Graziano Onder

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint High prevalence of poor quality drug prescribing in older individuals: a nationwide report from the Italian Medicines Agency (AIFA)
    Graziano Onder
    Centro Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Roma, Italy
    J Gerontol A Biol Sci Med Sci 69:430-7. 2014
  2. doi request reprint Drug use and iatrogenic illness in complex older adults with kidney disease
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Nephrol 25:S32-7. 2012
  3. doi request reprint Polypharmacy in nursing home in Europe: results from the SHELTER study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Roma, Italy
    J Gerontol A Biol Sci Med Sci 67:698-704. 2012
  4. pmc Assessment of nursing home residents in Europe: the Services and Health for Elderly in Long TERm care (SHELTER) study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica Sacro Cuore, Rome, Italy
    BMC Health Serv Res 12:5. 2012
  5. pmc Physicians' knowledge of health-related quality of life and perception of its importance in daily clinical practice
    Maurizio Bossola
    Department of Surgery, Catholic University of the Sacred Heart, Largo A Gemelli, 8 00168, Rome, Italy
    Health Qual Life Outcomes 8:43. 2010
  6. ncbi request reprint Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, L go Francesco Vito 1, 00168, Roma, Italy
    Eur J Clin Pharmacol 59:157-62. 2003
  7. ncbi request reprint Adverse drug reactions and cognitive function among hospitalized older adults
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur J Clin Pharmacol 58:371-7. 2002
  8. ncbi request reprint Preoperative assessment and risk factors in the surgical treatment of lung cancer: the role of age
    Graziano Onder
    Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Centro Medicina dell Invecchiamento Università Cattolica Sacro Cuore, Policlinico A Gemelli, Roma, Italy
    Rays 29:407-11. 2004
  9. ncbi request reprint Impact of inappropriate drug use among hospitalized older adults
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, L go Francesco Vito 1, 00168, Roma, Italy
    Eur J Clin Pharmacol 61:453-9. 2005
  10. ncbi request reprint Association between pain and depression among older adults in Europe: results from the Aged in Home Care (AdHOC) project: a cross-sectional study
    Graziano Onder
    Department of Gerontologic Science, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Psychiatry 66:982-8. 2005

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint High prevalence of poor quality drug prescribing in older individuals: a nationwide report from the Italian Medicines Agency (AIFA)
    Graziano Onder
    Centro Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Roma, Italy
    J Gerontol A Biol Sci Med Sci 69:430-7. 2014
    ..The present study describes a set of prescribing quality indicators developed by the Geriatrics Working Group of the Italian Medicines Agency (AIFA) and estimates their prevalence in the entire elderly (≥ 65 years) population in Italy...
  2. doi request reprint Drug use and iatrogenic illness in complex older adults with kidney disease
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Nephrol 25:S32-7. 2012
    ..For this reason, a complete and global examination of patient characteristics is mandatory in the drug prescribing process. Assessment of renal function must be considered part of this process...
  3. doi request reprint Polypharmacy in nursing home in Europe: results from the SHELTER study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Roma, Italy
    J Gerontol A Biol Sci Med Sci 67:698-704. 2012
    ..This study assesses prevalence and patients characteristics related to polypharmacy in a sample of nursing home residents...
  4. pmc Assessment of nursing home residents in Europe: the Services and Health for Elderly in Long TERm care (SHELTER) study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica Sacro Cuore, Rome, Italy
    BMC Health Serv Res 12:5. 2012
    ..to present the results about the test-retest and inter-rater reliability of the interRAI LTCF instrument translated into the languages of participating countries; 3 to illustrate the characteristics of NH residents at study entry...
  5. pmc Physicians' knowledge of health-related quality of life and perception of its importance in daily clinical practice
    Maurizio Bossola
    Department of Surgery, Catholic University of the Sacred Heart, Largo A Gemelli, 8 00168, Rome, Italy
    Health Qual Life Outcomes 8:43. 2010
    ..The present study aimed at assessing the level of knowledge of QoL and the perceived importance of incorporating QoL assessment in clinical practice among physicians of a tertiary level academic hospital in Rome, Italy...
  6. ncbi request reprint Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, L go Francesco Vito 1, 00168, Roma, Italy
    Eur J Clin Pharmacol 59:157-62. 2003
    ..To determine the prevalence of inappropriate medication use among hospitalized older adults and to identify predictors of this use...
