Enzo Bonora

Summary

Country: Italy

Publications

  1. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000
  2. ncbi Intracellular partition of plasma glucose disposal in hypertensive and normotensive subjects with type 2 diabetes mellitus
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    J Clin Endocrinol Metab 86:2073-9. 2001
  3. ncbi Plasma glucose levels throughout the day and HbA(1c) interrelationships in type 2 diabetes: implications for treatment and monitoring of metabolic control
    E Bonora
    Division of Endocrinology and Metabolic Disease, University of Verona Medical School, Verona, Italy
    Diabetes Care 24:2023-9. 2001
  4. ncbi Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence
    E Bonora
    Division of Endocrinology and Metabolic Disease, University of Verona Medical School, Ospedale Maggiore, Piazzale Stefani 1, Verona, Italy
    Diabetologia 44:2107-14. 2001
  5. ncbi HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study
    Enzo Bonora
    Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes Care 25:1135-41. 2002
  6. ncbi Predictors of insulin sensitivity in Type 2 diabetes mellitus
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabet Med 19:535-42. 2002
  7. ncbi Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study
    Enzo Bonora
    Endocrinologia e Malattie del Metabolismo, Ospedale Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Diabetes Care 30:318-24. 2007
  8. ncbi Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes 53:1782-9. 2004
  9. doi Variability of body weight, pulse pressure and glycaemia strongly predict total mortality in elderly type 2 diabetic patients. The Verona Diabetes Study
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Diabetes Metab Res Rev 24:624-8. 2008
  10. ncbi Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial)
    Elisabetta Bacchi
    Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Hepatology 58:1287-95. 2013

