E Grossi

Summary

Affiliation: Bracco Imaging SpA
Country: Italy

Publications

  1. pmc Artificial Adaptive Systems and predictive medicine: a revolutionary paradigm shift
    Enzo Grossi
    Centro Diagnostico Italiano, Milano, Italy
    Immun Ageing 7:S3. 2010
  2. pmc A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis
    Maira Gironi
    Semeion Research Center, Via Sersale 117, Rome, 00128, Italy
    Immun Ageing 10:1. 2013
  3. pmc Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia
    Federico Licastro
    Department of Experimental Pathology, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S4. 2010
  4. pmc Placental determinants of fetal growth: identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks
    Maria E Street
    Department of Pediatrics, University of Parma, 43100 Parma, Italy
    BMC Pediatr 8:24. 2008
  5. pmc Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks
    Fabio Coppede
    Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy
    BMC Med Genomics 3:42. 2010
  6. pmc New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background
    Silvana Penco
    Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca Granda Hospital P za Ospedale Maggiore 3, 20100 Milan, Italy
    BMC Bioinformatics 9:254. 2008
  7. pmc The single individual in medicine: how to escape from the probability theory trap
    Enzo Grossi
    Dipartimento Farma Italia, Bracco S, P, A, Via XXV Aprile, 420097 San Donato Milanese, Italy
    Cases J 1:58. 2008
  8. doi request reprint Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with acute diarrhea: a multicenter, randomized study in primary care
    Enzo Grossi
    Medical Department Bracco S p A, Milano, Italy
    J Clin Gastroenterol 44:S35-41. 2010
  9. ncbi request reprint Introduction to artificial neural networks
    Enzo Grossi
    Bracco SpA Medical Department, Milan, Italy
    Eur J Gastroenterol Hepatol 19:1046-54. 2007
  10. pmc Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study
    Enzo Grossi
    Bracco SpA Medical Department, Milan, Italy
    BMC Neurol 7:15. 2007

