G Mingrone

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    Obesity (Silver Spring) 16:1831-7. 2008
  2. ncbi Effects of transoral gastroplasty on glucose homeostasis in obese subjects
    Laura Leccesi
    MD, PhD, Department of Internal Medicine, Università Cattolica Sacrp Cuore, Largo A Gemelli, 8, 00168 Rome, Italy
    J Clin Endocrinol Metab 98:1901-10. 2013
  3. ncbi Use of dicarboxylic acids in type 2 diabetes
    Geltrude Mingrone
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Br J Clin Pharmacol 75:671-6. 2013
  4. ncbi Twenty-four hour energy expenditure and skeletal muscle gene expression changes after bariatric surgery
    Samuele Iesari
    Department of Internal Medicine, Largo A Gemelli, 8, 00168 Rome, Italy
    J Clin Endocrinol Metab 98:E321-7. 2013
  5. ncbi Bariatric surgery versus conventional medical therapy for type 2 diabetes
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    N Engl J Med 366:1577-85. 2012
  6. ncbi Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test
    Simona Panunzi
    CNR Institute of Systems Analysis and Computer Science IASI, BioMathLab, Rome, Italy
    Theor Biol Med Model 7:9. 2010
  7. ncbi A mathematical model of the euglycemic hyperinsulinemic clamp
    Umberto Picchini
    CNR IASI BioMatLab, Rome, Italy
    Theor Biol Med Model 2:44. 2005
  8. ncbi Ultradian ghrelin pulsatility is disrupted in morbidly obese subjects after weight loss induced by malabsorptive bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Am J Clin Nutr 83:1017-24. 2006
  9. ncbi Unreliable use of standard muscle hydration value in obesity
    G Mingrone
    Istituto di Medicina Interna e Geriatria, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Am J Physiol Endocrinol Metab 280:E365-71. 2001
  10. ncbi Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?
    G Mingrone
    Department of Internal Medicine, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Diabetologia 48:2108-14. 2005

Collaborators

Detail Information

Publications97

  1. ncbi Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    Obesity (Silver Spring) 16:1831-7. 2008
    ..Hyperprolactinemia is associated with obesity. Furthermore, in human adipose tissue cultured in vitro, prolactin (PRL) inhibited lipoprotein lipase (LPL) activity via functional PRL receptors...
  2. ncbi Effects of transoral gastroplasty on glucose homeostasis in obese subjects
    Laura Leccesi
    MD, PhD, Department of Internal Medicine, Università Cattolica Sacrp Cuore, Largo A Gemelli, 8, 00168 Rome, Italy
    J Clin Endocrinol Metab 98:1901-10. 2013
    ..001). Conclusions: TOGA induced glucose disposal improvement with regression of diabetes to NGT or IGT and regression of IGT and IFG to NGT in half of the cases. Regressors showed a much larger increase of GLP-1 levels than progressors...
  3. ncbi Use of dicarboxylic acids in type 2 diabetes
    Geltrude Mingrone
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Br J Clin Pharmacol 75:671-6. 2013
    ..In this article, we review the natural sources of DAs, their fate in animals and humans and their effect in improving glucose metabolism in type 2 diabetes...
  4. ncbi Twenty-four hour energy expenditure and skeletal muscle gene expression changes after bariatric surgery
    Samuele Iesari
    Department of Internal Medicine, Largo A Gemelli, 8, 00168 Rome, Italy
    J Clin Endocrinol Metab 98:E321-7. 2013
    ..Furthermore, the concomitant increase in DIT, PA, and exercise in BPD patients may partly explain their ability to sustained long-term weight loss and may contribute to the improved insulin sensitivity...
  5. ncbi Bariatric surgery versus conventional medical therapy for type 2 diabetes
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    N Engl J Med 366:1577-85. 2012
    ..Prospective, randomized trials comparing these procedures with medical therapy for the treatment of diabetes are needed...
  6. ncbi Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test
    Simona Panunzi
    CNR Institute of Systems Analysis and Computer Science IASI, BioMathLab, Rome, Italy
    Theor Biol Med Model 7:9. 2010
    ..The recently proposed Single Delay Model (SDM) is evaluated as a practical alternative...
  7. ncbi A mathematical model of the euglycemic hyperinsulinemic clamp
    Umberto Picchini
    CNR IASI BioMatLab, Rome, Italy
    Theor Biol Med Model 2:44. 2005
    ..In the present study, sixteen subjects with BMI between 18.5 and 63.6 kg/m(2) were studied by long-duration (five hours) EHC...
