
    ..Here we review the available evidence for a direct regulation of tomato lycopene on cholesterol metabolism using results from experimental and human studies...
  2. ncbi Lycopene modulation of molecular targets affected by smoking exposure
    P Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Curr Cancer Drug Targets 12:640-57. 2012
    ..This review summarizes the background information about the interactions of lycopene with smoke in experimental models and presents the most current knowledge with respect to lycopene role in smoke-related diseases...
  3. ncbi Lycopene as a guardian of redox signalling
    Paola Palozza
    Institute of General Pathology, Catholic University, School of Medicine, Rome, Italy
    Acta Biochim Pol 59:21-5. 2012
    ..Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2...
  4. ncbi Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 100168 Rome, Italy
    Inflamm Allergy Drug Targets 11:36-47. 2012
    ..Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-κB are involved...
  5. ncbi Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2
    P Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Carcinogenesis 27:2383-91. 2006
    ..These data point out that the carotenoid may enhance cigarette smoke-induced oxidative stress and exert potential deleterious effects at the pO2 normally present in lung tissue...
  6. ncbi beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 8:1069-80. 2006
    ..The role of HO-1 repression in increasing cell growth was also confirmed in Mv1Lu cells by the "knock down" of the Bach1 gene, thus demonstrating as HO-1 repression is a conserved mechanism by which cells can react to oxidative stress...
  7. ncbi Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Free Radic Biol Med 42:1579-90. 2007
    ..These data suggest a possible antiatherogenic role of beta-carotene through the prevention of 7-KC toxicity in human macrophages...
  8. ncbi Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168, Rome, Italy
    Mol Cell Biochem 287:21-32. 2006
    ..In view of these results, FeAox-6 represents a new potential preventive agent in chronic diseases in which oxidative stress plays a pathogenic role...
  9. ncbi The protective role of carotenoids against 7-keto-cholesterol formation in solution
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, 00168 Rome, Italy
    Mol Cell Biochem 309:61-8. 2008
    ....
  10. doi Design, synthesis, and antioxidant potency of novel alpha-tocopherol analogues in isolated membranes and intact cells
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168 Rome, Italy
    Free Radic Biol Med 44:1452-64. 2008
    ..3) The presence of polyunsaturated double bonds in the side chain in the Z configuration (FEBL-53, FEBL-162) increased the antioxidant potency of the molecule with respect to the E configuration (FEBL-50, FEBL-161)...
  11. ncbi Interplay of carotenoids with cigarette smoking: implications in lung cancer
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, Rome, Italy
    Curr Med Chem 15:844-54. 2008
    ..This review summarizes the available evidences in cultured cells, animal models and humans for a modulatory action of carotenoids on the dangerous effects of smoke and focuses on the main molecular pathways involved in this process...
  12. ncbi The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito, 1 00168 Rome, Italy
    Br J Nutr 98:789-95. 2007
    ..Moreover, we have shown that tomato digestate is able to inhibit the growth of colon cancer cells by modulating the expression of regulators of the cell cycle and apoptosis...
  13. doi The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cells
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, Rome 00168, Italy
    Carcinogenesis 29:2153-61. 2008
    ..All together, these data suggest that the modulation of cav-1 pathway by beta-carotene could be a novel mechanism by which the carotenoid acts as a potent growth-inhibitory agent in cancer cells...
  14. doi Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, 1 00168 Rome, Italy
    J Nutr Biochem 21:34-46. 2010
    ..Our study suggests that lycopene may act as a potential antiatherogenic agent by preventing 7-KC-induced oxidative stress and apoptosis in human macrophages...
  15. doi Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Cancer Lett 283:108-17. 2009
    ..Growth-inhibitory effects by H. pluvialis were also observed in HT-29, LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer...
  16. ncbi Tomato lycopene and inflammatory cascade: basic interactions and clinical implications
    P Palozza
    Institute of General Pathology, Catholic University, School of Medicine, Lgo F Vito, 1 00168 Rome, Italy
    Curr Med Chem 17:2547-63. 2010
    ..A clear understanding of the molecular mechanisms of action of lycopene is crucial in the valuation of this molecule as a potential preventive and therapeutic agent...
  17. doi Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
    J Nutr Biochem 22:259-68. 2011
    ..Taken all together, these data bring new information on the anti-atherogenic properties of lycopene, and on its mechanisms of action in atherosclerosis prevention...
  18. doi Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies
    Paola Palozza
    Institute of General Pathology, Catholic University, School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Arch Biochem Biophys 504:26-33. 2010
    ..Focusing on cell culture studies, this review summarizes the experimental evidence for a role of lycopene in the different phases of atherosclerotic process...