  7. ncbi request reprint Adverse drug reactions and cognitive function among hospitalized older adults
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur J Clin Pharmacol 58:371-7. 2002
    ..To explore the relationship between cognitive function and the detection of adverse drug reactions (ADRs) and to evaluate whether cognitive function could influence the association between age and ADRs...
  8. ncbi request reprint Preoperative assessment and risk factors in the surgical treatment of lung cancer: the role of age
    Graziano Onder
    Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Centro Medicina dell Invecchiamento Università Cattolica Sacro Cuore, Policlinico A Gemelli, Roma, Italy
    Rays 29:407-11. 2004
    ....
  9. ncbi request reprint Impact of inappropriate drug use among hospitalized older adults
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, L go Francesco Vito 1, 00168, Roma, Italy
    Eur J Clin Pharmacol 61:453-9. 2005
    ..The objective of this study was to evaluate the impact of inappropriate drug use on all-cause mortality, adverse drug reactions (ADRs) and length of stay among in-hospital patients...
  10. ncbi request reprint Association between pain and depression among older adults in Europe: results from the Aged in Home Care (AdHOC) project: a cross-sectional study
    Graziano Onder
    Department of Gerontologic Science, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Psychiatry 66:982-8. 2005
    ..To assess the association between pain and depression in a population of older adults...
  11. ncbi request reprint Chewing problems and mortality in older adults in home care: results from the Aged in Home Care study
    Graziano Onder
    Department of Gerontology, Catholic University Sacred Heart, Rome, Italy
    J Am Geriatr Soc 55:1961-6. 2007
    ..To assess the association between chewing problems and risk of mortality in an older population receiving home care in Europe...
  12. ncbi request reprint Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Università Cattolica del Sacro Cuore Policlinico A Gemelli, L go Francesco Vito 1, 00168 Roma, Italy
    J Gerontol A Biol Sci Med Sci 60:74-9. 2005
    ..The authors evaluated the ability of upper and lower extremity performance measures to predict progressive and catastrophic disability in activities of daily living (ADL), mobility, and upper extremity function...
  13. ncbi request reprint Serum cholesterol levels and in-hospital mortality in the elderly
    Graziano Onder
    Department of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy
    Am J Med 115:265-71. 2003
    ..We explored whether total cholesterol levels were independently associated with in-hospital mortality among elderly patients...
  14. ncbi request reprint Association of calcium channel blocker use and pregnancy-associated plasma protein-A among older adults with hypertension: results from the ilSIRENTE study
    Graziano Onder
    Department of Geriatrics, Catholic University of the Sacred Heart, Italy
    J Gerontol A Biol Sci Med Sci 62:1274-8. 2007
    ..The aim of the present cross-sectional study was to evaluated if, among older hypertensive adults, PAPP-A levels differ according to use of CCB...
  15. ncbi request reprint Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA)
    G Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Cephalalgia 23:901-6. 2003
    ..44; 95% CI 0.20-0.95). In conclusion, this study suggests that among hypertensive subjects use of ACE inhibitors is associated with a reduced risk of headache caused by nitrates...
  16. ncbi request reprint Sexual satisfaction and risk of disability in older women
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, N C, USA
    J Clin Psychiatry 64:1177-82. 2003
    ....
  17. pmc Necrotizing pneumonia and sepsis due to Clostridium perfringens: a case report
    Cristina Palmacci
    Department of Geriatrics, Policlinico A, Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
    Cases J 2:50. 2009
    ..We report a rare case of necrotizing pneumonia and sepsis due to Clostridium perfringens not related to iatrogenic causes or injuries in an 82 years old woman...
  18. ncbi request reprint Vitamin D receptor polymorphisms and falls among older adults living in the community: results from the ilSIRENTE study
    Graziano Onder
    Department of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy
    J Bone Miner Res 23:1031-6. 2008
    ..Further studies conducted in larger population are needed to confirm the association of BsmI genotype and falls and to understand reasons for these findings...
  19. ncbi request reprint Depression and adverse drug reactions among hospitalized older adults
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, L go Francesco Vito 1, 00168 Rome, Italy
    Arch Intern Med 163:301-5. 2003
    ..The aim of this study was to assess whether depression may be a risk factor for adverse drug reactions (ADRs) among hospitalized older adults...
  20. ncbi request reprint Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)
    Graziano Onder
    Section of Gerontology and Geriatrics, Sticht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 50:1962-8. 2002
    ....
  21. ncbi request reprint Use of ACE inhibitors is associated with elevated levels of IGFBP-3 among hypertensive older adults: results from the IlSIRENTE study
    Graziano Onder
    Department of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy
    Eur J Clin Pharmacol 63:389-95. 2007
    ..However, this relationship has only rarely been investigated in humans. The aim of the present cross-sectional study was to assess the association of ACE inhibitors with free IGF-1 and IGFBP-3 in the blood of older hypertensive adults...
