Matteo Fumagalli

Summary

Affiliation: Bosisio Parini
Country: Italy

Publications

  1. pmc Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, 23842 Bosisio Parini, LC, Italy
    BMC Evol Biol 11:171. 2011
  2. pmc Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution
    Matteo Fumagalli
    Scientific Institute IRCCS E Medea, Bioinformatic Lab, Bosisio Parini, Italy
    PLoS Genet 7:e1002355. 2011
  3. doi Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes
    Matteo Fumagalli
    Bioinformatic Lab, Scientific Institute Istituto di Ricovero e Cura a Carattere Scientifico E Medea, Bosisio Parini, Lecco, Italy
    Mol Biol Evol 27:2555-66. 2010
  4. doi A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection
    Rachele Cagliani
    Scientific Institute IRCCS E Medea, via Don L Monza 20, Bosisio Parini LC, Italy
    Evolution 65:3311-22. 2011
  5. pmc A complex selection signature at the human AVPR1B gene
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Bosisio Parini, LC, Italy
    BMC Evol Biol 9:123. 2009
  6. pmc The signature of long-standing balancing selection at the human defensin beta-1 promoter
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Bosisio Parini LC, Italy
    Genome Biol 9:R143. 2008
  7. doi Polymorphisms in the CPB2 gene are maintained by balancing selection and result in haplotype-preferential splicing of exon 7
    Rachele Cagliani
    Bioinformatic Laboratory, Scientific Institute IRCCS E Medea, Bosisio Parini LC, Italy
    Mol Biol Evol 27:1945-54. 2010
  8. doi Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis
    Rachele Cagliani
    Bioinformatic Lab, Scientific Institute IRCCS E Medea, via Don L Monza 20, 23842, Bosisio Parini, LC, Italy
    Hum Genet 131:87-97. 2012
  9. pmc The landscape of human genes involved in the immune response to parasitic worms
    Matteo Fumagalli
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Via don L, Monza 20, 23842 Bosisio, Parini, LC, Italy
    BMC Evol Biol 10:264. 2010
  10. pmc Genome-wide identification of susceptibility alleles for viral infections through a population genetics approach
    Matteo Fumagalli
    Scientific Institute IRCCS E Medea, Bioinformatic Lab, Bosisio Parini LC, Italy
    PLoS Genet 6:e1000849. 2010

