Barbara Borroni

Summary

Country: Italy

Publications

  1. ncbi request reprint ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model
    Barbara Borroni
    Department of Neurology, University of Brescia, Piazzale Spediale Civili 1, 25123 Brescia, Italy
    Eur Neuropsychopharmacol 12:195-200. 2002
  2. ncbi request reprint Primitive reflex evaluation in the clinical assessment of extrapyramidal syndromes
    B Borroni
    Department of Neurological Sciences, University of Brescia, Brescia, Italy
    Eur J Neurol 13:1026-8. 2006
  3. ncbi request reprint APOE genotype and cholesterol levels in lewy body dementia and Alzheimer disease: investigating genotype-phenotype effect on disease risk
    Barbara Borroni
    Centre for Ageing Brain and Dementia, Department of Neurology, the III Laboratory of Biotechnology and Department of Biochemistry, University of Brescia, Brescia, Italy
    Am J Geriatr Psychiatry 14:1022-31. 2006
  4. ncbi request reprint Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura
    Barbara Borroni
    Department of Medical Sciences, Neurological Clinic, University of Brescia, Brescia, Italy
    Headache 46:1575-9. 2006
  5. ncbi request reprint Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia
    Barbara Borroni
    Department of Medical Sciences, Center for Brain Aging and Neurodegenerative Disorders, University of Brescia, Piazza Spedali Civili 1, 25100 Brescia, Italy
    Arch Neurol 64:246-51. 2007
  6. pmc Clinical, biological, and imaging features of monogenic Alzheimer's Disease
    Andrea Pilotto
    Clinica Neurologica, Universita degli Studi di Brescia, Pza Spedali Civili, 1 25100 Brescia, Italy
    Biomed Res Int 2013:689591. 2013
  7. doi request reprint Heterozygous TREM2 mutations in frontotemporal dementia
    Barbara Borroni
    Center of Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy Electronic address
    Neurobiol Aging 35:934.e7-10. 2014
  8. ncbi request reprint The brain in late-onset glycogenosis II: a structural and functional MRI study
    Barbara Borroni
    Neurology Unit, University of Brescia, Piazza Spedali Civili 1, 25125, Brescia, Italy
    J Inherit Metab Dis 36:989-95. 2013
  9. pmc Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease
    Monica Di Luca
    Centre of Excellence for Neurodegenerative Disorders, Department of Pharmacological Sciences, University of Milan, Italy
    J Transl Med 3:30. 2005
  10. ncbi request reprint Reserve mechanisms in neurodegenerative diseases: from bench to bedside and back again
    B Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Italy
    Curr Med Chem 19:6112-8. 2012

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model
    Barbara Borroni
    Department of Neurology, University of Brescia, Piazzale Spediale Civili 1, 25123 Brescia, Italy
    Eur Neuropsychopharmacol 12:195-200. 2002
    ..0001). The present study provides evidence that donepezil influences APP metabolism in platelets, and suggests that ApoE genotype might be an important modulating factor for drug responsiveness in AD...
  2. ncbi request reprint Primitive reflex evaluation in the clinical assessment of extrapyramidal syndromes
    B Borroni
    Department of Neurological Sciences, University of Brescia, Brescia, Italy
    Eur J Neurol 13:1026-8. 2006
    ..7 (95% CI 3.7-104.3) compared with PD. These data suggest that the occurrence of combination of PRs might be an useful additional warning sign of possible diffuse Lewy body pathology more than other causes of extrapyramidal syndrome...
  3. ncbi request reprint APOE genotype and cholesterol levels in lewy body dementia and Alzheimer disease: investigating genotype-phenotype effect on disease risk
    Barbara Borroni
    Centre for Ageing Brain and Dementia, Department of Neurology, the III Laboratory of Biotechnology and Department of Biochemistry, University of Brescia, Brescia, Italy
    Am J Geriatr Psychiatry 14:1022-31. 2006
    ..APOE is the most recognized genetic risk factor for sporadic late-onset Alzheimer disease (AD). The role of APOE genotype in Lewy body dementia (LBD) is still unknown as well as the relationship between APOE genotype and cholesterol levels...
  4. ncbi request reprint Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura
    Barbara Borroni
    Department of Medical Sciences, Neurological Clinic, University of Brescia, Brescia, Italy
    Headache 46:1575-9. 2006
    ..The aim of the present study was to evaluate whether the functional endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism, which has been demonstrated to decrease the endothelial NOS activity, might be a risk factor for migraine...
  5. ncbi request reprint Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia
    Barbara Borroni
    Department of Medical Sciences, Center for Brain Aging and Neurodegenerative Disorders, University of Brescia, Piazza Spedali Civili 1, 25100 Brescia, Italy
    Arch Neurol 64:246-51. 2007
    ..Two major clinical variants of frontotemporal dementia (FTD) have been described: frontal variant (fvFTD) and temporal variant (tvFTD)...