  8. ncbi Ultradian ghrelin pulsatility is disrupted in morbidly obese subjects after weight loss induced by malabsorptive bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Am J Clin Nutr 83:1017-24. 2006
    ..Suppression of ghrelin production after Roux-en-Y gastric bypass that suggested its contribution to appetite reduction has been reported...
  9. ncbi Unreliable use of standard muscle hydration value in obesity
    G Mingrone
    Istituto di Medicina Interna e Geriatria, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Am J Physiol Endocrinol Metab 280:E365-71. 2001
    ..In conclusion, although the hydration of fat-free SM mass may be unchanged in obese subjects, the hydration of in toto muscle mass decreases as its lipid content increases...
  10. ncbi Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?
    G Mingrone
    Department of Internal Medicine, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Diabetologia 48:2108-14. 2005
    ..The aim of this study was to verify whether MFN2 might be implicated in the metabolic inflexibility of obesity...
  11. ncbi Leptin pulsatility in formerly obese women
    Geltrude Mingrone
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    FASEB J 19:1380-2. 2005
    ..Finally, since leptin inhibits GH secretion, a reduction of circulating leptin levels might have produced an increase in GH secretion, as observed in our series...
  12. ncbi Carnitine in type 2 diabetes
    Geltrude Mingrone
    Department of Internal Medicine, Catholic University, School of Medicine, 00135 Roma, Italy
    Ann N Y Acad Sci 1033:99-107. 2004
    ....
  13. ncbi Effects of dietary fatty acids on insulin sensitivity and secretion
    Melania Manco
    Institute of Internal Medicine, Catholic University, 00168 Rome, Italy
    Diabetes Obes Metab 6:402-13. 2004
    ..In humans, acute and prolonged effects of FAs on glucose-stimulated insulin secretion have been widely investigated as well as the effect of high-fat diets on insulin sensitivity and secretion and on the development of type 2 diabetes...
  14. ncbi Role of the incretin system in the remission of type 2 diabetes following bariatric surgery
    G Mingrone
    Department of Internal Medicine, Universita Cattolica Sacro Cuore, Largo Agostino Gemelli, 8, Rome, Italy
    Nutr Metab Cardiovasc Dis 18:574-9. 2008
    ..The purpose of this viewpoint is to try to elucidate the mechanisms involved in the resolution/remission of diabetes after bariatric surgery, in particular highlighting the role played by the modifications in incretin secretion...
  15. ncbi Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery
    Caterina Guidone
    Dipartimento di Medicina Interna, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Diabetes 55:2025-31. 2006
    ..This operation may affect the enteroinsular axis function by diverting nutrients away from the proximal gastrointestinal tract and by delivering incompletely digested nutrients to the ileum...
  16. ncbi Medium-chain, even-numbered dicarboxylic acids as novel energy substrates: an update
    Geltrude Mingrone
    Institute of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    Nutr Rev 64:449-56. 2006
    ..Therefore, dicarboxylic acids might be a suitable fuel substrate, particularly in clinical conditions in which marked insulin resistance and/or impairment of aerobic glycolysis occur...
  17. ncbi Influence of maternal obesity on insulin sensitivity and secretion in offspring
    Geltrude Mingrone
    Medicine and Diabetes Center, Universita Cattolica S Cuore, Rome, Italy
    Diabetes Care 31:1872-6. 2008
    ..The purpose of this study was to clarify the effects of maternal obesity on insulin sensitivity and secretion in offspring...
  18. ncbi Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion
    G Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    Diabetologia 52:873-81. 2009
    ..We tested the hypothesis that the reversibility of insulin resistance and diabetes observed after biliopancreatic diversion (BPD) is related to changes in circadian rhythms of gastrointestinal hormones...
  19. ncbi Bariatric surgery: unstressing or boosting the beta-cell?
    G Mingrone
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetes Obes Metab 11:130-42. 2009
    ..The mechanism allowing diabetes resolution after surgical intestinal manipulation is extremely interesting but only partially understood...
  20. ncbi Mechanisms of early improvement/resolution of type 2 diabetes after bariatric surgery
    G Mingrone
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetes Metab 35:518-23. 2009
    ....
