Cesare Mancuso

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. doi request reprint Ferulic acid: pharmacological and toxicological aspects
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito, 1, 00168 Rome, Italy Electronic address
    Food Chem Toxicol 65:185-95. 2014
  2. doi request reprint Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo F Vito, 1, 00168 Rome, Italy
    Neurosci Lett 518:101-5. 2012
  3. doi request reprint Natural substances and Alzheimer's disease: from preclinical studies to evidence based medicine
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito, 1 00168 Rome, Italy
    Biochim Biophys Acta 1822:616-24. 2012
  4. pmc The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile
    Daria Brambilla
    Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy
    Nutr J 7:29. 2008
  5. doi request reprint Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before
    Cesare Mancuso
    Catholic University School of Medicine, Institute of Pharmacology, Largo Francesco Vito, 1, 00168 Rome, Italy
    Expert Opin Investig Drugs 20:1243-61. 2011
  6. doi request reprint Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    J Neurochem 113:563-75. 2010
  7. ncbi request reprint The heme oxygenase/biliverdin reductase pathway in drug research and development
    C Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo F Vito, 1 00168 Roma, Italy
    Curr Drug Metab 10:579-94. 2009
  8. ncbi request reprint Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy
    Biochem Pharmacol 66:2355-63. 2003
  9. ncbi request reprint Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Redox Rep 11:207-13. 2006
  10. ncbi request reprint Albumin-bound bilirubin interacts with nitric oxide by a redox mechanism
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 8:487-94. 2006