  6. pmc Clinical, biological, and imaging features of monogenic Alzheimer's Disease
    Andrea Pilotto
    Clinica Neurologica, Universita degli Studi di Brescia, Pza Spedali Civili, 1 25100 Brescia, Italy
    Biomed Res Int 2013:689591. 2013
    ..This review will focus on the clinical and instrumental markers useful for the very early identification of AD monogenic cases, pivotal in the development, and evaluation of disease-modifying therapy. ..
  7. doi request reprint Heterozygous TREM2 mutations in frontotemporal dementia
    Barbara Borroni
    Center of Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy Electronic address
    Neurobiol Aging 35:934.e7-10. 2014
    ..Additional studies are warranted to investigate the possible role of these mutations in the pathogenesis of neurodegenerative disorders...
  8. ncbi request reprint The brain in late-onset glycogenosis II: a structural and functional MRI study
    Barbara Borroni
    Neurology Unit, University of Brescia, Piazza Spedali Civili 1, 25125, Brescia, Italy
    J Inherit Metab Dis 36:989-95. 2013
    ..Despite evidence at autopsy of glycogen accumulation in the brain, no study exploring brain functions is yet available...
  9. pmc Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease
    Monica Di Luca
    Centre of Excellence for Neurodegenerative Disorders, Department of Pharmacological Sciences, University of Milan, Italy
    J Transl Med 3:30. 2005
    ....
  10. ncbi request reprint Reserve mechanisms in neurodegenerative diseases: from bench to bedside and back again
    B Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Italy
    Curr Med Chem 19:6112-8. 2012
    ....
  11. doi request reprint Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD
    Barbara Borroni
    Centre for Aging Brain and Neurodegenerative Disorder, Neurology Unit, University of Brescia, Brescia, Italy
    Neurobiol Aging 33:2506-20. 2012
    ..Our findings suggest that compensatory mechanisms of brain plasticity are present in GRN-related FTLD, but with different patterns at a preclinical and symptomatic disease stage...
  12. doi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced hippocampus perfusion in frontotemporal lobar degeneration
    Barbara Borroni
    The Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy
    J Alzheimers Dis 31:243-51. 2012
    ..BDNF Val66Met polymorphism may play a role as a modulator of the FTLD expression and may drive a selective damage in specific brain region affected by the disease...
  13. doi request reprint Neuroanatomical correlates of behavioural phenotypes in behavioural variant of frontotemporal dementia
    B Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    Behav Brain Res 235:124-9. 2012
    ..Targeting behavioural phenotypes instead of single behavioural symptoms may potentially provide a disease model in which to investigate brain substrates of behavioural abnormalities...
  14. doi request reprint Prevalence and demographic features of early-onset neurodegenerative dementia in Brescia County, Italy
    Barbara Borroni
    Department of Neurology, University of Brescia, Italy
    Alzheimer Dis Assoc Disord 25:341-4. 2011
    ..The improvement of knowledge on early-onset neurodegenerative dementias allows us to reconsider its epidemiology and to rethink its impact on public polices. This would be crucial for defining the urgency of treatment approaches...
  15. doi request reprint Is long-term prognosis of frontotemporal lobar degeneration predictable by neuroimaging? Evidence from a single-subject functional brain study
    Barbara Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    J Alzheimers Dis 29:883-90. 2012
    ..We suggest that SPECT imaging, beyond a helpful tool in diagnostic assessment, may be an easily and accessible marker of disease outcome in FTLD. Further studies considering structural neuroimaging are warranted...
  16. doi request reprint Atypical presentation of a novel Presenilin 1 R377W mutation: sporadic, late-onset Alzheimer disease with epilepsy and frontotemporal atrophy
    Barbara Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Piazza Spedali Civili 1, 25125 Brescia, Italy
    Neurol Sci 33:375-8. 2012
    ..The case herein reported further confirms the heterogeneity of PSEN1 mutations and the need to take into account genetic screening in those cases with atypical presentation...
  17. ncbi request reprint Disease-modifying therapies in frontotemporal lobar degeneration
    B Bigni
    Department of Medicinal Chemistry, Ljubljana, Slovenia
    Curr Med Chem 19:1008-20. 2012
    ..In this continuously new findings on molecular targets and modifying therapies in FTLD...
  18. pmc Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroinflammation 8:65. 2011
    ..Thus, our findings point to IL-6 as a possible specific mediator and a potential therapeutic target in this monogenic disease, suggesting that an enhanced inflammatory response might be indeed involved in its progression...
  19. doi request reprint Founder effect and estimation of the age of the Progranulin Thr272fs mutation in 14 Italian pedigrees with frontotemporal lobar degeneration
    Barbara Borroni
    The Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy
    Neurobiol Aging 32:555.e1-8. 2011
    ....
  20. doi request reprint Understanding the underpinnings of the frontotemporal lobar degeneration: evidence for benign and malignant forms
    Barbara Borroni
    Centre for Aging Brain and Neurology Disorders, Neurology, University of Brescia, Italy
    Am J Geriatr Psychiatry 18:830-8. 2010
    ..Establishing whether FTLD represents a continuum or recognizes distinct subgroups may be crucial for diagnostic purposes and therapeutic approaches...
  21. ncbi request reprint Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease
    B Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Italy
    Neurobiol Aging 28:1231-8. 2007
    ....