  21. ncbi Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects
    Geltrude Mingrone
    Istituto di Clinica Medica and Clinica Chirurgica and Centro CNR Fisiopatologia Shock, Universita Cattolica S Cuore, Rome, Italy
    Obes Res 11:632-40. 2003
    ..To examine the muscular uncoupling protein expression 2 (UCP2) and UCP3 gene expression in morbid obese subjects before and after bariatric surgery [bilio-pancreatic diversion (BPD)]...
  22. ncbi Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity
    G Mingrone
    Istituto di Clinica Medica, Universita Cattolica del Sacro Cuore, Rome, Italy
    Atherosclerosis 170:155-61. 2003
    ....
  23. ncbi Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery
    G Mingrone
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    Atherosclerosis 161:455-62. 2002
    ..Finally, in obese patients, SHBG levels seem to be an indicator of total adiposity rather than an index of an altered insulin/glucose homeostasis...
  24. ncbi Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement
    G Mingrone
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    Int J Obes Relat Metab Disord 26:1165-72. 2002
    ..The aim of the present study was to investigate the relationship between intramyocytic triglycerides levels, muscle TNF-alpha and GLUT4 expression and insulin resistance...
  25. ncbi Elevated diet-induced thermogenesis and lipid oxidation rate in Crohn disease
    G Mingrone
    Cattedra di Medicina Interna II, Centro di Fisiopatologia dello Shock del CNR, Universita Cattolica del Sacro Cuore, Rome, Italy
    Am J Clin Nutr 69:325-30. 1999
    ..Although malnutrition is frequently observed in Crohn disease (CD), its cause is not clear. Regulation of energy metabolism and diet-induced thermogenesis (DIT) have not been adequately studied in CD...
  26. ncbi Study of the effects of transoral gastroplasty on insulin sensitivity and secretion in obese subjects
    C Chiellini
    Institute of Internal Medicine, Catholic University, School of Medicine, Largo A Gemelli 8, 00168 Rome, Italy
    Nutr Metab Cardiovasc Dis 20:202-7. 2010
    ..However, so far there are no data on the effects on insulin sensitivity in the literature. Our aim is to evaluate the effect of TOGA on insulin sensitivity and secretion...
  27. ncbi High-fat feeding stimulates endocrine, glucose-dependent insulinotropic polypeptide (GIP)-expressing cell hyperplasia in the duodenum of Wistar rats
    D Gniuli
    Department of Internal Medicine and Diabetes Unit, Universita Cattolica del Sacro Cuore, L go Gemelli 8, 00168 Roma, Italy
    Diabetologia 53:2233-40. 2010
    ....
  28. ncbi Twenty-four-hour energy balance in Crohn disease patients: metabolic implications of steroid treatment
    G Mingrone
    Istituto di Medicina Interna, Universita Cattolica del Sacro Cuore, Rome, Italy
    Am J Clin Nutr 67:118-23. 1998
    ..In conclusion, prednisone treatment in Crohn disease patients stimulates food intake, promoting an overall positive energy balance despite large fecal nutrient losses...
  29. ncbi Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency
    G Mingrone
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetes 48:1258-63. 1999
    ..These cases provide evidence that insulin-resistant diabetes can be caused by extremely high levels of TGs...
  30. ncbi Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery
    S Salinari
    Department of Systems Analysis and Informatics, University of Rome La Sapienza, Via Ariosto 25, 00185, Rome, Italy
    Diabetologia 51:1276-84. 2008
    ....
  31. ncbi Glucose disposal in morbidly obese patients in the early post-operative period
    D Gniuli
    Istituto di Medicina Interna, Divisione di Malattie del Ricambio, Universita Cattolica del S Cuore, L go A Gernelli, 8, 00168 Rome, Italy
    Obes Surg 11:686-92. 2001
    ..We investigated fuel metabolism and glucose and protein turnover in 15 obese subjects who underwent biliopancreatic diversion (BPD) by using stable labelled isotopes...
  32. ncbi Fat mass largely contributes to insulin mediated glucose uptake in morbidly obese subjects
    D Gniuli
    Department of Medicine, Universita Cattolica S Cuore, Rome, Italy
    Int J Obes (Lond) 34:1726-32. 2010
    ..Furthermore, we aimed at verifying which surrogate insulin-sensitivity index can better substitute the euglycemic clamp values and whether the insulin secretion/insulin resistance index is meaningful also in MO subjects...
