Luigi Buonaguro

Summary

Country: Italy

Publications

  1. pmc Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration
    Luigi Buonaguro
    Laboratory of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy
    Clin Vaccine Immunol 19:970-3. 2012
  2. ncbi request reprint Introducing the immunovirology section of journal of translational medicine
    Luigi Buonaguro
    Lab of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy and Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Transl Med 8:3. 2010
  3. pmc Systems biology applied to vaccine and immunotherapy development
    Luigi Buonaguro
    Molecular Biology and Viral Oncology, Dept of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    BMC Syst Biol 5:146. 2011
  4. pmc Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example
    Luigi Buonaguro
    Lab of Viral Oncogenesis and Immunotherapy and AIDS Refer Center, Ist Naz Tumori Fond G Pascale, Naples, Italy
    Retrovirology 4:34. 2007
  5. pmc Multiparametric analyses of human PBMCs loaded ex vivo with a candidate idiotype vaccine for HCV-related lymphoproliferative disorders
    Annacarmen Petrizzo
    Laboratory of Molecular Biology and Viral Oncogenesis, National Cancer Institute Fond G Pascale, Naples, Italy
    PLoS ONE 7:e44870. 2012
  6. doi request reprint MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Biomarkers 16:42-50. 2011
  7. pmc Molecular immune signatures of HIV-1 vaccines in human PBMCs
    Alessandro Monaco
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health Bethesda, MD, USA
    FEBS Lett 583:3004-8. 2009
  8. ncbi request reprint Human papillomavirus genotypes and HPV16 variants in penile carcinoma
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    Int J Cancer 122:132-7. 2008
  9. pmc Gene profiling, biomarkers and pathways characterizing HCV-related hepatocellular carcinoma
    Valeria De Giorgi
    Molecular Biology and Viral Oncogenesis and AIDS Refer, Center, IST, Naz, Tumori Fond, G Pascale, Naples, Italy
    J Transl Med 7:85. 2009
  10. doi request reprint Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagus
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit and AIDS Reference Centre, National Cancer Institute Fond Pascale, Naples, Italy
    J Clin Virol 45:28-33. 2009

