Research Topics
| P PalozzaSummaryAffiliation: Catholic University Country: Italy Publications
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Publications
Effect of lycopene and tomato products on cholesterol metabolismP Palozza
Institute of General Pathology, School of Medicine, Catholic University, Rome, Italy
Ann Nutr Metab 61:126-34. 2012..There is also a need for more well-designed human dietary intervention studies to better clarify the role of lycopene as a hypocholesterolemic agent...- Lycopene modulation of molecular targets affected by smoking exposureP Palozza
Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
Curr Cancer Drug Targets 12:640-57. 2012..This review summarizes the background information about the interactions of lycopene with smoke in experimental models and presents the most current knowledge with respect to lycopene role in smoke-related diseases... - Lycopene as a guardian of redox signallingPaola Palozza
Institute of General Pathology, Catholic University, School of Medicine, Rome, Italy
Acta Biochim Pol 59:21-5. 2012..Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2... - Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smokePaola Palozza
Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 100168 Rome, Italy
Inflamm Allergy Drug Targets 11:36-47. 2012..Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-κB are involved... - Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2P Palozza
Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
Carcinogenesis 27:2383-91. 2006..These data point out that the carotenoid may enhance cigarette smoke-induced oxidative stress and exert potential deleterious effects at the pO2 normally present in lung tissue... - beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growthPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
Antioxid Redox Signal 8:1069-80. 2006.... - Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophagesPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
Free Radic Biol Med 42:1579-90. 2007..These data suggest a possible antiatherogenic role of beta-carotene through the prevention of 7-KC toxicity in human macrophages... - Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cellsPaola Palozza
Institute of General Pathology, Catholic University, 00168, Rome, Italy
Mol Cell Biochem 287:21-32. 2006..In view of these results, FeAox-6 represents a new potential preventive agent in chronic diseases in which oxidative stress plays a pathogenic role... - The protective role of carotenoids against 7-keto-cholesterol formation in solutionPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, 00168 Rome, Italy
Mol Cell Biochem 309:61-8. 2008.... 
Design, synthesis, and antioxidant potency of novel alpha-tocopherol analogues in isolated membranes and intact cellsPaola Palozza
Institute of General Pathology, Catholic University, 00168 Rome, Italy
Free Radic Biol Med 44:1452-64. 2008..3) The presence of polyunsaturated double bonds in the side chain in the Z configuration (FEBL-53, FEBL-162) increased the antioxidant potency of the molecule with respect to the E configuration (FEBL-50, FEBL-161)...- Interplay of carotenoids with cigarette smoking: implications in lung cancerPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, Rome, Italy
Curr Med Chem 15:844-54. 2008..This review summarizes the available evidences in cultured cells, animal models and humans for a modulatory action of carotenoids on the dangerous effects of smoke and focuses on the main molecular pathways involved in this process... - The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xLPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Largo F Vito, 1 00168 Rome, Italy
Br J Nutr 98:789-95. 2007..Moreover, we have shown that tomato digestate is able to inhibit the growth of colon cancer cells by modulating the expression of regulators of the cell cycle and apoptosis... - The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cellsPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, Rome 00168, Italy
Carcinogenesis 29:2153-61. 2008..All together, these data suggest that the modulation of cav-1 pathway by beta-carotene could be a novel mechanism by which the carotenoid acts as a potent growth-inhibitory agent in cancer cells... - Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophagesPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, 1 00168 Rome, Italy
J Nutr Biochem 21:34-46. 2010..Our study suggests that lycopene may act as a potential antiatherogenic agent by preventing 7-KC-induced oxidative stress and apoptosis in human macrophages... - Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cellsPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
Cancer Lett 283:108-17. 2009..Growth-inhibitory effects by H. pluvialis were also observed in HT-29, LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer... - Tomato lycopene and inflammatory cascade: basic interactions and clinical implicationsP Palozza
Institute of General Pathology, Catholic University, School of Medicine, Lgo F Vito, 1 00168 Rome, Italy
Curr Med Chem 17:2547-63. 2010..A clear understanding of the molecular mechanisms of action of lycopene is crucial in the valuation of this molecule as a potential preventive and therapeutic agent... - Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expressionPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
J Nutr Biochem 22:259-68. 2011..Taken all together, these data bring new information on the anti-atherogenic properties of lycopene, and on its mechanisms of action in atherosclerosis prevention... - Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studiesPaola Palozza
Institute of General Pathology, Catholic University, School of Medicine, L go F Vito, 1 00168 Rome, Italy
