Alice Borghini

Summary

Country: Italy

Publications

  1. doi request reprint N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides as potent and selective ligands for A₁ adenosine receptors
    Alice Borghini
    Dipartimento di Farmacia, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Chem Biol Drug Des 82:22-38. 2013
  2. ncbi request reprint Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors
    Irene Giorgi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    Bioorg Med Chem 17:1817-30. 2009
  3. ncbi request reprint N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors
    Irene Giorgi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 43:1639-47. 2008
  4. doi request reprint Chemical reactivity predictions: use of data mining techniques for analyzing regioselective azidolysis of epoxides
    Alice Borghini
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, Pisa 56126, Italy
    J Comput Chem 31:2612-9. 2010
  5. doi request reprint Structure-activity relationships on purine and 2,3-dihydropurine derivatives as antitubercular agents: a data mining approach
    Daniele Pietra
    Centro Interdipartimentale di Farmacologia Clinica e Terapia Sperimentale, University of Pisa, Pisa, Italy
    Chem Biol Drug Des 78:718-24. 2011
  6. pmc Berberine exposure triggers developmental effects on planarian regeneration
    Linda Balestrini
    Dipartimento di Biologia, Universita di Pisa, S S Abetone e Brennero 4, 56126 Pisa, Italy
    Sci Rep 4:4914. 2014
  7. ncbi request reprint QSAR study on thiazole and thiadiazole analogues as antagonists for the adenosine A1 and A3 receptors
    Alice Borghini
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 13:5330-7. 2005

Collaborators

  • Daniele Pietra
  • Irene Giorgi
  • Anna Maria Bianucci
  • Linda Balestrini
  • Michele Leonardi
  • Giuliana Biagi
  • Maria Emilia Isolani
  • Paolo Deri
  • Renata Batistoni
  • Ilaria Massarelli
  • Osele Ciampi
  • Alma Martelli
  • Vincenzo Calderone
  • Oreste Livi

Detail Information

Publications7

  1. doi request reprint N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides as potent and selective ligands for A₁ adenosine receptors
    Alice Borghini
    Dipartimento di Farmacia, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Chem Biol Drug Des 82:22-38. 2013
    ..Furthermore, a molecular docking study was carried out to assess hypothetical binding mode of N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides to A₁ adenosine receptors...
  2. ncbi request reprint Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors
    Irene Giorgi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    Bioorg Med Chem 17:1817-30. 2009
    ..The obtained models can assist in the design of new compounds selectively active on A(1) adenosine receptor...
  3. ncbi request reprint N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors
    Irene Giorgi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 43:1639-47. 2008
    ..This evidence was also strengthened by functional data. Other compounds can act as negative modulators. Furthermore these compounds show inhibitory properties for A(1) and A(3) adenosine receptors...
  4. doi request reprint Chemical reactivity predictions: use of data mining techniques for analyzing regioselective azidolysis of epoxides
    Alice Borghini
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, Pisa 56126, Italy
    J Comput Chem 31:2612-9. 2010
    ....
  5. doi request reprint Structure-activity relationships on purine and 2,3-dihydropurine derivatives as antitubercular agents: a data mining approach
    Daniele Pietra
    Centro Interdipartimentale di Farmacologia Clinica e Terapia Sperimentale, University of Pisa, Pisa, Italy
    Chem Biol Drug Des 78:718-24. 2011
    ..The obtained prediction model is based on a classification tree; it was built with a small number of descriptors, which allowed us to outline structural features important to predict antitubercular activity of such classes of compounds...
  6. pmc Berberine exposure triggers developmental effects on planarian regeneration
    Linda Balestrini
    Dipartimento di Biologia, Universita di Pisa, S S Abetone e Brennero 4, 56126 Pisa, Italy
    Sci Rep 4:4914. 2014
    ....
  7. ncbi request reprint QSAR study on thiazole and thiadiazole analogues as antagonists for the adenosine A1 and A3 receptors
    Alice Borghini
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 13:5330-7. 2005
    ..The obtained models allowed us to understand the main structural features that strongly correlate with the target property...