G Calviello

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi request reprint beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Carcinogenesis 25:1315-25. 2004
  2. ncbi request reprint n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
  3. ncbi request reprint Reduction of Oxidative/Nitrosative Stress in Brain and its Involvement in the Neuroprotective Effect of n-3 PUFA in Alzheimer's Disease
    Simona Serini
    Institute of General Pathology, Catholic University, L go F Vito, 1 00168, Rome, Italy
    Curr Alzheimer Res 13:123-34. 2016
  4. pmc Experimental evidence of ω-3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: their potential role in inflammatory, neurodegenerative, and neoplastic diseases
    Gabriella Calviello
    Institute of General Pathology, School of Medicine, Catholic University, 00168 Rome, Italy
    Biomed Res Int 2013:743171. 2013
  5. doi request reprint Antineoplastic effects of n-3 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies
    G Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, Rome 00168, Italy
    Nutr Cancer 61:287-301. 2009
  6. ncbi request reprint n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved
    G Calviello
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Curr Med Chem 14:3059-69. 2007
  7. ncbi request reprint Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2
    Gabriella Calviello
    Institute of General Pathology, Institute of Human Anatomy, Catholic University, Rome, Italy
    Carcinogenesis 28:1202-9. 2007
  8. ncbi request reprint gamma-Tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c release
    Gabriella Calviello
    Institutes of General Pathology and Pathology, Catholic University, L go F Vito, 1 00168 Rome, Italy
    Carcinogenesis 24:427-33. 2003
  9. ncbi request reprint DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism
    Gabriella Calviello
    Institute of General Pathology, Catholic University L go F Vito, 1 00168 Rome, Italy
    Toxicol Appl Pharmacol 211:87-96. 2006
  10. ncbi request reprint Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168, Rome, Italy
    Cancer Chemother Pharmacol 55:12-20. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Carcinogenesis 25:1315-25. 2004
    ..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate...
  2. ncbi request reprint n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  3. ncbi request reprint Reduction of Oxidative/Nitrosative Stress in Brain and its Involvement in the Neuroprotective Effect of n-3 PUFA in Alzheimer's Disease
    Simona Serini
    Institute of General Pathology, Catholic University, L go F Vito, 1 00168, Rome, Italy
    Curr Alzheimer Res 13:123-34. 2016
    ....
  4. pmc Experimental evidence of ω-3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: their potential role in inflammatory, neurodegenerative, and neoplastic diseases
    Gabriella Calviello
    Institute of General Pathology, School of Medicine, Catholic University, 00168 Rome, Italy
    Biomed Res Int 2013:743171. 2013
    ....
  5. doi request reprint Antineoplastic effects of n-3 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies
    G Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, Rome 00168, Italy
    Nutr Cancer 61:287-301. 2009
    ....
  6. ncbi request reprint n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved
    G Calviello
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Curr Med Chem 14:3059-69. 2007
    ..The aim of the present review is to analyze the anti-neoplastic effect of n-3 PUFAs towards colon cancer, and examine the molecular mechanisms involved...
  7. ncbi request reprint Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2
    Gabriella Calviello
    Institute of General Pathology, Institute of Human Anatomy, Catholic University, Rome, Italy
    Carcinogenesis 28:1202-9. 2007
    ..The present study, thus, raises the possibility that DHA may exert pro-apoptotic and antitumoral effects through proteasomal regulation of beta-catenin levels and alterations in the expression of TCF-beta-catenin target genes...
  8. ncbi request reprint gamma-Tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c release
    Gabriella Calviello
    Institutes of General Pathology and Pathology, Catholic University, L go F Vito, 1 00168 Rome, Italy
    Carcinogenesis 24:427-33. 2003
    ..The late activation of caspase-8 and data showing the partial cleavage of pro-apoptotic protein BID suggest that the initial activation of caspase-9 may be potentiated by a feedback amplification loop involving the caspase-8/BID pathway...
  9. ncbi request reprint DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism
    Gabriella Calviello
    Institute of General Pathology, Catholic University L go F Vito, 1 00168 Rome, Italy
    Toxicol Appl Pharmacol 211:87-96. 2006
    ..On the other hand, the proapoptotic effect of Mancozeb suggests its possible relevance in the pathogenesis of neurodegenerative diseases, often related to the exposition of pesticides...
