M C Bosco

Summary

Country: Italy

Publications

  1. ncbi request reprint The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages
    M C Bosco
    Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
    J Immunol 164:3283-91. 2000
  2. ncbi request reprint Engineering of macrophages to produce IFN-gamma in response to hypoxia
    L Carta
    Laboratory of Molecular Biology, G. Gaslini Institute, Genoa, Italy
    J Immunol 166:5374-80. 2001
  3. ncbi request reprint Generation of high-titer retroviral vector-producing macrophages as vehicles for in vivo gene transfer
    S Pastorino
    Laboratory of Molecular Biology, G Gaslini Institute, Largo G Gaslini 5, 16147, Genova, Italy
    Gene Ther 8:431-41. 2001
  4. ncbi request reprint Picolinic acid- or desferrioxamine-inducible autocrine activation of macrophages engineered to produce IFNgamma: an approach for gene therapy
    S Pastorino
    Laboratory of Molecular Biology, G Gaslini Institute, Largo Gaslini, Genova, Italy
    Gene Ther 11:560-8. 2004

Collaborators

  • S Pastorino
  • L Carta
  • L Varesio
  • G Melillo
  • S Massazza
  • M Puppo
  • M Cilli

Detail Information

Publications4

  1. ncbi request reprint The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages
    M C Bosco
    Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
    J Immunol 164:3283-91. 2000
    ..These results establish the importance of PA as an activator of macrophage proinflammatory functions, providing the first evidence that this molecule can be biologically active without the need for a costimulatory agent...
  2. ncbi request reprint Engineering of macrophages to produce IFN-gamma in response to hypoxia
    L Carta
    Laboratory of Molecular Biology, G. Gaslini Institute, Genoa, Italy
    J Immunol 166:5374-80. 2001
    ....
  3. ncbi request reprint Generation of high-titer retroviral vector-producing macrophages as vehicles for in vivo gene transfer
    S Pastorino
    Laboratory of Molecular Biology, G Gaslini Institute, Largo G Gaslini 5, 16147, Genova, Italy
    Gene Ther 8:431-41. 2001
    ..v. injection into mice. These data demonstrate that Mphi can be engineered as cellular vehicles for recombinant retroviruses carrying heterologous genes and suggest potential applications of this novel vector system for gene therapy...
  4. ncbi request reprint Picolinic acid- or desferrioxamine-inducible autocrine activation of macrophages engineered to produce IFNgamma: an approach for gene therapy
    S Pastorino
    Laboratory of Molecular Biology, G Gaslini Institute, Largo Gaslini, Genova, Italy
    Gene Ther 11:560-8. 2004
    ..Furthermore, we demonstrate that extracellular iron can downregulate such response, thereby identifying an additional tool for the fine tuning of the Mphi vector response to stimulation...