Amelia Evoli

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint Paraneoplastic diseases associated with thymoma
    Amelia Evoli
    Dept of Neurosciences, Catholic University, Largo F Vito, 00168 Rome, Italy
    J Neurol 254:756-62. 2007
  2. ncbi request reprint Response to therapy in myasthenia gravis with anti-MuSK antibodies
    Amelia Evoli
    Department of Neurosciences, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Ann N Y Acad Sci 1132:76-83. 2008
  3. ncbi request reprint Antibodies in myasthenia gravis and related disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:324-35. 2003
  4. ncbi request reprint Clinical aspects of neuromuscular transmission disorders
    Amelia Evoli
    Neuroscience Department, Catholic University, Roma, Italy
    Acta Neurol Scand Suppl 183:8-11. 2006
  5. doi request reprint Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management
    A Evoli
    Istituto di Neurologia, Universita Cattolica, Roma, Italy
    Neurol Sci 35:515-20. 2014
  6. doi request reprint Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase
    Amelia Evoli
    Institute of Neurology, Catholic University, Largo F Vito 1, 00168 Roma, Italy
    Autoimmun Rev 12:931-5. 2013
  7. doi request reprint Management challenges in muscle-specific tyrosine kinase myasthenia gravis
    Amelia Evoli
    Institute of Neurology, Catholic University, Rome, Italy
    Ann N Y Acad Sci 1274:86-91. 2012
  8. ncbi request reprint Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis
    Amelia Evoli
    Department of Neuroscience, Catholic University, Roma, Italy
    Brain 126:2304-11. 2003
  9. ncbi request reprint Thymoma in patients with MG: characteristics and long-term outcome
    A Evoli
    Institute of Neurology, Catholic University, L go F Vito, 1 00168 Rome, Italy
    Neurology 59:1844-50. 2002
  10. ncbi request reprint Acquired myasthenia gravis in childhood
    Amelia Evoli
    Neuroscience Department, Catholic University, Roma, Italy
    Curr Opin Neurol 23:536-40. 2010

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Paraneoplastic diseases associated with thymoma
    Amelia Evoli
    Dept of Neurosciences, Catholic University, Largo F Vito, 00168 Rome, Italy
    J Neurol 254:756-62. 2007
    ..Thymoma is frequently associated with paraneoplastic diseases (PDs), most commonly with myasthenia gravis (MG). This association is thought to depend on thymoma's capacity to produce and export T lymphocytes...
  2. ncbi request reprint Response to therapy in myasthenia gravis with anti-MuSK antibodies
    Amelia Evoli
    Department of Neurosciences, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Ann N Y Acad Sci 1132:76-83. 2008
    ..Thymectomy is mostly considered scarcely effective; however, at present, no firm conclusions can be drawn on its role in the treatment of this form of MG...
  3. ncbi request reprint Antibodies in myasthenia gravis and related disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:324-35. 2003
    ..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively...
  4. ncbi request reprint Clinical aspects of neuromuscular transmission disorders
    Amelia Evoli
    Neuroscience Department, Catholic University, Roma, Italy
    Acta Neurol Scand Suppl 183:8-11. 2006
    ..In neuromyotonia and cramp-fasciculation syndrome, that are thought to be due to anti-voltage-gated potassium channel abs, signs of peripheral nerve hyperexcitability can be associated with CNS features...
  5. doi request reprint Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management
    A Evoli
    Istituto di Neurologia, Universita Cattolica, Roma, Italy
    Neurol Sci 35:515-20. 2014
    ..The Italian Working Group on Myasthenic Syndromes developed diagnostic and therapeutic algorithms that could serve in routine clinical practice as tools for a patient-tailored approach...
  6. doi request reprint Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase
    Amelia Evoli
    Institute of Neurology, Catholic University, Largo F Vito 1, 00168 Roma, Italy
    Autoimmun Rev 12:931-5. 2013
    ..Since treatment with rituximab, in uncontrolled studies, induced sustained benefit in patients with refractory disease, B cell depletion is an attractive option for MuSK-MG patients unresponsive to conventional immunosuppressants...