  10. ncbi request reprint Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168, Rome, Italy
    Cancer Chemother Pharmacol 55:12-20. 2005
    ....
  11. ncbi request reprint beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells
    P Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Free Radic Biol Med 30:1000-7. 2001
    ..These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties...
  12. ncbi request reprint Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved
    S Serini
    Institute of General Pathology, Universita Cattolica del Sacro Cuore, Largo F Vito, 1 00168 Rome, Italy
    Curr Med Chem 18:4065-75. 2011
    ..Possible reasons for this discrepancy are discussed and pathways of cell growth that could be differentially influenced by EPA and DHA are described...
  13. ncbi request reprint beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    J Nutr 135:129-36. 2005
    ..Here, we report that the suppression of COX-2 by beta-carotene may represent a molecular mechanism by which this compound acts as an antitumor agent in colon carcinogenesis...
  14. ncbi request reprint Redox regulation of cell proliferation by pyrrolidine dithiocarbamate in murine thymoma cells transplanted in vivo
    F Di Nicuolo
    Institute of General Pathology, Catholic University, Rome, Italy
    Free Radic Biol Med 31:1424-31. 2001
    ..In addition, we suggest that the ability of PDTC to bind and transport metals inside the cell and its pro-oxidant property may be factors underlying its effects on thymoma cell proliferation and cell cycle distribution...
  15. ncbi request reprint Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2
    P Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Carcinogenesis 27:2383-91. 2006
    ..These data point out that the carotenoid may enhance cigarette smoke-induced oxidative stress and exert potential deleterious effects at the pO2 normally present in lung tissue...
  16. ncbi request reprint Mitogenic and apoptotic signaling by carotenoids: involvement of a redox mechanism
    P Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    IUBMB Life 52:77-81. 2001
    ..In particular, we report demonstrations for the anti-oxidant or pro-oxidant effects of carotenoids in vitro and in vivo, focusing our attention on the relationship existing between cell growth and redox status...
  17. ncbi request reprint Beta-carotene regulates NF-kappaB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    J Nutr 133:381-8. 2003
    ..These data suggest that the redox regulation of NF-kappaB induced by beta-carotene is involved in the growth-inhibitory and proapoptotic effects of the carotenoid in tumor cells...
  18. ncbi request reprint Dietary n-3 PUFA vascular targeting and the prevention of tumor growth and age-related macular degeneration
    S Serini
    Institute of General Pathology, Lgo F Vito, 1, 00168 Rome, Italy
    Curr Med Chem 16:4511-26. 2009
    ....
  19. doi request reprint Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression
    Simona Serini
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Apoptosis 13:1172-83. 2008
    ..Moreover, they support the hypothesis that DHA may exert chemopreventive action in lung cancer...
  20. ncbi request reprint N-3 polyunsaturated fatty acid effect in periodontal disease: state of art and possible mechanisms involved
    L Raffaelli
    Institute of Clinical Dentistry, Catholic University, Largo F Vito 1, Rome, Italy
    Int J Immunopathol Pharmacol 21:261-6. 2008
    ....
  21. ncbi request reprint Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Nutr Cancer 47:76-87. 2003
    ..These results support a pharmacological role for beta-Carotene as a candidate antitumor agent and show a possible sequence of molecular events by which this molecule may induce apoptosis in tumor cells...
  22. ncbi request reprint Prooxidant effects of beta-carotene in cultured cells
    Paola Palozza
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Mol Aspects Med 24:353-62. 2003
    ..This review summarizes the available evidence for a prooxidant activity of beta-carotene in cultured cells, focusing on biochemical and molecular markers of oxidative stress, which have been reported to be enhanced by the carotenoid...
  23. ncbi request reprint beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, Rome, Italy
    Antioxid Redox Signal 8:1069-80. 2006
    ..The role of HO-1 repression in increasing cell growth was also confirmed in Mv1Lu cells by the "knock down" of the Bach1 gene, thus demonstrating as HO-1 repression is a conserved mechanism by which cells can react to oxidative stress...