Collaborators

Detail Information

Publications37

  1. pmc Artificial Adaptive Systems and predictive medicine: a revolutionary paradigm shift
    Enzo Grossi
    Centro Diagnostico Italiano, Milano, Italy
    Immun Ageing 7:S3. 2010
    ....
  2. pmc A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis
    Maira Gironi
    Semeion Research Center, Via Sersale 117, Rome, 00128, Italy
    Immun Ageing 10:1. 2013
    ..abstract:..
  3. pmc Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia
    Federico Licastro
    Department of Experimental Pathology, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S4. 2010
    ..CONCLUSION : This map of variables may be use to identify subjects with increased risk of developing cognitive decline end/or dementia and provide pivotal information for early intervention protocols for prevention of dementia...
  4. pmc Placental determinants of fetal growth: identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks
    Maria E Street
    Department of Pediatrics, University of Parma, 43100 Parma, Italy
    BMC Pediatr 8:24. 2008
    ....
  5. pmc Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks
    Fabio Coppede
    Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy
    BMC Med Genomics 3:42. 2010
    ..Data were analysed using TWIST system in combination with supervised artificial neural networks, and a semantic connectivity map...
  6. pmc New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background
    Silvana Penco
    Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca Granda Hospital P za Ospedale Maggiore 3, 20100 Milan, Italy
    BMC Bioinformatics 9:254. 2008
    ..The results obtained have been compared with those derived from the use of standard neural networks and classical statistical analysis..
  7. pmc The single individual in medicine: how to escape from the probability theory trap
    Enzo Grossi
    Dipartimento Farma Italia, Bracco S, P, A, Via XXV Aprile, 420097 San Donato Milanese, Italy
    Cases J 1:58. 2008
    ..Yet recent developments in mathematics and science should allow us to do much better...
  8. doi request reprint Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with acute diarrhea: a multicenter, randomized study in primary care
    Enzo Grossi
    Medical Department Bracco S p A, Milano, Italy
    J Clin Gastroenterol 44:S35-41. 2010
    ..paracasei B-21060, with lactobacillus GG (FlorVis GG) in the treatment of acute presumed infectious diarrhea...
  9. ncbi request reprint Introduction to artificial neural networks
    Enzo Grossi
    Bracco SpA Medical Department, Milan, Italy
    Eur J Gastroenterol Hepatol 19:1046-54. 2007
    ....
  10. pmc Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study
    Enzo Grossi
    Bracco SpA Medical Department, Milan, Italy
    BMC Neurol 7:15. 2007
    ..The aim of this study is to discover the hidden and non-linear associations among AD pathognomonic brain lesions and the clinical diagnosis of AD in participants in the Nun Study through Artificial Neural Networks (ANNs) analysis..
  11. ncbi request reprint Technology transfer from the science of medicine to the real world: the potential role played by artificial adaptive systems
    Enzo Grossi
    Bracco SpA, Milan, Italy
    Subst Use Misuse 42:267-304. 2007
    ....
  12. pmc Non-linear associations between laryngo-pharyngeal symptoms of gastro-oesophageal reflux disease: clues from artificial intelligence analysis
    E Grossi
    Medical Department, Bracco SpA, Milano, Italy
    Acta Otorhinolaryngol Ital 26:293-8. 2006
    ..PST algorithm was employed. This study shows that laryngo-pharyngeal symptoms related to gastro-oesophageal reflux disease are correlated even if in a non-linear way...
  13. ncbi request reprint International experience on the use of artificial neural networks in gastroenterology
    E Grossi
    Bracco SpA Medical Department, Via E Folli 50, 20136 Milan, Italy
    Dig Liver Dis 39:278-85. 2007
    ....
  14. pmc Development and validation of the short version of the Psychological General Well-Being Index (PGWB-S)
    Enzo Grossi
    Medical Department Bracco SpA, Milan, Italy
    Health Qual Life Outcomes 4:88. 2006
    ..The purpose of the present paper is to describe the methods adopted and to report and discuss the relevance of results...
  15. pmc Medical concepts related to individual risk are better explained with "plausibility" rather than "probability"
    Enzo Grossi
    Medical Department, Bracco SpA Milan, Italy
    BMC Cardiovasc Disord 5:31. 2005
    ..Few articles by the way have tried to focus the concept of "risk" at the individual subject level rather than at population level...
  16. pmc How artificial intelligence tools can be used to assess individual patient risk in cardiovascular disease: problems with the current methods
    Enzo Grossi
    Medical Department, Bracco SpA Milan, Italy
    BMC Cardiovasc Disord 6:20. 2006
    ..These algorithms consider a number of variables and express their results as the percentage risk of developing a major fatal or non-fatal cardiovascular event in the following 10 to 20 years..
  17. ncbi request reprint Two different Alzheimer diseases in men and women: clues from advanced neural networks and artificial intelligence
    Enzo Grossi
    Bracco Imaging SpA, Medical Department, Milan, Italy
    Gend Med 2:106-17. 2005
    ..Studies of the gender-related differences in the clinical presentation of Alzheimer's disease (AD) have focused on specific aspects of the disease (eg, circulating metabolites, cognitive capacity, or epidemiologic trends)...
  18. ncbi request reprint The I.F.A.S.T. model allows the prediction of conversion to Alzheimer disease in patients with mild cognitive impairment with high degree of accuracy
    M Buscema
    Semeion Research Centre of Sciences of Communication, Rome, Italy
    Curr Alzheimer Res 7:173-87. 2010
    ....
  19. ncbi request reprint Auto-Contractive Maps: an artificial adaptive system for data mining. An application to Alzheimer disease
    M Buscema
    Semeion Research Center, Rome, Italy
    Curr Alzheimer Res 5:481-98. 2008
    ..The example of the Alzheimer data base is extremely useful to figure out how this new approach can help to re design bottom-up the overall structure of factors related to a complex disease like this...
  20. ncbi request reprint An optimized experimental protocol based on neuro-evolutionary algorithms application to the classification of dyspeptic patients and to the prediction of the effectiveness of their treatment
    M Buscema
    Semeion Research Center for Sciences of Communication, Via Sersale 117, 00128 Rome, Italy
    Artif Intell Med 34:279-305. 2005
    ....