  22. doi request reprint Cerebrospinal fluid tau in frontotemporal lobar degeneration: clinical, neuroimaging, and prognostic correlates
    Barbara Borroni
    The Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy
    J Alzheimers Dis 23:505-12. 2011
    ..Further studies aimed at defining the biological underpinnings of these findings are warranted...
  23. pmc Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration
    Barbara Borroni
    Centre for Aging Brain and Neurodegenerative Disorders, Department of Neurology, University of Brescia, Italy
    BMC Neurol 6:31. 2006
    ..The aim of this study was to determine whether ApoE genotype might play a key-role in influencing the cerebral functional pattern as well as the degree of memory deficits in FTLD patients...
  24. pmc Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates
    Barbara Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    BMC Neurol 7:9. 2007
    ..The aim of this study was to identify clinical FTLD presentation, based on cognitive and behavioural profile, and to define their SPECT functional correlations...
  25. ncbi request reprint VEGF haplotypes are associated with increased risk to progressive supranuclear palsy and corticobasal syndrome
    Barbara Borroni
    Department of Neurology, University of Brescia, Centre for Aging Brain and Neurodegenerative Disorders, Brescia, Italy
    J Alzheimers Dis 21:87-94. 2010
    ..These data argue that additional genes may confer disease risk to PSP and CBS, and to FTD as well, beyond the MAPT tau haplotype. Further studies are warranted...
  26. doi request reprint TARDBP mutations in frontotemporal lobar degeneration: frequency, clinical features, and disease course
    B Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, University of Brescia, Brescia, Italy
    Rejuvenation Res 13:509-17. 2010
    ..This work further supports the need for TARDBP screening in FTLD. Also intronic splicing that affects mutations should be considered as well...
  27. doi request reprint A combination of CSF tau ratio and midsaggital midbrain-to-pons atrophy for the early diagnosis of progressive supranuclear palsy
    Barbara Borroni
    The Centre for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    J Alzheimers Dis 22:195-203. 2010
    ..001). The combined marker increases the discriminative power in identifying PSP and suggests that the interplay of different markers should be considered in future trials to enhance diagnostic accuracy from the early stages...
  28. ncbi request reprint New insights into biological markers of frontotemporal lobar degeneration spectrum
    Barbara Borroni
    Department of Neurology and Centre for Ageing Brain and Neurodegenerative Disorders, University of Brescia, Italy
    Curr Med Chem 17:1002-9. 2010
    ..In this review, we summarise the most recent findings on biological markers and their usefulness in clinical practice for the diagnosis and management of FTLD...
  29. doi request reprint Is frontotemporal lobar degeneration a rare disorder? Evidence from a preliminary study in Brescia county, Italy
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    J Alzheimers Dis 19:111-6. 2010
    ..FTLD is a more common form of dementia than previously recognized. Our results claimed that FTLD is not only an early-onset disorder, but it is frequent in advanced age as well...
  30. doi request reprint Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers
    B Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Rejuvenation Res 11:585-95. 2008
    ..Alteration of fiber tracts within the perisylvian language network might represent the early hallmark of subsequent aphasia onset. The study of other pedigrees of asymptomatic PGRN mutation carriers is warranted...
  31. doi request reprint Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease
    B Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, University of Brescia, Brescia, Italy
    Hum Mutat 30:E974-83. 2009
    ..Our study suggests that TARDBP mutations can be pathogenetic of bvFTD without motor neuron disease. TARDBP screening needs to be considered in FTD cases...
  32. ncbi request reprint Is early-onset clinically different from late-onset frontotemporal dementia?
    B Borroni
    Department of Neurology, University of Brescia, Center for Aging Brain and Dementia, Brescia, Italy
    Eur J Neurol 15:1412-5. 2008
    ..Aim of the study was to evaluate whether age at disease onset modulate the heterogeneity of either cognitive impairment or behavioural disturbances in patients affected by bvFTD...
  33. doi request reprint Establishing short-term prognosis in Frontotemporal Lobar Degeneration spectrum: role of genetic background and clinical phenotype
    Barbara Borroni
    Centre for Aging Brain and Dementia, Department of Neurology, University of Brescia, 1 25100 Brescia, Italy
    Neurobiol Aging 31:270-9. 2010
    ..No reliable neuropsychological assessment balancing all FTLD aspects is available yet, thus no clear-cut follow-up study has been performed...
  34. doi request reprint BDNF genetic variations increase the risk of Alzheimer's disease-related depression
    Barbara Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, 1 25100 Brescia, Italy
    J Alzheimers Dis 18:867-75. 2009
    ..44-8.76, P = 0.006) and C-C-A-C haplotypes (OR = 1.72, 95% CI = 1.03-2.87, P = 0.037) were overrepresented in AD-D. This study suggests that BDNF genetic variations play a role in the susceptibility to AD-related depression...
  35. doi request reprint Progranulin genetic variations in frontotemporal lobar degeneration: evidence for low mutation frequency in an Italian clinical series
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Neurogenetics 9:197-205. 2008
    ..In conclusion, this study supports a lower frequency of PGRN mutations amongst FTLD patients in Italy compared to literature data and further underlies the genetic heterogeneity of FTLD...
