E Boncinelli

Summary

Country: Italy

Publications

  1. ncbi request reprint Organization of human class I homeobox genes
    E Boncinelli
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Richerche, Naples, Italy
    Genome 31:745-56. 1989
  2. ncbi request reprint Homeobox genes and disease
    E Boncinelli
    Department of Biotechnology DIBIT, Istituto Scientifico H San Raffaele, Milano, Italy
    Curr Opin Genet Dev 7:331-7. 1997
  3. ncbi request reprint Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells
    S Guazzi
    Department of Biology and Biotechnology, H San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
    J Biol Chem 273:11092-9. 1998
  4. pmc The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins
    S Guazzi
    Department of Biology and Biotechnology, Istituto Scientifico H S Raffaele, Milano, Italy
    EMBO J 13:3339-47. 1994
  5. pmc The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins
    L Arcioni
    Department of Biology and Biotechnology, Istituto Scientifico San Faffaele, Milano, Italy
    EMBO J 11:265-77. 1992
  6. ncbi request reprint The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
    M Pannese
    DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    Development 121:707-20. 1995
  7. ncbi request reprint OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area
    A Mallamaci
    DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    Mech Dev 58:165-78. 1996
  8. ncbi request reprint The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex
    A Mallamaci
    Department of Biological and Technological Research DIBIT, Istituto Scientifico H San Raffaele, 20132 Milano, Italy
    J Neurosci 20:1109-18. 2000
  9. ncbi request reprint EMX2 protein in the developing mouse brain and olfactory area
    A Mallamaci
    DIBIT, Istituto Scientifico H San Raffaele, Via Olgettina 60, 20132, Milano, Italy
    Mech Dev 77:165-72. 1998
  10. ncbi request reprint Emx homeogenes and mouse brain development
    C Cecchi
    Molecular Developmental Biology Unit, DIBIT, Istituto Scientifico H San Raffaele, 20132 Milan, Italy
    Trends Neurosci 23:347-52. 2000

Collaborators

  • A Mallamaci
  • S Guazzi
  • P Briata
  • Cristina Cecchi
  • A Simeone
  • V Broccoli
  • Robert Vignali
  • L Puelles
  • S W Wilson
  • K T Nguyen Ba-Charvet
  • K Detmer
  • Massimiliano Andreazzoli
  • P Bovolenta
  • A Faiella
  • M Pannese
  • R Morgan
  • A S Fernandez
  • M Mariani
  • M T Corsetti
  • G G Consalez
  • A Cama
  • S M Barabino
  • A Bosetti
  • O V Kazanskaya
  • V Capra
  • S Brunelli
  • M Pellegrini
  • G Corte
  • S Ferrini
  • R Meazza
  • M Delarue
  • M H Hooiveld
  • J P Thiery
  • G Dati
  • F Broders
  • A J Durston
  • F Albani
  • R Fesce
  • J Reperant
  • B Kanzler
  • A Corradi
  • S Martinez
  • D Baldessari
  • M Zortea
  • M Wassef
  • O Pozzoli
  • N Malgaretti
  • C Pieau
  • E Barbaria
  • K A Barth
  • S A Lukyanov
  • E A Severtzova
  • F Spada
  • A G Zaraisky
  • A O Benyumov
  • G V Ermakova
  • F Cotelli
  • V Nigro
  • H J Lawrence
  • A Mansouri
  • P Gruss
  • G Barsacchi
  • C Polo
  • D Duboule
  • G Levi
  • I Airoldi
  • F Lancia
  • L Sanseverino
  • B Kablar
  • M H Sham
  • H Le Mouellic
  • E Migliaccio
  • J P Viallet
  • D Dhouailly
  • L Arcioni
  • V Zappavigna
  • K M Stage
  • C H Mathews
  • M MacKenzie
  • C Largman
  • R Scibienski
  • L A Cannizzaro
  • N Papalopulu
  • P Dolle
  • R Krumlauf
  • F Mavilio
  • M D'ESPOSITO
  • A Graham
  • S Nonchev
  • L Cianetti