  33. ncbi Different limit to the body's ability of increasing fat-free mass
    G Mingrone
    Istituto di Medicina Interna, Universita Cattolica del Sacro Cuore, Rome, Italy
    Metabolism 50:1004-7. 2001
    ..These limits are different between the sexes, with women tending to approach more rapidly than men a lower maximal AFT for the same height...
  34. ncbi Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study
    Eleni Rebelos
    Department of Internal Medicine, University of Pisa, Italy
    Diabetes 60:1938-45. 2011
    ..Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes...
  35. ncbi Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects
    Giuseppina Rosa
    Department of Internal Medicine, Consiglio Nazionale delle Richerche CNR Center, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Obes Res 11:1306-12. 2003
    ..We assessed ACC2 mRNA expression variations in skeletal muscle of subjects who have undergone biliopancreatic diversion (BPD) operation. BPD, in fact inducing a massive lipid malabsorption, leads to a reversion of insulin resistance...
  36. ncbi Changes in body composition, substrate oxidation, and resting metabolic rate in adult celiac disease patients after a 1-y gluten-free diet treatment
    E Capristo
    Department of Internal Medicine, CNR Centro Fisiopatologia dello Shock, Universita Cattolica del Sacro Cuore, Rome, Italy
    Am J Clin Nutr 72:76-81. 2000
    ..The incidence of celiac disease has been on the rise in both Europe and the United States. Celiac disease patients are at high risk of undernutrition because of nutrient malabsorption...
  37. ncbi Molecular mechanisms of diabetes reversibility after bariatric surgery
    G Rosa
    Department of Internal Medicine, Catholic University S Cuore, Rome, Italy
    Int J Obes (Lond) 31:1429-36. 2007
    ..Peripheral insulin sensitivity and insulin secretion was also measured...
  38. ncbi Reduced PDK4 expression associates with increased insulin sensitivity in postobese patients
    Giuseppina Rosa
    Department of Internal Medicine, Surgery, and Consiglio Nazionale della Ricerca CNR Center Catholic University of the Sacred Heart, Rome, Italy
    Obes Res 11:176-82. 2003
    ....
  39. ncbi Blunted glucose metabolism in anorexia nervosa
    D Gniuli
    Department of Metabolic Disease, Catholic University, School of Medicine, Rome, Italy
    Metabolism 50:876-81. 2001
    ..01 +/- 12.32 micromol/L/300 min in CB, P <.0001). Anorectic patients displayed a low REE and GIT. Carbohydrate oxidation was similar between groups; lipid oxidation was extremely reduced. An increased protein catabolism was observed...
  40. ncbi The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women
    Elza Muscelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:364-70. 2009
    ....
  41. ncbi Serum leptin levels in post-hepatitis liver cirrhosis
    A V Greco
    Istituto di Medicina Interna e Geriatria, Catholic University, Rome, Italy
    J Hepatol 33:38-42. 2000
    ..The behaviour of serum leptin in patients with different Child-Pugh score, post-hepatitis liver cirrhosis and insulin sensitivity has therefore been investigated and compared with that in alcoholic Child C patients...
  42. ncbi The effect of bilio-pancreatic diversion on type 2 diabetes in patients with BMI <35 kg/m2
    C Chiellini
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetologia 52:1027-30. 2009
    ..To aim of the study was to investigate the effect of bilio-pancreatic diversion (BPD) on type 2 diabetes in patients with BMI <35 kg/m(2)...
  43. ncbi Mechanisms of hyperinsulinaemia in Child's disease grade B liver cirrhosis investigated in free living conditions
    A V Greco
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    Gut 51:870-5. 2002
    ..To investigate these issues, insulin secretion-during 24 hours of standardised living conditions-insulin sensitivity, and hepatic insulin extraction were assessed in cirrhotic patients compared with matched healthy subjects...
  44. ncbi Effects of binge eating behavior on fuel oxidation and body composition
    Donatella Gniuli
    Istituto di Medicina Interna e Geriatria, Sezione di Malattie del Ricambio Università Cattolica del Sacro Cuore, Largo Gemelli 8, 00168 Rome, Italy
    J Am Coll Nutr 24:244-9. 2005
    ..To investigate energy expenditure and glucose metabolism after a standard oral glucose load (75 g) in 8 normal weight bulimic women and 8 normal weight control women and to evaluate the relative endocrine implication...