  36. doi request reprint Revisiting brain reserve hypothesis in frontotemporal dementia: evidence from a brain perfusion study
    B Borroni
    Centre for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    Dement Geriatr Cogn Disord 28:130-5. 2009
    ..Literature data on Alzheimer's disease suggest that years of schooling and occupational level are associated with a reserve mechanism. No data on patients with behavioral variant frontotemporal dementia (bvFTD) are available yet...
  37. doi request reprint Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression
    B Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Italy
    Neurobiol Aging 30:1406-12. 2009
    ..No study has investigated the role of BDNF genetic variation and depressive symptoms in Alzheimer's disease (AD)...
  38. doi request reprint Tau haplotype influences cerebral perfusion pattern in frontotemporal lobar degeneration and related disorders
    B Borroni
    Department of Neurological Sciences, University of Brescia, Brescia, Italy
    Acta Neurol Scand 117:359-66. 2008
    ..The aim of this study was to determine whether tau genetic variability modulates the brain functional and the clinical phenotypic expression of FTLD...
  39. doi request reprint Education plays a different role in Frontotemporal Dementia and Alzheimer's disease
    Barbara Borroni
    Department of Neurology, University of Brescia, Italy
    Int J Geriatr Psychiatry 23:796-800. 2008
    ..In particular, low education levels have been reported to be a risk factor for AD, but their contribution in FTD is yet not known...
  40. doi request reprint Blood cell markers in Alzheimer Disease: Amyloid Precursor Protein form ratio in platelets
    Barbara Borroni
    Centre for Brain Aging and Neurodegenerative Disorders, Department of Neurology, University of Brescia, Italy
    Exp Gerontol 45:53-6. 2010
    ..Approaches combining APP form ratio along with neuroimaging markers show the promise to accurately identify AD, even in the pre-symptomatic stage...
  41. ncbi request reprint Genetic susceptibility to behavioural and psychological symptoms in Alzheimer disease
    Barbara Borroni
    Centre for Brain Aging and Neurodegenerative Disorders, Department of Neurology, University of Brescia, Italy
    Curr Alzheimer Res 7:158-64. 2010
    ..In the present review, we summarise the current literature on genetic risk factors to BPSD susceptibility in AD and discuss future possible treatment strategies...
  42. doi request reprint Behavioral dimensions and acetylcholinesterase inhibitor-related effect in Alzheimer disease over time: a latent trajectory modeling
    Barbara Borroni
    Department of Neurology, Center for Aging Brain and Dementia, University of Brescia, Italy
    Cogn Behav Neurol 22:222-8. 2009
    ..To evaluate whether treatment with acetylcholinesterase inhibitors (AChEIs) exerts a favorable effect on the behavioral dimensions in Alzheimer disease (AD) over time...
  43. ncbi request reprint Cognitive and behavioral assessment in the early stages of neurodegenerative extrapyramidal syndromes
    B Borroni
    Neurology Unit, Department of Medical Sciences, University of Brescia, Piazza Spedali Civili 1, I 25125 Brescia, Italy
    Arch Gerontol Geriatr 47:53-61. 2008
    ..The observation of overlapping clinical entities points the attention on the need of adjunctive diagnostic markers for early differential diagnosis...
  44. doi request reprint Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy
    Barbara Borroni
    Department of Neurology, University of Brescia, Italy
    Int Psychogeriatr 21:463-8. 2009
    ..The study aimed to evaluate the frequency and pattern of presentation of behavioral disturbances in a large sample of CBDS and PSP patients by FBI...
  45. ncbi request reprint Predicting Alzheimer dementia in mild cognitive impairment patients. Are biomarkers useful?
    Barbara Borroni
    Department of Medical Sciences, University of Brescia, Italy
    Eur J Pharmacol 545:73-80. 2006
    ..More work is needed but available novel perspectives offered by recent introduced technologies shed some lights in identifying incipient Alzheimer disease in mild cognitive impairment subjects...
  46. doi request reprint CSF Alzheimer's disease-like pattern in corticobasal syndrome: evidence for a distinct disorder
    Barbara Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy
    J Neurol Neurosurg Psychiatry 82:834-8. 2011
    ..The neuropathology of CBS is still unpredictable. CSF tau/abeta ratio is a reliable marker of AD...
  47. ncbi request reprint The FTLD-modified Clinical Dementia Rating scale is a reliable tool for defining disease severity in frontotemporal lobar degeneration: evidence from a brain SPECT study
    B Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    Eur J Neurol 17:703-7. 2010
    ..Reliable scales of global impairment are under evaluation. A consortium of Mayo Clinic and University of California FTLD Centers has recently developed the FTLD-modified Clinical Dementia Rating (CDR) scale to assess FTLD severity...
  48. ncbi request reprint Predicting cognitive decline in Alzheimer disease. Role of platelet amyloid precursor protein
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Alzheimer Dis Assoc Disord 18:32-4. 2004
    ..Lower APPr at baseline was the only predictor of progressive cognitive decline, suggesting that this biomarker might be a useful indicator of prognosis for patients with AD...