Arch Biochem Biophys 504:26-33. 2010..Focusing on cell culture studies, this review summarizes the experimental evidence for a role of lycopene in the different phases of atherosclerotic process... - Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell linesPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 00168 Rome, Italy
Carcinogenesis 31:1813-21. 2010..These findings provide a novel mechanistic insight into the growth-inhibitory effects of lycopene in cancer... - Lycopene regulation of cholesterol synthesis and efflux in human macrophagesPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
J Nutr Biochem 22:971-8. 2011.... - Role of lycopene in the control of ROS-mediated cell growth: implications in cancer preventionP Palozza
Institute of General Pathology, Catholic University, School of Medicine, Rome, Italy
Curr Med Chem 18:1846-60. 2011..Moreover, we speculate on the possible influence that lycopene may have as a redox agent in cancer... - Solubilization and stabilization of beta-carotene in niosomes: delivery to cultured cellsPaola Palozza
Institute of General Pathology, Catholic University, 00168, Rome, Italy
Chem Phys Lipids 139:32-42. 2006..1 to 2 microM. Therefore, niosomes provide a convenient, nontoxic and inexpensive vehicle for beta-carotene in cell culture... - Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBadP Palozza
Institute of General Pathology, Catholic University, Rome, Italy
Apoptosis 10:1445-56. 2005..This study suggests that lycopene, differently from beta-carotene, can exert protective effects against cigarette smoke condensate... - beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensatePaola Palozza
Institute of General Pathology, Catholic University, Rome, Italy
Carcinogenesis 25:1315-25. 2004..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate... - Can beta-carotene regulate cell growth by a redox mechanism? An answer from cultured cellsPaola Palozza
Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
Biochim Biophys Acta 1740:215-21. 2005..In this context, it may regulate cell growth and death by the modulation of redox-sensitive genes and transcription factors... - Design, synthesis, and antioxidant activity of FeAOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moietiesPaola Palozza
Institute of General Pathology, Catholic University, Rome, Italy
Free Radic Biol Med 33:1724-35. 2002..In the cell model, the compound also provides a higher antioxidant capacity than alpha-tocopherol and lycopene, alone or in combination, suggesting the possibility of an oxidative intramolecular cooperation... - Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cellsPaola Palozza
Institute of General Pathology, Catholic University, Largo F Vito 1, 00168 Rome, Italy
Nutr Cancer 47:76-87. 2003..These results support a pharmacological role for beta-Carotene as a candidate antitumor agent and show a possible sequence of molecular events by which this molecule may induce apoptosis in tumor cells... - Modulation of apoptotic signalling by carotenoids in cancer cellsPaola Palozza
Institute of General Pathology, Catholic University, Rome, Italy
Arch Biochem Biophys 430:104-9. 2004..This review summarizes the available evidence for a modulatory action of carotenoids on apoptosis and focuses on the main molecular pathways involved in this process... - beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cellsP Palozza
Institute of General Pathology, Catholic University, Rome, Italy
Free Radic Biol Med 30:1000-7. 2001..These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties... - DNA oxidative damage during differentiation of HL-60 human promyelocytic leukemia cellsV Covacci
Institute of General Pathology and Giovanni XXIII Cancer Research Center, Faculty of Medicine, Catholic University of Sacred Heart, Rome, Italy
Chem Res Toxicol 14:1492-7. 2001..These results illustrate correlations between the oxidant/antioxidant balance and DNA damage and suggest that the capability of a cell population to withstand oxidative stress and DNA damage may depend on its degree of differentiation... - Redox regulation of cell proliferation by pyrrolidine dithiocarbamate in murine thymoma cells transplanted in vivoF Di Nicuolo
Institute of General Pathology, Catholic University, Rome, Italy
Free Radic Biol Med 31:1424-31. 2001..In addition, we suggest that the ability of PDTC to bind and transport metals inside the cell and its pro-oxidant property may be factors underlying its effects on thymoma cell proliferation and cell cycle distribution... - Effect of beta-carotene-rich tomato lycopene beta-cyclase ( tlcy-b) on cell growth inhibition in HT-29 colon adenocarcinoma cellsPaola Palozza
Institute of General Pathology, Catholic University School of Medicine, Largo F Vito, Roma, Italy
Br J Nutr 102:207-14. 2009.... - beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cellsPaola Palozza
Institute of General Pathology, Catholic University, Rome, Italy
J Nutr 135:129-36. 2005..Here, we report that the suppression of COX-2 by beta-carotene may represent a molecular mechanism by which this compound acts as an antitumor agent in colon carcinogenesis... - Mitogenic and apoptotic signaling by carotenoids: involvement of a redox mechanismP Palozza
Institute of General Pathology, Catholic University, Rome, Italy
IUBMB Life 52:77-81. 2001..In particular, we report demonstrations for the anti-oxidant or pro-oxidant effects of carotenoids in vitro and in vivo, focusing our attention on the relationship existing between cell growth and redox status... - Beta-carotene regulates NF-kappaB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cellsPaola Palozza
Institute of General Pathology, Catholic University, Rome, Italy