Detail Information

Publications43

  1. pmc Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration
    Luigi Buonaguro
    Laboratory of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy
    Clin Vaccine Immunol 19:970-3. 2012
    ..The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level...
  2. ncbi request reprint Introducing the immunovirology section of journal of translational medicine
    Luigi Buonaguro
    Lab of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy and Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Transl Med 8:3. 2010
    ..ABSTRACT: A new section of the Journal of Translational Medicine has been launched, devoted to promoting the field of Immunovirology...
  3. pmc Systems biology applied to vaccine and immunotherapy development
    Luigi Buonaguro
    Molecular Biology and Viral Oncology, Dept of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    BMC Syst Biol 5:146. 2011
    ..Thus, the paradigm switch from "empirical" to "knowledge-based" conduct of medicine and immunotherapy in particular, leading to patient-tailored treatment...
  4. pmc Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example
    Luigi Buonaguro
    Lab of Viral Oncogenesis and Immunotherapy and AIDS Refer Center, Ist Naz Tumori Fond G Pascale, Naples, Italy
    Retrovirology 4:34. 2007
    ..The study and monitoring of the genetic evolution of the HIV-1 represent, therefore, an essential strategy for controlling the local as well as global HIV-1 epidemic and for developing efficient preventive and therapeutic strategies...
  5. pmc Multiparametric analyses of human PBMCs loaded ex vivo with a candidate idiotype vaccine for HCV-related lymphoproliferative disorders
    Annacarmen Petrizzo
    Laboratory of Molecular Biology and Viral Oncogenesis, National Cancer Institute Fond G Pascale, Naples, Italy
    PLoS ONE 7:e44870. 2012
    ....
  6. doi request reprint MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Biomarkers 16:42-50. 2011
    ..The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients...
  7. pmc Molecular immune signatures of HIV-1 vaccines in human PBMCs
    Alessandro Monaco
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health Bethesda, MD, USA
    FEBS Lett 583:3004-8. 2009
    ..This ex vivo screening strategy represents an efficient tool for guiding modifications/optimizations of vaccination strategies and understanding failures in individuals enrolled in clinical trials...
  8. ncbi request reprint Human papillomavirus genotypes and HPV16 variants in penile carcinoma
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    Int J Cancer 122:132-7. 2008
    ....
  9. pmc Gene profiling, biomarkers and pathways characterizing HCV-related hepatocellular carcinoma
    Valeria De Giorgi
    Molecular Biology and Viral Oncogenesis and AIDS Refer, Center, IST, Naz, Tumori Fond, G Pascale, Naples, Italy
    J Transl Med 7:85. 2009
    ..In the present study, a comparison of gene expression patterns has been performed by microarray analysis on liver biopsies from HCV-positive HCC patients and HCV-negative controls...
  10. doi request reprint Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagus
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit and AIDS Reference Centre, National Cancer Institute Fond Pascale, Naples, Italy
    J Clin Virol 45:28-33. 2009
    ..Still controversial is the association of HPV infection with oesophageal neoplasia...
  11. doi request reprint Immunogenomics approaches for vaccine evaluation
    Annacarmen Petrizzo
    Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Naples, Italy
    J Immunotoxicol 9:236-40. 2012
    ..Such approach, indeed, would enable the switch from 'empirical' to 'knowledge-based' vaccinology, leading to a patient-tailored treatment...
  12. pmc Effects of adjuvants on IgG subclasses elicited by virus-like particles
    Maria Luisa Visciano
    Lab, of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond, G, Pascale, Naples Italy
    J Transl Med 10:4. 2012
    ..In the present study, the elicitation of different patterns of IgG subclasses by VLPs, administered in CpG ODN1826 or poly(I:C) adjuvants, has been evaluated in an animal model...
  13. doi request reprint High prevalence of human papillomavirus infection in Eastern European and West African women immigrants in South Italy
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    APMIS 119:701-9. 2011
    ..The implementation of vaccination strategies and cervical cancer surveillance are critical for women in this risk group...
  14. doi request reprint Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit, Department of Experimental Oncology, National Cancer Institute, Fond Pascale, Naples, Italy
    Genomics 102:74-83. 2013
    ..015). The extended analysis of genetic alterations will help to identify molecular markers for liver cancer prevention, diagnosis and treatment of HBV and HCV-associated liver cancer. ..
