R Pallini

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor
    Francesco Facchiano
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Rome, Italy
    J Neurosurg 97:161-8. 2002
  2. doi request reprint Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Cancer 117:162-74. 2011
  3. ncbi request reprint Phenotypic change of human cultured meningioma cells
    R Pallini
    Institute of Neurosurgery, CNR, Rome, Italy
    J Neurooncol 49:9-17. 2000
  4. ncbi request reprint Evidence for telomerase involvement in the angiogenesis of astrocytic tumors: expression of human telomerase reverse transcriptase messenger RNA by vascular endothelial cells
    R Pallini
    Istituto di Neurochirurgia, Universita Cattolica, Rome, Italy
    J Neurosurg 94:961-71. 2001
  5. ncbi request reprint Telomerase inhibition by stable RNA interference impairs tumor growth and angiogenesis in glioblastoma xenografts
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Int J Cancer 118:2158-67. 2006
  6. ncbi request reprint Chordoma of the skull base: predictors of tumor recurrence
    Roberto Pallini
    Institute of Neurosurgery, Departmnet of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurosurg 98:812-22. 2003
  7. ncbi request reprint Homologous transplantation of neural stem cells to the injured spinal cord of mice
    Roberto Pallini
    Department of Neurosurgery, Laboratory for Neural Stem Cells, Center for Research on Regeneration of the Nervous System, Catholic University School of Medicine, Rome, Italy
    Neurosurgery 57:1014-25; discussion 1014-25. 2005
  8. pmc Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas
    C Ciceroni
    IRCCS San Raffaele Pisana, Rome, Italy
    Cell Death Differ 20:396-407. 2013
  9. doi request reprint Mesenchymal differentiation of glioblastoma stem cells
    L Ricci-Vitiani
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:1491-8. 2008
  10. ncbi request reprint Microsatellite instability in primary brain tumors
    E Alvino
    Institute of Experimental Medicine, National Council of Research CNR, Rome, Italy
    Neurol Res 22:571-5. 2000

Collaborators

  • Liverana Lauretti
  • E Fernandez
  • G Maira
  • Carlo Cenciarelli
  • Nicola Montano
  • M L Falchetti
  • Luca Massimi
  • L Denaro
  • F Salvinelli
  • E Alvino
  • S Giannetti
  • Giuseppe Luigi Banna
  • C Zona
  • Valeria Di Giorgi Gerevini
  • Lucio Crino
  • M Miscusi
  • Rossana Romani
  • M Mehta
  • L Aloe
  • Lucia Ricci-Vitiani
  • Patrizia Casalbore
  • C Ciceroni
  • L Ricci-Vitiani
  • Ruggero De Maria
  • R De Maria
  • Giovanna Petrucci
  • Luigi Maria Larocca
  • Luigi M Larocca
  • D Melchiorri
  • G Battaglia
  • A Arcella
  • E Mastrantoni
  • L M Larocca
  • F Nicoletti
  • Cristiana Mollinari
  • Corrado Lucantoni
  • Maurizio Martini
  • Manuela Budoni
  • Marcello D'Ascenzo
  • Cesare Peschle
  • Adriana Eramo
  • Francesco Doglietto
  • Gelsomina De Stasio
  • Francesco Facchiano
  • M Bonelli
  • P Spinsanti
  • A Traficante
  • M Laurenza
  • C Niccolini
  • Daniela Merlo
  • Anna Maria Rinaldi
  • Massimo Pieri
  • Luisa Milazzo
  • Mauro Racaniello
  • Elisabetta Tabolacci
  • Enrico Garaci
  • P Sale
  • M A Oliva
  • F Pierconti
  • F Santoro
  • G Petrucci
  • G Carpinelli
  • D G Lombardi
  • P Mosillo
  • Giuseppe Luongo
  • Tonia Cenci
  • M Signore
  • F Giangaspero
  • Claudio Grassi
  • Eugenio Parati
  • Gian Battista Azzena
  • Roberto Piacentini
  • Valeria Di Giorgio Gerevini
  • Quintino Giorgio D'Alessandris
  • Dario Giuseppe Lombardi
  • Francesco Pierconti
  • Katherine L Richter
  • Fiorenza Lotti
  • Mary K Gilles
  • Monica Bartucci
  • John F Crawford
  • Deepika Rajesh
  • Rachel J Cannara
  • Bradley H Frazer
  • Delio Mercanti
  • Mariella Patti
  • Robert J Erhardt
  • Sebastien Schaub
  • Benjamin Gilbert
  • Michele Signore

Detail Information

Publications36

  1. ncbi request reprint Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor
    Francesco Facchiano
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Rome, Italy
    J Neurosurg 97:161-8. 2002
    ..Because most growth factors are rapidly inactivated in the extracellular environment, the authors used an adenovirus coding for VEGF165 to maintain its activity for several days...
