R Landolfi

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint Aspirin for the control of platelet activation and prevention of thrombosis in essential thrombocythemia and polycythemia vera: current insights and rationale for future studies
    Raffaele Landolfi
    Institute of Internal Medicine and Geriatrics, Catholic Uinversity School of Medicine, Rome, Italy
    Semin Thromb Hemost 32:251-9. 2006
  2. ncbi request reprint Thrombosis and bleeding in polycythemia vera and essential thrombocythemia: pathogenetic mechanisms and prevention
    Raffaele Landolfi
    Internal Medicine Head of Hemostasis and Thrombosis Unit, Catholic University of Rome, Italy
    Best Pract Res Clin Haematol 19:617-33. 2006
  3. doi request reprint Polycythemia vera
    Raffaele Landolfi
    Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Catholic University School of Medicine, Largo Agostino Gemelli 8, Rome, Italy
    Intern Emerg Med 5:375-84. 2010
  4. doi request reprint Polycythemia vera: gender-related phenotypic differences
    Raffaele Landolfi
    Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Catholic University School of Medicine, Rome, Italy
    Intern Emerg Med 7:509-15. 2012
  5. doi request reprint Thrombosis in myeloproliferative and myelodysplastic syndromes
    Raffaele Landolfi
    Catholic University School of Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Largo Agostino Gemelli 8, 00168 Rome, Italy
    Hematology 17:S174-6. 2012
  6. ncbi request reprint Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
    Raffaele Landolfi
    Catholic University School of Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Rome, Italy
    Blood 109:2446-52. 2007
  7. doi request reprint Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation
    R Landolfi
    Department of Internal Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Catholic University School of Medicine, Rome, Italy
    Leukemia 22:2020-8. 2008
  8. ncbi request reprint Efficacy and safety of low-dose aspirin in polycythemia vera
    Raffaele Landolfi
    Catholic University School of Medicine, Rome, Italy
    N Engl J Med 350:114-24. 2004
  9. ncbi request reprint Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
    E De Candia
    Institute of Medical Semeiotics, Haemostasis Research Center and Department of Hematology, Catholic University School of Medicine, 00168 Rome, Italy
    J Biol Chem 276:4692-8. 2001
  10. doi request reprint Reflux symptoms in wind instrument players
    G Cammarota
    Institute of Internal Medicine, Catholic University of Medicine and Surgery, Rome, Italy
    Aliment Pharmacol Ther 31:593-600. 2010

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Aspirin for the control of platelet activation and prevention of thrombosis in essential thrombocythemia and polycythemia vera: current insights and rationale for future studies
    Raffaele Landolfi
    Institute of Internal Medicine and Geriatrics, Catholic Uinversity School of Medicine, Rome, Italy
    Semin Thromb Hemost 32:251-9. 2006
    ..Future studies should assess primarily the efficacy and safety of aspirin in essential thrombocythemia, and test the possible use of more aggressive antithrombotic strategies in high-risk polycythemic patients...
  2. ncbi request reprint Thrombosis and bleeding in polycythemia vera and essential thrombocythemia: pathogenetic mechanisms and prevention
    Raffaele Landolfi
    Internal Medicine Head of Hemostasis and Thrombosis Unit, Catholic University of Rome, Italy
    Best Pract Res Clin Haematol 19:617-33. 2006
    ..This might require either the availability of safer cytoreductive agents or, alternatively, the use of more aggressive antiplatelet regimens in patients at high thrombotic risk...
  3. doi request reprint Polycythemia vera
    Raffaele Landolfi
    Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Catholic University School of Medicine, Largo Agostino Gemelli 8, Rome, Italy
    Intern Emerg Med 5:375-84. 2010
    ..The use of pegylated interferon, imatinib, and JAK2 inhibitors is currently being evaluated...
  4. doi request reprint Polycythemia vera: gender-related phenotypic differences
    Raffaele Landolfi
    Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Catholic University School of Medicine, Rome, Italy
    Intern Emerg Med 7:509-15. 2012
    ..2 vs. 0.6 cases per 100 person-years; P > 0.05). These data show several gender-related differences both in the thrombotic diathesis and in the prevalence of vascular risk factors of PV patients...
  5. doi request reprint Thrombosis in myeloproliferative and myelodysplastic syndromes
    Raffaele Landolfi
    Catholic University School of Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Largo Agostino Gemelli 8, 00168 Rome, Italy
    Hematology 17:S174-6. 2012
    ..In this short review, we focus the attention on the main aspects of thrombophilia in both disorders...