  49. doi request reprint Survival in frontotemporal lobar degeneration and related disorders: latent class predictors and brain functional correlates
    B Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    Rejuvenation Res 12:33-44. 2009
    ....
  50. ncbi request reprint Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
    Barbara Borroni
    Clinica Neurologica, Universita degli Studi di Brescia, Pza Spedali Civili, 1, 25100 Brescia, Italy
    J Neurol 252:1359-62. 2005
    ..87, and the negative predictive value was 0.90. This observation suggests that the interplay of different markers should be considered for enhancing diagnostic accuracy of pre-clinical AD...
  51. ncbi request reprint Genetic correlates of behavioral endophenotypes in Alzheimer disease: role of COMT, 5-HTTLPR and APOE polymorphisms
    B Borroni
    Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Italy
    Neurobiol Aging 27:1595-603. 2006
    ....
  52. ncbi request reprint Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD
    B Borroni
    Department of Neurological Sciences, Neurologic Clinic, University of Brescia, P za Spedali Civili 1, 25100 Brescia, Italy
    Neurobiol Aging 27:24-31. 2006
    ..8%. The pattern of hypoperfusion 99mTc-ECD SPECT and the severity of memory deficits predict the risk of progression to probable AD dementia in MCI subjects...
  53. ncbi request reprint Genetic contributors to frontotemporal lobar degeneration: beyond monogenic disease
    B Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, University of Brescia, Italy
    Mini Rev Med Chem 11:988-1001. 2011
    ..The aim of the present review is to discuss the impact and the role of genetic background in non-monogenic forms of FTLD, to highlight new potential pathogenetic and therapeutic targets...
  54. pmc Functional serotonin 5-HTTLPR polymorphism is a risk factor for migraine with aura
    Barbara Borroni
    Department of Neurology, University of Brescia, Piazza Spedali Civili 1, I 25100 Brescia, Italy
    J Headache Pain 6:182-4. 2005
    ..42-3.21) compared to MO. These data provide a further insight on the complex genotype-phenotype relationship involved in MA pathogenesis, and might eventually result in new and individualised prognostic and therapeutic measures...
  55. ncbi request reprint Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer Disease
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Neurosci Lett 370:127-9. 2004
    ..These findings suggest that COMT polymorphism influences on the risk of psychosis since the early stages, and claims for the possibility to identify distinct phenotypes on genetic basis among AD patients...
  56. ncbi request reprint Cumulative effect of COMT and 5-HTTLPR polymorphisms and their interaction with disease severity and comorbidities on the risk of psychosis in Alzheimer disease
    Barbara Borroni
    Centre for Ageing Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy
    Am J Geriatr Psychiatry 14:343-51. 2006
    ..The objective of this study was to investigate the cumulative effect of the genes likely involved in Alzheimer disease (AD)-related psychosis and their interaction with disease stage and environmental factors...
  57. ncbi request reprint Genetic bases of Progressive Supranuclear Palsy: the MAPT tau disease
    Barbara Borroni
    Centre for Ageing Brain and Neurodegenerative Disorders, Department of Neurology, University of Brescia, Brescia, Italy
    Curr Med Chem 18:2655-60. 2011
    ..Conversely, no major environmental risk factors have been reported so far. A proper evaluation of known susceptibility factors related to PSP pathogenesis may help in defining neuroprotective therapeutic approaches...
  58. ncbi request reprint Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators
    Barbara Borroni
    Neurologic Clinic, University of Brescia, Spedali Civili de Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy
    Neurobiol Aging 25:747-51. 2004
    ..02). These findings provide direct evidence that CYP46 and ApoE polymorphisms synergically increase the risk for AD development, and influence on the rate of cognitive decline...
  59. doi request reprint Beyond cognitive reserve: behavioural reserve hypothesis in Frontotemporal Dementia
    Enrico Premi
    Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Italy
    Behav Brain Res 245:58-62. 2013
    ..In FTD, distinct behavioural phenotypes may be identified...
  60. pmc Cognitive reserve in granulin-related frontotemporal dementia: from preclinical to clinical stages
    Enrico Premi
    Centre for Neurodegenerative Disorders, University of Brescia, Brescia, Italy
    PLoS ONE 8:e74762. 2013
    ..We tested here the cognitive reserve hypothesis in patients with frontotemporal dementia (FTD), with or without pathogenetic granulin mutations (GRN+ and GRN-), and in presymptomatic GRN mutation carriers (aGRN+)...
  61. ncbi request reprint High cholesterol affects platelet APP processing in controls and in AD patients
    Barbara Borroni
    Department of Neurology, Clinica Neurologica, c o Spedali Civili di Brescia, University of Brescia, Brescia, Italy
    Neurobiol Aging 24:631-6. 2003
    ..These findings confirm the association between cholesterol and AD, and suggest that in vivo cholesterol affects APP processing by interfering with its maturation...
  62. ncbi request reprint Serum cholesterol levels modulate long-term efficacy of cholinesterase inhibitors in Alzheimer disease
    Barbara Borroni
    Department of Medical Sciences, Neurological Clinic, University of Brescia, P za Spedali Civili, 1, 25100 Brescia, Italy
    Neurosci Lett 343:213-5. 2003
    ....