  2. doi request reprint Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Cancer 117:162-74. 2011
    ..To date, however, there is no clinical evidence that the fraction of CD133-positive cells in glioblastoma that recurs after radiochemotherapy may be relevant for prognosis...
  3. ncbi request reprint Phenotypic change of human cultured meningioma cells
    R Pallini
    Institute of Neurosurgery, CNR, Rome, Italy
    J Neurooncol 49:9-17. 2000
    ..Our results show that phenotypic changes on human meningioma cells may occur in vitro. This phenomenon suggests caution when transposing the in vitro results to the in vivo condition...
  4. ncbi request reprint Evidence for telomerase involvement in the angiogenesis of astrocytic tumors: expression of human telomerase reverse transcriptase messenger RNA by vascular endothelial cells
    R Pallini
    Istituto di Neurochirurgia, Universita Cattolica, Rome, Italy
    J Neurosurg 94:961-71. 2001
    ....
  5. ncbi request reprint Telomerase inhibition by stable RNA interference impairs tumor growth and angiogenesis in glioblastoma xenografts
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Int J Cancer 118:2158-67. 2006
    ..Tumor xenografts that arose from telomerase-inhibited GBM cells also showed a less-malignant phenotype due both to the absence of massive necrosis and to reduced angiogenesis...
  6. ncbi request reprint Chordoma of the skull base: predictors of tumor recurrence
    Roberto Pallini
    Institute of Neurosurgery, Departmnet of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurosurg 98:812-22. 2003
    ..The classic pathological paradigms are poor predictors of outcome, and additional markers are needed to identify patients at risk for early tumor recurrence. In this study the authors describe such a marker...
  7. ncbi request reprint Homologous transplantation of neural stem cells to the injured spinal cord of mice
    Roberto Pallini
    Department of Neurosurgery, Laboratory for Neural Stem Cells, Center for Research on Regeneration of the Nervous System, Catholic University School of Medicine, Rome, Italy
    Neurosurgery 57:1014-25; discussion 1014-25. 2005
    ..In addition, we investigated whether transduced NSCs over-expressing vascular endothelial growth factor might exert any angiogenetic effect in the injured SC...
  8. pmc Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas
    C Ciceroni
    IRCCS San Raffaele Pisana, Rome, Italy
    Cell Death Differ 20:396-407. 2013
    ....
  9. doi request reprint Mesenchymal differentiation of glioblastoma stem cells
    L Ricci-Vitiani
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:1491-8. 2008
    ..The discovery of such biological properties might provide considerable information to the development of new therapeutic strategies aimed at forcing glioblastoma stem cell differentiation...
  10. ncbi request reprint Microsatellite instability in primary brain tumors
    E Alvino
    Institute of Experimental Medicine, National Council of Research CNR, Rome, Italy
    Neurol Res 22:571-5. 2000
    ....
  11. doi request reprint Type-3 metabotropic glutamate receptors negatively modulate bone morphogenetic protein receptor signaling and support the tumourigenic potential of glioma-initiating cells
    C Ciceroni
    I R C C S San Raffaele Pisana, Rome, Italy
    Neuropharmacology 55:568-76. 2008
    ..These findings pave the way to a new non-cytotoxic treatment of malignant gliomas based on the use of mGlu3 receptor antagonists...
