M C Bosco
- The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophagesM C Bosco
Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
J Immunol 164:3283-91. 2000..These results establish the importance of PA as an activator of macrophage proinflammatory functions, providing the first evidence that this molecule can be biologically active without the need for a costimulatory agent...
- Engineering of macrophages to produce IFN-gamma in response to hypoxiaL Carta
Laboratory of Molecular Biology, G. Gaslini Institute, Genoa, Italy
J Immunol 166:5374-80. 2001....
- Generation of high-titer retroviral vector-producing macrophages as vehicles for in vivo gene transferS Pastorino
Laboratory of Molecular Biology, G Gaslini Institute, Largo G Gaslini 5, 16147, Genova, Italy
Gene Ther 8:431-41. 2001..v. injection into mice. These data demonstrate that Mphi can be engineered as cellular vehicles for recombinant retroviruses carrying heterologous genes and suggest potential applications of this novel vector system for gene therapy...
- Picolinic acid- or desferrioxamine-inducible autocrine activation of macrophages engineered to produce IFNgamma: an approach for gene therapyS Pastorino
Laboratory of Molecular Biology, G Gaslini Institute, Largo Gaslini, Genova, Italy
Gene Ther 11:560-8. 2004..Furthermore, we demonstrate that extracellular iron can downregulate such response, thereby identifying an additional tool for the fine tuning of the Mphi vector response to stimulation...