  22. ncbi request reprint Total serum cholesterol and recovery from disability among hospitalized older adults
    Graziano Onder
    Department of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 61:736-42. 2006
    ..The objective of the present study was to determine within a cohort of acutely hospitalized disabled elderly patients whether total cholesterol predicts recovery from disability in basic activities of daily living (ADL)...
  23. ncbi request reprint Effects of ACE inhibitors on skeletal muscle
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome Italy
    Curr Pharm Des 12:2057-64. 2006
    ....
  24. ncbi request reprint Case management and risk of nursing home admission for older adults in home care: results of the AgeD in HOme Care Study
    Graziano Onder
    Department of Gerontology, Catholic University Sacred Heart, Rome, Italy
    J Am Geriatr Soc 55:439-44. 2007
    ..To explore the relationship between a case management approach and the risk of institutionalization in a large European population of frail, old people in home care...
  25. doi request reprint Distress of caregivers of older adults receiving home care in European countries: results from the AgeD in HOme Care Study
    Graziano Onder
    Department of Gerontology, Catholic University of Sacred Heart, Roma, Italy
    Am J Geriatr Psychiatry 17:899-906. 2009
    ..To identify factors associated with distress of caregivers of home care patients in Europe and to assess whether caregivers response to distress varies among countries...
  26. ncbi request reprint The risk of adverse drug reactions in older patients: beyond drug metabolism
    Graziano Onder
    Centro Medicina dell Invecchiamento Universita Cattolica del Sacro Cuore 00168, Rome, Italy
    Curr Drug Metab 12:647-51. 2011
    ..In addition, clinical guidelines providing recommendations regarding the use of drugs in chronic disease rarely assess the level of complexity observed in older adults and therefore they should be applied with caution in this population...
  27. ncbi request reprint Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study
    Graziano Onder
    Department of Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    Am J Physiol Endocrinol Metab 291:E829-34. 2006
    ..By contrast, no association was observed between IGFBP-3 and study outcomes, independently of BMI. In conclusion, high IGF-I level is associated with better physical function in older persons with obesity, but not in nonobese subjects...
  28. doi request reprint Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score
    Graziano Onder
    Department of Geriatrics, Policlinico A Gemelli, Catholic University of the Sacred Heart, Rome, Italy
    Arch Intern Med 170:1142-8. 2010
    ..The aim of the present study was to develop and validate a method of identifying elderly patients who are at increased risk for an adverse drug reaction (ADR)...
  29. ncbi request reprint Association between daily pain and physical function among old-old adults living in the community: results from the ilSIRENTE study
    Graziano Onder
    Department of Gerontology, Catholic University of Sacred Heart, Rome, Italy
    Pain 121:53-9. 2006
    ..In conclusion, the present study shows that among old-old subjects living in the community, daily pain is highly prevalent and that this condition is associated with impaired muscle strength and physical performance...
  30. ncbi request reprint Depression and risk of nursing home admission among older adults in home care in Europe: results from the Aged in Home Care (AdHOC) study
    Graziano Onder
    Department of Gerontology, Catholic University of Sacred Heart, Rome, Italy
    J Clin Psychiatry 68:1392-8. 2007
    ..The aim of the present study was to assess the effect of depression on the risk of nursing home admission in a group of older adults receiving home care in Europe...
  31. ncbi request reprint Change in physical performance over time in older women: the Women's Health and Aging Study
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 57:M289-93. 2002
    ....
  32. ncbi request reprint Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial
    Graziano Onder
    Department of Gerontology, Geriatrics and Psychiatry, Catholic University, Rome
    Br J Psychiatry 187:450-5. 2005
    ..Reality orientation therapy combined with cholinesterase inhibitors has not been evaluated in patients with Alzheimer's disease...
  33. ncbi request reprint Anemia is associated with depression in older adults: results from the InCHIANTI study
    Graziano Onder
    Geriatric Department, Catholic University of the Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 60:1168-72. 2005
    ..The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community...
  34. ncbi request reprint NSAID-related psychiatric adverse events: who is at risk?
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Drugs 64:2619-27. 2004
    ..Prescribers should consider warning patients of the possibility of an acute neuropsychiatric event when traditional NSAIDs or selective COX-2 inhibitors are prescribed...
