Valerio De Stefano

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease
    F Burzotta
    Department of Cardiology, Catholic University, Rome, Italy
    Eur Heart J 23:26-30. 2002
  2. ncbi request reprint The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis
    Valerio De Stefano
    Institute of Haematology, Catholic University, Rome, Italy
    Br J Haematol 135:386-91. 2006
  3. ncbi request reprint Prophylaxis and treatment of venous thromboembolism in individuals with inherited thrombophilia
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Semin Thromb Hemost 32:767-80. 2006
  4. ncbi request reprint Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders
    V De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    J Thromb Haemost 5:708-14. 2007
  5. ncbi request reprint Splanchnic vein thrombosis: clinical presentation, risk factors and treatment
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Intern Emerg Med 5:487-94. 2010
  6. pmc Causes of adult splanchnic vein thrombosis in the mediterranean area
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Mediterr J Hematol Infect Dis 3:e2011063. 2011
  7. ncbi request reprint Testing for inherited thrombophilia and consequences for antithrombotic prophylaxis in patients with venous thromboembolism and their relatives. A review of the Guidelines from Scientific Societies and Working Groups
    Valerio De Stefano
    Valerio De Stefano, MD, Institute of Hematology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy, Tel 39 06 30154968, Fax 39 06 30154206, E mail
    Thromb Haemost 110:697-705. 2013
  8. ncbi request reprint Abdominal thromboses of splanchnic, renal and ovarian veins
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli, Rome, Italy
    Best Pract Res Clin Haematol 25:253-64. 2012
  9. doi request reprint Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli 8, 00168, Rome, Italy
    Ann Hematol 89:141-6. 2010
  10. ncbi request reprint Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia
    Valerio De Stefano
    The Institute of Hematology, Catholic University, Rome, Italy
    Am J Hematol 85:97-100. 2010

Detail Information

Publications58

  1. ncbi request reprint Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease
    F Burzotta
    Department of Cardiology, Catholic University, Rome, Italy
    Eur Heart J 23:26-30. 2002
    ....
  2. ncbi request reprint The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis
    Valerio De Stefano
    Institute of Haematology, Catholic University, Rome, Italy
    Br J Haematol 135:386-91. 2006
    ..7-31.4) in overall carriers of factor V Leiden and 30% (95%CI 10.7-60.3) in carriers with a pregnancy-related first VTE, with a risk 6.8 times higher than in women without thrombophilia and with a non pregnancy-related first VTE...
  3. ncbi request reprint Prophylaxis and treatment of venous thromboembolism in individuals with inherited thrombophilia
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Semin Thromb Hemost 32:767-80. 2006
    ..In all cases, a careful balance of benefits and risks associated with prophylactic measures should be achieved, and patient preferences should be considered...
  4. ncbi request reprint Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders
    V De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    J Thromb Haemost 5:708-14. 2007
    ..The recently identified Janus kinase 2 (JAK2) V617F somatic mutation is closely related to chronic myeloproliferative disorders (CMD)...
  5. ncbi request reprint Splanchnic vein thrombosis: clinical presentation, risk factors and treatment
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Intern Emerg Med 5:487-94. 2010
    ..In patients with an unprovoked EHPVO and no prothrombotic conditions, or in those with a provoked EHPVO, anticoagulant treatment is recommended for a minimum of 3-6 months...
  6. pmc Causes of adult splanchnic vein thrombosis in the mediterranean area
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Mediterr J Hematol Infect Dis 3:e2011063. 2011
    ..Peculiar risk factors present in the area are Behçet's disease and hydatidosis; moreover, membraneous webs, typically found in Asian patients, are present in a significant portion of cases...
  7. ncbi request reprint Testing for inherited thrombophilia and consequences for antithrombotic prophylaxis in patients with venous thromboembolism and their relatives. A review of the Guidelines from Scientific Societies and Working Groups
    Valerio De Stefano
    Valerio De Stefano, MD, Institute of Hematology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy, Tel 39 06 30154968, Fax 39 06 30154206, E mail
    Thromb Haemost 110:697-705. 2013
    ....