  6. ncbi request reprint Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
    Raffaele Landolfi
    Catholic University School of Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Rome, Italy
    Blood 109:2446-52. 2007
    ..71; 95% CI, 1.10-2.65; P = .017), mainly deriving from an increased risk of myocardial infarction (HR, 2.84; 95% CI, 1.25-6.46; P = .013). Thus, leukocyte count may help in defining the vascular risk of polycythemic subjects...
  7. doi request reprint Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation
    R Landolfi
    Department of Internal Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Catholic University School of Medicine, Rome, Italy
    Leukemia 22:2020-8. 2008
    ..Although the pathogenesis of thrombophilia is still elusive, platelet and leukocyte abnormalities seem particularly critical and likely account for the antithrombotic efficacy of aspirin and hydroxyurea...
  8. ncbi request reprint Efficacy and safety of low-dose aspirin in polycythemia vera
    Raffaele Landolfi
    Catholic University School of Medicine, Rome, Italy
    N Engl J Med 350:114-24. 2004
    ..The use of aspirin for the prevention of thrombotic complications in polycythemia vera is controversial...
  9. ncbi request reprint Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
    E De Candia
    Institute of Medical Semeiotics, Haemostasis Research Center and Department of Hematology, Catholic University School of Medicine, 00168 Rome, Italy
    J Biol Chem 276:4692-8. 2001
    ..Altogether these results show that thrombin interaction with GpIb enhances the specificity of thrombin cleavage of PAR-1 on intact platelets, suggesting that GpIb may function as a "cofactor" for PAR-1 activation by thrombin...
  10. doi request reprint Reflux symptoms in wind instrument players
    G Cammarota
    Institute of Internal Medicine, Catholic University of Medicine and Surgery, Rome, Italy
    Aliment Pharmacol Ther 31:593-600. 2010
    ..An occupation-related susceptibility of orchestral wind instrument players to gastro-oesophageal reflux was hypothesized...
  11. ncbi request reprint Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus
    R De Cristofaro
    Center of Excellence on Aging, G D Annunziou University School of Medicine and Pharmacy, Chieti, Italy
    J Thromb Haemost 1:250-6. 2003
    ..In conclusion, OS in T2DM involves circulating proteins and is associated with an unbalanced promotion of procoagulant reactions. These effects in concert with platelet activation may contribute to atherothrombotic complications in T2DM...
  12. ncbi request reprint Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib
    R De Cristofaro
    Hemostasis Research Center, Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy
    Biochemistry 40:13268-73. 2001
    ..In conclusion, these experiments provide a structural and functional mapping of the thrombin HBS subregions involved in the binding to the platelet Gp(Ib)alpha and in the cell activation...
  13. ncbi request reprint Oxidation of human alpha-thrombin by the myeloperoxidase-H2O2-chloride system: structural and functional effects
    R De Cristofaro
    Hemostasis Research Center, Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy
    Thromb Haemost 83:253-61. 2000
    ..The above results indicate a high sensitivity of thrombin to oxidative modifications by myeloperoxidase. Perturbed interactions with Protein C and the heparin-ATIII complex were the most relevant functional abnormalities of ox-thrombin...
  14. ncbi request reprint Allosteric modulation of BPTI interaction with human alpha- and zeta-thrombin
    R De Cristofaro
    Department of Internal Medicine, Catholic University of Rome, Italy
    Eur J Biochem 260:97-102. 1999
    ....
  15. ncbi request reprint Plasma protein oxidation is associated with an increase of procoagulant markers causing an imbalance between pro- and anticoagulant pathways in healthy subjects
    Cristofaro Raimondo De
    Hemostasis Research Center, Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy
    Thromb Haemost 87:58-67. 2002
    ..This may open the way to further studies aimed at elucidating the mechanisms by which the oxidative stress is linked to activation of the coagulation system in atherothrombotic disorders...
  16. doi request reprint Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacter pylori: a clinical trial
    Giovanni Cammarota
    Institute of Internal Medicine, Catholic University of Medicine and Surgery, Rome, Italy
    Clin Gastroenterol Hepatol 8:817-820.e3. 2010
    ..This constitutes protection from antimicrobial agents. We assessed the role of a pretreatment with n-acetylcysteine in destroying biofilm and overcoming H pylori antibiotic resistance...
  17. ncbi request reprint Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives
    E De Candia
    Department of Internal Medicine, Haemostasis Research Centre, Agostino Gemelli Hospital, Catholic University School of Medicine, Rome, Italy
    J Thromb Haemost 5:551-9. 2007
    ..We report a novel case of gray platelet syndrome (GPS). A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly...