  63. ncbi request reprint Overlap between frontotemporal dementia and Alzheimer's disease: cerebrospinal fluid pattern and neuroimaging study
    Alessandro Padovani
    Centre for Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy
    J Alzheimers Dis 36:49-55. 2013
    ..Objective: To evaluate the presence of a CSF AD-like pattern in patients with FTD, and the related brain changes, to assess whether these patients had features resembling an AD pattern of hypoperfusion...
  64. doi request reprint Prevalence of frontotemporal lobar degeneration in an isolated population: the Vallecamonica study
    Nicola Gilberti
    Department of Neurology, University of Brescia, Brescia, Italy
    Neurol Sci 33:899-904. 2012
    ..A founder effect or a genetic drift might be considered for an allelic enrichment. Ongoing study aims to identify the presence of a new genetic form in those FTLD patients without known pathogenetic mutations in this isolated population...
  65. ncbi request reprint Universal grammar in the frontotemporal dementia spectrum: evidence of a selective disorder in the corticobasal degeneration syndrome
    Maria Cotelli
    IRCCS, S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neuropsychologia 45:3015-23. 2007
    ..In order to assess the status of syntactic knowledge in a group of patients belonging to the FTD spectrum, we investigated their ability to detect violations of Universal Grammar principles in a sentence judgement task...
  66. ncbi request reprint Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients
    Barbara Borroni
    Department of Medical Sciences, Neurological Clinic, University of Brescia, Italy
    J Neurol Sci 229:211-3. 2005
    ..05) and sE-sel (p<0.05) values towards the normal range was observed. These findings suggest that endothelial-related ChEIs action might contribute to the clinical efficacy in AD, slowing down pathology progression...
  67. ncbi request reprint Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease
    Alessandro Padovani
    Department of Neurology, University of Brescia, Piazza Ospedale 1, 25125, Brescia, Italy
    Arch Neurol 59:71-5. 2002
    ..Patients affected by sporadic Alzheimer disease (AD) show a significant alteration of amyloid precursor protein (APP) forms in platelets when compared with patients with dementia but without AD and age-matched controls...
  68. ncbi request reprint White matter changes in corticobasal degeneration syndrome and correlation with limb apraxia
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Arch Neurol 65:796-801. 2008
    ..The structural abnormalities related to a key feature of CBDS (limb apraxia) are unknown...
  69. ncbi request reprint Extrapyramidal symptoms in Frontotemporal Dementia: prevalence and clinical correlations
    Alessandro Padovani
    Department of Neurological Sciences, University of Brescia, Brescia, Italy
    Neurosci Lett 422:39-42. 2007
    ..Careful description of the spectrum of presentation of FTD may be of help for further understanding the underpinnings of the disease...
  70. ncbi request reprint Combined biomarkers for early Alzheimer disease diagnosis
    Barbara Borroni
    Department of Neurology, and Centre for Ageing Brain and Neurodegenerative Disorders, University of Brescia, Italy
    Curr Med Chem 14:1171-8. 2007
    ..In this review, we summarise the most recent findings on combined biomarkers and their usefulness in clinical practice for the early and preclinical diagnosis of AD...
  71. ncbi request reprint Increased prevalence of silent myocardial ischaemia and severe ventricular arrhythmias in untreated patients with Alzheimer's disease and mild cognitive impairment without overt coronary artery disease
    Roberto Zulli
    Institute of Internal Medicine, Department of Medical Sciences, University of Brescia, Brescia, Italy
    Clin Neurol Neurosurg 110:791-6. 2008
    ....
  72. ncbi request reprint Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Arch Neurol 60:1740-4. 2003
    ..Alteration of the amyloid precursor protein (APP) forms ratio has been described in the platelets of patients with dementia of Alzheimer type (DAT) and in a subset of subjects with mild cognitive impairment (MCI)...
  73. ncbi request reprint Investigating the association between Notch3 polymorphism and migraine
    Barbara Borroni
    Neurologic Clinic, Department of Neurology, University of Brescia, Italy
    Headache 46:317-21. 2006
    ....
  74. ncbi request reprint Is mild vascular cognitive impairment reversible? Evidence from a study on the effect of carotid endarterectomy
    Barbara Borroni
    Department of Medical Sciences, Neurological Clinic, University of Brescia, Italy
    Neurol Res 26:594-7. 2004
    ..These findings support that mVCI represents a heterogeneous, in some cases reversible condition. CEA might be considered a therapeutic option to treat and prevent cognitive decline in mVCI patients...
  75. doi request reprint The speech and language FOXP2 gene modulates the phenotype of frontotemporal lobar degeneration
    Alessandro Padovani
    Centre for Brain Aging and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Italy
    J Alzheimers Dis 22:923-31. 2010
    ..005). Genetic variations within FOXP2 do not represent a genetic risk to FTLD per se, but modulate FTLD presentation when disease is overt, affecting language performances and leading to hypoperfusion in language-associated brain areas...