Detail Information

Publications51

  1. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000
    ..To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans...
  2. ncbi Intracellular partition of plasma glucose disposal in hypertensive and normotensive subjects with type 2 diabetes mellitus
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    J Clin Endocrinol Metab 86:2073-9. 2001
    ..These results indicate that hypertension markedly aggravates insulin resistance featuring type 2 diabetes mellitus. The molecular defects underlying this phenomenon involve primarily GS...
  3. ncbi Plasma glucose levels throughout the day and HbA(1c) interrelationships in type 2 diabetes: implications for treatment and monitoring of metabolic control
    E Bonora
    Division of Endocrinology and Metabolic Disease, University of Verona Medical School, Verona, Italy
    Diabetes Care 24:2023-9. 2001
    ..To evaluate the extent of plasma glucose excursions with meals, the relations between plasma glucose levels at different times of the day, and the relations between the latter and HbA(1c) in non-insulin-treated type 2 diabetic subjects...
  4. ncbi Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence
    E Bonora
    Division of Endocrinology and Metabolic Disease, University of Verona Medical School, Ospedale Maggiore, Piazzale Stefani 1, Verona, Italy
    Diabetologia 44:2107-14. 2001
    ..Trials specifically designed to address this issue are needed to determine whether postprandial hyperglycaemia plays an independent and causative role in cardiovascular disease in patients with Type II diabetes...
  5. ncbi HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study
    Enzo Bonora
    Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes Care 25:1135-41. 2002
    ..To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes...
  6. ncbi Predictors of insulin sensitivity in Type 2 diabetes mellitus
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabet Med 19:535-42. 2002
    ..To identify the independent predictors of insulin sensitivity in Type 2 diabetes, and to establish whether isolated Type 2 diabetes (i.e. diabetes without overweight, dyslipidaemia and hypertension) is a condition of insulin resistance...
  7. ncbi Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study
    Enzo Bonora
    Endocrinologia e Malattie del Metabolismo, Ospedale Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Diabetes Care 30:318-24. 2007
    ....
  8. ncbi Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes 53:1782-9. 2004
    ....
  9. doi Variability of body weight, pulse pressure and glycaemia strongly predict total mortality in elderly type 2 diabetic patients. The Verona Diabetes Study
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Diabetes Metab Res Rev 24:624-8. 2008
    ....
  10. ncbi Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial)
    Elisabetta Bacchi
    Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Hepatology 58:1287-95. 2013
    ..Conclusion: This is the first randomized controlled study to demonstrate that resistance training and aerobic training are equally effective in reducing hepatic fat content among type 2 diabetic patients with NAFLD...
  11. doi Usefulness of the triglyceride to high-density lipoprotein cholesterol ratio for predicting mortality risk in type 2 diabetes: role of kidney dysfunction
    Giacomo Zoppini
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Atherosclerosis 212:287-91. 2010
    ....
  12. doi Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Clin Sci (Lond) 125:301-9. 2013
    ..The potential impact of NAFLD on AF deserves particular attention, especially with respect to the implications for screening and surveillance strategies in the growing number of patients with NAFLD...
  13. ncbi Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function
    Riccardo C Bonadonna
    Division of Endocrinology and Metabolic Diseases, University of Verona and Azienda Ospedaliera di Verona, Italy
    Diabetes 52:470-80. 2003
    ..Under conditions leading to decreased insulin sensitivity, these disturbed relationships may lead to progression to diabetes in OfT2D...
  14. pmc CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes. the Verona newly diagnosed type 2 diabetes study (VNDS) 3
    Maddalena Trombetta
    Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e32755. 2012
    ..The aim of the study was to test whether CACNA1E common variability affects beta cell function and/or insulin sensitivity in patients with newly diagnosed type 2 diabetes...
  15. ncbi Pulse pressure and mortality from cerebrovascular diseases in type 2 diabetic patients: the Verona Diabetes Study
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Cerebrovasc Dis 23:20-6. 2007
    ..The aim of the present study was to investigate the relationship between PP and specific cardiovascular mortality, i.e. from cerebrovascular and ischemic heart diseases, in a well-characterized cohort of type 2 diabetic patients...
  16. pmc Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function
    Giacomo Zoppini
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Diabetes Care 35:99-104. 2012
    ..We determined whether baseline serum uric acid levels predict the subsequent development of CKD in patients with type 2 diabetes...
  17. doi Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus
    Giacomo Zoppini
    Department of Medicine, Section of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Metabolism 61:22-9. 2012
    ....
  18. ncbi Relationships between cardiorespiratory fitness, metabolic control, and fat distribution in type 2 diabetes subjects
    Elisabetta Bacchi
    Unit of Endocrinology and Metabolism, Department of Medicine, University of Verona, P le Stefani 1, 37126, Verona, Italy
    Acta Diabetol 51:369-75. 2014
    ..Future research should target these features in prospective intervention studies. ..
  19. pmc Differences in the acute effects of aerobic and resistance exercise in subjects with type 2 diabetes: results from the RAED2 Randomized Trial
    Elisabetta Bacchi
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    PLoS ONE 7:e49937. 2012
    ..Our objective was to assess whether there may be a difference in acute blood glucose changes after a single bout of AER or RES exercise...
  20. pmc Comparison of two creatinine-based estimating equations in predicting all-cause and cardiovascular mortality in patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Diabetes Care 35:2347-53. 2012
    ..To compare the performance of two glomerular filtration rate (GFR)-estimating equations in predicting the risk of all-cause and cardiovascular mortality in type 2 diabetic patients...
  21. doi Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    J Hepatol 53:713-8. 2010
    ..To estimate the prevalence of non-alcoholic fatty liver disease (NAFLD) in type 1 diabetic individuals, and to evaluate whether NAFLD is associated with increased prevalence of cardiovascular disease (CVD)...
  22. ncbi Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes
    Giovanni Targher
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Diabetes Care 37:1729-36. 2014
    ..There is no information about the role of nonalcoholic fatty liver disease (NAFLD) in predicting the development of chronic kidney disease (CKD) in type 1 diabetes...
  23. pmc Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study)
    Elisabetta Bacchi
    Department of Medicine, University of Verona, Verona, Italy
    Diabetes Care 35:676-82. 2012
    ....
  24. doi Predictors of estimated GFR decline in patients with type 2 diabetes and preserved kidney function
    Giacomo Zoppini
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Italy
    Clin J Am Soc Nephrol 7:401-8. 2012