Detail Information

Publications41

  1. ncbi request reprint Organization of human class I homeobox genes
    E Boncinelli
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Richerche, Naples, Italy
    Genome 31:745-56. 1989
    ..The existence of an ancestral complex locus might have predated the divergence of vertebrates and invertebrates...
  2. ncbi request reprint Homeobox genes and disease
    E Boncinelli
    Department of Biotechnology DIBIT, Istituto Scientifico H San Raffaele, Milano, Italy
    Curr Opin Genet Dev 7:331-7. 1997
    ....
  3. ncbi request reprint Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells
    S Guazzi
    Department of Biology and Biotechnology, H San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
    J Biol Chem 273:11092-9. 1998
    ..Taken together, our data support the hypothesis that anteriorly expressed Hox genes might play a role in the refinement of the Otx2 early expression boundaries in vivo...
  4. pmc The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins
    S Guazzi
    Department of Biology and Biotechnology, Istituto Scientifico H S Raffaele, Milano, Italy
    EMBO J 13:3339-47. 1994
    ..Some of the DNA-protein complexes formed by the embryonic extracts are indistinguishable from those generated by HOXB3.(ABSTRACT TRUNCATED AT 250 WORDS)..
  5. pmc The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins
    L Arcioni
    Department of Biology and Biotechnology, Istituto Scientifico San Faffaele, Milano, Italy
    EMBO J 11:265-77. 1992
    ..The sequences on the HOX3D promoter involved in cross-regulation are different from those binding nuclear factors induced by RA...
  6. ncbi request reprint The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
    M Pannese
    DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    Development 121:707-20. 1995
    ..Microinjected transcripts of Xotx2 constructs containing a homeodomain where this lysine is substituted by a glutamine or a glutamic acid residue fail to cause these effects...
  7. ncbi request reprint OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area
    A Mallamaci
    DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    Mech Dev 58:165-78. 1996
    ....
  8. ncbi request reprint The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex
    A Mallamaci
    Department of Biological and Technological Research DIBIT, Istituto Scientifico H San Raffaele, 20132 Milano, Italy
    J Neurosci 20:1109-18. 2000
    ..In addition, restricted defects along the rostrocaudal and the mediolateral axes are present in the subplate, suggesting an Emx2-specific role in priming the proper development of this layer...
  9. ncbi request reprint EMX2 protein in the developing mouse brain and olfactory area
    A Mallamaci
    DIBIT, Istituto Scientifico H San Raffaele, Via Olgettina 60, 20132, Milano, Italy
    Mech Dev 77:165-72. 1998
    ....
  10. ncbi request reprint Emx homeogenes and mouse brain development
    C Cecchi
    Molecular Developmental Biology Unit, DIBIT, Istituto Scientifico H San Raffaele, 20132 Milan, Italy
    Trends Neurosci 23:347-52. 2000
    ..The graded distribution of EMX2 homeoprotein suggests a potential role for Emx2 in the subdivision of the cortex into territories and possibly areas...
  11. ncbi request reprint Conserved homeobox genes in the developing brain
    E Boncinelli
    Istituto Scientifico H S Raffaele, Milano, Italy
    C R Acad Sci III 316:972-84. 1993
    ..The structural organization and the regulation of these genes appear remarkably conserved in evolution...
  12. ncbi request reprint Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice
    A Mallamaci
    Department of Biological and Technological Research DIBIT, Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Nat Neurosci 3:679-86. 2000
    ..We found that the normal spectrum of cortical areal identities was encoded in these mutants, but areas with caudal-medial identities were reduced and those with anterior-lateral identities were relatively expanded in the cortex...
  13. ncbi request reprint Emx and Otx homeobox genes in the developing mouse brain
    E Boncinelli
    DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    J Neurobiol 24:1356-66. 1993
    ..5). It is tempting to speculate about a possible role of the four genes in establishing and/or signalling the limits of the various embryonic brain regions in a discrete progressive process with its center in the dorsal telencephalon...
  14. ncbi request reprint Linkage mapping of Emx2 to mouse chromosome 19
    A Bosetti
    Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, Milano, Italy
    Mamm Genome 8:71-2. 1997
  15. ncbi request reprint Downstream of Otx2, or how to get a head
    E Boncinelli