  7. doi request reprint Management challenges in muscle-specific tyrosine kinase myasthenia gravis
    Amelia Evoli
    Institute of Neurology, Catholic University, Rome, Italy
    Ann N Y Acad Sci 1274:86-91. 2012
    ..It is yet to be clarified whether the early use of rituximab could prevent the permanent bulbar weakness, which constitutes a relevant disability in these patients...
  8. ncbi request reprint Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis
    Amelia Evoli
    Department of Neuroscience, Catholic University, Roma, Italy
    Brain 126:2304-11. 2003
    ....
  9. ncbi request reprint Thymoma in patients with MG: characteristics and long-term outcome
    A Evoli
    Institute of Neurology, Catholic University, L go F Vito, 1 00168 Rome, Italy
    Neurology 59:1844-50. 2002
    ..To examine the characteristics of thymoma when associated with MG and to evaluate those conditions that can complicate management and affect survival...
  10. ncbi request reprint Acquired myasthenia gravis in childhood
    Amelia Evoli
    Neuroscience Department, Catholic University, Roma, Italy
    Curr Opin Neurol 23:536-40. 2010
    ..This review discusses recent studies on myasthenia gravis with onset in childhood (juvenile myasthenia gravis) and neonatal myasthenia gravis...
  11. ncbi request reprint Thymopoiesis, regulatory T cells, and TCRVbeta expression in thymoma with and without myasthenia gravis, and modulatory effects of steroid therapy
    Andrea Fattorossi
    Laboratory of Immunology, Oncology Department, Catholic University, Campobasso, Italy
    J Clin Immunol 28:194-206. 2008
    ..Most alterations in thymopoiesis were corrected by therapeutic corticosteroid administration, and the effects of steroid administration may be mediated by thymic microenvironment...
  12. doi request reprint Single-centre 40-year results of redo operation for recurrent thymomas
    Stefano Margaritora
    Department of General Thoracic Surgery, Catholic University, Rome, Italy
    Eur J Cardiothorac Surg 40:894-900. 2011
    ..Modes of treatment for recurrent thymoma remain controversial. The aim of this study is to analyse the early and long-term results of surgical intervention for this condition...
  13. ncbi request reprint Identification of disease-specific autoantibodies in seronegative myasthenia gravis
    Emanuela Bartoccioni
    Institute of General Pathology, Catholic University, 00168 Rome, Italy
    Ann N Y Acad Sci 998:356-8. 2003
  14. pmc Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment
    Andrea Fattorossi
    Department of Oncological Gynaecology, Catholic Univeristy, Rome, Italy
    Immunology 116:134-41. 2005
    ..Treg normalization appears to be largely thymus independent and possibly reflects the reported capacity of corticosteroids to promote Treg-cell development...
  15. doi request reprint Anti-acetylcholinesterase antibodies associate with ocular myasthenia gravis
    Carlo Provenzano
    Institute of General Pathology, Catholic University, 00168 Rome, Italy
    J Neuroimmunol 218:102-6. 2010
    ..According to an experimental model, we hypothesize that anti-AChE abs could contribute to ptosis through an inhibition of the sympathetic innervation of the tarsal muscle...
  16. ncbi request reprint Anti-p110 autoantibodies identify a subtype of "seronegative" myasthenia gravis with prominent oculobulbar involvement
    Flavia Scuderi
    Institute of General Pathology, Catholic University, Rome, Italy
    Lab Invest 82:1139-46. 2002
    ..Our results confirm the presence of these antibodies in SNMG and suggest that anti-P110/MuSK autoantibodies identify a subtype of SNMG in which the different pathogenesis induces the distinct clinical picture...
  17. ncbi request reprint T cell repertoire in DQ5-positive MuSK-positive myasthenia gravis patients
    Mariapaola Marino
    General Pathology Institute, Universita Cattolica del Sacro Cuore, Largo F Vito, 1, 00168 Rome, Italy
    J Autoimmun 52:113-21. 2014
    ..This oligoclonal restriction of T cells will allow the identification of immunodominant epitopes in the antigen, providing therefore new tools for diagnosis and targeted therapy. ..
