Jianqing Chen

Summary

Affiliation: Bracco Imaging SpA
Country: Italy

Publications

  1. ncbi Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting
    Jianqing Chen
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    Cancer 94:1196-201. 2002
  2. ncbi Radioiodination of rhenium cyclized alpha-melanocyte-stimulating hormone resulting in enhanced radioactivity localization and retention in melanoma
    Zhen Cheng
    Department of Chemistry, Chemistry Building, University of Missouri Columbia, Columbia, MO 65211, USA
    Cancer Res 64:1411-8. 2004
  3. ncbi Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 14:1177-84. 2003
  4. ncbi Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues
    Zhen Cheng
    Department of Chemistry, 125 Chemistry Building, University of Missouri Columbia, Columbia, MO 65211, USA
    J Med Chem 45:3048-56. 2002
  5. ncbi 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer
    Laura E Lantry
    Ernst Felder Laboratories, Bracco Research USA Inc, Princeton, New Jersey 08540 6608, USA
    J Nucl Med 47:1144-52. 2006
  6. doi In vitro binding evaluation of 177Lu-AMBA, a novel 177Lu-labeled GRP-R agonist for systemic radiotherapy in human tissues
    Regi Thomas
    Discovery Biology, Ernst Felder Laboratories, Bracco Research USA, Princeton, NJ 08540, USA
    Clin Exp Metastasis 26:105-19. 2009
  7. doi In vitro and in vivo metabolism of Lu-AMBA, a GRP-receptor binding compound, and the synthesis and characterization of its metabolites
    Karen E Linder
    Bracco Research USA Inc, 305 College Road East, Princeton, New Jersey 08540, USA
    Bioconjug Chem 20:1171-8. 2009
  8. doi 177Lu-AMBA biodistribution, radiotherapeutic efficacy, imaging, and autoradiography in prostate cancer models with low GRP-R expression
    Mary Ellen Maddalena
    Ernst Felder Laboratories, Bracco Research USA Inc, Princeton, New Jersey 08540 6608, USA
    J Nucl Med 50:2017-24. 2009
  9. doi Synthesis, stabilization and formulation of [177Lu]Lu-AMBA, a systemic radiotherapeutic agent for Gastrin Releasing Peptide receptor positive tumors
    Jianqing Chen
    Bracco Research USA Inc, 305 College Road East, Princeton, NJ 08540, USA
    Appl Radiat Isot 66:497-505. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting
    Jianqing Chen
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    Cancer 94:1196-201. 2002
    ....
  2. ncbi Radioiodination of rhenium cyclized alpha-melanocyte-stimulating hormone resulting in enhanced radioactivity localization and retention in melanoma
    Zhen Cheng
    Department of Chemistry, Chemistry Building, University of Missouri Columbia, Columbia, MO 65211, USA
    Cancer Res 64:1411-8. 2004
    ..Therefore Ac-D-Lys-ReCCMSH(Arg(11)) is an excellent candidate for additional therapeutic studies...
  3. ncbi Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 14:1177-84. 2003
    ..Moreover, the biodistribution properties of (188)Re-(Arg(11))CCMSH and (188)Re-CCMSH highlight their potential as therapeutic agents for human melanoma...
  4. ncbi Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues
    Zhen Cheng
    Department of Chemistry, 125 Chemistry Building, University of Missouri Columbia, Columbia, MO 65211, USA
    J Med Chem 45:3048-56. 2002
    ..13 +/- 1.47% ID/g for (111)In-10 at 4 h pi. Complex 6 showed high melanoma uptake and lower kidney uptake than the corresponding Lys(11) analogues, supporting 6 for further investigations as a potential therapeutic radiopharmaceutical...
  5. ncbi 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer
    Laura E Lantry
    Ernst Felder Laboratories, Bracco Research USA Inc, Princeton, New Jersey 08540 6608, USA
    J Nucl Med 47:1144-52. 2006
    ..We describe a new radiolabeled bombesin (BBN) analog for imaging and systemic radiotherapy that has improved pharmacokinetics (PK) and better retention of radioactivity in the tumor...
  6. doi In vitro binding evaluation of 177Lu-AMBA, a novel 177Lu-labeled GRP-R agonist for systemic radiotherapy in human tissues
    Regi Thomas
    Discovery Biology, Ernst Felder Laboratories, Bracco Research USA, Princeton, NJ 08540, USA
    Clin Exp Metastasis 26:105-19. 2009
    ..secondary) of prostate and breast cancer tissues. These data represent the molecular basis for clinical applications of (177)Lu-AMBA for diagnosis and treatment of GRP-R and NMB-R positive tumors...
  7. doi In vitro and in vivo metabolism of Lu-AMBA, a GRP-receptor binding compound, and the synthesis and characterization of its metabolites
    Karen E Linder
    Bracco Research USA Inc, 305 College Road East, Princeton, New Jersey 08540, USA
    Bioconjug Chem 20:1171-8. 2009
    ..These results demonstrate that the tumor uptake observed with (177)Lu-AMBA is due to parent drug and not due to any of its identified metabolites...
  8. doi 177Lu-AMBA biodistribution, radiotherapeutic efficacy, imaging, and autoradiography in prostate cancer models with low GRP-R expression
    Mary Ellen Maddalena
    Ernst Felder Laboratories, Bracco Research USA Inc, Princeton, New Jersey 08540 6608, USA
    J Nucl Med 50:2017-24. 2009
    ..We sought to evaluate the tumor binding and imaging potential of (177)Lu-AMBA in low GRP-R models of prostate cancer and determine how reduced expression affects (177)Lu-AMBA radiotherapy efficacy...
  9. doi Synthesis, stabilization and formulation of [177Lu]Lu-AMBA, a systemic radiotherapeutic agent for Gastrin Releasing Peptide receptor positive tumors
    Jianqing Chen
    Bracco Research USA Inc, 305 College Road East, Princeton, NJ 08540, USA
    Appl Radiat Isot 66:497-505. 2008
    ..The method of stabilization should be useful for other methionine-containing peptide radiopharmaceuticals in diagnostic and therapeutic applications...