Detail Information

Publications21

  1. pmc Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, 23842 Bosisio Parini, LC, Italy
    BMC Evol Biol 11:171. 2011
    ..We aimed at testing the hypothesis whereby balancing selection has shaped the frequency of opposite risk alleles...
  2. pmc Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution
    Matteo Fumagalli
    Scientific Institute IRCCS E Medea, Bioinformatic Lab, Bosisio Parini, Italy
    PLoS Genet 7:e1002355. 2011
    ....
  3. doi Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes
    Matteo Fumagalli
    Bioinformatic Lab, Scientific Institute Istituto di Ricovero e Cura a Carattere Scientifico E Medea, Bosisio Parini, Lecco, Italy
    Mol Biol Evol 27:2555-66. 2010
    ....
  4. doi A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection
    Rachele Cagliani
    Scientific Institute IRCCS E Medea, via Don L Monza 20, Bosisio Parini LC, Italy
    Evolution 65:3311-22. 2011
    ..Our data represent an example of how the selective pressures exerted by extinct or unknown viral agents can be exploited to provide valuable information on the allelic determinants of susceptibility to modern infections...
  5. pmc A complex selection signature at the human AVPR1B gene
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Bosisio Parini, LC, Italy
    BMC Evol Biol 9:123. 2009
    ....
  6. pmc The signature of long-standing balancing selection at the human defensin beta-1 promoter
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Bosisio Parini LC, Italy
    Genome Biol 9:R143. 2008
    ....
  7. doi Polymorphisms in the CPB2 gene are maintained by balancing selection and result in haplotype-preferential splicing of exon 7
    Rachele Cagliani
    Bioinformatic Laboratory, Scientific Institute IRCCS E Medea, Bosisio Parini LC, Italy
    Mol Biol Evol 27:1945-54. 2010
    ..These data highlight the contribution of population genetics approaches to the analysis of functional genetic variation and may orient further biochemical and genetics studies on the pathophysiologic role of CPB2 gene products...
  8. doi Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis
    Rachele Cagliani
    Bioinformatic Lab, Scientific Institute IRCCS E Medea, via Don L Monza 20, 23842, Bosisio Parini, LC, Italy
    Hum Genet 131:87-97. 2012
    ....
  9. pmc The landscape of human genes involved in the immune response to parasitic worms
    Matteo Fumagalli
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Via don L, Monza 20, 23842 Bosisio, Parini, LC, Italy
    BMC Evol Biol 10:264. 2010
    ..The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight. Therefore, helminth infections can be regarded as a strong selective pressure...
  10. pmc Genome-wide identification of susceptibility alleles for viral infections through a population genetics approach
    Matteo Fumagalli
    Scientific Institute IRCCS E Medea, Bioinformatic Lab, Bosisio Parini LC, Italy
    PLoS Genet 6:e1000849. 2010
    ....
  11. doi Crohn's disease loci are common targets of protozoa-driven selection
    Rachele Cagliani
    Bioinformatics Laboratory, Scientific Institute IRCCS E Medea, Bosisio Parini, LC, Italy
    Mol Biol Evol 30:1077-87. 2013
    ..Thus, we show that protozoa-driven selective pressure had a major role in shaping predisposition to CD. We next used this information for the identification of three bona fide novel susceptibility loci...
  12. pmc Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions
    Matteo Fumagalli
    Scientific Institute IRCCS E Medea, Bioinformatic Laboratory, 23842 Bosisio Parini, Italy
    J Exp Med 206:1395-408. 2009
    ..These data support the hygiene hypothesis for IBD and provide a large set of putative targets for susceptibility to helminth infections...
  13. doi Genetic variability in the ACE gene region surrounding the Alu I/D polymorphism is maintained by balancing selection in human populations
    Rachele Cagliani
    Scientific Institute IRCCS E Medea, Bioinformatic Laboratory, Bosisio Parini LC, Italy
    Pharmacogenet Genomics 20:131-4. 2010
    ..The aim of our study was to verify whether the Alu insertion/deletion (Alu I/D) polymorphism or any linked variant has been maintained by natural selection in human populations...
  14. pmc Diverse evolutionary histories for beta-adrenoreceptor genes in humans
    Rachele Cagliani
    Bioinformatic Lab, Scientific Institute IRCCS E Medea, via Don L Monza 20, 23842 Bosisio Parini, LC, Italy
    Am J Hum Genet 85:64-75. 2009
    ..Given the previous association of the ancestral ADRB3 Arg64 allele with obesity and type 2 diabetes, dietary adaptations might represent the underlying selective force...
  15. doi Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection
    Rachele Cagliani
    Bioinformatic Laboratory, Scientific Institute IRCCS E Medea, via Don L Monza 20, Bosisio Parini LC, Italy
    Hum Mol Genet 19:4705-14. 2010
    ....
  16. pmc Widespread balancing selection and pathogen-driven selection at blood group antigen genes
    Matteo Fumagalli
    Scientific Institute IRCCS E Medea, Bioinformatic Lab, 23842 Bosisio Parini LC, Italy
    Genome Res 19:199-212. 2009
    ....
  17. doi Long-standing balancing selection in the THBS4 gene: influence on sex-specific brain expression and gray matter volumes in Alzheimer disease
    Rachele Cagliani
    Scientific Institute IRCCS E Medea, Bosisio Parini, Italy
    Hum Mutat 34:743-53. 2013
    ..The selection signature associated with THBS4 might not be related to AD pathogenesis, but rather to inflammatory responses...
  18. doi The role of protozoa-driven selection in shaping human genetic variability
    Uberto Pozzoli
    Scientific Institute IRCCS E Medea, Bioinformatic Laboratory, via Don L Monza 20, 23842 Bosisio Parini LC, Italy
    Trends Genet 26:95-9. 2010
    ..We provide a genome-wide estimate of protozoa-driven selective pressure and identify candidate susceptibility genes for protozoa-borne diseases...
  19. doi Variants in SNAP25 are targets of natural selection and influence verbal performances in women
    Rachele Cagliani
    Bioinformatic Lab, Scientific Institute IRCCS E Medea, via Don L Monza 20, Bosisio Parini, LC, Italy
    Cell Mol Life Sci 69:1705-15. 2012
    ..Although caution should be used in inferring selective pressures from observed signatures, SNAP25 might represent the first description of an adaptively evolving gene with a role in cognition...
  20. doi An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases
    Manuela Sironi
    Bioinformatics Laboratory, Scientific Institute IRCCS E Medea, Bosisio Parini LC, Italy
    Mol Biol Evol 28:3319-29. 2011
    ..Other genes with a role in RICD have previously been associated with autoimmunity in humans, suggesting that this pathway and RAC2 may represent novel therapeutic targets in autoimmune disorders...
  21. pmc Both selective and neutral processes drive GC content evolution in the human genome
    Uberto Pozzoli
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Via don L, Monza 20, 23842 Bosisio Parini LC, Italy
    BMC Evol Biol 8:99. 2008
    ..Mammalian genomes consist of regions differing in GC content, referred to as isochores or GC-content domains. The scientific debate is still open as to whether such compositional heterogeneity is a selected or neutral trait...