Silvia Bruno

Summary

Country: Italy

Publications

  1. ncbi Apoptosis of squamous cells at different stages of carcinogenesis following 4-HPR treatment
    Silvia Bruno
    Section of Human Anatomy, Department of Experimental Medicine, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    Carcinogenesis 23:447-56. 2002
  2. ncbi Human cytomegalovirus regulates surface expression of the viral protein UL18 by means of two motifs present in the cytoplasmic tail
    Massimo Maffei
    Human Anatomy Section, Department of Experimental Medicine, University of Genoa, Genova, Italy
    J Immunol 180:969-79. 2008
  3. ncbi Specific recognition of the viral protein UL18 by CD85j/LIR-1/ILT2 on CD8+ T cells mediates the non-MHC-restricted lysis of human cytomegalovirus-infected cells
    Daniele Saverino
    Human Anatomy Section, Department of Experimental Medicine, University of Genova, Genoa, Italy
    J Immunol 172:5629-37. 2004
  4. ncbi Death of T cell precursors in the human thymus: a role for CD38
    Claudya Tenca
    Section of Human Anatomy, Department of Experimental Medicine, University of Genova, 16132 Genova, Italy
    Int Immunol 15:1105-16. 2003
  5. ncbi Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic
    Fabio Ghiotto
    Department of Experimental Medicine, Section of Human Anatomy, University of Genoa, Genoa, Italy
    Cancer Biol Ther 8:263-71. 2009
  6. ncbi Dissecting the structural determinants of the interaction between the human cytomegalovirus UL18 protein and the CD85j immune receptor
    Marzia Occhino
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    J Immunol 180:957-68. 2008
  7. doi A vector design that allows fast and convenient production of differently tagged proteins
    Omar Scapolan
    Department of Experimental Medicine, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    Mol Biotechnol 52:16-25. 2012
  8. pmc Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells
    Fabio Ghiotto
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    Mol Med 17:1188-95. 2011
  9. ncbi The PML gene is not involved in the regulation of MHC class I expression in human cell lines
    Silvia Bruno
    Department of Experimental Medicine, Section of Human Anatomy, Genoa University, Genoa, Italy
    Blood 101:3514-9. 2003
  10. doi BH3-only proteins: the death-puppeteer's wires
    Fabio Ghiotto
    Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Genoa 16132, Italy
    Cytometry A 77:11-21. 2010