  18. ncbi request reprint Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo
    R Landolfi
    Department of Medicine, Catholic University School of Medicine, Rome, Italy
    Blood 80:1965-71. 1992
    ..This in vivo abnormality in platelet biochemistry can be largely suppressed by low doses of aspirin...
  19. ncbi request reprint Effect of fibrinogen concentration and platelet count on the inhibitory effect of abciximab and tirofiban
    Giulia Renda
    Research Center on Pathophysiology of Haemostasis, Catholic University School of Medicine, Rome, Italy
    Thromb Haemost 89:348-54. 2003
    ..A role for fibrinogen and/or platelet count in influencing the antithrombotic properties of platelet GpIIb-IIIa antagonists can be hypothesized...
  20. ncbi request reprint Low-dose aspirin for the prevention of atherothrombosis
    Carlo Patrono
    Department of Pharmacology, University of Rome La Sapienza, Rome, Italy
    N Engl J Med 353:2373-83. 2005
  21. ncbi request reprint Prothrombotic response to coronary angioplasty in patients with unstable angina and raised C-reactive protein
    Alessandro Sciahbasi
    Institute of Cardiology, Catholic University, Rome, Italy
    J Thromb Thrombolysis 14:131-8. 2002
    ....
  22. ncbi request reprint Relationship between changes in platelet reactivity and changes in platelet receptor expression induced by physical exercise
    Cristina Aurigemma
    Institute of Cardiology, Universita Cattolica del Sacro Cuore, Rome, Italy
    Thromb Res 120:901-9. 2007
    ..Whether exercise-induced changes in platelet reactivity correlate with changes in platelet membrane receptors in patients with CAD is unknown...
  23. ncbi request reprint Abnormal pH-sensing of platelet Na+/H+ exchanger in patients with cardiac syndrome X
    Erica De Candia
    Haemostasis Research Center, Universita Cattolica del Sacro Cuore, Rome, Italy
    Int J Cardiol 100:371-6. 2005
    ..32) was also found. Thus our data demonstrate an alkaline shift in pH-dependence of platelet NHE of syndrome X patients. This abnormality does not seem to be associated with increased platelet activation...
  24. pmc Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment
    Francesca R Ponziani
    Department of Internal Medicine, Catholic University of Rome, 00168 Rome, Italy
    World J Gastroenterol 16:143-55. 2010
    ..Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses...
  25. ncbi request reprint Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype
    Sepideh Akhavan
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital University of Milan, Milan, Italy
    Blood 100:1347-53. 2002
    ..The mild hemorrhagic phenotype might be explained by abnormalities that ultimately counterbalance each other...
  26. ncbi request reprint Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study
    Guido Finazzi
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Blood 105:2664-70. 2005
    ..84-16.25; P = .0023), but not to hydroxyurea (HU) alone (HR, 0.86; 95% CI, 0.26-2.88; P = .8021), had an independent role in producing an excess risk for progression to AML/MDS compared with treatment with phlebotomy or interferon...
  27. ncbi request reprint Vascular and neoplastic risk in a large cohort of patients with polycythemia vera
    Roberto Marchioli
    European Collaboration on Low Dose Aspirin in Polycythemia Vera Coordinating Centre, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Italy
    J Clin Oncol 23:2224-32. 2005
    ..The aim of this study was to assess the rate of these complications in subjects receiving currently recommended treatments...
  28. ncbi request reprint The haematocrit and platelet target in polycythemia vera
    Marcello Di Nisio
    Department of Medicine and Aging, School of Medicine, and Aging Research Centre, Ce S I, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    Br J Haematol 136:249-59. 2007
    ..Our findings do not suggest that the range of haematocrit (<55%) and platelet counts (<600 x 10(9)/l) we encountered in our population had an impact on the outcome of PV patients treated by current therapeutic strategies...
  29. doi request reprint Prevention of thrombosis in polycythemia vera and essential thrombocythemia
    Raffaele Landolfi
    Haematologica 93:331-5. 2008
  30. ncbi request reprint The P303T mutation in the human factor VII (FVII) gene alters the conformational state of the enzyme and causes a severe functional deficiency
    Flora Peyvandi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, 9 20122 Milan, Italy
    Br J Haematol 127:576-84. 2004
    ..Altogether, these defects may explain the severe bleeding symptoms in a patient carrying the FVIIP303T mutation...
  31. ncbi request reprint Surgical bleeding after pre-operative unfractionated heparin and low molecular weight heparin for coronary bypass surgery
    Giulia Renda
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Haematologica 92:366-73. 2007
    ....
  32. ncbi request reprint Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
    Raffaele Landolfi
    Lancet 360:257. 2002