  35. doi request reprint Sarcopenia and mortality among older nursing home residents
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy
    J Am Med Dir Assoc 13:121-6. 2012
    ..The aim of the current study was to explore the relationship between sarcopenia and all-cause mortality in a population of elderly persons aged 70 years and older living in a nursing home in Italy...
  36. ncbi request reprint Depression and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE Study)
    Andrea Russo
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    J Geriatr Psychiatry Neurol 20:131-7. 2007
    ..In conclusion, physical performance and functional status measures are significantly and negatively influenced by the presence of depression in community-dwelling older persons aged 80 years and older...
  37. doi request reprint Association of anorexia with sarcopenia in a community-dwelling elderly population: results from the ilSIRENTE study
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Eur J Nutr 52:1261-8. 2013
    ..There is increasing evidence that anorexia of aging can cause physical and mental impairment. The aim of the present study was to evaluate the relationship between anorexia and sarcopenia in elderly persons aged 80 years or older...
  38. ncbi request reprint Physical activity prevented functional decline among frail community-living elderly subjects in an international observational study
    Francesco Landi
    Department of Gerontology Geriatric, Catholic University Sacred Heart, Rome, Italy
    J Clin Epidemiol 60:518-24. 2007
    ..The aims of the study were to describe the prevalence of physical activity in a sample of older adults in home care in Europe and to examine the relationship between physical activity and incident disability...
  39. ncbi request reprint Comorbidity and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)
    Matteo Cesari
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Gerontology 52:24-32. 2006
    ..Physical function measures have gained increased importance in the evaluation of older persons. The presence of comorbidity is a major and growing issue in geriatrics...
  40. ncbi request reprint The effects of cognitive impairment on mortality among hospitalized patients with heart failure
    Giuseppe Zuccala
    Department of Gerontology, Catholic University of the Sacred Heart, Rome, Italy
    Am J Med 115:97-103. 2003
    ..Because cerebral metabolic abnormalities have been associated with reduced survival in younger patients with advanced heart failure, we assessed the effect of cognitive impairment on the survival of older patients with heart failure...
  41. ncbi request reprint Non malignant daily pain and risk of disability among older adults in home care in Europe
    Manuel Soldato
    Department of Gerontology, Catholic University of Sacred Heart, Roma, Italy
    Pain 129:304-10. 2007
    ..36; 95% CI: 1.05-1.78). The risk of disability increased with pain severity and with number of painful sites. In conclusion among old subjects living in the community, daily pain is associated with an increased risk of disability...
  42. doi request reprint Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy
    Clin Nutr 31:652-8. 2012
    ..Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. We evaluated the relationship between sarcopenia and 2-year risk of falls in a population of persons aged 80 years or older...
  43. ncbi request reprint Psychotropic medications and risk for falls among community-dwelling frail older people: an observational study
    Francesco Landi
    Department of Gerontology Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 60:622-6. 2005
    ..Although a small number of falls have a single cause, the majority have many different causes resulting from the interactions between intrinsic or extrinsic risk factors...
  44. ncbi request reprint The ilSIRENTE study: a prospective cohort study on persons aged 80 years and older living in a mountain community of Central Italy
    Francesco Landi
    Department of Gerontology, Geriatric and Physiatric, Catholic University of Sacred Heart, Rome, Italy
    Aging Clin Exp Res 17:486-93. 2005
    ....
  45. ncbi request reprint Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    Age Ageing 42:203-9. 2013
    ..32, 95% CI: 1.01-5.43). Conclusions: our results obtained from a representative sample of very old and frail subjects show that sarcopenia is associated with mortality, independently of age and other clinical and functional variables...
  46. ncbi request reprint Anemia status, hemoglobin concentration, and mortality in nursing home older residents
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy
    J Am Med Dir Assoc 8:322-7. 2007
    ..Anemia status is a typical feature of the "frailty syndrome" of elderly subjects. Increasing evidences suggest that low hemoglobin concentration is common in elderly subjects and adversely affects morbidity and mortality...
  47. doi request reprint Midarm muscle circumference, physical performance and mortality: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy
    Clin Nutr 29:441-7. 2010
    ..We evaluated the relationship between midarm muscle circumference (MAMC) and physical performance, muscle strength, functional status and survival in persons aged 80 years or older...
  48. ncbi request reprint Impact of inappropriate drug use on physical performance among a frail elderly population living in the community
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Eur J Clin Pharmacol 63:791-9. 2007
    ..The aim of the present study was to evaluate the relationship between the use of inappropriate drugs and measures of physical performance, muscle strength and functional status in an elderly population (80+ years)...