  45. ncbi Changes in fat mass influence SREBP-1c and UCP-2 gene expression in formerly obese subjects
    Donatella Gniuli
    Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Obes Res 13:567-73. 2005
    ..Body composition was assessed by isotopic dilution method and insulin sensitivity by euglycemic-hyperinsulinemic clamp...
  46. ncbi Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab
    Paola Di Rocco
    Institute of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy
    Obes Res 12:734-9. 2004
    ..To verify whether Infliximab could modify insulin sensitivity and TNF-alpha and GLUT4 mRNA expression in muscle and adipose tissue of morbidly obese subjects. Soluble TNF receptors I and II (TNFR-I and TNFR-II) were also assayed...
  47. ncbi Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: a preliminary report
    G Gasbarrini
    Institute of Internal Medicine, Catholic University Policlinico A Gemelli Largo Gemelli, 8 00168 Roma, Italy
    Hepatogastroenterology 50:1385-9. 2003
    ..To study the tolerability of propionyl-L-carnitine administered as rectal irrigation and its efficacy in improving the clinical picture of distal ulcerative colitis...
  48. ncbi Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype
    R Calvani
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Int J Obes (Lond) 34:1095-8. 2010
    ..These preliminary results confirmed that in humans the gut microflora metabolism is strongly linked to the obesity phenotype. Moreover, the typical obese metabotype is lost after weight loss induced by bariatric surgery...
  49. ncbi Nutritional aspects in patients with non-alcoholic steatohepatitis (NASH)
    E Capristo
    Institute of Internal Medicine, Catholic University, Rome, Italy
    Eur Rev Med Pharmacol Sci 9:265-8. 2005
    ..The reduction in RMR, coupled with increase energy intake may explain the body composition alterations found in these patients...
  50. ncbi Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery
    Maria E Valera-Mora
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Clin Nutr 81:1292-7. 2005
    ..Initial fat mass, but not residual intestinal length, is the strongest predictor of weight loss after BPD...
  51. ncbi Comparison of insulin response to intravenous glucose in healed myocardial infarction, in "cooled-off" unstable and stable angina pectoris, and in healthy subjects
    F Andreotti
    Institute of Cardiology and Internal Medicine, Catholic University, Rome, Italy
    Am J Cardiol 84:870-5. 1999
    ....
  52. ncbi Effect of a vegetable-protein-rich polymeric diet treatment on body composition and energy metabolism in inactive Crohn's disease
    E Capristo
    Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur J Gastroenterol Hepatol 12:5-11. 2000
    ....
  53. ncbi A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples
    E Capristo
    Istituto di Medicina Interna e Geriatria, Universita Cattolica S Cuore, Largo A Gemelli, 8 00168, Rome, Italy
    Clin Chim Acta 289:11-21. 1999
    ....
  54. ncbi High saturated-fat diet induces apoptosis in rat enterocytes and blunts GIP and insulin-secretive response to oral glucose load
    D Gniuli
    Department of Internal Medicine, Catholic University, Rome, Italy
    Int J Obes (Lond) 32:871-4. 2008
    ..The reduction of circulating GIP levels might contribute to hypoinsulinemia and hyperglycemia...
  55. ncbi Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon?
    Melania Manco
    Liver Unit, Bambino Gesù Hospital and Research Institute, Rome, Italy
    Diabetes Care 30:1494-500. 2007
    ..In this study, we aim to investigate the effects of massive weight loss on cortisol suppressibility, cortisol-binding globulin (CBG), and free cortisol index (FCI) in formerly obese women...
  56. ncbi Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects
    Serenella Salinari
    Dipartimento di Informatica e Sistemistica, Universita di Roma La Sapienza, Rome, Italy
    Am J Physiol Endocrinol Metab 291:E1051-8. 2006
    ....
  57. ncbi Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 95:4703-11. 2010
    ..What defects in glucose metabolism are present in offspring of type 2 diabetic patients (FHD(+) with a positive family history of diabetes) and to what extent they depend on line of inheritance are uncertain...
  58. ncbi Disposition of dodecanedioic acid in humans
    A Bertuzzi
    Istituto di Analisi dei Sistemi ed Informatica del CNR, Universita di Roma La Sapienza, Rome, Italy
    J Pharmacol Exp Ther 292:846-52. 2000
    ..08 mmol/min, with a maximal calorie delivery of 750 kcal/day. These results appear promising for C12 utilization in parenteral nutrition, because C12 elimination with urine is low, whereas tissue uptake and oxidation are rather efficient...
