Research Topics
Genomes and GenesSpecies | Z AkpinarSummaryAffiliation: Catholic University Country: Italy Publications
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Detail Information
Publications
Neurophysiological predictors of long term response to AChE inhibitors in AD patientsV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Neurol Neurosurg Psychiatry 76:1064-9. 2005..SAI is reduced in Alzheimer's disease (AD) and drugs enhancing cholinergic transmission increase SAI...
Dissociated effects of diazepam and lorazepam on short-latency afferent inhibitionVincenzo Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Physiol 569:315-23. 2005..This dissociation suggests, for the first time, that TMS measures of cortical inhibition provide the opportunity to segregate differences of benzodiazepine action in human central nervous system circuits...
GABAA receptor subtype specific enhancement of inhibition in human motor cortexVincenzo Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Physiol 575:721-6. 2006....
Direct demonstration that repetitive transcranial magnetic stimulation can enhance corticospinal excitability in strokeVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
Stroke 37:2850-3. 2006..However, there is no direct evidence that the cortex of patients with stroke can respond in this fashion; hence, the basis of these new approaches has been questioned...
BDNF plasma levels in acute strokeV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Neurosci Lett 422:128-30. 2007..Our data, though indirectly, suggest that there is no significant increase in endogenous extracellular BDNF after a stroke in humans...
I-wave origin and modulationV Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
Brain Stimul 5:512-25. 2012..The integrative properties of the circuit also provide a good framework for the interpretation of the changes in the cortical output produced by paired and repetitive TMS...
Delayed hypothermia in malignant ischaemic strokeVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168, Rome, Italy
Neurol Sci 33:661-4. 2012..This single case study suggests a beneficial effect of hypothermia in the treatment of severe space-occupying ischemic infarction even on the third day after stroke onset...
Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulationF Ranieri
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Neurophysiol 107:1868-80. 2012..The present data demonstrate that it is possible to modulate LTP by using DCS and provide the rationale for the use of DCS in neurological diseases to promote the adaptive and suppress the maladaptive forms of brain plasticity...
The level of cortical afferent inhibition in acute stroke correlates with long-term functional recovery in humansVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
Stroke 43:250-2. 2012..Using transcranial magnetic stimulation, we investigated short-interval intracortical inhibition and short-latency afferent inhibition in acute ischemic stroke...
Functional evaluation of cerebral cortex in dementia with Lewy bodiesVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Neuroimage 37:422-9. 2007....
Repetitive transcranial magnetic stimulation for ALS. A preliminary controlled studyVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Neurosci Lett 408:135-40. 2006..The results of the pilot study might open up a new therapeutic perspective in ALS based on neuromodulation...
Origin of facilitation of motor-evoked potentials after paired magnetic stimulation: direct recording of epidural activity in conscious humansV Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
J Neurophysiol 96:1765-71. 2006....
Trigemino-cervical reflexes: clinical applications and neuroradiological correlationsV Di Lazzaro
Istituto di Neurologia, , L. go A. Gemelli 8, 00168 Rome, Italy
Suppl Clin Neurophysiol 58:110-9. 2006
In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementiasV Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
Neurology 66:1111-3. 2006..SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD...
Direct demonstration of the effects of repetitive paired-pulse transcranial magnetic stimulation at I-wave periodicityV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, Rome, Italy
Clin Neurophysiol 118:1193-7. 2007..To investigate the central nervous system level at which paired-pulse repetitive transcranial magnetic stimulation at I-wave periodicity (iTMS) produces a facilitation of motor evoked potential (MEP) amplitude...
Segregating two inhibitory circuits in human motor cortex at the level of GABAA receptor subtypes: a TMS studyV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 118:2207-14. 2007..To investigate if different interneuronal circuits in human motor cortex mediate inhibition through different subtypes of the gamma-aminobutyric acid A receptor (GABAAR)...
Modulating cortical excitability in acute stroke: a repetitive TMS studyV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 119:715-23. 2008..The aim of present study was to evaluate the effects of TBS on cortical excitability in acute stroke...
The physiological basis of the effects of intermittent theta burst stimulation of the human motor cortexV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Physiol 586:3871-9. 2008..However the circuits affected differ from those influenced by the inhibitory, cTBS, protocol. The implication is that cTBS and iTBS may have different therapeutic targets...
Modulation of motor cortex neuronal networks by rTMS: comparison of local and remote effects of six different protocols of stimulationV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Neurophysiol 105:2150-6. 2011..Head-to-head comparison of the different protocols enabled us to identify the most effective paradigms for modulating the excitatory and inhibitory circuits activated by TMS...
