Research Topics
| B BiondiSummaryCountry: Italy Publications
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Publications
Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess. A case report in a young girl with recurrent, functioning paragaM Pulcrano
Department of Clinical and Molecular Endocrinology and Oncology, Federico II University School of Medicine, Naples, Italy
J Endocrinol Invest 27:774-7. 2004....
Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patientsB Biondi
Departments of Endocrinology and Internal Medicine, University of Naples Federico II Medical School, 80131 Naples, Italy
J Clin Endocrinol Metab 85:4701-5. 2000....
Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemmaBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Eur J Endocrinol 162:587-9. 2010....
Cardiovascular safety of acute recombinant human thyrotropin administration to patients monitored for differentiated thyroid cancerBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, 80131 Naples, Italy
J Clin Endocrinol Metab 88:211-4. 2003..Our data demonstrate that rhTSH does not alter cardiovascular function acutely. Consequently, it can safely be used in the routine staging of patients affected by differentiated thyroid cancer...
Effects of subclinical thyroid dysfunction on the heartBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, 80131 Naples, Italy
Ann Intern Med 137:904-14. 2002..Mounting evidence indicates that subclinical thyroid dysfunction has important clinical effects and prognostic implications, supporting the view that it is not a compensated biochemical change sensu strictu...
Subclinical hypothyroidism and cardiac functionBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, Naples, Italy
Thyroid 12:505-10. 2002..Therefore, it would seem appropriate to initiate timely treatment of patients with mild thyroid failure to prevent cardiac involvement...
Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidismBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University Federico II School of Medicine, 80131 Naples, Italy
J Clin Endocrinol Metab 87:968-74. 2002
Myocardial contractility and total arterial stiffness in patients with overt hyperthyroidism: acute effects of beta1-adrenergic blockadeE A Palmieri
Department of Clinical Medicine and Cardiovascular Sciences, University Federico II School of Medicine, Napoli, Italy
Eur J Endocrinol 150:757-62. 2004..To ascertain whether myocardial contractility and total arterial stiffness are significantly altered in human thyrotoxicosis, and to what extent they are affected by acute beta(1)-adrenergic blockade...
Follow-up of differentiated thyroid carcinomaL Pagano
Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, School of Medicine, Naples, Italy
Minerva Endocrinol 29:161-74. 2004..On the contrary, detectable Tg after TSH stimulation is an indicator in selecting patients who are candidates for further diagnostic procedures...
[New therapeutic strategies in gastroenteropancreatic neuroendocrine tumours]A Colao
Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita Federico II, Naples, Italy
Minerva Endocrinol 26:231-8. 2001....
Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center studyG Lombardi
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
J Endocrinol Invest 25:971-6. 2002..3% of patients before treatment vs 16.5%, after treatment. In conclusion, lanreotide reduced the left ventricular mass, and improved ventricular filling and ventricular arrhythmic profile...
High serum osteoprotegerin levels in patients with hyperthyroidism: effect of medical treatmentG Amato
Department of Clinical and Experimental Medicine F. Magrassi and A. Lanzara, Second University of Naples, 80121, Naples, Italy
Bone 35:785-91. 2004..Medical treatment of hyperthyroidism normalizes serum OPG levels in temporal relationship with the normalization of bone metabolism markers, even in presence of persistent abnormal bone structure as determined by ultrasonography...
Impact of hyperthyroidism and its correction on vascular reactivity in humansR Napoli
Department of Internal Medicine and Cardiovascular Sciences, University Federico II School of Medicine, Naples, Italy
Circulation 104:3076-80. 2001..The data demonstrate that vascular endothelium is a specific target of TH...
Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau diseaseM Pulcrano
Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
J Endocrinol Invest 31:352-9. 2008..The results of this study suggest that [111In-DTPA0] octreotide scintigraphy may be helpful in the routine work-up of VHL patients for diagnostic and therapeutic purposes...
The clinical significance of subclinical thyroid dysfunctionBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Endocr Rev 29:76-131. 2008..Lastly, we address the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age...
Thyroid-hormone therapy and thyroid cancer: a reassessmentBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
Nat Clin Pract Endocrinol Metab 1:32-40. 2005..5 mU/l). Only selected patients with high-risk papillary and follicular thyroid cancer require long-term TSH-suppressive doses of L-T(4). In these patients, careful monitoring is necessary to avoid undesirable effects on bone and heart...