    Molecular Biology of Development, DIBIT, Instituto Scientifico H San Raffaele, Via Olgettina, 58, 20132, Milan, Italy
    Trends Genet 17:633-6. 2001
    ..Furthermore, there is evidence that Otx2 coordinates the activity of unrelated genes that have overlapping functions, and that it does so directly without intermediate transcriptional or signaling activity...
  16. pmc A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 12:2735-47. 1993
    ..Its gene product contains a homeodomain of the bicoid class and is able to recognize and transactivate a bicoid target sequence...
  17. ncbi request reprint A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
    K T Nguyen Ba-Charvet
    Institut Alfred Fessard, CNRS UPR 2212, Avenue de la Terrasse, France
    Development 125:4273-82. 1998
    ..These data suggest that Otx2 might be involved in defining local substrata for axon extension in the forebrain...
  18. ncbi request reprint Calponin modulates the exclusion of Otx-expressing cells from convergence extension movements
    R Morgan
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Cell Biol 1:404-8. 1999
    ..XclpH3 is a Xenopus homologue of the mammalian calponin gene, the product of which binds both actin and myosin and prevents the generation of contractile force by actin filaments...
  19. ncbi request reprint Differential expression of two different homeobox gene families during mouse tegument morphogenesis
    B Kanzler
    Laboratoire de Biologie de la Différenciation Epithéliale, Universite Joseph Fourier, Grenoble, France
    Int J Dev Biol 38:633-40. 1994
    ..those of the hair matrix of the caudal pelage hair follicles. Taken together, these observations strengthen the hypothesis that different homeobox gene families specify the regional identity of the skin in the cephalic and body regions...
  20. ncbi request reprint EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2
    M D'ESPOSITO
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Genomics 10:43-50. 1991
    ..We have identified for the first time a homeogene of a different class at a HOX locus. These findings are relevant to the understanding of the evolution of HOX gene clusters and their regulation...
  21. ncbi request reprint Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes
    R Meazza
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Blood 85:2084-90. 1995
    ..The early expression and the nucleolar localization suggest an involvement of HOXC4 in the regulation of genes controlling lymphocyte activation and/or proliferation...
  22. ncbi request reprint The caudal limit of Otx2 expression positions the isthmic organizer
    V Broccoli
    GSF Research Centre for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Nature 401:164-8. 1999
    ..These findings show that the caudal limit of Otx2 expression is sufficient for positioning the isthmic organizer and encoding caudal midbrain fate within the mid/hindbrain domain...
  23. ncbi request reprint Expression pattern of cSix3, a member of the Six/sine oculis family of transcription factors
    P Bovolenta
    Unidad de Neurobiologia del Desarollo, Instituto Cajal, Madrid, Spain
    Mech Dev 70:201-3. 1998
    ..In the developing neural retina, cSix3 is expressed in the entire undifferentiated neuroepithelium but is rapidly downregulated, first in the postmitotic photoreceptors and later in the majority of retinal ganglion cells...
  24. ncbi request reprint Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes
    A S Fernandez
    CNRS URA 1414, Equipe Régionalisation nerveuse, Ecole Normale Superieure, 46, rue d Ulm 75230 PARIS Cedex 05 France
    Development 125:2099-111. 1998
    ..Homologies between forebrain subdivisions are proposed based on the conservation and divergence of these gene expression patterns...
  25. ncbi request reprint A genetic polymorphism in the human HOXB1 homeobox gene implying a 9bp tandem repeat in the amino-terminal coding region. Mutations in brief no. 200. Online
    A Faiella
    DIBIT, Istituto Scientifico H S Raffaele, 20132 Milan, Italy
    Hum Mutat 12:363. 1998
    ..1). 7 mouse strains, namely 129, BALB/c, C57BL/6, C57BL/10, CAST/Ei, C3H and SPRET/Ei, are homozygous for this allele. The allele present in gibbon and rhesus monkey appears to be identical to the human HOXB1b (Fig. 1)...
  26. pmc Molecular mechanisms underlying the expression of the human HOX-5.1 gene
    L Cianetti
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Rome, Italy
    Nucleic Acids Res 18:4361-8. 1990
    ....
  27. ncbi request reprint Mab21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development
    M Mariani
    Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Mech Dev 79:131-5. 1998