Long-term motor cortex stimulation for amyotrophic lateral sclerosisVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, Rome, Italy
Brain Stimul 3:22-7. 2010....
State of the art: Physiology of transcranial motor cortex stimulationVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, 00168 Rome, Italy
Brain Stimul 1:345-62. 2008..An updated overview of human and animal studies on the physiologic mechanisms of intact motor cortex stimulation is presented...
The effects of motor cortex rTMS on corticospinal descending activityV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 121:464-73. 2010..These recordings provided insight into the physiological basis of the effects of rTMS and the specific motor cortical circuits involved...
Low-frequency repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortexV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Physiol 586:4481-7. 2008..The earliest I-wave was not significantly modified by rTMS. The present results show that 1 Hz rTMS may decrease the amplitude of later descending waves, consistent with a cortical origin of the effect of 1 Hz rTMS on MEPs...
Motor cortex plasticity predicts recovery in acute strokeVincenzo Di Lazzaro
Istituto di Neurologia, Universita Cattolica, 00168 Rome, Italy
Cereb Cortex 20:1523-8. 2010..Functional recovery is directly correlated with LTP-like changes in AH and LTD-like changes in UH and inversely correlated with the baseline excitability of UH...
Motor cortex stimulation for ALS: a double blind placebo-controlled studyVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, 00168 Rome, Italy
Neurosci Lett 464:18-21. 2009..0) in those receiving placebo stimulation. Although cTBS proved a safe procedure, on the basis of the present findings a larger randomized confirmatory trial seems unjustified in ALS patients, at least in advanced stage of the disease...
LTD-like plasticity induced by paired associative stimulation: direct evidence in humansVincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Exp Brain Res 194:661-4. 2009..PAS10 significantly reduced the amplitude of later descending waves while the earliest descending wave was not modified. Present results confirm the cortical origin of the effect of PAS10...
Reduced cerebral cortex inhibition in dystonia: direct evidence in humansV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 120:834-9. 2009..We had the almost unique opportunity to record directly motor cortex output after brain stimulation, in a dystonic patient who had epidural electrodes implanted in the upper cervical cord...
Associative motor cortex plasticity: direct evidence in humansV Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
Cereb Cortex 19:2326-30. 2009..The present results show that PAS may increase the amplitude of later corticospinal volleys, consistent with a cortical origin of the effect of PAS...
In vivo functional evaluation of central cholinergic circuits in vascular dementiaV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 119:2494-500. 2008..The objective of present study was to evaluate central cholinergic circuits in patients with Vascular Dementia (VaD)...
Theta-burst repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortexV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, Rome, Italy
J Physiol 565:945-50. 2005....
Bilateral chorea-ballism after cardiac arrestV Di Lazzaro
Istituto di Neurologia, , L.go A. Gemelli 8, 00168 Rome, Italy
Neurology 64:E20. 2005
An unusual cause of dysphagia and dysphoniaV Di Lazzaro
Istituto di Neurologia, , L.go A. Gemelli 8, 00168 Rome, Italy
Neurology 64:922. 2005
The effect on corticospinal volleys of reversing the direction of current induced in the motor cortex by transcranial magnetic stimulationV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Exp Brain Res 138:268-73. 2001..Some sites or neurones that are relatively inaccessible to PA stimulation may be the low-threshold targets of AP stimulation...
Direct recording of the output of the motor cortex produced by transcranial magnetic stimulation in a patient with cerebral cortex atrophyV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 115:112-5. 2004..To examine the descending motor activity evoked by transcranial magnetic stimulation (TMS) in a chronic alcoholic patient with a slight atrophy of the peri-central cortex and compare with that observed in neurologically intact subjects...
Comparison of descending volleys evoked by monophasic and biphasic magnetic stimulation of the motor cortex in conscious humansV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Exp Brain Res 141:121-7. 2001..The pattern of recruitment of descending activity depends on the intensity of the stimulus and the relative threshold of each volley to each direction of current flow...
Descending spinal cord volleys evoked by transcranial magnetic and electrical stimulation of the motor cortex leg area in conscious humansV Di Lazzaro
Institute of Neurology, Catholic University, L go A Gemelli 8, 00168 Rome, Italy
J Physiol 537:1047-58. 2001..A more secure way to ensure D wave activation of corticospinal fibres from the leg area is to place the anode 2 cm lateral to the vertex...