  49. pmc All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study
    Rosa Liperoti
    Centro di Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8 0168 Rome, Italy
    J Clin Psychiatry 70:1340-7. 2009
    ..We conducted a retrospective cohort study to compare the risk of death associated with atypical and conventional antipsychotics in a large population of nursing home residents with dementia...
  50. doi request reprint Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    Prev Med 47:422-6. 2008
    ..The aim of the present study was to explore the relationship between regular walking and the risk of all-cause death in a large population of frail and very old people living in community...
  51. ncbi request reprint Indwelling urethral catheter and mortality in frail elderly women living in community
    Francesco Landi
    Department of Gerontology Geriatric and Physiatric, Catholic University of Sacred Heart, Rome, Italy
    Neurourol Urodyn 23:697-701. 2004
    ..The aims of present study were to describe the prevalence of bladder catheter in a population of older women living in community and to examine the relationship between urinary catheter and mortality...
  52. ncbi request reprint Comorbidity and social factors predicted hospitalization in frail elderly patients
    Francesco Landi
    Instituto di Medicina Interna e Geriatria, Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Clin Epidemiol 57:832-6. 2004
    ....
  53. ncbi request reprint Impact of hospitalization on blood pressure control in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)
    Graziano Onder
    Section of Gerontology and Geriatrics, Stricht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Pharmacotherapy 23:240-7. 2003
    ..To evaluate whether hospitalization affects blood pressure control in hypertensive patients, and to identify factors associated with attainment of adequate blood pressure control and with aggressive pharmacologic treatment...
  54. ncbi request reprint Disability, more than multimorbidity, was predictive of mortality among older persons aged 80 years and older
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Clin Epidemiol 63:752-9. 2010
    ..In this study, we evaluate the impact of disability and multimorbidity on the risk of all-cause death in a population of frail older persons living in community...
  55. ncbi request reprint Moderate alcohol consumption and adverse drug reactions among older adults
    Graziano Onder
    Section of Gerontology and Geriatrics, Sticht Center on Aging, Wake Forest University, Baptist Medical Center, Winston Salem, NC, USA
    Pharmacoepidemiol Drug Saf 11:385-92. 2002
    ..To assess the effect of moderate alcohol consumption on Adverse Drug Reactions (ADRs) among older adults admitted to acute care hospitals and to examine the consistency of this effect across gender and age groups...
  56. doi request reprint Polypharmacy and mortality among nursing home residents with advanced cognitive impairment: results from the SHELTER study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica Sacro Cuore, Rome, Italy
    J Am Med Dir Assoc 14:450.e7-12. 2013
    ..The aim of the present study was to assess if, in a sample of nursing home (NH) residents with advanced cognitive impairment, the effect of polypharmacy on mortality differs depending on estimated life expectancy...
  57. doi request reprint Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals
    Silvia Giovannini
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Am Geriatr Soc 59:1679-85. 2011
    ..To investigate whether interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) protein levels predict all-cause mortality in older persons living in the community...
  58. ncbi request reprint In a prospective observational study, influenza vaccination prevented hospitalization among older home care patients
    Francesco Landi
    Department of Gerontology Geriatric and Physiatric, Catholic University of Sacred Heart, 00168 Rome, Italy
    J Clin Epidemiol 59:1072-7. 2006
    ..The aim of the study is (1) to describe the prevalence of vaccination against influenza in older home care patients and (2) to investigate the protective effect of influenza vaccination for hospitalization events...
  59. ncbi request reprint Anemia and cognitive performance in hospitalized older patients: results from the GIFA study
    Valentina Zamboni
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Int J Geriatr Psychiatry 21:529-34. 2006
    ..Anemia represents a major risk factor for adverse health-related events in older persons. The aim of this study was to evaluate the association between hemoglobin levels/anemia and cognitive function in hospitalized older persons...
  60. ncbi request reprint Insulin-like growth factor-binding protein 3 and hemoglobin concentration in older persons living in the community
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy
    Int J Hematol 85:294-9. 2007
    ..This finding suggests that the growth hormone/IGF axis may play an important role in hematopoiesis, and it may be implicated in the age-related decline in hemoglobin concentration...
  61. ncbi request reprint Non-steroidal anti-inflammatory drug (NSAID) use and Alzheimer disease in community-dwelling elderly patients
    Francesco Landi
    Department of Gerontology Geriatric and Physiatric, Catholic University of the Sacred Heart, Rome, Italy
    Am J Geriatr Psychiatry 11:179-85. 2003
    ..The aim of the present study was to examine the relationship between NSAIDs use and AD in a large sample of community-dwelling elderly people...