Collaborators

Detail Information

Publications32

  1. doi request reprint Ferulic acid: pharmacological and toxicological aspects
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito, 1, 00168 Rome, Italy Electronic address
    Food Chem Toxicol 65:185-95. 2014
    ..New efforts and resources are needed in clinical research for the complete evaluation of FA therapeutic potential in chronic diseases. ..
  2. doi request reprint Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo F Vito, 1, 00168 Rome, Italy
    Neurosci Lett 518:101-5. 2012
    ..In conclusion, both bilirubin and biliverdin exhibited a greater antioxidant activity than alpha-tocopherol in preventing oxidative stress damage in rat brain...
  3. doi request reprint Natural substances and Alzheimer's disease: from preclinical studies to evidence based medicine
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito, 1 00168 Rome, Italy
    Biochim Biophys Acta 1822:616-24. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  4. pmc The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile
    Daria Brambilla
    Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy
    Nutr J 7:29. 2008
    ..In this line, the inappropriate assumption of some lipophylic vitamins has been associated with increased incidence of cancer rather than with beneficial effects...
  5. doi request reprint Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before
    Cesare Mancuso
    Catholic University School of Medicine, Institute of Pharmacology, Largo Francesco Vito, 1, 00168 Rome, Italy
    Expert Opin Investig Drugs 20:1243-61. 2011
    ..Acetylcholinesterase inhibitors or NMDA glutamate receptor antagonists are currently used for the treatment of AD, but only the former have weak beneficial effects on cognitive function...
  6. doi request reprint Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    J Neurochem 113:563-75. 2010
    ..This review examines the complex roles of NO, CO, and H(2)S in modulation of stress-axis activity, with particular emphasis on the regulatory effects they exert at the hypothalamic level...
  7. ncbi request reprint The heme oxygenase/biliverdin reductase pathway in drug research and development
    C Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo F Vito, 1 00168 Roma, Italy
    Curr Drug Metab 10:579-94. 2009
    ..The solution may lie in the use of novel drug-delivery systems that allow targeted delivery of low doses of the HO/BVR modulator to selected tissues...
  8. ncbi request reprint Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy
    Biochem Pharmacol 66:2355-63. 2003
    ..Taken together, these data suggest that BR should not be considered only as an endogenous antioxidant but also as a molecule with the potential ability to counteract intracellular nitrosative stress reactions...
  9. ncbi request reprint Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Redox Rep 11:207-13. 2006
    ..The aim of this paper is to give an overview of the interaction between bilirubin and nitric oxide/reactive nitrogen species; furthermore, the possible pathophysiological and clinical relevance of this interaction will be discussed...
  10. ncbi request reprint Albumin-bound bilirubin interacts with nitric oxide by a redox mechanism
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 8:487-94. 2006
    ..Taken together, these data suggest that albumin-bound bilirubin maintains its ability to interact with NO also in the bloodstream counteracting extracellular nitrosative reactions...
  11. ncbi request reprint Heme oxygenase and its products in the nervous system
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 6:878-87. 2004
    ....
  12. doi request reprint Heme oxygenase-derived carbon monoxide modulates gonadotropin-releasing hormone release in immortalized hypothalamic neurons
    Stefania Errico
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito, 1 00168 Roma, Italy
    Neurosci Lett 471:175-8. 2010
    ....
  13. doi request reprint Bilirubin as an endogenous modulator of neurotrophin redox signaling
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
    J Neurosci Res 86:2235-49. 2008
    ..Taken together, these observations indicate an important action of bilirubin on redox signaling by neurotrophins, with either inhibitory or agonistic effects based on growth factor availability...
  14. doi request reprint HO-1/BVR-a system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease
    Fabio Di Domenico
    Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy
    J Alzheimers Dis 32:277-89. 2012
    ..We hypothesize that the HO-1/BVR-A system status in plasma might reflect the ongoing situation in the brain, offering an important biochemical tool for the potential prediction of AD at the earliest stages of the disease...
  15. ncbi request reprint Experimental research on nitric oxide and the therapy of Alzheimer disease: a challenging bridge
    Raffaella Siciliano
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito, Rome, Italy
    CNS Neurol Disord Drug Targets 10:766-76. 2011
    ..In addition, the risk/benefit ratio related to the modulation of the nitric oxide synthase/nitric oxide system in AD brain will be analyzed...
  16. ncbi request reprint Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Front Biosci 12:1107-23. 2007
    ..Food supplementation with curcumin and ferulic acid is considered a nutritional approach to reduce oxidative damage and amyloid pathology in Alzheimer disease...
  17. ncbi request reprint Natural antioxidants in Alzheimer's disease
    Cesare Mancuso
    Catholic University School of Medicine, Institute of Pharmacology, Largo F Vito, 00168 Roma, Italy
    Expert Opin Investig Drugs 16:1921-31. 2007
    ..The association with new drug delivery systems may be desirable and useful for the therapeutic use of antioxidants in human neurodegenerative diseases...
  18. doi request reprint Characterization of the S-denitrosylating activity of bilirubin
    Eugenio Barone
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    J Cell Mol Med 13:2365-75. 2009
    ....
  19. doi request reprint Ferulic acid and its therapeutic potential as a hormetin for age-related diseases
    Eugenio Barone
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168, Rome, Italy
    Biogerontology 10:97-108. 2009
    ..New efforts and resources should be transferred to clinical research for the complete evaluation of the therapeutic potential of FA in chronic diseases...
  20. ncbi request reprint The protective role of carotenoids against 7-keto-cholesterol formation in solution
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Largo F Vito 1, 00168 Rome, Italy
    Mol Cell Biochem 309:61-8. 2008
    ....
  21. pmc Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53
    Ada Fiorini
    Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy
    PLoS ONE 7:e49846. 2012
    ..Our investigation on isolated brain mitochondria from p53((-/-)) mice also provides a better understanding of the p53-mitochondria relationship and its involvement in the development of many diseases...
  22. pmc Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment
    Eugenio Barone
    Department of Chemistry, Center of Membrane Sciences and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Free Radic Biol Med 52:2292-301. 2012
    ..The significance of these findings is profound and opens new avenues into the comprehension of the role of HO-1 in the pathogenesis of AD...
  23. doi request reprint Heme oxygenase expression and activity in immortalized hypothalamic neurons GT1-7
    Nadia Mores
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Roma, Italy
    Neurosci Lett 444:106-8. 2008
    ..Taken together, these results suggest the presence of functional HO-1 in GT1-7 immortalized hypothalamic neurons and open new avenues about the use of this cell line for the study of HO modulation of GnRH secretion and reproduction...
  24. ncbi request reprint Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    J Neurosci Res 84:1385-91. 2006
    ..The importance of the interaction between HO and COX in the regulation of physiologic brain functions, and its relevance to neuroprotective or neurodegenerative mechanisms are discussed...
  25. ncbi request reprint beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 8:1069-80. 2006
    ..The role of HO-1 repression in increasing cell growth was also confirmed in Mv1Lu cells by the "knock down" of the Bach1 gene, thus demonstrating as HO-1 repression is a conserved mechanism by which cells can react to oxidative stress...
  26. ncbi request reprint Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease
    Vittorio Calabrese
    Department of Chemistry, Biochemistry, and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 8:1975-86. 2006
    ..Our data support a role for nitrative stress in the pathogenesis of AD and indicate that the stress-responsive genes, such as HO-1 and TRXr, may represent important targets for novel cytoprotective strategies...
  27. ncbi request reprint Redox regulation of cellular stress response in neurodegenerative disorders
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Mol Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Ital J Biochem 55:263-82. 2006
    ..This review summarizes the complex regulation of cellular stress signaling and its relevance to human physiology and disease...
  28. ncbi request reprint In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurochem 101:709-17. 2007
    ..Our data are in favor of the importance of the heat shock signal pathway as a basic mechanism of defense against neurotoxicity elicited by free radical oxygen and nitrogen species produced in aging and neurodegenerative disorders...
  29. doi request reprint Redox regulation of cellular stress response by ferulic acid ethyl ester in human dermal fibroblasts: role of vitagenes
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    Clin Dermatol 26:358-63. 2008
    ..These findings provide evidence for the protective role of vitagenes in free radical-induced skin damage and highlight the potential protective use of nutritional antioxidants, such as ferulic acid and its derivatives...
  30. doi request reprint Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state
    Vittorio Calabrese
    Department of Chemistry, Clinical Biochemistry and Clinical Molecular Biology Chair, University of Catania, Italy
    Methods Enzymol 441:83-110. 2008
    ....
  31. ncbi request reprint Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Nat Rev Neurosci 8:766-75. 2007
    ..In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic...
  32. ncbi request reprint Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria 6, 95100, Catania, Italy
    Neurochem Res 32:757-73. 2007
    ..We review here some of the emerging concepts of pathways to neurodegeneration and how these may be overcome by a nutritional approach...