  76. ncbi request reprint Microvascular damage and platelet abnormalities in early Alzheimer's disease
    Barbara Borroni
    Clinica Neurologica, Spedali Civili di Brescia, Universita degli Studi di Brescia, Piazza Ospedale 1, Brescia 25125, Italy
    J Neurol Sci 203:189-93. 2002
    ..These findings strongly indicate that platelet dysfunction and microvasculature deficiencies occur rather early during the course of AD, thus suggesting a further link between AD-related processes and vascular disorders...
  77. ncbi request reprint Advances on biological markers in early diagnosis of Alzheimer disease
    Alessandro Padovani
    Department of Neurological Sciences, University of Brescia, 25100 Brescia, Italy
    Adv Clin Chem 39:107-29. 2005
  78. doi request reprint The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is not significantly correlated to Transient Global Amnesia: preliminary results of an on-going study in Brescia Province, Italy
    C Agosti
    Department of Neurology, University of Brescia, Italy
    Neurosci Lett 443:228-31. 2008
    ..This study, that firstly looked at genetic background in TGA, did not show a significant correlation between the BDNF Val66Met polymorphism and age of onset, risk factors, duration or recurrence of TGA...
  79. ncbi request reprint Is transient global amnesia a risk factor for amnestic mild cognitive impairment?
    Barbara Borroni
    Dipto Scienze Mediche e Chirurgiche, Clinica Neurologica Università degli Studi di Brescia, Piazza Spedali Civili 1, 25100, Brescia, Italy
    J Neurol 251:1125-7. 2004
    ....
  80. ncbi request reprint QT dispersion and heart rate variability abnormalities in Alzheimer's disease and in mild cognitive impairment
    Roberto Zulli
    Institute of Internal Medicine, Department of Medical Sciences, University of Brescia, Brescia, Italy
    J Am Geriatr Soc 53:2135-9. 2005
    ..To investigate the effect of cardiovascular changes (i.e., QT interval, QT dispersion (QTD), heart rate variability (HRV), and other cardiovascular measures) in subjects with Alzheimer's disease (AD) and mild cognitive impairment (MCI)...
  81. doi request reprint Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy
    B Borroni
    Centre for Aging Brain and Dementia, Department of Neurology, University of Brescia, Italy
    Neurology 71:1796-803. 2008
    ....
  82. ncbi request reprint Right hemisphere involvement in non-fluent primary progressive aphasia
    Claudia Repetto
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Behav Neurol 18:239-43. 2007
    ..This unexpected finding shows that NfPPA may arise not only from cortical abnormalities in the language-dominant left hemisphere, but also from right hemisphere involvement in a right hander (crossed aphasia)...
  83. ncbi request reprint Preliminary evidence that VEGF genetic variability confers susceptibility to frontotemporal lobar degeneration
    B Borroni
    Centre for Aging Brain and Neurodegenerative Disorders, Department of Neurology, University of Brescia, Piazza Spedali Civili, Brescia, Italy
    Rejuvenation Res 11:773-80. 2008
    ..Overall, these data provide evidence for the first time that VEGF gene variability represents a susceptibility factor for sporadic FTLD, at least in an Italian population. Future confirmatory studies are mandatory...
  84. ncbi request reprint The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease
    A Alberici
    Department of Neurological Sciences, University of Brescia, Pzz le Spedali Civili 1, I 25100 Brescia, Italy
    Neurol Sci 28:80-6. 2007
    ..FTLD patients showed a characteristic behavioural profile. The FBI might be a reliable and useful diagnostic tool for dementias in clinical practice...
  85. doi request reprint Two sequential Tc-99m ECD SPECT studies in a case of sporadic Creutzfeldt-Jakob disease confirmed at autopsy
    Barbara Paghera
    Nuclear Medicine Department, Brescia Hospital, University of Brescia, p le Spedali Civili 1, Brescia, Italy
    Clin Nucl Med 36:669-71. 2011
    ..Creutzfeldt-Jakob disease (CJD) is a subacute spongiform encephalopathy characterized by rapidly progressive dementia, hard to diagnose during life...
  86. ncbi request reprint Volume reduction in cerebral blood flow in patients with Alzheimer's disease: a sonographic study
    N Maalikjy Akkawi
    Department of Neurology, Civil Hospital of Brescia, Brescia, Italy
    Dement Geriatr Cogn Disord 16:163-9. 2003
    ..The ability of ultrasonography to characterize flow decreases makes such a technique an attractive tool for the study of AD, for the evaluation of pharmacological therapies and, possibly, for early diagnosis...
  87. ncbi request reprint Behavioral and psychological symptoms in dementia with Lewy-bodies (DLB): frequency and relationship with disease severity and motor impairment
    B Borroni
    Department of Neurological Sciences, University of Brescia, Piazza Spedali Civili 1, I 25125 Brescia, Italy
    Arch Gerontol Geriatr 46:101-6. 2008
    ..Knowledge of the specific weight of BPSD in DLB would contribute to improve the allocation of health resources for dementia and to a better management of the disease...