    ..This study examined predictors of the annual decline in estimated GFR (eGFR) in patients with type 2 diabetes and preserved kidney function...
  25. ncbi Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database
    Enzo Bonora
    University of Verona, Verona, Italy
    Nutr Metab Cardiovasc Dis 18:624-31. 2008
    ..We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects...
  26. pmc Elevated serum uric acid concentrations independently predict cardiovascular mortality in type 2 diabetic patients
    Giacomo Zoppini
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Diabetes Care 32:1716-20. 2009
    ..We assessed the predictive role of serum uric acid levels on all-cause and cardiovascular mortality in a large cohort of type 2 diabetic individuals...
  27. pmc Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients
    Giacomo Zoppini
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy
    PLoS ONE 8:e82733. 2013
    ..Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients...
  28. pmc Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes
    Andrea Rossi
    Section of Cardiology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Diabetes Care 35:1781-6. 2012
    ..To examine the association of aortic valve sclerosis (AVS) and mitral annulus calcification (MAC) with all-cause and cardiovascular mortality in type 2 diabetic individuals...
  29. doi Increased risk of cardiovascular disease and chronic kidney disease in NAFLD
    Enzo Bonora
    Endocrinology, Diabetes and Metabolic Diseases, University and Azienda Ospedaliera Universitaria Integrata of Verona, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Nat Rev Gastroenterol Hepatol 9:372-81. 2012
    ....
  30. ncbi Carotid atherosclerosis and coronary heart disease in the metabolic syndrome: prospective data from the Bruneck study
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes Care 26:1251-7. 2003
    ..The present study aimed at prospectively evaluating carotid atherosclerosis and coronary heart disease (CHD) in subjects with the metabolic syndrome...
  31. pmc Supervised walking groups to increase physical activity in type 2 diabetic patients
    Carlo Negri
    Unit of Endocrinology and Metabolism, Azienda Ospedaliera Universitaria Integrata di Verona, Department of Medicine, University of Verona, Verona, Italy
    Diabetes Care 33:2333-5. 2010
    ..To evaluate the impact of an exercise program organized into supervised walking groups in subjects with type 2 diabetes...
  32. pmc High-normal HbA1c is a strong predictor of type 2 diabetes in the general population
    Enzo Bonora
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Diabetes Care 34:1038-40. 2011
    ..In this study we evaluated how high-normal HbA(1c) levels predict type 2 diabetes...
  33. doi Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?
    Giovanni Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University Hospital, Verona, Italy
    J Hepatol 54:1020-9. 2011
    ....
  34. doi Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome
    Paolo Moghetti
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Piazzale Stefani, Verona, Italy
    J Clin Endocrinol Metab 98:E628-37. 2013
    ..Insulin sensitivity was measured by the glucose clamp technique...
  35. ncbi Protection of pancreatic beta-cells: is it feasible?
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Nutr Metab Cardiovasc Dis 18:74-83. 2008
    ..Anti-diabetic agents targeting the intimate mechanisms of beta-cell damage might change the scenario in the near future...
  36. ncbi The metabolic syndrome and cardiovascular disease
    Enzo Bonora
    Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Ann Med 38:64-80. 2006
    ..The risk related to the metabolic syndrome is definitely higher when subjects affected are compared to subjects free of any metabolic abnormality...
  37. ncbi Mortality from chronic liver diseases in diabetes
    Giacomo Zoppini
    Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Hospital Trust of Verona, Verona, Italy
    Am J Gastroenterol 109:1020-5. 2014
    ..The aim of this study was to assess mortality rates from CLD by etiology in known diabetic subjects living in the Veneto Region, Northern Italy...
  38. ncbi Mortality from site-specific malignancies in type 2 diabetic patients from Verona
    Giuseppe Verlato
    Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy
    Diabetes Care 26:1047-51. 2003
    ..The aim of the present work was to compare mortality from site-specific malignancies in type 2 diabetic patients with those in the general population...
  39. pmc Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2
    Sara Bonetti
    Department ofMedicine, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Diabetes Care 34:1205-10. 2011
    ..We tested whether GCKR variability affects type 2 diabetes or kidney-related phenotypes in newly diagnosed type 2 diabetes...
  40. doi Hemostatic and fibrinolytic abnormalities in endocrine diseases: a narrative review
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Semin Thromb Hemost 35:605-12. 2009
    ..Nevertheless, the prompt recognition of potentially severe disorders of blood coagulation is mandatory for the correct management of these patients...
  41. ncbi Insulin causes endothelial dysfunction in humans: sites and mechanisms
    Guido Arcaro
    Division of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona Medical School and Azienda Ospedaliera di Verona, Verona, Italy
    Circulation 105:576-82. 2002
    ..Endothelium plays a central role in atherogenesis. The in vivo effects of hyperinsulinemia on endothelial function of large conduit arteries are unknown...
  42. ncbi [Abdominal obesity and diabetes]
    Enzo Bonora
    Sezione di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Biomediche e Chirurgiche, Universita degli Studi, Verona
    G Ital Cardiol (Rome) 9:40S-53S. 2008
    ..ceramide) within the key organs of glucose metabolism (liver, skeletal muscle, pancreatic islets). This phenomenon seems to contribute to both insulin resistance and beta-cell dysfunction, favoring abnormalities of glucose homeostasis...
  43. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  44. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by r
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Doublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:E1-40. 2007
  45. ncbi Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
    Diabetes Metab Res Rev 24:130-6. 2008
    ..We assessed the accuracy of the American Diabetes Association (ADA)2003 definition of impaired fasting glucose (IFG) in identifying subjects with low insulin sensitivity, and determined cardiovascular risk factors in ADA2003 IFG subjects...
  46. ncbi Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment of substrates metabolism
    Livio Luzi
    Department of Medicine, San Raffaele Scientific Institute, and University of Milano, Milano, Italy
    Diabetes Metab Res Rev 24:205-10. 2008
    ..The mutations do not affect the insulin-receptor binding affinity and insulin-stimulated auto-phosphorylation of the receptor...
  47. ncbi [European practice guidelines on prevention of cardiovascular diseases: executive summary]
    Ian Graham
    European Society of Cardiology
    G Ital Cardiol (Rome) 9:11-59. 2008
  48. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  49. ncbi Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database
    Giorgio Sesti
    Diabetes Care 30:e33. 2007
  50. ncbi Imatinib and regression of type 2 diabetes
    Dino Veneri
    N Engl J Med 352:1049-50. 2005
  51. ncbi Serum leptin level and the risk of nontraumatic fracture
    Georg Schett
    Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Austria
    Am J Med 117:952-6. 2004