  8. ncbi request reprint Abdominal thromboses of splanchnic, renal and ovarian veins
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli, Rome, Italy
    Best Pract Res Clin Haematol 25:253-64. 2012
    ..Vitamin K-antagonists are recommended for 3-6 months, and long-term in patients with Budd-Chiari syndrome, unprovoked splanchnic vein thrombosis, or renal vein thrombosis with a permanent prothrombotic state such as nephrotic syndrome...
  9. doi request reprint Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli 8, 00168, Rome, Italy
    Ann Hematol 89:141-6. 2010
    ..15, 95% CI 1.51-24.92). In conclusion, a homozygous JAK2 V617F mutation is an independent risk factor for recurrent thrombosis in patients with ET...
  10. ncbi request reprint Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia
    Valerio De Stefano
    The Institute of Hematology, Catholic University, Rome, Italy
    Am J Hematol 85:97-100. 2010
    ..4 x 10(9)/L at the time of the first thrombotic episode. The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged <60 years (HR for arterial recurrence 3.35, 95% CI 1.22-9.19)...
  11. ncbi request reprint Inherited thrombophilia and life-time risk of venous thromboembolism: is the burden reducible?
    V De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    J Thromb Haemost 2:1522-5. 2004
  12. pmc Influence of the JAK2 V617F mutation and inherited thrombophilia on the thrombotic risk among patients with essential thrombocythemia
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Haematologica 94:733-7. 2009
    ..In conclusion, in the younger patients with ET the thrombotic risk is higher in the JAK2 V617F-mutated and is further increased by the presence of inherited thrombophilia...
  13. ncbi request reprint The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Haematologica 91:695-8. 2006
    ..9, 95% CI 1.0-3.9); the carriers of PC or PS deficiency had a marginal increase in risk (hazard ratio 1.4, 95% CI 0.9-2.2). In conclusion, patients with AT deficiency are potential candidates for long-term oral anticoagulation...
  14. ncbi request reprint [Inherited thrombophilia]
    V De Stefano
    Istituto di Ematologia, Universita Cattolica, Largo Gemelli, 8 00168 Roma, Italy
    G Ital Nefrol 26:14-9. 2009
    ....
  15. ncbi request reprint Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: incidence, risk factors, and effect of treatments
    Valerio De Stefano
    Institute of Hematology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Haematologica 93:372-80. 2008
    ..Prior thrombosis is a well-established risk factor for re-thrombosis in polycythemia vera and essential thrombocythemia but scarce data are available on the rate of re-thrombosis and the optimal strategy for prevention of recurrence...
  16. doi request reprint The risk of symptomatic pulmonary embolism due to proximal deep venous thrombosis differs in patients with different types of inherited thrombophilia
    Elena Rossi
    Institute of Hematology, Catholic University, Rome, Italy
    Thromb Haemost 99:1030-4. 2008
    ..7, 95%CI 0.5-1.0) in comparison with those with unknown inherited defect. These data suggest that patients with proximal DVT have different risks of symptomatic PE according to the type of inherited thrombophilia...
  17. doi request reprint In families with inherited thrombophilia the risk of venous thromboembolism is dependent on the clinical phenotype of the proband
    Elena Rossi
    Institute of Hematology, Catholic University, Rome, Italy
    Thromb Haemost 106:646-54. 2011
    ..This should be taken with caution regarding families with deficiency of natural anticoagulants, given the low number of cases analysed...
  18. ncbi request reprint Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance: incidence and risk factors in a cohort of 1491 patients
    Tommaso Za
    Institute of Haematology, Catholic University, Rome, Italy
    Br J Haematol 160:673-9. 2013
    ..Finally, the risk of venous thrombosis did increase when the M-protein concentration exceeded >16 g/l...
  19. ncbi request reprint G20210A prothrombin gene variant and clinical outcome in patients with a first acute coronary syndrome
    Francesco Burzotta
    Institute of Cardiology, Catholic University, Rome, Italy
    Haematologica 89:1134-8. 2004
    ..The prognostic value of the G20210A prothrombin gene polymorphism in patients with a first acute coronary syndrome has not been previously assessed. We conducted a prospective study to investigate this issue...
  20. ncbi request reprint Screening for inherited thrombophilia: indications and therapeutic implications
    Valerio De Stefano
    Institute of Hematology, Catholic University, Roma, Italy
    Haematologica 87:1095-108. 2002
    ..The most common inherited traits (deficiency in antithrombin, protein C, or protein S, factor V Leiden, prothrombin G20210A) and mild hyperhomocysteinemia are diagnosed in at least 40% of patients with venous thromboembolism (VTE)...