  88. ncbi request reprint Pattern of Tau forms in CSF is altered in progressive supranuclear palsy
    B Borroni
    Department of Neurology, University of Brescia, Italy
    Neurobiol Aging 30:34-40. 2009
    ..These findings are promising in suggesting the identification of a marker for PSP diagnosis in clinical practice...
  89. ncbi request reprint Neuropsychiatric symptoms in amnestic and nonamnestic mild cognitive impairment
    L Rozzini
    Neurological Clinic, University of Brescia, Brescia, Italy
    Dement Geriatr Cogn Disord 25:32-6. 2008
    ..The information regarding neuropsychiatric symptoms in the subtypes of mild cognitive impairment (MCI) is inadequate...
  90. pmc Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
    A Padovani
    Department of Medical Sciences, Neurology, University of Brescia, Italy
    J Neurol Neurosurg Psychiatry 77:457-63. 2006
    ..A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy (PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available...
  91. ncbi request reprint Action and object naming in frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration
    M Cotelli
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neuropsychology 20:558-65. 2006
    ..These findings indicate that action naming impairment is not a general feature of FTD, but rather is associated with conditions that affect the frontoparietal-subcortical circuits involved in action knowledge and action representation...
  92. ncbi request reprint Volume cerebral blood flow reduction in pre-clinical stage of Alzheimer disease: evidence from an ultrasonographic study
    Nabil Maalikjy Akkawi
    Dept of Neurological Sciences, University of Brescia, P za Spedali Civili, 1, 25100 Brescia, Italy
    J Neurol 252:559-63. 2005
    ..4%) within a two year follow-up. Ultrasonography of the cervical arteries is a simple, non invasive and widespread technique useful in detecting CBF decline during the MCI stage, thus identifying patients who later will convert to AD...
  93. ncbi request reprint Amyloid precursor protein in platelets: a peripheral marker for the diagnosis of sporadic AD
    A Padovani
    Dipt Scienze Mediche e Chirurgiche, Unita di Neurologia, Universita degli Studi di Brescia, Italy
    Neurology 57:2243-8. 2001
    ..An altered pattern of amyloid precursor protein (APP) forms consisting in a reduced ratio between the upper (130 kDa) and the lower (106 to 110 kDa) immunoreactivity bands has been described in platelets of patients with AD...
  94. doi request reprint Serum leptin levels are higher in females affected by frontotemporal lobar degeneration than Alzheimer's disease
    A Alberici
    Department of Neurology, Brescia University, P zzale Spedali Civili 1, 25100 Brescia, Italy
    J Neurol Neurosurg Psychiatry 79:712-5. 2008
    ..The present study showed a selective gender difference in leptin levels between females with FTLD and AD, which may suggest specific cognitive and behavioural networks need to be investigated...
  95. ncbi request reprint Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms
    B Borroni
    Clinica Neurologica, Dipartimento di Scienze Mediche e Chirurgiche, Universita degli Studi di Brescia, Piazza Ospedale 1, Italy
    Neurol Sci 23:207-10. 2002
    ..50+/-0.3, p<0.0001). These findings indicate that alteration of APP processing in platelets is an early event and suggest that this assay might be of diagnostic value in differentiating mild AD from normal ageing...
  96. ncbi request reprint Weather conditions and transient global amnesia. A six-year study
    N Maalikjy Akkawi
    Dept of Neurology, Piazzale Spedali Civili, Brescia, Italy
    J Neurol 253:194-8. 2006
    ..This prompted us to evaluate the influence of climatic parameters, and their variation on the incidence of TGA...
  97. ncbi request reprint Action and object naming in Parkinson's disease without dementia
    M Cotelli
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Eur J Neurol 14:632-7. 2007
    ..The current study supports the view that action naming is affected in patients with PD, possibly reflecting the presence of prefrontal dysfunction...
  98. ncbi request reprint Parkinson's disease and dementia
    A Padovani
    Department Medical and Surgical Sciences, Institute of Neurology, University of Brescia, P zza Spedali Civili 1, I 25125 Brescia, Italy
    Neurol Sci 27:S40-3. 2006
    ..The overlap between PDD and dementia with Lewy bodies suggests that they likely share similar underlying neuropathological processes...
  99. doi request reprint Transient global amnesia and brain lesions: new hints into clinical criteria
    C Agosti
    Department of Neurological Sciences, University of Brescia, Brescia, Italy
    Eur J Neurol 15:981-4. 2008
    ..However, spare descriptions of TGA in patients with brain structural lesions have been reported. The aim of this study was to evaluate the prevalence of brain structural lesions among TGA patients...
  100. ncbi request reprint Peripheral blood abnormalities in Alzheimer disease: evidence for early endothelial dysfunction
    B Borroni
    Department of Neurology, University of Brescia, Italy
    Alzheimer Dis Assoc Disord 16:150-5. 2002
    ..No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients...
  101. ncbi request reprint Platelet amyloid precursor protein forms in AD: a peripheral diagnostic tool and a pharmacological target
    A Padovani
    Dipartimento Scienze Mediche e Chirurgiche, Clinica Neurologica Università degli Studi di Brescia, Piazza Ospedale 1, 25125, Brescia, Italy
    Mech Ageing Dev 122:1997-2004. 2001
    ....