  15. doi request reprint A pilot study on the distribution of human papillomavirus genotypes and HPV-16 variants in cervical neoplastic lesions from Ecuadorian women
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 80:1959-65. 2008
    ....
  16. doi request reprint Developments in virus-like particle-based vaccines for HIV
    Luigi Buonaguro
    Department of Experimental Oncology, Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Expert Rev Vaccines 12:119-27. 2013
    ..This review describes an update on the development and use of VLPs as vaccine approaches for HIV...
  17. pmc HIV p24 as scaffold for presenting conformational HIV Env antigens
    Maria Tagliamonte
    Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy
    PLoS ONE 7:e43318. 2012
    ..This strongly support the feasibility of developing a scaffolding strategy based on p24 CA proteins displaying conformational minimal structural, antigenic HIV Env epitopes...
  18. doi request reprint Virus-like particle vaccines and adjuvants: the HPV paradigm
    Franco Maria Buonaguro
    Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Expert Rev Vaccines 8:1379-98. 2009
    ....
  19. pmc Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies
    Maria Tagliamonte
    Lab, of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Istituto Nazionale Tumori Fond, G, Pascale, Naples, Italy
    J Transl Med 9:S1. 2011
    ..The relevance of conformational HIV-1 Envelope proteins presented on Virus-like Particles for appropriate assessment of this molecular interaction, is also discussed...
  20. ncbi request reprint Evolution of the HIV-1 V3 region in the Italian epidemic
    Luigi Buonaguro
    Laboratory of Viral Oncogenesis and Immunotherapy and AIDS Reference Center, National Cancer Institute Fond G Pascale, Naples, Italy
    New Microbiol 30:1-11. 2007
    ..Here we review the genetic evolution of HIV-1 spreading within the Italian epidemic...
  21. doi request reprint Developments in virus-like particle-based vaccines for infectious diseases and cancer
    Luigi Buonaguro
    Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Expert Rev Vaccines 10:1569-83. 2011
    ..This article provides an update on the development and use of virus-like particles as vaccine approaches for infectious diseases and cancer...
  22. doi request reprint Human papillomavirus infection in urine samples from male renal transplant patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Naples, Italy
    J Med Virol 82:1179-85. 2010
    ....
  23. pmc TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients
    Valeria Di Vuolo
    Molecular Biology and Viral Oncology and AIDS Ref, Centre, National Cancer Institute Fond, Pascale, Naples, Italy
    Infect Agent Cancer 6:13. 2011
    ..abstract:..
  24. pmc Immunogenomics and systems biology of vaccines
    Luigi Buonaguro
    Laboratory of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Naples, Italy
    Immunol Rev 239:197-208. 2011
    ....
  25. doi request reprint Prediction of individual immune responsiveness to a candidate vaccine by a systems vaccinology approach
    Annacarmen Petrizzo
    Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione Pascale IRCCS, Naples, Italy
    J Transl Med 12:11. 2014
    ....
  26. pmc Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate
    Maria Luisa Visciano
    Molecular Biology and Viral Oncogenesis Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Pascale IRCCS, Naples, Italy
    J Transl Med 11:165. 2013
    ..Our results provide a rationale for the design and evaluation of immunogens and the clade A gp14094UG018 shows promising characteristics for potential involvement in an effective HIV vaccine with broad activity. ..
  27. ncbi request reprint Prevalence of alpha-papillomavirus genotypes in cervical squamous intraepithelial lesions and invasive cervical carcinoma in the Italian population
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 78:1663-72. 2006
    ....
  28. doi request reprint Mutations of the TP53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit, and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Gynecol Oncol 128:442-8. 2013
    ..This study provides a detailed analysis of TP53 mutation spectra in cervical squamous cell carcinoma and adenocarcinoma from different geographical regions...
  29. ncbi request reprint Characterization of the human papillomavirus (HPV) integration sites into genital cancers
    Clorinda Annunziata
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Cappella Cangiani, 80131, Naples, Italy
    Pathol Oncol Res 18:803-8. 2012
    ..3, within the intronic region of TRAP1 gene. These results confirm previous observations, summarized in a systematic review of the literature, on the HPV integration events in gene loci relevant to cancer pathogenesis...
  30. pmc Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer
    Clorinda Annunziata
    Molecular Biology and Viral Oncology, National Cancer Institute Fond, Pascale, Cappella Cangiani, 80131, Naples, Italy
    Infect Agent Cancer 8:2. 2013
    ....