  12. ncbi request reprint Telomerase in brain tumors
    M L Falchetti
    Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx 15, 00137 Rome, Italy
    Childs Nerv Syst 18:112-7. 2002
    ..Thus, the assessment of the role of telomerase activity in neoplastic transformation has become a key issue in oncology, as stated by the exponential increase of papers on telomerase in the last 5 years...
  13. ncbi request reprint Telomerase inhibition impairs tumor growth in glioblastoma xenografts
    Maria Laura Falchetti
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    Neurol Res 28:532-7. 2006
    ..On the contrary, development of tumors upon subcutaneously grafting of U87MG and TB10 cells and intracranial implantation of U87MG cells in nude athymic mice was strongly reduced by telomerase inhibition...
  14. doi request reprint Downregulation of thymosin beta4 in neural progenitor grafts promotes spinal cord regeneration
    Cristiana Mollinari
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Cell Sci 122:4195-207. 2009
    ..Moreover, NPCs with reduced Tbeta4 levels generate an L1-enriched environment in the lesioned spinal cord that favors growth and sprouting of spared host axons and enhances the endogenous tissue-repair processes...
  15. doi request reprint Teaching NeuroImage: hemorrhagic ependymoma in the elderly: a rare cause of headache and gait imbalance
    N Montano
    Institute of Neurosurgery, Catholic University School of Medicine, Largo Agostino Gemelli, 8, 00168 Rome, Italy
    Neurology 70:e95. 2008
  16. ncbi request reprint Reinnervation of extraocular muscles by facial-to-oculomotor nerve anastomosis in rats: anatomic nuclear changes
    Eduardo Fernandez
    Department of Neurosurgery, Catholic University, Rome, Italy
    Neurosurgery 53:409-14; discussion 414-5. 2003
    ..Here, we present an experimental anatomic study in rats related to the motor nuclear organization after facial-to-oculomotor nerve anastomosis...
  17. ncbi request reprint Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts
    Maria Laura Falchetti
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    Int J Cancer 122:1236-42. 2008
    ..Our data demonstrate that telomerase upregulation by the ECs is a key requisite for GBM tumor angiogenesis...
  18. ncbi request reprint The adult "paraplegic" rat: treatment with cell graftings
    Eduardo Fernandez
    Department of Neurosurgery, Center of Research on Regeneration in the Nervous System, Catholic University School of Medicine, 00168 Rome, Italy
    Surg Neurol 65:223-37. 2006
    ..Function and anatomic results are undisputed only after spinal cord transection...
  19. doi request reprint Lower trunk of brachial plexus injury in the neonate rat: effects of timing repair
    Liverana Lauretti
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Neurol Res 31:518-27. 2009
    ..In this study, we investigated the functional and anatomical results after immediate and delayed repair of the lower trunk of brachial plexus (BP) sectioned at birth in rats...
  20. ncbi request reprint Long survival in an untreated solitary choroid plexus metastasis from renal cell carcinoma: case report and review of the literature
    Liverana Lauretti
    Department of Neurosurgery, Catholic University School of Medicine, Largo Agostino Gemelli 8, 00168, Rome, Italy
    J Neurooncol 71:157-60. 2005
    ..To our knowledge, this 46 months survival is the longest survival of a patient affected by a single choroid plexus metastasis from RCC...
  21. ncbi request reprint Motoneurons innervating facial muscles after hypoglossal and hemihypoglossal-facial nerve anastomosis in rats
    Eduardo Fernandez
    Center of Research on Regeneration in the Nervous System, Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Neurol Res 26:395-400. 2004
    ..No labeled motoneurons were seen contralaterally as we observed previously after section and repair of several nerves...
  22. ncbi request reprint Primary hemorrhagic intramedullary melanoma. Case report with emphasis on the difficult preoperative diagnosis
    L Denaro
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurosurg Sci 51:181-3. 2007
    ..We report this case to underline the importance and difficulties concerning the preoperative diagnosis of a hemorrhagic intramedullary lesion...