  62. ncbi request reprint Anemia and decline in physical performance among older persons
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Med 115:104-10. 2003
    ..We examined whether anemia in older persons increases the risk of subsequent decline in physical function, as measured by objective performance-based tests...
  63. doi request reprint GSTM1-null polymorphism as possible risk marker for hypertension: results from the aging and longevity study in the Sirente Geographic Area (ilSIRENTE study)
    Ettore Capoluongo
    Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, Roma, Italy
    Clin Chim Acta 399:92-6. 2009
    ..This study analyzes a possible association between GSTM1-null and GSTT1-null polymorphisms and the hypertension status in a very old population (>80 years)...
  64. ncbi request reprint Free insulin-like growth factor-I and cognitive function in older persons living in community
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, 00168, Roma, Italy
    Growth Horm IGF Res 17:58-66. 2007
    ..Increasing evidences from experimental and human studies suggest that the activity of the growth hormone (GH/insulin-like growth factor-I) axis may contribute to the age-related cognitive decline and poor cognition in late life...
  65. doi request reprint Prevalence and risk factors of sarcopenia among nursing home older residents
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy
    J Gerontol A Biol Sci Med Sci 67:48-55. 2012
    ..We evaluated the prevalence of sarcopenia and its association with functional and clinical status in a population of elderly persons aged 70 years and older living in nursing homes...
  66. pmc Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study
    Matteo Cesari
    Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Roma, Italy
    BMC Geriatr 8:34. 2008
    ..Aim of the present study is to compare the predictive value for mortality of measures of physical function and SRH status, and test their possible interactions...
  67. ncbi request reprint HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study)
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    Age Ageing 36:514-20. 2007
    ..We evaluate the relationship of HDL-cholesterol with measures of physical performance, muscle strength, and functional status in older persons aged 80years or older...
  68. doi request reprint Metacognitive unawareness correlates with executive function impairment after severe traumatic brain injury
    Paola Ciurli
    Post Coma Unit, Santa Lucia Foundation, Rome, Italy
    J Int Neuropsychol Soc 16:360-8. 2010
    ..This study suggests the importance of integrating an overall assessment of cognitive functions with a specific evaluation of SA to treat self-awareness and executive functions together during the rehabilitation process...
  69. ncbi request reprint Patient depression and caregiver attitudes: results from The AgeD in HOme Care study
    Manuel Soldato
    Department of Gerontology, Catholic University of Sacred Heart, Roma, Italy
    J Affect Disord 106:107-15. 2008
    ..The present cross-sectional study was aimed to evaluate the association between care recipient depression and caregiver attitudes...
  70. doi request reprint Myeloperoxidase levels and mortality in frail community-living elderly individuals
    Silvia Giovannini
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 65:369-76. 2010
    ....
  71. ncbi request reprint Hemoglobin levels and skeletal muscle: results from the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 59:249-54. 2004
    ..Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat...
  72. ncbi request reprint Predictors of rehabilitation outcomes in frail patients treated in a geriatric hospital
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Am Geriatr Soc 50:679-84. 2002
    ..To evaluate the effect of medical indicators of health status on functional gain during rehabilitation of frail older patients...
  73. ncbi request reprint Prevalence and predictors of influenza vaccination among frail, community-living elderly patients: an international observational study
    Francesco Landi
    Department of Gerontology Geriatric, Catholic University Sacred Heart, Rome, Italy
    Vaccine 23:3896-901. 2005
    ..In conclusion, more than 40% of subjects in this sample of home care patients in Europe did not receive influenza vaccination. Recommendations for influenza vaccination have not been adequately implemented...
  74. doi request reprint Interaction between GSTM1 genotype and IL-6 on mortality in older adults: results from the ilSIRENTE study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Cytokine 53:301-5. 2011
    ..The aim of the present study was to assess if, in a population of older adults, the effect of antioxidant genes GSTM1 and GSTT1 genotypes on mortality may differ depending on levels of inflammation...
  75. ncbi request reprint Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study
    Mauro Di Bari
    Department of Internal Medicine, Sticht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:961-6. 2004
    ..To evaluate whether older persons using angiotensin-converting enzyme (ACE) inhibitors have a larger lower extremity muscle mass (LEMM) than users of other antihypertensive drugs...
  76. ncbi request reprint Impact of a new assessment system, the MDS-HC, on function and hospitalization of homebound older people: a controlled clinical trial
    F Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Am Geriatr Soc 49:1288-93. 2001
    ..CONCLUSIONS: The MDS-HC assessment instrument may provide a cost-saving approach to reducing institutionalization and functional decline in older people living in the community...