Collaborators

Detail Information

Publications15

  1. ncbi Apoptosis of squamous cells at different stages of carcinogenesis following 4-HPR treatment
    Silvia Bruno
    Section of Human Anatomy, Department of Experimental Medicine, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    Carcinogenesis 23:447-56. 2002
    ..We found that caspases 8, 9 and 3 participate in 4-HPR-mediated apoptosis of squamous cells, and that MPT is an upstream event that regulates caspase activity. Caspase 8 was activated independently of the Fas-Fas ligand pathway...
  2. ncbi Human cytomegalovirus regulates surface expression of the viral protein UL18 by means of two motifs present in the cytoplasmic tail
    Massimo Maffei
    Human Anatomy Section, Department of Experimental Medicine, University of Genoa, Genova, Italy
    J Immunol 180:969-79. 2008
    ..We disclosed a control mechanism used by the HCMV to regulate the availability of UL18 on the infected-cell surface to allow interaction with its ligand on T and NK cells...
  3. ncbi Specific recognition of the viral protein UL18 by CD85j/LIR-1/ILT2 on CD8+ T cells mediates the non-MHC-restricted lysis of human cytomegalovirus-infected cells
    Daniele Saverino
    Human Anatomy Section, Department of Experimental Medicine, University of Genova, Genoa, Italy
    J Immunol 172:5629-37. 2004
    ....
  4. ncbi Death of T cell precursors in the human thymus: a role for CD38
    Claudya Tenca
    Section of Human Anatomy, Department of Experimental Medicine, University of Genova, 16132 Genova, Italy
    Int Immunol 15:1105-16. 2003
    ..In addition, CD28 expression on developing thymocytes also appears to play a role for their selection and it synergizes with CD38 to induce apoptosis of DP thymocytes...
  5. ncbi Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic
    Fabio Ghiotto
    Department of Experimental Medicine, Section of Human Anatomy, University of Genoa, Genoa, Italy
    Cancer Biol Ther 8:263-71. 2009
    ..Altogether, we demonstrate that 072RB induces significant apoptosis of B-CLL cells subsequent to Bcl-X(L) and Mcl-1 downregulation...
  6. ncbi Dissecting the structural determinants of the interaction between the human cytomegalovirus UL18 protein and the CD85j immune receptor
    Marzia Occhino
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    J Immunol 180:957-68. 2008
    ..The higher affinity of UL18 to CD85j, compared with MHC class I, seems to be due not to additional interaction regions but to an overall better fit of the two molecules...
  7. doi A vector design that allows fast and convenient production of differently tagged proteins
    Omar Scapolan
    Department of Experimental Medicine, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    Mol Biotechnol 52:16-25. 2012
    ....
  8. pmc Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells
    Fabio Ghiotto
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    Mol Med 17:1188-95. 2011
    ..The data indicate a different mutation pattern between κ and λ isotype CLL clones and suggest an antigenic selection that, in κ samples, operates against CDR variation...
  9. ncbi The PML gene is not involved in the regulation of MHC class I expression in human cell lines
    Silvia Bruno
    Department of Experimental Medicine, Section of Human Anatomy, Genoa University, Genoa, Italy
    Blood 101:3514-9. 2003
    ..We conclude that, in human cell lines, PML is not involved directly in the regulation of MHC class I expression...
  10. doi BH3-only proteins: the death-puppeteer's wires
    Fabio Ghiotto
    Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Genoa 16132, Italy
    Cytometry A 77:11-21. 2010
    ..Nevertheless, the knowledge about the cellular and molecular mechanisms that regulate responsiveness to BH3 therapy has to be further expanded and will benefit from recent advances in cytometric quantitative technologies...
  11. ncbi Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?
    Franco Fais
    Section of Human Anatomy, Department of Experimental Medicine, University of Genoa
    Ital J Anat Embryol 115:79-84. 2010
    ..These studies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/expansion and underscore the informative value represented by BcR analyses...
  12. ncbi Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells
    Daniele Saverino
    Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    J Immunol 168:207-15. 2002
    ..In contrast, cross-linking of this receptor down-regulates Ag-specific CD4+ T cell proliferation and increases IL-10 and TGF-beta production...
  13. ncbi A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity
    Raffaella Ponassi
    Department of Oncology, University of Genoa, Genoa, Italy
    Cell Cycle 7:3211-24. 2008
    ..Altogether, these observations support the therapeutic potentials of this novel BH3 mimetic...
  14. pmc Neuroblastoma-targeted nanoparticles entrapping siRNA specifically knockdown ALK
    Daniela Di Paolo
    Department of Experimental Medicine, Experimental Therapy Unit, Laboratory of Oncology, Istituto G Gaslini, Genoa, Italy
    Mol Ther 19:1131-40. 2011
    ..v.) injection of the targeted ALK-siRNA liposomes showed gene-specific antitumor activity with no side effects. ALK-selective siRNA entrapped in anti-GD₂-targeted nanoparticles is a promising new modality for NB treatment...
  15. ncbi Prognostic effect of DNA aneuploidy from bladder washings in superficial bladder cancer
    Matteo Puntoni
    Division of Medical Oncology, E O Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy
    Cancer Epidemiol Biomarkers Prev 16:979-83. 2007
    ..Superficial (papillary) bladder cancer is associated with progression and death from muscle-invasive bladder cancer, but no reliable predictors of the outcomes have been identified...