  23. ncbi request reprint Acrylic hydrogel implants after spinal cord lesion in the adult rat
    S Giannetti
    Institute of Anatomy, Catholic University Medical School, Rome, Italy
    Neurol Res 23:405-9. 2001
    ..These results demonstrate that poly-2-hydroxyethyl methacrylate sponges represent a safe supportive material for regenerating spinal cord axons...
  24. ncbi request reprint Radial nerve palsy caused by spontaneously occurring nerve torsion. Case report
    E Fernandez
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurosurg 94:627-9. 2001
    ..Straightening of the twisted nerve and fixation accomplished using epiperineurium-fascia stitches to avoid a new torsion resulted in complete functional recovery of the radial nerve...
  25. pmc Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1
    Patrizia Casalbore
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    PLoS ONE 4:e4434. 2009
    ..However, the constitutive activation of the cellular machinery required to bypass apoptosis and senescence places these cells at risk for malignant transformation...
  26. doi request reprint Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    Roberto Pallini
    Department of Neurosurgery, Catholic University of Rome, Rome, Italy
    Clin Cancer Res 14:8205-12. 2008
    ..The stem cell antigen CD133 identifies such a tumorigenic population in a subset of glioblastoma patients. We conducted a prospective study to explore the prognostic potential of CSC analysis in glioblastoma patients...
  27. ncbi request reprint Establishing tumor cell lines from aggressive telomerase-positive chordomas of the skull base. Technical note
    Lucia Ricci-Vitiani
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    J Neurosurg 105:482-4. 2006
    ..In vitro, chordoma cells overexpressed telomerase, supporting the hypothesis that this enzyme is required for the immortalization process...
  28. ncbi request reprint Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord
    Lucia Ricci-Vitiani
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Neurol Res 28:488-92. 2006
    ..Here, we tested the hypothesis that inflammatory cytokines (ICs) may be involved in the restricted differentiation of NSCs after grafting onto the injured SC...
  29. ncbi request reprint Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction
    Adriana Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cancer Res 65:11469-77. 2005
    ..Thus, the combination of TRAIL and demethylating agents may provide a key tool to overcome glioblastoma resistance to therapeutic treatments...
  30. ncbi request reprint In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system
    Carlo Cenciarelli
    Istituto di Neurochirurgia, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, Roma 00168, Italy
    Neurol Res 28:505-12. 2006
    ..We obtained NSC-derived cell lines which express human NGF in relevant amount to exploit their ability for therapeutic applications...
  31. ncbi request reprint Clivus chordoma associated with a pontine arachnoid cyst
    Francesco Doglietto
    Institute of Neurosurgery, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Lancet Oncol 6:536. 2005
  32. doi request reprint Clivus metastases: report of seven patients and literature review
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Roma, Italy
    Acta Neurochir (Wien) 151:291-6; discussion 296. 2009
    ..Here, we describe seven such examples and review the pertinent literature...
  33. doi request reprint Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme
    Maurizio Martini
    Department of Pathology, Catholic University of Sacred Heart, Rome, Italy
    Int J Cancer 123:2955-60. 2008
    ..0002). Our data suggest that methylation of SOCS3 may be involved in the pathogenesis of GBM and in the resistance of this neoplasm to conventional treatment...
  34. ncbi request reprint Glioblastoma induces vascular endothelial cells to express telomerase in vitro
    Maria Laura Falchetti
    Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle Ricerche, Rome 00137, Italy
    Cancer Res 63:3750-4. 2003
    ..These results provide strong evidence of the involvement of telomerase in tumor angiogenesis and will stimulate research on antitelomerase drugs for treatment of malignant brain gliomas...
  35. ncbi request reprint Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation
    Marcello D'Ascenzo
    Institute of Human Physiology, Medical School, Catholic University S Cuore, Largo F Vito 1, I 00168 Rome, Italy
    Eur J Neurosci 23:935-44. 2006
    ....
  36. ncbi request reprint Are gadolinium contrast agents suitable for gadolinium neutron capture therapy?
    Gelsomina De Stasio
    University of Wisconsin Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton, WI 53589, USA
    Neurol Res 27:387-98. 2005
    ..Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd compounds commonly used for magnetic resonance imaging, to evaluate their potential as GdNCT agents...