  19. doi Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 00168 Rome, Italy
    Carcinogenesis 31:1813-21. 2010
    ..These findings provide a novel mechanistic insight into the growth-inhibitory effects of lycopene in cancer...
  20. doi Lycopene regulation of cholesterol synthesis and efflux in human macrophages
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    J Nutr Biochem 22:971-8. 2011
    ....
  21. ncbi Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention
    P Palozza
    Institute of General Pathology, Catholic University, School of Medicine, Rome, Italy
    Curr Med Chem 18:1846-60. 2011
    ..Moreover, we speculate on the possible influence that lycopene may have as a redox agent in cancer...
  22. ncbi Solubilization and stabilization of beta-carotene in niosomes: delivery to cultured cells
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168, Rome, Italy
    Chem Phys Lipids 139:32-42. 2006
    ..1 to 2 microM. Therefore, niosomes provide a convenient, nontoxic and inexpensive vehicle for beta-carotene in cell culture...
  23. ncbi Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad
    P Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Apoptosis 10:1445-56. 2005
    ..This study suggests that lycopene, differently from beta-carotene, can exert protective effects against cigarette smoke condensate...
  24. ncbi beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Carcinogenesis 25:1315-25. 2004
    ..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate...
  25. ncbi Can beta-carotene regulate cell growth by a redox mechanism? An answer from cultured cells
    Paola Palozza
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Biochim Biophys Acta 1740:215-21. 2005
    ..In this context, it may regulate cell growth and death by the modulation of redox-sensitive genes and transcription factors...
  26. ncbi Design, synthesis, and antioxidant activity of FeAOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moieties
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Free Radic Biol Med 33:1724-35. 2002
    ..In the cell model, the compound also provides a higher antioxidant capacity than alpha-tocopherol and lycopene, alone or in combination, suggesting the possibility of an oxidative intramolecular cooperation...
  27. ncbi Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Nutr Cancer 47:76-87. 2003
    ..These results support a pharmacological role for beta-Carotene as a candidate antitumor agent and show a possible sequence of molecular events by which this molecule may induce apoptosis in tumor cells...
  28. ncbi Modulation of apoptotic signalling by carotenoids in cancer cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Arch Biochem Biophys 430:104-9. 2004
    ..This review summarizes the available evidence for a modulatory action of carotenoids on apoptosis and focuses on the main molecular pathways involved in this process...
  29. ncbi beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells
    P Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Free Radic Biol Med 30:1000-7. 2001
    ..These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties...
  30. ncbi DNA oxidative damage during differentiation of HL-60 human promyelocytic leukemia cells
    V Covacci
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, Faculty of Medicine, Catholic University of Sacred Heart, Rome, Italy
    Chem Res Toxicol 14:1492-7. 2001
    ..These results illustrate correlations between the oxidant/antioxidant balance and DNA damage and suggest that the capability of a cell population to withstand oxidative stress and DNA damage may depend on its degree of differentiation...
  31. ncbi Redox regulation of cell proliferation by pyrrolidine dithiocarbamate in murine thymoma cells transplanted in vivo
    F Di Nicuolo
    Institute of General Pathology, Catholic University, Rome, Italy
    Free Radic Biol Med 31:1424-31. 2001
    ..In addition, we suggest that the ability of PDTC to bind and transport metals inside the cell and its pro-oxidant property may be factors underlying its effects on thymoma cell proliferation and cell cycle distribution...
  32. doi Effect of beta-carotene-rich tomato lycopene beta-cyclase ( tlcy-b) on cell growth inhibition in HT-29 colon adenocarcinoma cells
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito, Roma, Italy
    Br J Nutr 102:207-14. 2009
    ....
  33. ncbi beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    J Nutr 135:129-36. 2005
    ..Here, we report that the suppression of COX-2 by beta-carotene may represent a molecular mechanism by which this compound acts as an antitumor agent in colon carcinogenesis...
  34. ncbi Mitogenic and apoptotic signaling by carotenoids: involvement of a redox mechanism
    P Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    IUBMB Life 52:77-81. 2001
    ..In particular, we report demonstrations for the anti-oxidant or pro-oxidant effects of carotenoids in vitro and in vivo, focusing our attention on the relationship existing between cell growth and redox status...
  35. ncbi Beta-carotene regulates NF-kappaB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    J Nutr 133:381-8. 2003
    ..These data suggest that the redox regulation of NF-kappaB induced by beta-carotene is involved in the growth-inhibitory and proapoptotic effects of the carotenoid in tumor cells...
  36. ncbi Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168 Rome, Italy
    Carcinogenesis 23:11-8. 2002
    ..In addition, since cell growth inhibitory effects were reached at beta-carotene concentrations achievable in vivo following its supplementation, this study provides a rational approach for the use of beta-carotene in colon cancer...
