Genomes and Genes
Affiliation: Catholic University
- The S100B protein in biological fluids: more than a lifelong biomarker of brain distressFabrizio Michetti
Institute of Anatomy and Cell Biology, Universita Cattolica Sacro Cuore, Roma, Italy
J Neurochem 120:644-59. 2012..This possibility makes this protein a candidate not only for a biomarker but also for a potential therapeutic target...
- S100B protein in biological fluids: a tool for perinatal medicineFabrizio Michetti
Institute of Anatomy, Catholic University, Largo Francesco Vito 1, I 00168 Rome, Italy
Clin Chem 48:2097-104. 2002..Finally, because of the neurotrophic role putatively played by S100B, its measurement in biological fluids at pre-/perinatal ages makes it a candidate for the laboratory evaluation of brain maturation...
- S100B testing in pregnancyFabrizio Michetti
Institute of Anatomy and Cell Biology, Catholic University, Largo Francesco Vito 1, I 00168, Rome, Italy
Clin Chim Acta 335:1-7. 2003..It appears also to be relevant that a neurotrophic role has been hypothesized for the protein, which in fact exhibits in amniotic fluid, in cord blood and in placenta patterns of concentration related to the gestational age...
- Neurotrophic features of human adipose tissue-derived stromal cells: in vitro and in vivo studiesWanda Lattanzi
Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, 00168 Rome, Italy
J Biomed Biotechnol 2011:468705. 2011..Our observation adds useful information to recent evidence proposing these cells as a suitable tool for cell-based applications in neuroregenerative medicine...
- Trimethyltin intoxication up-regulates nitric oxide synthase in neurons and purinergic ionotropic receptor 2 in astrocytes in the hippocampusLaura Latini
Santa Lucia Foundation IRCCS, Rome, Italy
J Neurosci Res 88:500-9. 2010..Finally, the temporal relations between P2XR and NOS expression and neuronal degeneration suggest interactions between P2XR/NO signaling and cell survival...
- Enhanced neurogenesis during trimethyltin-induced neurodegeneration in the hippocampus of the adult ratValentina Corvino
Institute of Anatomy and Cell Biology, Catholic University, L.go F. Vito 1, 00168 Rome, Italy
Brain Res Bull 65:471-7. 2005....
- Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expressionMarta Barba
Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, Lgo F Vito 1, 00168 Rome, Italy
J Biomed Biotechnol 2012:813894. 2012....
- Transplantation of foetal neural stem cells into the rat hippocampus during trimethyltin-induced neurodegenerationMaria Concetta Geloso
Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Rome, Italy
Neurochem Res 32:2054-61. 2007....
- Protease-activated receptor-1 expression in rat microglia after trimethyltin treatmentElena Pompili
Department of Human Anatomy, University of Rome La Sapienza, Rome, Italy
J Histochem Cytochem 59:302-11. 2011..These data provide further evidence that PAR-1 may be involved in microglial response to brain damage...
- Undifferentiated human adipose tissue-derived stromal cells induce mandibular bone healing in ratsClaudio Parrilla
Department of Otolaryngology, Universita Cattolica del Sacro Cuore, School of Medicine A Gemelli, Rome, Italy
Arch Otolaryngol Head Neck Surg 137:463-70. 2011..Human dermal fibroblasts (HDFs) were used as a differentiated cellular control in the study...
- Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulationNathalie Saulnier
Department of Internal Medicine and Gastroenterology, Gemelli University Hospital, Catholic University of Sacred Heart, Rome, Italy
Cytotherapy 13:329-40. 2011..The aim of this study was to compare the genome-wide expression profiles of bone marrow-and adipose tissue-derived MSC, in order to identify a common molecular stemness core...
- Lim mineralization protein is involved in the premature calvarial ossification in sporadic craniosynostosesWanda Lattanzi
Institute of Anatomy and Cell Biology, Universita Cattolica S Cuore, Rome, Italy
Bone 52:474-84. 2013..the molecular basis of the overactive osteogenic process may at least in part involve a deregulation of the LMP-related pathway in calvarial cells...
- Genome-wide gene expression profiling of human narcolepsyCamilla Bernardini
Institute of Anatomy and Cell Biology, Catholic University, Rome, Italy
Gene Expr 15:171-81. 2012..In conclusion, the gene expression profile associated to NRLCP suggested that molecular markers of neurological impairment, dysmetabolic and immune-related mechanisms, can be detected in blood of NRLCP patients...
