Affiliation: Catholic University
Palozza P, Simone R, Catalano A, Boninsegna A, Böhm V, Fröhlich K, et al
. Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J Nutr Biochem. 2010;21:34-46 pubmed publisher
..Our study suggests that lycopene may act as a potential antiatherogenic agent by preventing 7-KC-induced oxidative stress and apoptosis in human macrophages. ..
Palozza P, Parrone N, Catalano A, Simone R. Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications. Curr Med Chem. 2010;17:2547-63 pubmed
..A clear understanding of the molecular mechanisms of action of lycopene is crucial in the valuation of this molecule as a potential preventive and therapeutic agent. ..
Palozza P, Parrone N, Simone R, Catalano A. Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention. Curr Med Chem. 2011;18:1846-60 pubmed
..Moreover, we speculate on the possible influence that lycopene may have as a redox agent in cancer. ..
Palozza P, Simone R, Catalano A, Saraceni F, Celleno L, Mele M, et al
. Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke. Inflamm Allergy Drug Targets. 2012;11:36-47 pubmed
..Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-?B are involved. ..
Palozza P, Serini S, Di Nicuolo F, Boninsegna A, Torsello A, Maggiano N, et al
. beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. Carcinogenesis. 2004;25:1315-25 pubmed
..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate. ..
Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele M, et al
. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009;283:108-17 pubmed publisher
..Growth-inhibitory effects by H. pluvialis were also observed in HT-29, LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer. ..
Palozza P, Sheriff A, Serini S, Boninsegna A, Maggiano N, Ranelletti F, et al
. Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad. Apoptosis. 2005;10:1445-56 pubmed
..This study suggests that lycopene, differently from beta-carotene, can exert protective effects against cigarette smoke condensate. ..
Palozza P, Barone E, Mancuso C, Picci N. The protective role of carotenoids against 7-keto-cholesterol formation in solution. Mol Cell Biochem. 2008;309:61-8 pubmed
Palozza P, Sestito R, Picci N, Lanza P, Monego G, Ranelletti F. The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cells. Carcinogenesis. 2008;29:2153-61 pubmed publisher
..All together, these data suggest that the modulation of cav-1 pathway by beta-carotene could be a novel mechanism by which the carotenoid acts as a potent growth-inhibitory agent in cancer cells. ..