  31. pmc Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation
    Luigi Buonaguro
    Lab, Viral Oncogenesis and Immunotherapies and AIDS Reference Center, Department of Experimental Oncology, Istituto Nazionale Tumori Fond, G, Pascale, 80131 Napoli, Italy
    BMC Bioinformatics 9:S5. 2008
    ..Baculovirus-expressed HIV-1 Pr55gag Virus-Like Particles (HIV-VLPs) induce maturation and activation of monocyte-derived dendritic cells (MDDCs) with a production of Th1- and Th2-specific cytokines...
  32. doi request reprint Plant-based anti-HIV-1 strategies: vaccine molecules and antiviral approaches
    Nunzia Scotti
    CNR IGV, Institute of Plant Genetics, Portici, Naples, Italy
    Expert Rev Vaccines 9:925-36. 2010
    ..Furthermore, plant-based anti-HIV strategies can be administered not only parenterally but also by the more convenient and safer oral route, which is a more suitable approach for possible mass vaccination...
  33. doi request reprint TP53 codon 72 polymorphism in classic, endemic and epidemic Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Naples, Italy
    Oncology 77:328-34. 2009
    ..Several studies have examined the association of codon 72 polymorphism of the TP53 gene, encoding either arginine or proline, in several tumor types but none have investigated its role in Kaposi's sarcoma (KS) development...
  34. doi request reprint Oncolytic virus therapies
    Franco Maria Buonaguro
    Unit of Molecular Biology and Viral Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Pharm Pat Anal 1:621-7. 2012
    ..Clinical results, although effective only for a limited period of time, are encouraging. Combined treatments with radio or chemotherapeutic protocols are also in progress. ..
  35. doi request reprint Chemokine receptor interactions with virus-like particles
    Luigi Buonaguro
    Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy
    Methods Mol Biol 1013:57-66. 2013
    ..Here, we describe a method to evaluate HIV-VLP binding to cellular chemokine co-receptors, by carboxyfluorescein succinimidyl ester labeling and cellular uptake...
  36. pmc Innate immunity and hepatitis C virus infection: a microarray's view
    Luigi Buonaguro
    Molecular Biology and Viral Oncogenesis Unit, Istituto Nazionale Tumori Fond, G, Pascale, 80131, Naples, Italy
    Infect Agent Cancer 7:7. 2012
    ....
  37. doi request reprint Advances in viral oncology research: summary of the 3rd International Meeting
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, Istituto Nazionale Tumori Fond Pascale, Naples, Italy
    Expert Rev Vaccines 11:411-4. 2012
    ..More than 100 scientists attended the meeting. A summary of the invited lectures and oral selected presentations is reported...
  38. doi request reprint New adjuvants in evolving vaccine strategies
    Franco M Buonaguro
    Molecular Biology and Viral Oncology, Dpt of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Napoli, Italy
    Expert Opin Biol Ther 11:827-32. 2011
    ..In the May issue of this journal, Garcon and colleagues describe the highly enhanced humoral and memory B cellular immunity of the AS04-adjuvanted HPV vaccine, which results in a long-lasting and broad spectrum immunity...
  39. doi request reprint Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology, National Cancer Institute Fondazione Pascale, Cappella Cangiani, 80131 Naples, Italy
    Biomed Res Int 2013:519619. 2013
    ....
  40. ncbi request reprint Screening of HIV-1 isolates by reverse heteroduplex mobility assay and identification of non-B subtypes in Italy
    Luigi Buonaguro
    Viral Oncology and AIDS Refer Center, Ist Naz Tumori Fond G Pascale, Naples, Italy
    J Acquir Immune Defic Syndr 37:1295-306. 2004
    ....
  41. pmc Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders
    Luigi Buonaguro
    Lab, of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Istituto Nazionale Tumori Fond, G, Pascale, Naples, Italy
    J Transl Med 8:18. 2010
    ..This objective has been pursued by implementing high-throughput technologies such as multiparameter flow cytometry and multiplex analysis of cytokines and chemokines...
  42. ncbi request reprint Virus-like particles as particulate vaccines
    Luigi Buonaguro
    Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Department of Experimental Oncology, Istituto Nazionale Tumori Fond G Pascale, 80131 Napoli, Italy
    Curr HIV Res 8:299-309. 2010
    ..The present review will address the biological and immunological properties of particulate structures, in particular VLPs, as platform for vaccine development...
  43. ncbi request reprint Analysis of human papillomavirus type-16 variants in Italian women with cervical intraepithelial neoplasia and cervical cancer
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 74:117-26. 2004
    ..The increased frequency of non-European variants in invasive lesions suggests that they are more oncogenic than European variants. This could have implications for future diagnostic and therapeutic strategies...