  37. ncbi Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Int J Cancer 97:593-600. 2002
    ..They also suggest that differentiated cells may be less susceptible to the carotenoid than highly neoplastic undifferentiated cells...
  38. ncbi Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2
    Gabriella Calviello
    Institute of General Pathology, Institute of Human Anatomy, Catholic University, Rome, Italy
    Carcinogenesis 28:1202-9. 2007
    ..The present study, thus, raises the possibility that DHA may exert pro-apoptotic and antitumoral effects through proteasomal regulation of beta-catenin levels and alterations in the expression of TCF-beta-catenin target genes...
  39. ncbi Regulation of magnesium content during proliferation of mammary epithelial cells (HC-11)
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Centre, Catholic University of Sacred Heart, Faculty of Medicine, L go F Vito, 1 00168 Rome, Italy
    Front Biosci 9:2056-62. 2004
    ....
  40. ncbi gamma-Tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c release
    Gabriella Calviello
    Institutes of General Pathology and Pathology, Catholic University, L go F Vito, 1 00168 Rome, Italy
    Carcinogenesis 24:427-33. 2003
    ..The late activation of caspase-8 and data showing the partial cleavage of pro-apoptotic protein BID suggest that the initial activation of caspase-9 may be potentiated by a feedback amplification loop involving the caspase-8/BID pathway...
  41. ncbi Prooxidant effects of beta-carotene in cultured cells
    Paola Palozza
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Mol Aspects Med 24:353-62. 2003
    ..This review summarizes the available evidence for a prooxidant activity of beta-carotene in cultured cells, focusing on biochemical and molecular markers of oxidative stress, which have been reported to be enhanced by the carotenoid...
  42. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  43. ncbi DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism
    Gabriella Calviello
    Institute of General Pathology, Catholic University L go F Vito, 1 00168 Rome, Italy
    Toxicol Appl Pharmacol 211:87-96. 2006
    ..On the other hand, the proapoptotic effect of Mancozeb suggests its possible relevance in the pathogenesis of neurodegenerative diseases, often related to the exposition of pesticides...
  44. ncbi Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168, Rome, Italy
    Cancer Chemother Pharmacol 55:12-20. 2005
    ....
  45. ncbi Repeated exposure to pyrrolidine-dithiocarbamate induces peripheral nerve alterations in rats
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Toxicol Lett 158:61-71. 2005
    ..The observation that a 15-day treatment with low doses of PDTC causes functional and morphological derangement of peripheral nerves advices against the possible use of this compound as a chemopreventive agent against cancer...
  46. ncbi Protective effects of Fe-Aox29, a novel antioxidant derived from a molecular combination of Idebenone and vitamin E, in immortalized fibroblasts and fibroblasts from patients with Friedreich Ataxia
    Matthias L Jauslin
    Santhera Pharmaceuticals, Hammerstrasse 47, Liestal 4410, Switzerland
    Mol Cell Biochem 302:79-85. 2007
    ..These results indicate, that idebenone and vitamin E might act synergistically to counteract oxidative stress in fibroblasts from FRDA patients...
  47. doi Role of the life span determinant P66(shcA) in ethanol-induced liver damage
    Osvaldo R Koch
    Department of Pathology, Faculty of Medicine University of Buenos Aires, Buenos Aires, Argentina
    Lab Invest 88:750-60. 2008
    ..Taken together, the above observations clearly indicate a role for p66 in alcohol-induced cell damage, likely via a cell-autonomous mechanism involving reduced expression of antioxidant defenses and mitochondrial dysfunction...
  48. ncbi Is there a room for vitamins?
    Tommaso Galeotti
    Mol Aspects Med 24:315-6. 2003
  49. ncbi Antioxidant effect of FeAOX-6 on free radical species produced during iron catalyzed breakdown of tert-butyl hydroperoxide
    Cristina Rota
    University of Modena and Reggio Emilia, Department of Biomedical Sciences, Modena, Italy
    Free Radic Res 40:141-6. 2006
    ..Lycopene is able to quench alkoxyl radical, while it has no effect on peroxyl radical, showing a different antioxidant activity compared to other carotenoids, such as beta-carotene and lutein...
  50. ncbi Antioxidant effect of ferulic acid in isolated membranes and intact cells: synergistic interactions with alpha-tocopherol, beta-carotene, and ascorbic acid
    Sonia Trombino
    Department of Pharmaceutical Sciences, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy
    J Agric Food Chem 52:2411-20. 2004
    ..Synergistic interactions were observed when the compound was used in combination with the other antioxidants, suggesting that they can cooperate in preserving physiological integrity of cells exposed to free radicals...