  59. ncbi Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa 56122, Italy
    Eur Heart J 31:1511-9. 2010
    ..This study investigated whether sedentary behaviour and different activity levels have an independent association with carotid intima-media thickness (IMT) and with the 3-year IMT progression in different carotid segments...
  60. ncbi Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery
    Maria E Valera Mora
    Department of Internal Medicine, Metabolic Unit, Universita Cattolica S Cuore, Rome, Italy
    Obesity (Silver Spring) 15:2012-8. 2007
    ..The objective was to evaluate ghrelin and growth hormone (GH) interactions and responses to a growth hormone-releasing hormone (GHRH)/arginine test in severe obesity before and after surgically-induced weight loss...
  61. ncbi Restoration of adiponectin pulsatility in severely obese subjects after weight loss
    Menotti Calvani
    Department of Internal Medicine, Consiglio Nazionale delle Ricerche Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Diabetes 53:939-47. 2004
    ....
  62. ncbi Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women
    Melania Manco
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Clin Endocrinol Metab 92:483-90. 2007
    ..Obesity may be regarded as a low-grade inflammatory state...
  63. ncbi Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome
    Melania Manco
    Department of Internal Medicine, Catholic University, School of Medicine, Rome, Italy
    Obes Surg 15:286-9. 2005
    ..The HAIR-AN syndrome is a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The IR is likely due to a primary defect of the insulin receptor...
  64. ncbi Insulin sensitivity and secretion modifications after bariatric surgery
    L Castagneto-Gissey
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    J Endocrinol Invest 35:692-8. 2012
    ..Incretin secretion is dramatically increased under nutrient stimulation after gastric bypass leading, probably, to an overstimulation of pancreatic β-cells resulting in the increase of insulin secretion...
  65. ncbi Subclinical hepatic encephalopathy: role of tryptophan binding to albumin and the competition with indole-3-acetic acid
    A V Greco
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    J Investig Med 48:274-80. 2000
    ..The presence of a relationship between encephalopathy severity and circulating free TRY was also investigated...
  66. ncbi Beta-cell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery
    Stefania Camastra
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 30:1002-4. 2007
  67. ncbi Preliminary studies of a dicarboxylic acid as an energy substrate in man
    G Mingrone
    Instituto di Clinica Medica, Universita, Cattolica S Cuore, Rome, Italy
    JPEN J Parenter Enteral Nutr 13:299-305. 1989
    ..However, the remaining portion was cleared from the plasma in 200 min suggesting an uptake by body tissues which was also confirmed by indirect calorimetric analysis...
  68. ncbi Thyroid function and insulin sensitivity before and after bilio-pancreatic diversion
    Donatella Gniuli
    Department of Internal Medicine and Diabetes Center, Catholic University, L go Gemelli 8, 00168 Rome, Italy
    Obes Surg 20:61-8. 2010
    ..The aim of the study was to evaluate the modifications of circulating thyroid hormones after BPD, a surgical procedure which interferes with the entero-hepatic circulation of biliary metabolites...
  69. ncbi Nonalcoholic fatty liver disease in children
    Melania Manco
    Catholic University, Rome, Italy
    J Am Coll Nutr 27:667-76. 2008
    ..In this article, we review the current concepts about paediatric NAFLD, its pathogenesis, diagnosis and treatment, with particular regard to lifestyle and foods habits...
  70. ncbi Increased serum high-density lipoprotein-cholesterol concentration in celiac disease after gluten-free diet treatment correlates with body fat stores
    Esmeralda Capristo
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Clin Gastroenterol 43:946-9. 2009
    ..We evaluated blood lipids and body composition in 26 CD patients with low HDL-C level (<1.0 mmol/L) at diagnosis and after GFD...
  71. ncbi Low 25-hydroxyvitamin D does not affect insulin sensitivity in obesity after bariatric surgery
    Melania Manco
    Department of Internal Medicine, Catholic University, School of Medicine, 484 Pineta Sacchetti, 00168 Rome, Italy
    Obes Res 13:1692-700. 2005
    ..We aimed to test the hypothesis that concentration of 25(OH)D influences insulin sensitivity in obesity before and after weight loss...
