Research Topics
Genomes and Genes | Alfonso CatalanoSummaryCountry: Italy Publications
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Publications
New aspects on the role of lipoxygenases in cancer progressionA Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Via Ranieri, 60131 Ancona, Italy
Histol Histopathol 20:969-75. 2005..Moreover, we discuss how this new perspective on the roles of LOXs and their metabolites can have important implications to cancer therapy...- Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and functionAlfonso Catalano
Dipartimento di Patologia Molecolare, Politecnica delle Marche, Via Ranieri, 60131, Ancona, Italy
Blood 107:3321-9. 2006..These results suggest that Sema-3A inhibits primary T-cell activation and imply that it can contribute to the T-cell dysfunction in the tumor microenvironment... - 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activationAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
EMBO J 24:170-9. 2005..These data link the 5LO pathway to oxidative crises of primary fibroblast and suggest that the ability of 5LO to induce senescence-like growth arrest may be important in the pathogenesis of 5LO-associated disorders... - 5-lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear traffickingAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
FASEB J 18:1740-2. 2004..Moreover, they provide a rationale to the therapeutic use of 5-LO inhibitors to enhance cancer chemosensitivity in selected tumors... - Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cellsAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona 60131, Italy
J Biol Chem 279:46706-14. 2004.... - Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemopreventionAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
Int J Cancer 109:322-8. 2004..These data demonstrate that celecoxib may have antitumor properties in MM and provide a rationale for the therapeutic use of celecoxib in combination with a selective VEGF inhibitor... - Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferationAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Laboratory of Experimental Pathology, Polytechnic University of Marche, Ancona, Italy
FASEB J 18:358-60. 2004..Therefore, these results delineate a new role of Sema-3A in VEGF function mediated by p38 MAPK and suggest that the abrogation of regulated Sema-3A expression is responsible for VEGF-driven growth of tumor cells... - Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasisDaniele Martarelli
Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
BMC Cancer 6:130. 2006..Our work aimed at establishing a nude mouse model xenotransplanted with human MPM cell lines in which tumor progression exhibits some features of the human disease... - Enhanced antitumor therapy by inhibition of p21waf1 in human malignant mesotheliomaRaffaella Lazzarini
Department of Molecular Pathology and Innovative Therapies, Marche University, Ancona, Italy
Clin Cancer Res 14:5099-107. 2008..Recent data indicate that p21 keeps tumor cells alive after DNA damage, favoring a survival advantage. In this study, we assessed the possibility of p21 suppression as a therapeutic target for MPM... - FLIP overexpression inhibits death receptor-induced apoptosis in malignant mesothelial cellsMaria Rita Rippo
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, 60100 Ancona, Italy
Oncogene 23:7753-60. 2004..These results indicate that MM cells develop an intrinsic resistance to apoptosis induced by death receptors upregulating the expression of the antiapoptotic protein c-FLIP... - The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cellsAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Marche University, Ancona, Italy
Cancer Res 69:1485-93. 2009..This work identifies a new biological function of semaphorins in cancer cells and suggests the involvement of an undescribed survival pathway during MPM tumorigenesis... - Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid raftsSimona Moretti
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
Blood 111:2290-9. 2008..This work identifies a novel biologic function of semaphorins and presents an unexpected signaling mechanism linking semaphorin to the tumor necrosis factor family receptors... - Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigenAlfonso Catalano
Institute of Experimental Pathology, University of Ancona, Faculty of Medicine, Via Ranieri, 60131 Ancona, Italy
Oncogene 21:2896-900. 2002..These data indicate that VEGF regulation by SV40 transforming proteins can represent a key event in SV40 signaling relevant for tumor progression... - The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritisAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
J Immunol 185:6373-83. 2010.... - Neuronal semaphorins regulate a primary immune responseSimona Moretti
Department of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, Ancona, Italy
Curr Neurovasc Res 3:295-305. 2006..This paper discusses the functions of these semaphorins in the immune system, focusing on their roles in T cell-APC interactions... - Experimental therapy of malignant mesothelioma: new perspectives from anti-angiogenic treatmentsAlfonso Catalano
Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Via Ranieri 6, Ancona 60131, Italy
Crit Rev Oncol Hematol 50:101-9. 2004..It seems likely that no single treatment modality will be effective by itself. Studies that use combinations of the newer agents, including angiostatic drugs, with chemotherapy, should be conducted...