  21. ncbi request reprint Recognition of patients with cardiovascular disease by artificial neural networks
    Damiano Baldassarre
    E Grossi Paoletti Center, Department of Pharmacological Sciences and Niguarda Hospital, University of Milan, Milan, Italy
    Ann Med 36:630-40. 2004
    ..When exposed to complex data sets, ANNs can learn the mechanisms that correlate different variables and perform complex classification tasks...
  22. ncbi request reprint The REALAB project: a new method for the formulation of reference intervals based on current data
    Enzo Grossi
    Research and Development, Centro Diagnostico Italiano, Milan, Italy
    Clin Chem 51:1232-40. 2005
    ....
  23. doi request reprint Is it possible to clinically differentiate erosive from nonerosive reflux disease patients? A study using an artificial neural networks-assisted algorithm
    Fabio Pace
    Division of Gastroenterology, Department of Clinical Sciences, L Sacco University Hospital, Milano, Italy
    Eur J Gastroenterol Hepatol 22:1163-8. 2010
    ..However, the differentiation between the erosive and nonerosive reflux disease based upon symptoms at presentation still remains inconclusive...
  24. ncbi request reprint Artificial neural networks are able to recognize gastro-oesophageal reflux disease patients solely on the basis of clinical data
    Fabio Pace
    Department of Gastroenterology, L Sacco H, Milan, Italy
    Eur J Gastroenterol Hepatol 17:605-10. 2005
    ..Artificial neural networks (ANN) are modelling mechanisms that are highly flexible and adaptive to solve the non-linearity inherent in the relationship between symptoms and underlying pathology...
  25. ncbi request reprint Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis
    Edith Lahner
    Digestive and Liver Disease Unit, II Medical School, Sant Andrea Hospital, University La Sapienza, Rome, Italy
    World J Gastroenterol 11:5867-73. 2005
    ....
  26. pmc Artificial neural networks and artificial organisms can predict Alzheimer pathology in individual patients only on the basis of cognitive and functional status
    Massimo Buscema
    Semeion Research Center, Rome, Italy
    Neuroinformatics 2:399-416. 2004
    ..These findings strengthen the hypothesis that neurofibrillary pathology may represent the major anatomic substrate of the cognitive impairment found in AD...
  27. doi request reprint Is it possible to automatically distinguish resting EEG data of normal elderly vs. mild cognitive impairment subjects with high degree of accuracy?
    Paolo M Rossini
    Associazione Fatebenefratelli per la Ricerca, S Giovanni Calibita Isola Tiberina, Rome, Italy
    Clin Neurophysiol 119:1534-45. 2008
    ....
  28. ncbi request reprint Age and gender relationships of serum alanine aminotransferase values in healthy subjects
    Enzo Grossi
    Am J Gastroenterol 101:1675-6. 2006
  29. ncbi request reprint "Appropriateness" or "prioritization" for GI endoscopic procedures?
    Angelo Andriulli
    Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Gastrointest Endosc 63:1034-6. 2006
  30. ncbi request reprint The IFAST model, a novel parallel nonlinear EEG analysis technique, distinguishes mild cognitive impairment and Alzheimer's disease patients with high degree of accuracy
    Massimo Buscema
    Semeion Research Centre, Via Sersale, 117, 00128 Rome, Italy
    Artif Intell Med 40:127-41. 2007
    ..The principal aim of the study was testing the hypothesis that automatic classification of MCI and AD subjects can be reasonably correct when the spatial content of the EEG voltage is properly extracted by ANNs...
  31. ncbi request reprint The traveling salesman problem as a new screening test in early Alzheimer's disease: an exploratory study. Visual problem-solving in AD
    Luc Pieter De Vreese
    Special Dementia Care Unit, Nursing Home Facility IX Gennaio, Modena, Italy
    Aging Clin Exp Res 17:458-64. 2005
    ..Some preliminary information was collected on the diagnostic accuracy of the Traveling Salesman Problem (TSP) compared with the Mini-Mental State Examination (MMSE) in recognizing early AD from normal aging...
  32. ncbi request reprint Use of an Italian version of the telephone interview for cognitive status in Alzheimer's disease
    Gloria Dal Forno
    Clinical Neurology, University Campus Biomedico, Rome, Italy
    Int J Geriatr Psychiatry 21:126-33. 2006
    ..Validation of an Italian version of the Telephone Interview for Cognitive Status (I-TICS)...
  33. ncbi request reprint Visuospatial planning and problem solving in Alzheimer's disease patients: a study with the Tower of London Test
    Massimo Franceschi
    Neurology Department, IRCCS Multimedica, Castellanza, Italy
    Dement Geriatr Cogn Disord 24:424-8. 2007
    ..The Tower of London (ToL), a task specifically devised to test executive functions of visuospatial planning and problem solving, has frequently been used in neuropsychological experiments, but rarely in the clinical ground...
  34. ncbi request reprint Artificial neural networks can classify uninvestigated patients with dyspepsia
    Angelo Andriulli
    Division of Gastroenterology, Casa Sollievo Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Eur J Gastroenterol Hepatol 19:1055-8. 2007
    ..With this ability, ANNs can be used to assist in the classification and treatment of patients with uninvestigated dyspepsia, and to bring a greater level of confidence to this process...
  35. doi request reprint Functional disability in early Alzheimer's disease - a validation study of the Italian version of the disability assessment for dementia scale
    Luc Pieter De Vreese
    Special Dementia Care Unit, Nursing Home Facility IX Gennaio, Modena, Italy
    Dement Geriatr Cogn Disord 25:186-94. 2008
    ..To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD)...
  36. doi request reprint Platelet aggregation and recruitment with aspirin-clopidogrel therapy
    Cathy M Helgason
    Department of Neurology, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    Cerebrovasc Dis 25:392-400. 2008
    ..Aspirin-clopidogrel combination therapy inhibits platelet aggregation. The effect on platelet recruitment is unknown...
  37. ncbi request reprint Use of artificial networks in clinical trials: a pilot study to predict responsiveness to donepezil in Alzheimer's disease
    Patrizia Mecocci
    Department of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    J Am Geriatr Soc 50:1857-60. 2002
    ..To evaluate the accuracy of artificial neural networks compared with discriminant analysis in classifying positive and negative response to the cholinesterase inhibitor donepezil in a group of Alzheimer's disease (AD) patients...