  18. doi request reprint Thymectomy in myasthenia gravis: proposal for a predictive score of postoperative myasthenic crisis
    Giovanni Leuzzi
    Department of Surgical Oncology, Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
    Eur J Cardiothorac Surg 45:e76-88; discussion e88. 2014
    ..Thymectomy plays an important role in patients with myasthenia gravis (MG). This study aimed to explore predictors of postoperative myasthenic crisis (POMC) after thymectomy and to define a predictive score of respiratory failure...
  19. doi request reprint Novel prognostic groups in thymic epithelial tumors: assessment of risk and therapeutic strategy selection
    Rolando M D'Angelillo
    Campus Bio Medico University, Rome, Italy
    Int J Radiat Oncol Biol Phys 71:420-7. 2008
    ..e., thymomas and thymic squamous cell carcinoma) and to define the prognostic classes according to the Masaoka and World Health Organization histologic classification systems...
  20. ncbi request reprint PTPN22 and myasthenia gravis: replication in an Italian population and meta-analysis of literature data
    Carlo Provenzano
    Institute of General Pathology, Catholic University, Largo Francesco Vito 1, 00168 Rome, Italy
    Neuromuscul Disord 22:131-8. 2012
    ..Both polymorphisms were in tight linkage disequilibrium in controls, not in patients. Our results suggest that SNPs in this gene different from rs2476601, and/or epigenetic interactions, could play a greater role...
  21. ncbi request reprint Thirty-five-year follow-up analysis of clinical and pathologic outcomes of thymoma surgery
    Stefano Margaritora
    Division of General Thoracic Surgery, Catholic University, Rome, Italy
    Ann Thorac Surg 89:245-52; discussion 252. 2010
    ..With the unique opportunity of a 35-year follow-up in a single institution, thymomatous myasthenia gravis cohort, we investigated the influence of early and long-term clinical predictors...
  22. doi request reprint Thymectomy in myasthenia gravis via original video-assisted infra-mammary cosmetic incision and median sternotomy: long-term results in 180 patients
    Elisa Meacci
    Division of Thoracic Surgery, Catholic University of Sacred Heart of Rome, Largo A Gemelli 8, Rome 00168, Italy
    Eur J Cardiothorac Surg 35:1063-9; discussion 1069. 2009
    ..The original surgical access, consisting of a video-assisted infra-mammary cosmetic incision and median sternotomy, has originally been designed and described by our group...
  23. ncbi request reprint The role of cholinergic transmission in outer hair cell functioning evaluated by distortion product otoacoustic emissions in myasthenic patients
    G Paludetti
    Institutes of Otorhinolaryngology, Universita Cattolica del Sacro Cuore, Rome, Italy
    Acta Otolaryngol 121:119-21. 2001
    ..These data seem to confirm the role of ACh in the neurotransmission of the auditory efferent system and may represent a new in vivo model for the investigation of the physiology of this system...
  24. ncbi request reprint Myasthenia gravis: an unrecognized cause of head drop in Parkinson's disease
    A Fasano
    Istituto di Neurologia, Universita Cattolica del Sacro Cuore, Roma, Italia
    Parkinsonism Relat Disord 14:164-5. 2008
    ..Clinical, radiological, and neurophysiological features together with responsiveness to anticholinesterases and plasma exchanges indicated the possibility of a concomitant myasthenia gravis...
  25. ncbi request reprint The difficulty in confirming clinical diagnosis of myasthenia gravis in a seronegative patient: a possible neurophysiological approach
    P Caliandro
    Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy
    Neuromuscul Disord 19:825-7. 2009
    ....
  26. ncbi request reprint Seronegative myasthenia gravis: comparison of neurophysiological picture in MuSK+ and MuSK- patients
    L Padua
    Department of Neuroscience, Catholic University, Rome, Italy
    Eur J Neurol 13:273-6. 2006
    ..With regard to SFEMG data, MuSK- patients were characterized to have more severe neurophysiological pattern. Our observations showed several differences between the clinical and neurophysiological pictures of MUSK+ and MUSK- patients...
