Stefania Boccia


Affiliation: Catholic University
Country: Italy


  1. request reprint
    Boccia S, Persiani R, La Torre G, Rausei S, Arzani D, Gianfagna F, et al. Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study. Cancer Lett. 2005;229:235-43 pubmed
    ..Our preliminary findings suggest for the first time that the SULT1A1 His213 allele may be important in the development of gastric cancer, with other factors modulating such effect. ..
  2. request reprint
    Boccia S, Gianfagna F, Persiani R, La Greca A, Arzani D, Rausei S, et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population. Biomarkers. 2007;12:635-44 pubmed
    ..A possible survival effect of the MTHFR C677T genotype in gastric cancer patients deserves further investigations with larger sample sizes. ..
  3. request reprint
    Mazzucco W, Rossi M, Cusimano R, Franchi M, Bonifazi M, Mistretta A, et al. Use of trastuzumab for breast cancer: the role of age. Curr Pharm Des. 2014;20:5957-62 pubmed
    ..Younger breast cancers patients were more likely to receive a trastuzumab treatment than elderly ones, but the difference declined over calendar period. ..
  4. Boccia S, Rothman K, Panic N, Flacco M, Rosso A, Pastorino R, et al. Registration practices for observational studies on indicated low adherence. J Clin Epidemiol. 2016;70:176-82 pubmed publisher
    ..During the period reviewed, few observational studies have been registered. Registration usually occurred after the study started, and prespecification of outcomes and statistical analysis rarely occurred. ..
  5. Leoncini E, Vukovic V, Cadoni G, Pastorino R, Arzani D, Bosetti C, et al. Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study. Cancer Epidemiol. 2015;39:367-74 pubmed publisher
    ..Increasing age and stage, and high alcohol consumption were unfavourable predictors of HNC survival overall. Duration of tobacco consumption before the first primary tumour was a risk factor for SPC. ..
  6. request reprint
    Boccia S, Pasquarella C, Colotto M, Barchitta M, Quattrocchi A, Agodi A. Molecular epidemiology tools in the management of healthcare-associated infections: towards the definition of recommendations. Epidemiol Prev. 2015;39:21-6 pubmed
    ..The present contribution aims to increase knowledge on the proper use of such methods, given the major challenge HAI represents for National Health systems. ..
  7. Leoncini E, Nedovic D, Panic N, Pastorino R, Edefonti V, Boccia S. Carotenoid Intake from Natural Sources and Head and Neck Cancer: A Systematic Review and Meta-analysis of Epidemiological Studies. Cancer Epidemiol Biomarkers Prev. 2015;24:1003-11 pubmed publisher
    ..Our systematic review and meta-analysis on dietary carotenoids intake and HNC showed carotenoids to act protectively against HNC, in relation to most of single nutrients and subsites. ..
  8. Ianuale C, Leoncini E, Mazzucco W, Marzuillo C, Villari P, Ricciardi W, et al. Public Health Genomics education in post-graduate schools of hygiene and preventive medicine: a cross-sectional survey. BMC Med Educ. 2014;14:213 pubmed publisher
    ..Results showed a good implementation of courses in PHG discipline in Italian post-graduate public health schools. However further harmonization of the training programs of schools in public health at EU level is needed. ..
  9. Lacorte E, Ferrigno L, Leoncini E, Corbo M, Boccia S, Vanacore N. Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: A systematic review. Neurosci Biobehav Rev. 2016;66:61-79 pubmed publisher
    ..However, cohort studies report a significantly higher number of cases of ALS in professional soccer and American football players, and a slightly increased risk of ALS in varsity athletes. ..

More Information


  1. Leoncini E, Edefonti V, Hashibe M, Parpinel M, Cadoni G, Ferraroni M, et al. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Eur J Epidemiol. 2016;31:369-83 pubmed publisher
    ..A diet rich in carotenoids may protect against HNC. Persons with both low carotenoid intake and high tobacco or alcohol are at substantially higher risk of HNC. ..
  2. Boccia S, Boffetta P, Brennan P, Ricciardi G, Gianfagna F, Matsuo K, et al. Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. Cancer Lett. 2009;273:55-61 pubmed publisher
  3. Galli P, Cadoni G, Volante M, De Feo E, Amore R, Giorgio A, et al. A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population. BMC Cancer. 2009;9:137 pubmed publisher
    ..Larger studies are required to confirm these findings. ..
  4. Boccia S, Sayed Tabatabaei F, Persiani R, Gianfagna F, Rausei S, Arzani D, et al. Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. BMC Cancer. 2007;7:206 pubmed
    ..The increased risk for the carriers of CYP2E1*5A or *6 alleles among drinkers need to be confirmed by larger prospective studies. ..
  5. request reprint
    Boccia S, Cadoni G, Sayed Tabatabaei F, Volante M, Arzani D, De Lauretis A, et al. CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer. J Cancer Res Clin Oncol. 2008;134:93-100 pubmed
    ..The lack of interaction between the studied polymorphisms and the environmental exposures suggests that chronic consumption of tobacco and alcohol overwhelm enzyme defences, irrespective of genotype. ..
  6. Lugo A, La Vecchia C, Boccia S, Murisic B, Gallus S. Patterns of smoking prevalence among the elderly in Europe. Int J Environ Res Public Health. 2013;10:4418-31 pubmed publisher
    ..9%). Anti-tobacco campaigns and smoking cessation interventions specifically targeted to the elderly are urgently needed in Europe. ..
  7. Boccia S, Hashibe M, Galli P, De Feo E, Asakage T, Hashimoto T, et al. Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev. 2009;18:248-54 pubmed publisher
    ..57; P for interaction = 0.43). Besides showing the effectiveness of the Mendelian randomization approach, these findings support the theory that alcohol increases head and neck cancer risk through the carcinogenic action of acetaldehyde. ..
  8. request reprint
    Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert M, Fang J, et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol. 2008;167:505-16 pubmed
    ..05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis. ..
  9. request reprint
    Boccia S, De Lauretis A, Gianfagna F, van Duijn C, Ricciardi G. CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature. Carcinogenesis. 2007;28:101-6 pubmed
    ..This meta-analysis suggests that the CYP2E1 PstI/RsaI polymorphism may be a risk factor for gastric cancer in Asians, and that a synergic relation among GSTM1 and CYP2E1 may account for a proportion of gastric cancer cases. ..
  10. request reprint
    Boccia S, Cadoni G, La Torre G, Arzani D, Volante M, Cattel C, et al. A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer. J Cancer Res Clin Oncol. 2006;132:466-72 pubmed
    ..82; 95% CI=1.10-30.68). These preliminary findings show for the first time that the SULT1A1 His (213) allele is a possible risk factor for head and neck cancer development. ..