Changes in motor cortex excitability in facioscapulohumeral muscular dystrophyV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, Rome 00168, Italy
Neuromuscul Disord 14:39-45. 2004..025) and in patients with other muscle diseases (mean responses +/-SD, reduced to 30.6+/-11.7% of the test size; P=0.046). No significant difference was found between the control group and patients with other muscle diseases (P=0.970)...
Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contractionV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Exp Brain Res 149:535-8. 2003..We confirm that fatigue suppresses I waves evoked by TMS. In addition, D waves were suppressed in two of the patients, suggesting that axonal excitability might also be compromised by a period of intense muscle contraction...
Corticospinal volleys evoked by transcranial stimulation of the brain in conscious humansVincenzo Di Lazzaro
Institute of Neurology, Catholic University, L go A Gemelli 8, 00168 Rome, Italy
Neurol Res 25:143-50. 2003....
Ketamine increases human motor cortex excitability to transcranial magnetic stimulationV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
J Physiol 547:485-96. 2003..We suggest that the enhancement of human motor cortex excitability to transcranial magnetic stimulation is the effect of an increase in glutamatergic transmission at non-NMDA receptors similar to that described in experimental studies...
Direct demonstration of long latency cortico-cortical inhibition in normal subjects and in a patient with vascular parkinsonismV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 113:1673-9. 2002..Although previous studies have agreed that the effect is cortical, there is disagreement over exactly which cortical mechanisms are involved. The aim of this study was to provide further evidence for cortical involvement in LICI...
Short-term reduction of intracortical inhibition in the human motor cortex induced by repetitive transcranial magnetic stimulationV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Exp Brain Res 147:108-13. 2002....
Descending volleys evoked by transcranial magnetic stimulation of the brain in conscious humans: effects of coil shapeV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 113:114-9. 2002..To directly compare the volleys evoked by figure-of-eight and circular magnetic coil stimulation of the motor cortex and to correlate the descending volleys with the EMG responses in distal hand muscles...
The physiological basis of transcranial motor cortex stimulation in conscious humansV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168, Rome, Italy
Clin Neurophysiol 115:255-66. 2004..These recordings provide insights about the physiological basis of the excitatory and inhibitory phenomena produced by transcranial stimulation...
Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's diseaseV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
J Neurol Neurosurg Psychiatry 75:555-9. 2004..The aim of the present study was to determine whether hyperexcitability is due to the impairment of intracortical inhibitory circuits or to an independent abnormality of excitatory circuits...
Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humansV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
J Physiol 564:661-8. 2005..19, P = 0.039). In contrast to SICI, SAI was significantly reduced by lorazepam (F(3,9) = 9.39, P = 0.0002). Our findings demonstrate that GABA(A) activity enhancement determines a suppression of SAI and an increase of SICI...
Role of motor evoked potentials in diagnosis of cauda equina and lumbosacral cord lesionsV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Neurology 63:2266-71. 2004..To determine the diagnostic value of motor evoked potentials (MEPs) in the diagnosis of lumbosacral cord disorders...
Radicular myoclonus induced by repetitive neck movements in a patient with cervical spondylosisV Di Lazzaro
Istituto di Neurologia, , L.go A. Gemelli 8, 00168 Rome, Italy
Neurology 63:2190-1. 2004
Generation of I waves in the human: spinal recordingsV Di Lazzaro
Department of Neurology, , L. go A. Gemelli 8, 00168 Rome, Italy
Suppl Clin Neurophysiol 56:143-52. 2003
Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortexV Di Lazzaro
Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
Exp Brain Res 144:549-53. 2002..Both effects were still evident 2 min after the end of the rTMS. The effects are compatible with a short-term increase in cortical excitability during suprathreshold rTMS...
Effects of vagus nerve stimulation on cortical excitability in epileptic patientsV Di Lazzaro
Institutes of Neurology, Universita Cattolica, Rome, Italy
Neurology 62:2310-2. 2004..Patients were examined with the stimulator on and off. VNS determined a selective and pronounced increase in the inhibition produced by paired-pulse TMS with no effects on the excitability by single-pulse TMS...
Muscarinic receptor blockade has differential effects on the excitability of intracortical circuits in the human motor cortexV Di Lazzaro
Istituto di Neurologia, Universita Cattolica, Rome, Italy
Exp Brain Res 135:455-61. 2000....
Motor cortex stimulation for amyotrophic lateral sclerosis. Time for a therapeutic trial?Vincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
Clin Neurophysiol 115:1479-85. 2004....