  77. ncbi request reprint Trends in antihypertensive drugs in the elderly: the decline of thiazides
    G Onder
    Istituto di Medicina Interna e Geriatria, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Hum Hypertens 15:291-7. 2001
    ..A possible explanation is that the choice to prescribe a thiazides diuretic is influenced by age, functional status and comorbidity...
  78. ncbi request reprint Functional status and clinical correlates in cognitively impaired community-living older people
    F Landi
    Istituto di Medicina Interna e Geriatria, Centro di Medicina dell'Invecchiamento, , Rome, Italy
    J Geriatr Psychiatry Neurol 14:21-7. 2001
    ..The present findings support the possibility that severe cognitive impairment has an independent effect on survival...
  79. ncbi request reprint Second and third generation assessment instruments: the birth of standardization in geriatric care
    Roberto Bernabei
    Centro Medicina dell Invecchiamento CEMI, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Gerontol A Biol Sci Med Sci 63:308-13. 2008
    ....
  80. ncbi request reprint Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 359:926-30. 2002
    ..We aimed to see whether ACE inhibitors also prevent reduction in physical performance and in muscle strength in older women who do not have CHF...
  81. doi request reprint Heart failure and adverse drug reactions among hospitalized older adults
    C Catananti
    Department of Geriatrics, Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Clin Pharmacol Ther 86:307-10. 2009
    ..58; 95% CI 1.22-2.05) but not in the men (OR 0.99; 95% CI 0.74-1.34). In conclusion, HF appears to be associated with a higher rate of ADRs among hospitalized patients. Gender may influence the effect of HF on the risk of ADRs...
  82. ncbi request reprint Use of calcium antagonists and worsening renal function in patients receiving angiotensin-converting-enzyme inhibitors
    Giuseppe Zuccala
    Catholic University of the Sacred Heart, L go F Vito 1, 00168, Rome, Italy
    Eur J Clin Pharmacol 58:695-9. 2003
    ....
  83. doi request reprint Daily pain and functional decline among old-old adults living in the community: results from the ilSIRENTE Study
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of the Sacred Heart, Rome, Italy
    J Pain Symptom Manage 38:350-7. 2009
    ..94; 95% CI: 2.00-23.01). In conclusion, among very old subjects living in the community, moderate to severe daily pain is associated with a significant increased risk of disability, irrespective of potential confounders...
  84. ncbi request reprint Effects of influenza vaccination on mortality among frail, community-living elderly patients: an observational study
    Francesco Landi
    Department of Gerontology, Geriatric and Physiatric Medicine, Catholic University of the Sacred Heart, Roma, Italy
    Aging Clin Exp Res 15:254-8. 2003
    ..The aims of the present study were to describe the prevalence of vaccination against influenza in a population of older people living in the community, and to examine the relationship between influenza vaccination and mortality...
  85. ncbi request reprint Pharmacoepidemiology and disability in older adults: can medications slow the age-related decline in physical function?
    Anna Savo
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Roma, Italy
    Expert Opin Pharmacother 5:407-13. 2004
    ..The findings of these studies are not definite and need to be confirmed in large clinical trials...
  86. doi request reprint Anorexia, physical function, and incident disability among the frail elderly population: results from the ilSIRENTE study
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    J Am Med Dir Assoc 11:268-74. 2010
    ..The aim of the present study was to evaluate the relationship between anorexia of aging and measures of physical performance, muscle strength, and functional status in older persons aged 80 years or older...
  87. doi request reprint Predictors of rehabilitation outcome among frail elderly patients living in the community
    Domenico Fusco
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Largo Agostino Gemelli 8, Rome, Italy
    J Am Med Dir Assoc 10:335-41. 2009
    ..The purpose of this study is to evaluate the association of medical indicators of health status on functional recovery during rehabilitation of frail elderly living in the community...
  88. ncbi request reprint Physical activity and mortality in frail, community-living elderly patients
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatrics, Catholic University of the Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 59:833-7. 2004
    ..The authors describe the prevalence of moderate-intensity physical activity in a population of older persons living in the community. In addition, they explore the relationship between physical activity and mortality...
  89. doi request reprint Case management, preventive strategies, and caregiver attitudes among older adults in home care: results of the ADHOC study
    Graziano Onder
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    J Am Med Dir Assoc 9:337-41. 2008
    ..We hypothesized that such an approach may also result in a higher rate of use of preventive strategies and lower caregiver distress...