    ..Our data and the genetic interactions previously documented in the nematode suggest that Mab21 may represent a novel, important regulator of mammalian cerebellum and eye development...
  28. ncbi request reprint Anf: a novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis
    O V Kazanskaya
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Gene 200:25-34. 1997
    ....
  29. ncbi request reprint Inactivation of the zebrafish homologue of Chx10 by antisense oligonucleotides causes eye malformations similar to the ocular retardation phenotype
    S M Barabino
    DIBIT, H S Raffaele Scientific Institute, Milan, Italy
    Mech Dev 63:133-43. 1997
    ..The expression of other developmentally relevant genes such as pax(zf-a), pax(zf-b) and krx-20 was not affected in the antisense treated embryos...
  30. pmc Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions
    M H Sham
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    EMBO J 11:1825-36. 1992
    ..6 gene and the expression of transgenic and endogenous transcripts in a Hox-2.8 pattern, suggest that regulatory elements may be shared by neighbouring genes to establish the complete expression pattern...
  31. ncbi request reprint The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mech Dev 36:3-13. 1991
    ..8 is expressed in more posterodistal regions than those of its neighbour Hox-4.7. Hence, Hox-4.8 expression appears to be related to the last significant phenotypic changes towards the extremities of the embryonic body and limb axes...
  32. pmc Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development
    A Simeone
    Proc Natl Acad Sci U S A 84:4914-8. 1987
    ..Together, the results of the embryonic/fetal expression of c1 and c8 and those of two previously analyzed genes (c10 and c13) indicate a coherent pattern of expression of these genes in early human ontogeny...
  33. pmc Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13
    L A Cannizzaro
    Am J Hum Genet 41:1-15. 1987
    ..Neither of the class I homeo box-containing genes--c8 and c13--maps to a region of obvious homology to chromosomal positions of the presently known mouse homeo box-containing genes...
  34. ncbi request reprint A human homoeo box gene specifically expressed in spinal cord during embryonic development
    A Simeone
    Nature 320:763-5. 1986
    ..A major polyadenylated transcript of approximately 2.1 kilobases (kb), as well as RNA species of higher relative molecular mass (Mr), are specifically expressed at a constant level in spinal cord throughout this developmental period...
  35. ncbi request reprint Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells
    P Briata
    Laboratory of Immunobiology I S T, Advanced Biotechnology Center, Genova, Italy
    J Biol Chem 270:27695-701. 1995
    ..We speculate that the repressor function of EVX1 contributes to its proposed role in embryogenesis...
  36. ncbi request reprint Nucleolar localisation of three Hox homeoproteins
    M T Corsetti
    Advanced Biotechnology Center, C B A, IST, Genova, Italy
    J Cell Sci 108:187-93. 1995
    ..The functional significance of the nucleolar localisation of Hox proteins remains to be determined...
  37. ncbi request reprint Expression of HOX C homeobox genes in lymphoid cells
    H J Lawrence
    Veterans Affairs Medical Center, San Francisco, California 94121
    Cell Growth Differ 4:665-9. 1993
    ..However, the HOX C8 transcript pattern is lineage specific. These data, in conjunction with earlier findings, suggest that homeobox gene expression influences lineage determination during hematopoiesis...
  38. ncbi request reprint Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly
    S Brunelli
    DIBIT, Istituto Scientifico HS Raffaele, Milan, Italy
    Nat Genet 12:94-6. 1996
  39. ncbi request reprint EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons
    P Briata
    Laboratory of Immunobiology, Advanced Biotechnology Center, IST, Genova, Italy
    Mech Dev 57:169-80. 1996
    ..The protein is present in axons of olfactory sensory neurons along their entire length, including their terminals in spherical regions of neuropil in the olfactory bulb called glomeruli...
  40. ncbi request reprint Dentate gyrus formation requires Emx2
    M Pellegrini
    Max Planck Institute of Biophysical Chemistry, Gottingen
    Development 122:3893-8. 1996
    ..These findings demonstrate that Emx2 is required for the development of several forebrain structures...
  41. pmc Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 11:2541-50. 1992
    ..Emx1 is expressed exclusively there, whereas Emx2 is also expressed in some neuroectodermal areas in embryonic head including olfactory placodes in earlier stages and olfactory epithelia later in development...