J Nutr 133:381-8. 2003..These data suggest that the redox regulation of NF-kappaB induced by beta-carotene is involved in the growth-inhibitory and proapoptotic effects of the carotenoid in tumor cells... - Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteinsPaola Palozza
Institute of General Pathology, Catholic University, 00168 Rome, Italy
Carcinogenesis 23:11-8. 2002..In addition, since cell growth inhibitory effects were reached at beta-carotene concentrations achievable in vivo following its supplementation, this study provides a rational approach for the use of beta-carotene in colon cancer... - Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanismPaola Palozza
Institute of General Pathology, Catholic University, Rome, Italy
Int J Cancer 97:593-600. 2002..They also suggest that differentiated cells may be less susceptible to the carotenoid than highly neoplastic undifferentiated cells... - Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2Gabriella Calviello
Institute of General Pathology, Institute of Human Anatomy, Catholic University, Rome, Italy
Carcinogenesis 28:1202-9. 2007..The present study, thus, raises the possibility that DHA may exert pro-apoptotic and antitumoral effects through proteasomal regulation of beta-catenin levels and alterations in the expression of TCF-beta-catenin target genes... - Regulation of magnesium content during proliferation of mammary epithelial cells (HC-11)Federica I Wolf
Institute of General Pathology and Giovanni XXIII Cancer Research Centre, Catholic University of Sacred Heart, Faculty of Medicine, L go F Vito, 1 00168 Rome, Italy
Front Biosci 9:2056-62. 2004.... - gamma-Tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c releaseGabriella Calviello
Institutes of General Pathology and Pathology, Catholic University, L go F Vito, 1 00168 Rome, Italy
Carcinogenesis 24:427-33. 2003..The late activation of caspase-8 and data showing the partial cleavage of pro-apoptotic protein BID suggest that the initial activation of caspase-9 may be potentiated by a feedback amplification loop involving the caspase-8/BID pathway... - Prooxidant effects of beta-carotene in cultured cellsPaola Palozza
Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
Mol Aspects Med 24:353-62. 2003..This review summarizes the available evidence for a prooxidant activity of beta-carotene in cultured cells, focusing on biochemical and molecular markers of oxidative stress, which have been reported to be enhanced by the carotenoid... - n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathwayGabriella Calviello
Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
Carcinogenesis 25:2303-10. 2004..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed... - DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanismGabriella Calviello
Institute of General Pathology, Catholic University L go F Vito, 1 00168 Rome, Italy
Toxicol Appl Pharmacol 211:87-96. 2006..On the other hand, the proapoptotic effect of Mancozeb suggests its possible relevance in the pathogenesis of neurodegenerative diseases, often related to the exposition of pesticides... - Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracilGabriella Calviello
Institute of General Pathology, Catholic University, L go F Vito, 1, 00168, Rome, Italy
Cancer Chemother Pharmacol 55:12-20. 2005.... - Repeated exposure to pyrrolidine-dithiocarbamate induces peripheral nerve alterations in ratsGabriella Calviello
Institute of General Pathology, Catholic University, L.go F. Vito 1, 00168 Rome, Italy
Toxicol Lett 158:61-71. 2005..The observation that a 15-day treatment with low doses of PDTC causes functional and morphological derangement of peripheral nerves advices against the possible use of this compound as a chemopreventive agent against cancer... - Protective effects of Fe-Aox29, a novel antioxidant derived from a molecular combination of Idebenone and vitamin E, in immortalized fibroblasts and fibroblasts from patients with Friedreich AtaxiaMatthias L Jauslin
Santhera Pharmaceuticals, Hammerstrasse 47, Liestal 4410, Switzerland
Mol Cell Biochem 302:79-85. 2007..These results indicate, that idebenone and vitamin E might act synergistically to counteract oxidative stress in fibroblasts from FRDA patients... - Role of the life span determinant P66(shcA) in ethanol-induced liver damageOsvaldo R Koch
Department of Pathology, Faculty of Medicine University of Buenos Aires, Buenos Aires, Argentina
Lab Invest 88:750-60. 2008..Taken together, the above observations clearly indicate a role for p66 in alcohol-induced cell damage, likely via a cell-autonomous mechanism involving reduced expression of antioxidant defenses and mitochondrial dysfunction... - Is there a room for vitamins?Tommaso Galeotti
Mol Aspects Med 24:315-6. 2003 - Antioxidant effect of FeAOX-6 on free radical species produced during iron catalyzed breakdown of tert-butyl hydroperoxideCristina Rota
University of Modena and Reggio Emilia, Department of Biomedical Sciences, Modena, Italy
Free Radic Res 40:141-6. 2006..Lycopene is able to quench alkoxyl radical, while it has no effect on peroxyl radical, showing a different antioxidant activity compared to other carotenoids, such as beta-carotene and lutein... - Antioxidant effect of ferulic acid in isolated membranes and intact cells: synergistic interactions with alpha-tocopherol, beta-carotene, and ascorbic acidSonia Trombino
Department of Pharmaceutical Sciences, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy
J Agric Food Chem 52:2411-20. 2004..Synergistic interactions were observed when the compound was used in combination with the other antioxidants, suggesting that they can cooperate in preserving physiological integrity of cells exposed to free radicals...