  21. doi request reprint Early postoperative obstructive prosthetic mitral valve thrombosis in a patient double heterozygous for factor V Leiden and prothrombin G20210A mutation
    Stefano De Paulis
    Dipartimento di Medicina Cardiovascolare, Policlinico A Gemelli, Catholic University, Largo Gemelli 8, Rome, Italy
    Thromb Haemost 99:441-2. 2008
  22. ncbi request reprint Different circumstances of the first venous thromboembolism among younger or older heterozygous carriers of the G20210A polymorphism in the prothrombin gene
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Haematologica 88:61-6. 2003
    ..The aim of this study was to determine the risk of spontaneous or secondary venous thromboembolism (VTE) among younger and older carriers of the G20210A prothrombin polymorphism...
  23. doi request reprint Efficacy of lenalidomide plus dexamethasone for POEMS syndrome relapsed after autologous peripheral stem-cell transplantation
    Barbara Vannata
    Department of Hematology, Catholic University of the Sacred Heart, Hospital A Gemelli, Largo A Gemelli 8, Rome, Italy
    Am J Hematol 87:641-2. 2012
    ..Here, we report the successful use of lenalidomide in a patient who relapsed after aPBSCT...
  24. ncbi request reprint Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia
    Luciana Teofili
    Istituto di Ematologia and Istituto di Anatomia Patologica, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Clin Oncol 20:4249-54. 2002
    ....
  25. ncbi request reprint Analysis of MTHFR polymorphisms and P16 methylation and their correlation with clinical-biological features of multiple myeloma
    Patrizia Chiusolo
    Hematology Department, Universita Cattolica del Sacro Cuore, L go Gemelli 8, 00168, Rome, Italy
    Ann Hematol 85:474-7. 2006
    ..However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM...
  26. pmc Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls
    Benedetto Simone
    Institute of Public Health Section of Hygiene, Department of Public Health, Universita Cattolica del Sacro Cuore, L go F Vito 1, 00168, Rome, Italy
    Eur J Epidemiol 28:621-47. 2013
    ..Notably, double carriers of the two genetic variants produced an impact on VTE risk significantly increased but weaker than previously thought. ..
  27. ncbi request reprint Inherited thrombophilia: treatment during pregnancy
    Sara De Carolis
    Department of Obstetrics and Gynecology, Catholic University, Rome, Italy
    Fetal Diagn Ther 21:281-6. 2006
    ..Inherited thrombophilia is associated with thromboembolic events and/or poor obstetric outcome. We evaluated the pregnancy outcome in women with inherited thrombophilia treated with low-molecular-weight heparin (LMWH)...
  28. pmc IgD multiple myeloma a descriptive report of 17 cases: survival and response to therapy
    Francesco Pisani
    Department of Hematology, Regina Elena National Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 31:17. 2012
    ..Immunoglobulin D multiple myeloma (MM) is rare and has a poorer prognosis than other MM isotypes...
  29. ncbi request reprint Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
    Raffaele Landolfi
    Catholic University School of Medicine, Institute of Internal Medicine and Geriatrics, Haemostasis Research Center, Rome, Italy
    Blood 109:2446-52. 2007
    ..71; 95% CI, 1.10-2.65; P = .017), mainly deriving from an increased risk of myocardial infarction (HR, 2.84; 95% CI, 1.25-6.46; P = .013). Thus, leukocyte count may help in defining the vascular risk of polycythemic subjects...
  30. ncbi request reprint The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment
    V De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    J Thromb Haemost 3:1985-92. 2005
    ..Yet, most reports are anecdotical and scarce data are available on the risk of thrombosis in acute myeloid leukemia (AML)...
  31. ncbi request reprint Blood cells diseases and thrombosis
    G Leone
    Istituto di Ematologia, Universita Cattolica, Largo Gemelli 8, 00168 Rome, Italy
    Haematologica 86:1236-44. 2001
    ..Nevertheless the role of leukocytes and red cells in thrombogenesis is not well established and is probably underestimated...