  27. ncbi request reprint Circulating CD4+CD25+ T regulatory and natural killer T cells in patients with myasthenia gravis: a flow cytometry study
    A Battaglia
    Department of Oncological Gynecology, Catholic University, Roma, Italy
    J Biol Regul Homeost Agents 19:54-62. 2005
    ..Immunomagnetically purified CD4+CD25+ cells from MG, healthy subjects and cancer patients were anergic and suppressed the proliferative response of other T cells...
  28. ncbi request reprint Effects of contralateral white noise stimulation on distortion product otoacoustic emissions in myasthenic patients
    S Di Girolamo
    Institute of Otorhinolaryngology, Catholic University Sacro Cuore, Rome, Italy
    Hear Res 162:80-4. 2001
    ..These findings also suggest that DPOAEs may be useful in the diagnosis of MG and for monitoring the effectiveness of treatment...
  29. ncbi request reprint Intravenous immunoglobulin treatment in autoimmune neurological disorders--effects on quality of life
    L Padua
    Institute of Neurology, Universita Cattolica, Rome, Italy Fondazione don C Gnocchi, Rome, Italy
    Hum Immunol 66:417-21. 2005
    ..Further controlled studies on IVIG, including quality-of-life assessments, are necessary to develop needed evidence on the use of IVIG in clinical practice...
  30. ncbi request reprint Thymic disorders and myasthenia gravis: genetic aspects
    G Zelano
    Institute of Human Anatomy, Catholic University, Rome, Italy
    Ann Med 31:46-51. 1999
    ....
  31. doi request reprint Determinants of cognitive impairment in elderly myasthenia gravis patients
    Camillo Marra
    Department of Neuroscience, Catholic University, L go A Gemelli, 8, Rome 00168, Italy
    Muscle Nerve 40:952-9. 2009
    ..The impairments of attention, memory, and control tasks in MG are related to general visual motor slowness and to the concomitant presence of other diseases...
  32. ncbi request reprint Thymus changes in anti-MuSK-positive and -negative myasthenia gravis
    L Lauriola
    Catholic University, Rome, Italy
    Neurology 64:536-8. 2005
    ..Since hyperplastic changes were seen in 35% of MuSK-negative patients, the thymus could be involved in some of these cases...
  33. ncbi request reprint Anti-MuSK antibodies: correlation with myasthenia gravis severity
    E Bartoccioni
    Department of General Pathology, Catholic University, Rome, Italy
    Neurology 67:505-7. 2006
    ..Ab concentrations were often reduced by immunosuppression but not after thymectomy. Both in individual cases and in the whole population, a correlation between Ab levels and disease severity was found...
  34. ncbi request reprint Multiple paraneoplastic diseases associated with thymoma
    A Evoli
    Institute of Neurology and Hematology, Catholic University, Roma, Italy
    Neuromuscul Disord 9:601-3. 1999
    ..Five months later he developed mild generalised myasthenia gravis. Anti-acetylcholine receptor antibodies, previously repeatedly negative, were found positive at the onset of clinical signs of myasthenia gravis...
  35. doi request reprint Distinctive clinical and neuroimaging characteristics of longitudinally extensive transverse myelitis associated with aquaporin-4 autoantibodies
    Raffaele Iorio
    Institute of Neurology, Department of Geriatrics Neurosciences and Orthopedics, Catholic University, L go Gemelli, 8 00168 Rome, Italy
    J Neurol 260:2396-402. 2013
    ..In conclusion, this study provides clinical and spinal cord neuroimaging clues that can help distinguishing AQP4-IgG+ LETM patients. ..
  36. ncbi request reprint Thymic lesions and myasthenia gravis. Diagnosis based on mediastinal imaging and pathological findings
    T Pirronti
    Institutes of Radiology and Neurology, Catholic University, Rome, Italy
    Acta Radiol 43:380-4. 2002
    ..To achieve a better understanding of the role of CT and MR imaging in the study of the mediastinum in patients with myasthenia gravis (MG)...