Normal or enhanced short-latency afferent inhibition in Parkinson's disease?Vincenzo Di Lazzaro
Institute of Neurology, Universita Cattolica, Rome, Italy
Brain 127:E8; author reply E9. 2004
Craniopagus: the Thessaloniki-Rome experienceC Di Rocco
Pediatric Neurosurgery Unit, Catholic University Medical School, Largo A Gemelli, 8, 00168, Rome, Italy
Childs Nerv Syst 20:576-86. 2004..These conjoined twins were transferred to the Pediatric Neurosurgical Unit of the Gemelli Hospital, Catholic University Medical School, at the age of 4 months for possible surgical division...
The role of brain infarcts and hippocampal atrophy in subcortical ischaemic vascular dementiaG Gainotti
Institute of Neurology, Catholic University, Policlinico Gemelli, Largo A Gemelli 8, I 00168 Rome, Italy
Neurol Sci 25:192-7. 2004..Multiple subcortical infarcts alone are probably not able to cause clinical dementia but the presence of vascular lesions increases the expression of concomitant Alzheimer's disease...
3D rotational angiography for the diagnosis and preoperative assessment of intracranial aneurysms: preliminary experienceA Pedicelli
Dipartimento di Bioimmagini e Scienze Radiologiche, Istituto di Radiologia, Universita Cattolica del Sacro Cuore, Policl A Gemelli, Largo A Gemelli 1, Rome, Italy
Radiol Med 112:895-905. 2007..The aim of this study was to assess the value of the systematic use of 3D rotational angiography (3DRA) in the diagnosis and preoperative evaluation of cerebral aneurysms with a view to planning endovascular embolisation...
Metastatic lymphadenopathy from ENT carcinoma: role of diagnostic imagingT Tartaglione
Istituto di Radiologia, Universita Cattolica del S Cuore, Policlinico A Gemelli, Roma
Rays 25:429-46. 2000..Similarly to CT/MR, sonographic findings of extracapsular spread can be: 1) blurred margins and irregular contours; 2) invasion of an adjacent structure or muscle...
Atherosclerosis of carotid and intracranial arteriesM Rollo
Istituto di Radiologia, Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo A Gemelli, 00168 Roma, Italy
Rays 26:247-68. 2001..This is the reason why in diagnostic imaging of atheromatosis, digital angiography should be combined with color Doppler-US, CT and MRI...
Functional hemispherectomy in children with epilepsy and CSWS due to unilateral early brain injury including thalamus: sudden recovery of CSWSD Battaglia
Child Neurology, Catholic University of the Sacred Heart, Rome, Italy
Epilepsy Res 87:290-8. 2009....
Tourettism in multiple sclerosis: a case reportV Nociti
Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy
J Neurol Sci 287:288-90. 2009..In conclusion, we can hypothesize that in our case Tourettism and MS could be considered causal related more than coincidentally associated...
Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphomaA Antinori
Department of Infectious Diseases, Catholic University, Rome, Italy
J Clin Oncol 17:554-60. 1999..To determine the diagnostic capability of thallium-201 (201Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for the diagnosis of AIDS-related primary CNS lymphoma (PCNSL)...
Early hemispherectomy in catastrophic epilepsy: a neuro-cognitive and epileptic long-term follow-upD Lettori
Child Neurology and Psychiatry, Catholic University, Rome, Italy
Seizure 17:49-63. 2008..To confirm this suggestion, however, further experience with larger series is needed...
Observation of continuous spike-waves during slow sleep in children with myelomeningoceleD Battaglia
Department of Medical and Surgical Paediatrics and Developmental Neurosciences, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy
Childs Nerv Syst 20:462-7. 2004....
Os odontoideum in a patient with cervical vertigo: a case reportJ Galli
Institute of Otorhinolaryngology, University of the Sacred Heart ROMA, Rome, Italy
Am J Otolaryngol 22:371-3. 2001....
Diffuse craniospinal choroid plexus papilloma with involvement of both cerebellopontine anglesF Doglietto
Institute of Neurosurgery, Catholic University School of Medicine, 00168 Rome, Italy
Neurology 65:842. 2005
Monophasic demyelinating disease of the central nervous system associated with Hepatitis A infectionL Quaranta
J Neurol 253:944-5. 2006
Seizure semiology of lesional frontal lobe epilepsies in childrenD Battaglia
Catholic Uinversity, Child Neurology, Rome, Italy
Neuropediatrics 38:287-91. 2007....