  32. ncbi request reprint Molecular and clinical follow-up after stem cell transplantation for multiple myeloma
    P Chiusolo
    Istituto di Semeiotica Medica, Divisione di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy
    Ann Hematol 80:90-5. 2001
    ..Another patient died 4 months after transplantation after succumbing to fatal pneumonia showing myeloma progression...
  33. doi request reprint Prognostic factors associated with progression of smoldering multiple myeloma to symptomatic form
    Angela Rago
    Department of Cellular Biotechnologies and Hematology, Sapienza University Polo Pontino, Rome, Italy
    Cancer 118:5544-9. 2012
    ..In 144 patients with SMM, we also compared the risk of progression predicted by bone marrow plasma cell (BMPC) involvement on the bone marrow biopsy (BMB) versus bone marrow aspirates (BMA)...
  34. ncbi request reprint The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia
    Luciana Teofili
    Department of Hematology, Catholic University, Rome, Italy
    Blood 100:714-7. 2002
    ..Furthermore, detection of a significant percentage of weakly stained or c-mpl-negative megakaryocytes can identify patients with a higher risk of thrombosis...
  35. ncbi request reprint Novel antithrombotic agents: indirect synthetic inhibitors of factor Xa and direct thrombin inhibitors. Evidences from clinical studies
    Giuseppe Leone
    Institute of Hematology and Institute of cardiology, Catholic University, Rome, Italy
    Curr Med Chem Cardiovasc Hematol Agents 2:311-26. 2004
    ....
  36. ncbi request reprint Venous thromboembolism in multiple myeloma
    Valerio De Stefano
    Institute of Hematology, Department of Medical Sciences, Catholic University, Rome, Italy
    Semin Thromb Hemost 40:338-47. 2014
    ..LMWH shows an advantage in efficacy not statistically significant. Prophylaxis should be tailored considering individual risk factors for VTE, the stage of disease, the possible occurrence of thrombocytopenia, or renal insufficiency. ..
  37. doi request reprint Platelet activation and inhibition in polycythemia vera and essential thrombocythemia
    Carlo Patrono
    Department of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Blood 121:1701-11. 2013
    ..A clear pharmacodynamic rationale and analytical tools are available for a personalized approach to antiplatelet therapy in ET, and an improved regimen of low-dose aspirin therapy should be tested in a properly sized randomized trial...
  38. doi request reprint Impact of radiotherapy on pain relief and recalcification in plasma cell neoplasms: long-term experience
    Mario Balducci
    Radiotherapy Department, University Hospital Gemelli, Rome, Italy
    Strahlenther Onkol 187:114-9. 2011
    ..To evaluate the impact of radiotherapy on pain relief and on recalcification in patients with osteolytic lesions due to plasma cell neoplasm...
  39. doi request reprint Risk factor and etiology analysis of ischemic stroke in young adult patients
    Rosaria Renna
    Department of Neurology, Institute of Neurology, Catholic University, Rome, Italy Electronic address
    J Stroke Cerebrovasc Dis 23:e221-7. 2014
    ..Approximately 10%-14% of ischemic strokes occur in young adults...
  40. ncbi request reprint Myeloid sarcoma with megakaryoblastic differentiation mimicking a sellar tumor
    Mariangela Novello
    Department of Anatomic Pathology, Catholic University, Rome, Italy
    Neuropathology 34:179-84. 2014
    ..To the best of our knowledge, this is the first MS case with megakaryoblastic differentiation arising within the CNS. ..
  41. doi request reprint Autoimmune hemolytic anemia with gel-based immunohematology tests: neural network analysis
    Marco Lai
    Internal Medicine Department, Transfusion Centre, Catholic University, Largo A Gemelli 8, 00168, Rome, Italy
    Immunol Res 58:70-4. 2014
    ..This was the case for the IgG subclasses. However, it is very likely that the information given to the network from those tests is quantitative rather than qualitative...
  42. ncbi request reprint Recurrent venous thrombosis in a patient with haemophilia A and HIV infection
    Katleen de Gaetano Donati
    Dept Infectious Diseases, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Haematologica 87:ECR04. 2002
  43. ncbi request reprint Clonal hemopoiesis and risk of thrombosis in young female patients with essential thrombocythemia
    P Chiusolo
    Department of Hematology, , Rome, Italy
    Exp Hematol 29:670-6. 2001
    ..Clonal hemopoiesis is easily recognized by X-CIP, but its applicability is limited to the female sex and is hampered by the presence of age-related or constitutive skewing...