  24. ncbi request reprint Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins
    Paola Palozza
    Institute of General Pathology, Catholic University, 00168 Rome, Italy
    Carcinogenesis 23:11-8. 2002
    ..In addition, since cell growth inhibitory effects were reached at beta-carotene concentrations achievable in vivo following its supplementation, this study provides a rational approach for the use of beta-carotene in colon cancer...
  25. ncbi request reprint Modulation of apoptotic signalling by carotenoids in cancer cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Arch Biochem Biophys 430:104-9. 2004
    ..This review summarizes the available evidence for a modulatory action of carotenoids on apoptosis and focuses on the main molecular pathways involved in this process...
  26. ncbi request reprint Design, synthesis, and antioxidant activity of FeAOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moieties
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Free Radic Biol Med 33:1724-35. 2002
    ..In the cell model, the compound also provides a higher antioxidant capacity than alpha-tocopherol and lycopene, alone or in combination, suggesting the possibility of an oxidative intramolecular cooperation...
  27. ncbi request reprint Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Int J Cancer 97:593-600. 2002
    ..They also suggest that differentiated cells may be less susceptible to the carotenoid than highly neoplastic undifferentiated cells...
  28. ncbi request reprint Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad
    P Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Apoptosis 10:1445-56. 2005
    ..This study suggests that lycopene, differently from beta-carotene, can exert protective effects against cigarette smoke condensate...
  29. ncbi request reprint Chemoprevention of lung pathologies by dietary n-3 polyunsaturated fatty acids
    E Fasano
    Institute of General Pathology, Catholic University, Rome, Italy
    Curr Med Chem 17:3358-76. 2010
    ....
  30. ncbi request reprint Repeated exposure to pyrrolidine-dithiocarbamate induces peripheral nerve alterations in rats
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito 1, 00168 Rome, Italy
    Toxicol Lett 158:61-71. 2005
    ..The observation that a 15-day treatment with low doses of PDTC causes functional and morphological derangement of peripheral nerves advices against the possible use of this compound as a chemopreventive agent against cancer...
  31. ncbi request reprint Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines
    Marco Gessi
    Department of Pathology, Catholic University, Rome, Italy
    Acta Neuropathol 114:135-45. 2007
    ..This study indicates that hPTHrP and PTHR-1 are expressed in medulloblastoma and could promote tumor growth, protecting cells from apoptosis...
  32. ncbi request reprint Growth, viability, adhesion potential, and fibronectin expression in fibroblasts cultured on zirconia or feldspatic ceramics in vitro
    Luca Raffaelli
    Institute of Clinical Dentistry, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    J Biomed Mater Res A 86:959-68. 2008
    ..All these features suggest that zirconia could represent a more suitable biomaterial than FE ceramic for prosthesis in dentistry...
  33. doi request reprint Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer
    Simona Serini
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Apoptosis 14:135-52. 2009
    ..We will also pay attention to the recent findings regarding the possible role of PUFAs as regulators of the endoplasmic reticulum stress-pathway of apoptosis...
  34. ncbi request reprint Is there a room for vitamins?
    Tommaso Galeotti
    Mol Aspects Med 24:315-6. 2003
  35. ncbi request reprint Antioxidant effect of ferulic acid in isolated membranes and intact cells: synergistic interactions with alpha-tocopherol, beta-carotene, and ascorbic acid
    Sonia Trombino
    Department of Pharmaceutical Sciences, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy
    J Agric Food Chem 52:2411-20. 2004
    ..Synergistic interactions were observed when the compound was used in combination with the other antioxidants, suggesting that they can cooperate in preserving physiological integrity of cells exposed to free radicals...
  36. pmc Cytotoxic T lymphocyte-associated antigen-4 inhibits integrin-mediated stimulation
    Lucia Gatta
    Section of Toxicology and Biomedicine, ENEA C R Casaccia, Via Anguillarse 301, 00060 Rome, Italy
    Immunology 107:209-16. 2002
    ..Altogether these data indicate that through the control of signals induced by different receptors, CTLA-4 could be a global attenuator of T-cell activation...