- S100B protein and 4-hydroxynonenal in the spinal cord of wobbler miceValentina Corvino
Institute of Anatomy, Catholic University, Rome, Italy
Neurochem Res 28:341-5. 2003..In the same spinal cord regions, scattered neurons appeared to be immunostained for 4-hydroxynonenal-modified proteins, an indicator of lipid peroxidation. This finding constitutes a sign of oxidative stress-induced neurodegeneration...
- Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegenerationMaria Concetta Geloso
Institute of Anatomy and Cell Biology, , Largo Francesco Vito 1, I-00168 Rome, Italy
Neurosci Lett 357:103-6. 2004..This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation...
- Neural stem cells modified to express BDNF antagonize trimethyltin-induced neurotoxicity through PI3K/Akt and MAP kinase pathwaysPatrizia Casalbore
Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy
J Cell Physiol 224:710-21. 2010..We demonstrate that overexpression of BDNF firmly regulate cell survival and differentiation of NSC and protects differentiated NSC against TMT-induced neurotoxicity through the PI3K/Akt and MAPK signaling pathways...
- Genetic basis of single-suture synostoses: genes, chromosomes and clinical implicationsWanda Lattanzi
Latium Musculoskeletal Tissue Bank, Rome, Italy
Childs Nerv Syst 28:1301-10. 2012..Possible genotype/phenotype correlations are discussed as useful clues towards the definition of optimized clinical management flowcharts...
- Dysregulation of intracellular calcium homeostasis is responsible for neuronal death in an experimental model of selective hippocampal degeneration induced by trimethyltinRoberto Piacentini
Institute of Human Physiology, Medical School, Catholic University S Cuore, Rome, Italy
J Neurochem 105:2109-21. 2008....
- Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim mineralization protein 3Camilla Bernardini
Institute of Anatomy and Cell Biology, Catholic University, School of Medicine, Rome, Italy
Gene Expr 15:27-42. 2010..These results suggested that LMP3 could affect the fine balance between cell proliferation/differentiation of mesenchymal cells mostly by modulating the TGF-beta1 signaling pathway...
- Hypoxia-like transcriptional activation in TMT-induced degeneration: microarray expression analysis on PC12 cellsWanda Lattanzi
Institute of Anatomy and Cell Biology, Catholic University, Rome, Italy
J Neurochem 100:1688-702. 2007..Therefore, our data help to delineate general basic adaptive mechanisms possibly shared by cells responding to different death-inducing noxae, such as TMT...
- Ontogenetic localization and distribution of S-100beta protein in human placental tissuesEmanuela Marinoni
Laboratory of Perinatal Medicine and Molecular Biology, Second Institute of Obstetrics and Gynecology, University of Rome La Sapienza, Rome, Italy
Obstet Gynecol 99:1093-9. 2002..To investigate whether S-100beta, a brain-specific protein found in amniotic fluid and fetal circulation, is present in fetoplacental tissues throughout gestation...
- Gene expression profiling in human craniosynostoses: a tool to investigate the molecular basis of suture ossificationCamilla Bernardini
Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, Largo F Vito, 1, 00168, Rome, Italy
Childs Nerv Syst 28:1295-300. 2012..A promising tool to investigate the molecular mechanisms that may orchestrate this event is the comparative analysis of suture- and synostosis-derived tissues and cells...
- Cyclooxygenase-2 and caspase 3 expression in trimethyltin-induced apoptosis in the mouse hippocampusMaria Concetta Geloso
Institute of Anatomy, Catholic University, Rome
Exp Neurol 175:152-60. 2002..Inducible cyclooxygenase is also expressed at cytoplasmic level by degenerating granular neurons, suggesting that this enzyme may participate in TMT-induced neurodegeneration...
- Mitochondrial network genes in the skeletal muscle of amyotrophic lateral sclerosis patientsCamilla Bernardini
Institute of Anatomy and Cell Biology, School of Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
PLoS ONE 8:e57739. 2013..e. common expression trends) among genes, whose function seems to be aberrantly activated during the progression of muscle atrophy...
- Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processesMaria Concetta Geloso
Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, L go F Vito 1, 00168 Rome, Italy
Neurochem Int 58:729-38. 2011..This review summarizes current data from in vivo and in vitro studies of the neurotoxic effects of TMT, focusing on the hypotheses regarding the mechanisms leading to neuronal death induced by the toxin...
- De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampusRita Businaro
Department of Cardiovascular Sciences, University La Sapienza, Rome, Italy
Brain Res Mol Brain Res 98:141-4. 2002..The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats...
- Diminished expression of S100A2, a putative tumour suppressor, is an independent predictive factor of neck node relapse in laryngeal squamous cell carcinomaGiovanni Almadori
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy
J Otolaryngol Head Neck Surg 38:16-22. 2009..In the present work, the role of S100A2 protein expression in the prediction of regional metastasis-free survival (MFS) was investigated to guide neck management in LSCC...
- Urinary S100B protein concentrations are increased in intrauterine growth-retarded newbornsPasquale Florio
Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Siena, Italy
Pediatrics 118:e747-54. 2006..Longitudinal S100B protein measurements soon after birth are a useful tool to identify which intrauterine growth retardation infants are at risk of possible neurologic sequelae...
- S100B protein concentrations in amniotic fluid are higher in monoamniotic than in diamniotic twins and singleton pregnanciesDiego Gazzolo
Department of Pediatrics, Giannina Gaslini Children's University Hospital, I-16147 Genoa, Italy
Clin Chem 49:997-9. 2003
- Maternal glucocorticoid supplementation and S100B protein concentrations in cord blood and urine of preterm infantsDiego Gazzolo
Department of Pediatrics and Obstetrics, G Gaslini Children's University Hospital, I-16167 Genoa, Italy
Clin Chem 49:1215-8. 2003
- Measurement of urinary S100B protein concentrations for the early identification of brain damage in asphyxiated full-term infantsDiego Gazzolo
Department of Neonatology, Giannina Gaslini Children s University Hospital, Genoa, Italy
Arch Pediatr Adolesc Med 157:1163-8. 2003..We investigated whether measurements of urine levels of S100B in asphyxiated full-term newborns may be a useful tool for early detection of postasphyxia brain damage...
- Urinary S100B protein measurements: A tool for the early identification of hypoxic-ischemic encephalopathy in asphyxiated full-term infantsDiego Gazzolo
Department of Pediatrics, G Gaslini Children s University Hospital, Genoa, Italy
Crit Care Med 32:131-6. 2004..Hypoxic-ischemic encephalopathy (HIE) is one of the major causes of perinatal mortality and morbidity. To date, there are no reliable methods to detect which infants will develop brain damage after asphyxia insult...
- Amniotic fluid S100B protein in mid-gestation and intrauterine fetal deathPasquale Florio
Department of Paediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
Lancet 364:270-2. 2004..000 MoM [1.062-1.121]). Sensitivity, specificity, and positive and negative predictive values of S100B as a diagnostic test were 100%, suggesting that measurement of this protein at amniocentesis could be useful to identify at-risk women...
- Effects of temperature on pre-analytical stability of S100B protein concentrations in urine of healthy full-term infantsDiego Gazzolo
Clin Chim Acta 350:231-2. 2004
- S100B protein levels in saliva: correlation with gestational age in normal term and preterm newbornsDiego Gazzolo
Department of Pediatrics, Service of Epidemiology and Biostatistics Scientific Direction, Giannina Gaslini Children s University Hospital, Genoa, Italy
Clin Biochem 38:229-33. 2005..It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations...
- Amniotic fluid levels of S100B protein in normal and trisomy-21 foetusesDiego Gazzolo
Department of Paediatrics, Giannina Gaslini Children s University Hospital, I 16147 Genoa, Italy
Clin Chim Acta 330:131-3. 2003..The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21...
- Circulating S100beta protein is increased in intrauterine growth-retarded fetusesDiego Gazzolo
Department of Pediatrics, Giannina Gaslini Children s University Hospital, Genoa, Italy
Pediatr Res 51:215-9. 2002..This study provides evidence that circulating S100beta protein is increased in IUGR fetuses and correlates with cerebral hemodynamics, suggesting that it may represent an index of cerebral cell damage in the perinatal period...
- Human milk contains S100B proteinDiego Gazzolo
Department of Pediatrics, Giannina Gaslini Children s University Hospital, I 16147 Genoa, Italy
Biochim Biophys Acta 1619:209-12. 2003..This finding could be related to a possible trophic role, which has been hypothesized for the protein...