  72. ncbi Lowering of circulating free-fatty acids levels and reduced expression of leptin in white adipose tissue in postobesity status
    Aldo V Greco
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    J Investig Med 50:207-13. 2002
    ..Our aim was to investigate the regulation of the gene expression of leptin in subcutaneous adipose tissue biopsies in morbid obesity before and after biliopancreatic diversion (BPD)...
  73. ncbi beta-cell function in obesity: effects of weight loss
    Ele Ferrannini
    Department of Internal Medicine, Via Savi, 8, 56126 Pisa, Italy
    Diabetes 53:S26-33. 2004
    ..Lipid-triggered messages from the gastrointestinal tract to the insulin target tissues and endocrine pancreas are the subject of intense investigation...
  74. ncbi Reduced plasma ghrelin concentration in celiac disease after gluten-free diet treatment
    Esmeralda Capristo
    Institute of Internal Medicine, Metabolic Unit, Catholic University, Rome, Italy
    Scand J Gastroenterol 40:430-6. 2005
    ....
  75. ncbi Insulin clearance in obesity
    M Elena Valera Mora
    Institute of Internal Medicine, Catholic University of Rome, Largo Agostino Gemelli 8, 00168 Rome, Italy
    J Am Coll Nutr 22:487-93. 2003
    ..Insulin can be cleared also by muscle, adipocytes, gastrointestinal cells, fibroblasts, monocytes and lymphocytes which contain insulin receptors and internalization and regulation mechanism for insulin metabolism...
  76. ncbi Effects of weight loss and calorie restriction on carbohydrate metabolism
    Melania Manco
    Department of Internal Medicine and Clinical Science, Catholic University, Rome, Italy
    Curr Opin Clin Nutr Metab Care 8:431-9. 2005
    ..The topics covered include insulin secretion and resistance, glucose homeostasis and allostasis, changes in the secretive patterns of adipose tissue and the entero-insular axis...
  77. ncbi Ghrelin does not influence gastric emptying in obese subjects
    Maria E Valera Mora
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Obes Res 13:739-44. 2005
    ..DISCUSSION: This report shows that, in humans, gastric emptying is faster in obese subjects than in lean controls and that, whereas ghrelin is the best determinant of gastric kinetics in healthy controls, this action is lost in obesity...
  78. ncbi The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects
    Melania Manco
    Institute of Internal Medicine, Catholic University S Cuore, School of Medicine, Rome, Italy
    Br J Nutr 92:895-903. 2004
    ..The data are consistent with the hypothesis that acute excess lipid availability may lead to a compensatory elevation in glucose-induced insulin secretion as a result of the decline in insulin sensitivity and a reduced insulin clearance...
  79. ncbi Hypocalcemia complicating near-total thyroidectomy in patients with coexisting lipid malabsorption due to biliopancreatic diversion
    Melania Manco
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Obes Surg 14:1429-34. 2004
    ..Patients who have undergone biliopancreatic diversion (BPD) show a high incidence of mild hypocalcemia, which may become symptomatic and life-treating after an extensive thyroid operation...
  80. ncbi Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study
    D Gui
    Department of Surgery, Universita Cattolica del Sacro Cuore, Rome, Italy
    Aliment Pharmacol Ther 23:675-80. 2006
    ..Botulinum toxin A (Btx-A) is a long-acting inhibitor of acetylcholine-mediated peristalsis, which is mainly responsible for gastric motility...
  81. ncbi Menopause, insulin resistance, and risk factors for cardiovascular disease
    Melania Manco
    Institute of Internal Medicine, Catholic University, Rome, Italy
    Menopause 13:809-17. 2006
    ....
  82. ncbi VO2, VCO2, and RQ in a respiratory chamber: accurate estimation based on a new mathematical model using the Kalman-Bucy method
    L Granato
    Dipartimento di Informatica e Sistemistica Antonio Ruberti, , , Rome, Italy
    J Appl Physiol 96:1045-54. 2004
    ..3 x 10(-4) vs. 800 x 10(-4)). The presented study demonstrates the validity of the proposed model and the improvement in the results when using a KB estimation method to resolve it...
  83. ncbi Body composition and common carotid artery remodeling in a healthy population
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 93:3325-32. 2008
    ..Body composition (BC) influences systemic hemodynamics and may participate in the remodeling of common carotid artery (CCA), independently of risk factors...
  84. ncbi Effects of high-fat diet exposure during fetal life on type 2 diabetes development in the progeny
    Donatella Gniuli
    Department of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    J Lipid Res 49:1936-45. 2008
    ....