  44. ncbi request reprint The risk of recurrent venous thromboembolism among heterozygous carriers of the G20210A prothrombin gene mutation
    V De Stefano
    Department of Haematology, Catholic University, Rome, Italy
    Br J Haematol 113:630-5. 2001
    ..In conclusion, the carriers of the prothrombin mutation should be treated with oral anticoagulants after a first deep venous thrombosis for a similar length of time as patients with a normal genotype...
  45. ncbi request reprint The C807T/G873A polymorphism in the platelet glycoprotein Ia gene and the risk of acute coronary syndrome in the Italian population
    I Casorelli
    Department of Haematology, Catholic University, Rome, Italy
    Br J Haematol 114:150-4. 2001
    ..We conclude that the GP Ia 807 TT (873 AA) genotype is associated with an increased risk of acute coronary syndrome in the Italian population; conversely, the GP Ia 807 CC (873 GG) genotype seems to represent a protective factor...
  46. pmc G20210A prothrombin gene polymorphism and coronary ischaemic syndromes: a phenotype-specific meta-analysis of 12 034 subjects
    F Burzotta
    Institute of Cardiology, Catholic University, Rome, Italy
    Heart 90:82-6. 2004
    ..To investigate the possible link between the G20210A prothrombin gene variant and different forms of ischaemic heart disease...
  47. ncbi request reprint The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study
    D Tormene
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 5:2193-6. 2007
    ..However, because of the different design and sample sizes of these studies the estimated risks have varied...
  48. ncbi request reprint Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence
    A N Nicolaides
    Int Angiol 24:1-26. 2005
    ..The aim of this document is to provide guidelines for investigation and management of patients with thrombophilia in the presence or absence of venous thromboembolism (VTE)...
  49. ncbi request reprint The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210A
    I Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University of Milan and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 6:494-8. 2008
    ..Hence, whether or not these women deserve antithrombotic prophylaxis when pregnant is unknown...
  50. ncbi request reprint Two novel (R(-11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds
    H A Ireland
    Charing Cross and Westminster Medical School, London, UK
    Hum Mutat 7:176-9. 1996
  51. ncbi request reprint Coexistence of thrombophilic gene polymorphisms among 559 unrelated consecutive patients with a history of thrombosis
    P Madonna
    Thromb Res 101:317-9. 2001
  52. ncbi request reprint Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 86:800-3. 2001
    ..On the basis of these findings we recommend that these women receive anticoagulant prophylaxis at least in the postpartum, that should perhaps be extended to the whole pregnancy in homozygous carriers...
  53. ncbi request reprint Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism
    J Emmerich
    Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
    Thromb Haemost 86:809-16. 2001
    ..69). Conversely, factor II G20210A mutation was equally balanced in both patient groups...
  54. pmc Posterior knee pain: primary symptom of a small non-occlusive venous clot
    R Zannolli
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
    Arch Dis Child 88:728-9; discussion 728-9. 2003
    ..The case is relevant for its unique presentation and symptoms. Lack of recanalisation persisted at one year follow up...
  55. ncbi request reprint Complete nucleotide sequence of the antithrombin gene: evidence for homologous recombination causing thrombophilia
    R J Olds
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, U K
    Biochemistry 32:4216-24. 1993
    ..It is likely, therefore, that the deletion arose by homologous recombination between the two Alu elements...
  56. ncbi request reprint Long-lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3-year pharmacological management
    A Coppola
    Centro di Coordinamento Regionale per le Emocoagulopatie, Cattedra di Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, Universita Federico II, Napoli, Italy
    J Intern Med 252:271-5. 2002
    ....
  57. pmc Glycoprotein Ia C807T gene polymorphism and increased risk of recurrent acute coronary syndromes: a five year follow up
    A M Leone
    Heart 90:567-9. 2004
  58. ncbi request reprint Novel point mutations leading to type 1 antithrombin deficiency and thrombosis
    R J Olds
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford
    Br J Haematol 78:408-13. 1991
    ..We suggest that altered folding of the mutant protein may explain the AT deficiency...