  37. ncbi request reprint Juvenile myasthenia gravis with prepubertal onset
    A Evoli
    Institute of Neurology, Catholic University, Rome, Italy
    Neuromuscul Disord 8:561-7. 1998
    ..At the end of follow-up, most patients were in good condition. The frequency of immunosuppressive therapy and the rate of good therapeutic results did not differ from those observed in older patients...
  38. ncbi request reprint Therapeutic options in ocular myasthenia gravis
    A Evoli
    Institute of Neurology, Catholic University, Largo F Vito, 1 00168, Rome, Italy
    Neuromuscul Disord 11:208-16. 2001
    ..The indication for thymectomy in ocular myasthenia remains highly controversial and should be reserved for disabled patients in the early stages of the disease...
  39. ncbi request reprint A practical guide to the recognition and management of myasthenia gravis
    A Evoli
    Institute of Neurology, Catholic University, Rome, Italy
    Drugs 52:662-70. 1996
    ..Thymectomy improves the course of the disease and can increase remission rate; short term treatments are of benefit in the management of myasthenic emergencies...
  40. ncbi request reprint Health-related quality of life in patients with myasthenia gravis and the relationship between patient-oriented assessment and conventional measurements
    L Padua
    Institute of Neurology, Cattolic University, Rome, Italy
    Neurol Sci 22:363-9. 2001
    ..Our data demonstrated that clinical measurements are related to the HRQoL. The results may be useful in developing a disease-specific patient-oriented tool...
  41. ncbi request reprint Multinevritis of cranial nerves following inhalation of toxins
    Irene Aprile
    Institute of Neurology, Don C Gnocchi Foundation, Rome, Italy
    Neurol Res 25:208-10. 2003
    ..We believe physicians should be aware that multinevritis of the cranial nerves may be related to acute exposure to toxic substances. Missing this diagnosis could lead to a delay in therapy...
  42. ncbi request reprint Successful treatment of myasthenia gravis with tacrolimus
    Amelia Evoli
    Institute of Neurology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Muscle Nerve 25:111-4. 2002
    ..Tacrolimus proved to be effective in the treatment of MG, was not significantly hepatotoxic, and was less nephrotoxic than cyclosporine...
  43. ncbi request reprint Association of myasthenia gravis and antisynthetase syndrome: a case report
    M Diaco
    Department of Internal Medicine, Catholic University, Rome, Italy
    Int J Immunopathol Pharmacol 17:395-9. 2004
    ..To our knowledge, this is the first report on the association of Myasthenia gravis with antisynthetase syndrome...
  44. ncbi request reprint Myasthenia gravis self-administered questionnaire: development of regional domains
    L Padua
    Institute of Neurology, Universita Cattolica, L go F Vito 1, I 00168, Rome, Italy
    Neurol Sci 25:331-6. 2005
    ..Results of global MG score (GMG) and of domains appeared reliable. Domains were able to better assess the functional involvement of anatomical regions than main GMG, clinical examination and history...
  45. ncbi request reprint Myasthenia gravis outcome measure: development and validation of a disease-specific self-administered questionnaire
    L Padua
    Institute of Neurology, Catholic University, Largo F Vito, Rome, Italy
    Neurol Sci 23:59-68. 2002
    ..A 25-item MG questionnaire (MGQ) was generated. Results were related to conventional measures of MG severity. Furthermore, the MGQ appeared reliable, sensitive and reproducible. The questionnaire was validated as an outcome measure...
  46. ncbi request reprint Comment on "Cutting edge: human CD4-CD8- thymocytes express FOXP3 in the absence of a TCR"
    Alessandra Battaglia
    J Immunol 181:857-8; author reply 858. 2008
  47. ncbi request reprint SOX1 autoantibodies: tumor markers in LEMS patients?
    Bethan Lang
    Neurology 70:906-7. 2008
  48. ncbi request reprint Peginterferon and ribavirin for hepatitis C
    Amelia Evoli
    N Engl J Med 356:1269-70; author reply 1271. 2007
  49. ncbi request reprint IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset
    Francesca L Sciacca
    Neuromuscular Disease Department, National Neurological Institute, C Besta, Milan, Italy
    J Neuroimmunol 122:94-9. 2002
    ..022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2...