  85. ncbi First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery
    Serenella Salinari
    Department of Systems Analysis and Informatics, University of Rome La Sapienza, Rome, Italy
    Diabetes Care 32:375-80. 2009
    ..The purpose of this study was to elucidate the mechanisms of diabetes reversibility after malabsorptive bariatric surgery...
  86. ncbi A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder
    A V Greco
    Istituto di Clinica Medica, Universita Cattolica, Roma, Italy
    Experientia 46:452-4. 1990
    ....
  87. ncbi One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study
    Melania Manco
    Bambino Gesu Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Diabetes Care 33:2090-7. 2010
    ..The aim of this study was to characterize their metabolic phenotype...
  88. ncbi Effects of bilio-pancreatic diversion on diabetic complications: a 10-year follow-up
    Amerigo Iaconelli
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetes Care 34:561-7. 2011
    ..We aimed to determine whether patients with newly diagnosed type 2 diabetes who underwent bilio-pancreatic diversion (BPD) had less micro- and macrovascular complications than those who received conventional therapy...
  89. ncbi Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations
    Francesco Equitani
    Transfusion Medicine, SanFilippo Neri Hospital, Rome, Italy
    Diabetes Care 31:3-8. 2008
    ..To clarify the pathogenesis of diabetes associated with mutations of the hemochromatosis (HFE) gene, 17 carriers, 9 normal glucose tolerant (NGT) and 8 diabetic, were evaluated in an interventional trial...
  90. ncbi Approximate linear confidence and curvature of a kinetic model of dodecanedioic acid in humans
    Simona Panunzi
    Laboratorio di Biomatematica, Centro Nazionale delle Ricerche, Istituto di Analisi dei Sistemi ed Informatica A Ruberti, Rome, Italy
    Am J Physiol Endocrinol Metab 289:E915-22. 2005
    ..A suitable Monte Carlo simulation yielded empirical joint parameter distributions from which the approximate parameter variances could finally be obtained...
  91. ncbi Bioimpedance analysis: a useful technique for assessing appendicular lean soft tissue mass and distribution
    Serenella Salinari
    Dipartimento di Informatica e Sistemistica, Universita di Roma La Sapienza, 00184 Roma, Italy
    J Appl Physiol 94:1552-6. 2003
    ..4 and 5.9 +/- 3.4% in the two groups, respectively. Similar results were obtained by using five resistance values for the analysis. In conclusion, the proposed BIA model provides an adequate means of evaluating appendicular SM mass...
  92. ncbi NEFA-glucose comodulation model of beta-cell insulin secretion in 24-h multiple-meal test
    Serenella Salinari
    Department of Systems Analysis and Informatics, University of Rome La Sapienza, Italy
    Am J Physiol Endocrinol Metab 292:E1890-8. 2007
    ....
  93. ncbi Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6
    Daniel Bach
    Universitat de Barcelona, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Avda Diagonal 645, Barcelona, Spain
    Diabetes 54:2685-93. 2005
    ....
  94. ncbi The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
    ..We sought to distinguish between these two mechanisms...
  95. ncbi Insulin granule trafficking in beta-cells: mathematical model of glucose-induced insulin secretion
    Alessandro Bertuzzi
    Institute of Systems Analysis and Computer Science, Consiglio Nazionale delle Ricerche, Rome
    Am J Physiol Endocrinol Metab 293:E396-409. 2007
    ..Model parameter changes that may reflect alterations of beta-cell function present in type 2 diabetes are investigated, and the action of pharmacological agents that bind to sulfonylurea receptors is simulated...
  96. ncbi Reduced expression of uncoupling proteins-2 and -3 in adipose tissue in post-obese patients submitted to biliopancreatic diversion
    Roberto Vettor
    Endocrine Metabolic Laboratory, Internal Medicine, Department of Medical and Surgical Sciences, University of Padua, Via Ospedale 105, 35128 Padua, Italy
    Eur J Endocrinol 148:543-50. 2003
    ..We investigated whether the expression of UCP-2 and -3 in adipose tissue was affected by weight loss due to a biliopancreatic diversion (BPD) and related to the daily energy expenditure (24-h EE)...
  97. ncbi How to consider low serum vitamin D as a risk factor for insulin resistance?
    Melania Manco
    Am J Clin Nutr 80:1450-1; author reply 1452-3. 2004