- High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhageDiego Gazzolo
Department of Pediatrics and Neuroscience, G Gaslini Children s University Hospital, Genoa, Italy
Clin Chem 52:819-26. 2006..We also explored the prognostic accuracy of maternal serum S100B for IVH in the newborn...
- Pediatric concentrations of S100B protein in blood: age- and sex-related changesDiego Gazzolo
Department of Pediatrics, Giannina Gaslini Children's University Hospital, I-16147 Genoa, Italy
Clin Chem 49:967-70. 2003
- S100B blood levels correlate with rewarming time and cerebral Doppler in pediatric open heart surgeryDiego Gazzolo
Department of Pediatrics, Giannina Gaslini Children s University Hospital, 1 16147 Genoa, Italy
J Card Surg 17:279-84. 2002..Blood S100B levels are emerging as a marker of brain distress, and could offer a reliable monitoring tool at different times during and after open heart surgery...
- S100B protein in urine of preterm newborns with ominous outcomeDiego Gazzolo
Department of Pediatrics, G Gaslini Children s Hospital, University of Genoa, Italy
Pediatr Res 58:1170-4. 2005..The positive predictive value was 78.6%, the negative predictive value was 100%. Measurement of urine S100B protein levels in preterm newborns could be useful to identify newborns at higher risk of neonatal death...
- S100B protein is increased in asphyxiated term infants developing intraventricular hemorrhageDiego Gazzolo
Department of Neonatology, G Gaslini Children s University Hospital, Genoa, Italy
Crit Care Med 30:1356-60. 2002..To establish whether S100B protein may be useful in the early detection of intraventricular hemorrhage in asphyxiated term infants...
- Canine cognitive deficit correlates with diffuse plaque maturation and S100beta (-) astrocytosis but not with insulin cerebrospinal fluid levelMarco Pugliese
, , Facultat de Medicina, Universitat de Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain
Acta Neuropathol (Berl) 111:519-28. 2006....
- Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milksDiego Gazzolo
Department of Obstetrics and Pediatrics, Giannina Gaslini Children s University Hospital, I 16147 Genoa, Italy
Clin Nutr 23:23-6. 2004..The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae...
- S100b counteracts effects of the neurotoxicant trimethyltin on astrocytes and microgliaCamilla Reali
Department of Cytomorphology, University of Cagliari, Monserrato, Italy
J Neurosci Res 81:677-86. 2005..These results might help in understanding the role played by glial cells in brain injury after exposure to chemical neurotoxicants and support the view that S100B may protect brain cells in case of injury. (c) 2005 Wiley-Liss, Inc...
- S100B Protein concentration in milk-formulas for preterm and term infants. Correlation with industrial preparation proceduresFrancesco Nigro
Department of Maternal, Fetal and Neonatal Health, G Garibaldi Hospital, Catania, Italy
Mol Nutr Food Res 52:609-13. 2008..New feeding strategies in preterm and term infants are therefore warranted in order to preserve S100B protein during industrial preparation...
- S100A1B and S100BB urine levels in preterm and term healthy newbornsDiego Gazzolo
Clin Chim Acta 384:186-7. 2007
- Increased S100B in cerebrospinal fluid of infants with bacterial meningitis: relationship to brain damage and routine cerebrospinal fluid findingsDiego Gazzolo
Department of Pediatrics and Obstetrics and Gynecology, Giannina Gaslini Children's University Hospital, Genoa, Italy
Clin Chem 50:941-4. 2004
- Systemic endotoxin administration results in increased S100B protein blood levels and periventricular brain white matter injury in the preterm fetal sheepYves Garnier
Department of Obstetrics and Gynecology, University Hospitals of Aachen and Cologne, Kerpenerstrasse 62, 50924 Cologne, Germany
Eur J Obstet Gynecol Reprod Biol 124:15-22. 2006..The aim of the present study was to clarify, whether intravenous application of endotoxin results in neuropathological findings and increased blood levels of the S100B protein, which is a consolidated marker of brain injury...
- Maternal nitric oxide supplementation decreases cord blood S100B in intrauterine growth-retarded fetusesDiego Gazzolo
Clin Chem 48:647-50. 2002