  90. ncbi request reprint Effects of an occupational therapy program on functional outcomes in older stroke patients
    Francesco Landi
    Department of Gerontology Geriatric and Physiatric, Catholic University of Sacred Heart, Rome, Italy
    Gerontology 52:85-91. 2006
    ..Objective: To evaluate the efficacy of occupational therapy programs in patients with a recent stroke...
  91. ncbi request reprint Physical activity and risk of cognitive impairment among older persons living in the community
    Francesco Landi
    Department of Gerontology and Geriatrics, Catholic University of the Sacred Heart, Rome, Italy
    Aging Clin Exp Res 19:410-6. 2007
    ..The aim of the present study was to evaluate the relationship of lifetime physical activity with cognitive performance in older persons aged 80 years or older...
  92. ncbi request reprint Use of angiotensin-converting enzyme inhibitors and variations in cognitive performance among patients with heart failure
    Giuseppe Zuccala
    Catholic University, Department of Gerontology, Geriatrics, and Physiatrics, L go F Vito, I 00168 Rome, Italy
    Eur Heart J 26:226-33. 2005
    ..Our aim was to assess whether starting treatment with ACE-inhibitors might improve cognition in patients with heart failure...
  93. ncbi request reprint Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicenter survey
    G Zuccala
    Department of Gerontology, Catholic University of Rome, Italy
    Alcohol Clin Exp Res 25:1743-8. 2001
    ..We assessed the association between alcohol consumption and cognitive impairment in a series of older subjects enrolled in a multicenter pharmacoepidemiology survey...
  94. ncbi request reprint Hypotension and cognitive impairment: Selective association in patients with heart failure
    G Zuccala
    Department of Gerontology, Catholic University, Rome, Italy
    Neurology 57:1986-92. 2001
    ..The authors assessed whether arterial hypotension might be associated with cognitive impairment among older subjects with heart failure...
  95. ncbi request reprint Pain management in frail, community-living elderly patients
    F Landi
    Istituto di Medicina Interna e Geriatria, Universita Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, Italy
    Arch Intern Med 161:2721-4. 2001
    ..Pain is a common problem among older people living in different community settings. As indicated by the World Health Organization (WHO), pain can be relieved using pharmacologic agents. However, pain continues to be addressed inadequately...
  96. ncbi request reprint A new model of integrated home care for the elderly: impact on hospital use
    F Landi
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Clin Epidemiol 54:968-70. 2001
    ..In conclusion, an integrated home care program based on the implementation of a comprehensive geriatric assessment instrument guided by a case manager has a significant impact on hospitalization and is cost-effective...
  97. ncbi request reprint Predicting length of stay of older patients with exacerbated chronic obstructive pulmonary disease
    R A Incalzi
    Institute of Internal Medicine and Geriatrics, Universita Cattolica del Sacro Cuore, Roma, Italy
    Aging (Milano) 13:49-57. 2001
    ..Research is needed to verify whether these data can help program interventions aimed at shortening length of stay and, thus, at reducing annual hospitalization costs of the elderly...
  98. ncbi request reprint Pressure ulcer and mortality in frail elderly people living in community
    F Landi
    Department of Gerontology Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Arch Gerontol Geriatr 44:217-23. 2007
    ..92; 95% cl 1.52-2.43)...
  99. ncbi request reprint Minimum data set for home care: a valid instrument to assess frail older people living in the community
    F Landi
    Istituto di Medicina Interna e Geriatria, Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Med Care 38:1184-90. 2000
    ..To facilitate comprehensive assessment, as well as to generate a useful, policy-relevant patient database, standardized, multidimensional, and validated instruments are very helpful...
  100. pmc Cognitive dysfunction as a major determinant of disability in patients with heart failure: results from a multicentre survey. On behalf of the GIFA (SIGG-ONLUS) Investigators
    G Zuccala
    Department of Gerontology, Catholic University of the Sacred Heart, L go F Vito, 1 00168 Rome, Italy
    J Neurol Neurosurg Psychiatry 70:109-12. 2001
    ..As early recognition and treatment of low cardiac output states might reverse cognitive dysfunction, cost effective treatment for heart failure should include systematic diagnostic and therapeutic approaches to cognitive dysfunction...
  101. ncbi request reprint Anticholinergic drugs and physical function among frail elderly population
    F Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    Clin Pharmacol Ther 81:235-41. 2007
    ..Our results suggest that among old-old subjects the use of anticholinergic drugs is associated with impaired physical performance and functional status...