Subclinical hypothyroidism and cardiovascular risk: a reason to treat?Emiliano A Palmieri
Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II School of Medicine, Naples, Italy
Treat Endocrinol 3:233-44. 2004....
Short-term hypothyroidism after Levothyroxine-withdrawal in patients with differentiated thyroid cancer: clinical and quality of life consequencesLeonidas H Duntas
Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou St, 11528 Athens, Greece
Eur J Endocrinol 156:13-9. 2007....
Subclinical hyperthyroidism: clinical features and treatment optionsBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy
Eur J Endocrinol 152:1-9. 2005..Subclinical hyperthyroidism and its related clinical manifestations are reversible and may be prevented by timely treatment...
Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinomaGherardo Mazziotti
Department of Clinical and Experimental Medicine, F. Magrassi and A. Lanzara, Second University of Naples, Naples, Italy
J Bone Miner Res 20:480-6. 2005..The activity of TSH occurs specifically in postmenopausal women in whom the negative effects of L-T4 suppressive therapy on bone mass and metabolism are more marked compared with premenopausal women...
The importance of using strict inclusion criteria in subclinical hypothyroid studiesBernadette Biondi
Am J Med 114:76; author reply 77. 2003
Recombinant human thyrotropin reduces serum vascular endothelial growth factor levels in patients monitored for thyroid carcinoma even in the absence of thyroid tissueFrancesca Sorvillo
Department of Clinical and Experimental Medicine F. Magrassi and A. Lanzara, Second University of Naples, Italy
J Clin Endocrinol Metab 88:4818-22. 2003..This result would suggest that TSH may be able in vivo to regulate VEGF production from tissues other than the thyroid gland...
Effects of thyroid hormone on the cardiovascular systemSerafino Fazio
Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
Recent Prog Horm Res 59:31-50. 2004....
Screening and treatment for subclinical thyroid diseaseBernadette Biondi
JAMA 291:1562; author reply 1562-3. 2004
Cardiovascular effects of mild hypothyroidismBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
Thyroid 17:625-30. 2007....
Flow cytometry phenotypization of thyroidal lymphoid infiltrate and functional status in Hashimoto's thyroiditisPio Zeppa
Department of Anatomic Pathology and Cytopathology, Faculty of Medicine and Surgery, Universita di Napoli Federico II, Naples, Italy
Anal Quant Cytol Histol 28:148-56. 2006..To evaluate the thyroidal lymphoid infiltrate (TLI) in thyroidal functional status (TFS) for differences among patients with Hashimoto's thyroiditis (HT)...
Enhancement of vascular endothelial function by recombinant human thyrotropinRaffaele Napoli
Department of Internal Medicine and Cardiovascular Sciences, University Federico II, Via Pansini 5, Naples, Italy
J Clin Endocrinol Metab 93:1959-63. 2008..The possibility that TSH also affects the cardiovascular system has been poorly explored. Endothelial cells and vascular smooth muscle cells possess TSH receptors...
Hypothyroidism as a risk factor for cardiovascular diseaseBernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, Via S. Pansini 5, 80131, Naples, Italy
Endocrine 24:1-13. 2004..This constellation of reversible cardiovascular abnormalities in patient with TSH levels <10 mU/L indicate that the benefits of treatment of mild thyroid failure with appropriate doses of L-thyroxine outweigh the risk...
Thyroid B-flow twinkling sign: a new feature of papillary cancerLuca Brunese
Department of Health Science, Chair of Radiology, University of Molise, Campobasso, Italy
Eur J Endocrinol 159:447-51. 2008..Using B-flow imaging (BFI), we identified a new sign (the twinkling sign; BFI-TS) in 'suspect' PTC nodules, which appeared to be generated by microcalcifications...
A new marker for diagnosis of thyroid papillary cancer: B-flow twinkling signLuca Brunese
Department of Health Science, University of Molise, Campobasso, Italy
J Ultrasound Med 27:1187-94. 2008....
Should we treat all subjects with subclinical thyroid disease the same way?Bernadette Biondi
Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Eur J Endocrinol 159:343-5. 2008
Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular riskLibuse Tauchmanova
Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Via S Pansini n 5, 801 31 Naples, Italy
J Clin Endocrinol Metab 87:4872-8. 2002..This finding supports the concept that chronic mild endogenous cortisol excess may have important systemic effects on the human body...
