Giuliano Binetti

Summary

Country: Italy

Publications

  1. ncbi request reprint Atypical dementia associated with a novel presenilin-2 mutation
    Giuliano Binetti
    Neurobiology Lab and Memory Clinic, IRCCS Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
    Ann Neurol 54:832-6. 2003
  2. ncbi request reprint The H2 MAPT haplotype is associated with familial frontotemporal dementia
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Dis 22:357-62. 2006
  3. ncbi request reprint Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Exp Cell Res 308:78-84. 2005
  4. ncbi request reprint A novel deletion in progranulin gene is associated with FTDP-17 and CBS
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Aging 29:427-35. 2008
  5. ncbi request reprint Prevalence of TAU mutations in an Italian clinical series of familial frontotemporal patients
    Giuliano Binetti
    Neurobiology Laboratory, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Neurosci Lett 338:85-7. 2003
  6. ncbi request reprint Predictors of cognitive improvement after reality orientation in Alzheimer's disease
    Orazio Zanetti
    I R C C S S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Age Ageing 31:193-6. 2002
  7. ncbi request reprint Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease
    Mariacarla Ventriglia
    Genetics Unit, IRCCS S Giovanni di Dio, Ospedale Fatebenefratelli, Brescia, Italy
    Aging Clin Exp Res 17:445-8. 2005
  8. ncbi request reprint The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 21:266-76. 2009
  9. ncbi request reprint Radial width of the temporal horn: a sensitive measure in Alzheimer disease
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    AJNR Am J Neuroradiol 23:35-47. 2002
  10. ncbi request reprint Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and Americans
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Patient Educ Couns 64:285-93. 2006

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Atypical dementia associated with a novel presenilin-2 mutation
    Giuliano Binetti
    Neurobiology Lab and Memory Clinic, IRCCS Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
    Ann Neurol 54:832-6. 2003
    ..These observations suggest the importance of still unknown biological and perhaps environmental factors in the disease determination...
  2. ncbi request reprint The H2 MAPT haplotype is associated with familial frontotemporal dementia
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Dis 22:357-62. 2006
    ..67, P = 0.001). Our results support idea that the MAPT H2 haplotype is a risk factor for FFTD. This locus could contain this or other inheritable genetic determinants contributing to increase risk of developing dementia...
  3. ncbi request reprint Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Exp Cell Res 308:78-84. 2005
    ..We restored the impaired interaction by inducing heat shock proteins 70 and 90. In addition, we show that P301L tau mutation strongly affects tau and alpha-synuclein neuronal distribution...
  4. ncbi request reprint A novel deletion in progranulin gene is associated with FTDP-17 and CBS
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Aging 29:427-35. 2008
    ..Despite the profound differences in the biological functions of the encoded proteins, it is not possible to define a clinical phenotype distinguishing the disease caused by mutations in MAPT and PGRN genes...
  5. ncbi request reprint Prevalence of TAU mutations in an Italian clinical series of familial frontotemporal patients
    Giuliano Binetti
    Neurobiology Laboratory, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Neurosci Lett 338:85-7. 2003
    ..6%); based on our results we could argue the existence of other mutations in regulatory regions in the TAU gene or, on the other hand, other genes might be responsible for the most cases of familial FTD...
  6. ncbi request reprint Predictors of cognitive improvement after reality orientation in Alzheimer's disease
    Orazio Zanetti
    I R C C S S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Age Ageing 31:193-6. 2002
    ....
  7. ncbi request reprint Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease
    Mariacarla Ventriglia
    Genetics Unit, IRCCS S Giovanni di Dio, Ospedale Fatebenefratelli, Brescia, Italy
    Aging Clin Exp Res 17:445-8. 2005
    ..The object of this study was to investigate the association between this polymorphism of the MnSOD gene and AD in the Italian population...
  8. ncbi request reprint The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 21:266-76. 2009
    ....
  9. ncbi request reprint Radial width of the temporal horn: a sensitive measure in Alzheimer disease
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    AJNR Am J Neuroradiol 23:35-47. 2002
    ..The aim of this study was to explore the validity of a CT- and MR-based measure of MTL atrophy that would be feasible for routine clinical use...
  10. ncbi request reprint Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and Americans
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Patient Educ Couns 64:285-93. 2006
    ....
  11. ncbi request reprint No association between DCP1 genotype and late-onset Alzheimer disease
    Svenja Buss
    Department of Human Genetics, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Am J Med Genet 114:440-5. 2002
    ..Deviations from HWE may limit the comparability of study results and require clarification before drawing conclusions with respect to disease risk, health conditions, or longevity in association with DCP1 genotype...
  12. ncbi request reprint Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
    Neurosci Lett 353:201-4. 2003
    ..011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD...
  13. ncbi request reprint Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
    Neurobiol Dis 18:638-48. 2005
    ..A similar Ca2+ alteration occurred in HeLa and HEK293 cells transiently expressing PS2-T122R. Based on these data, the "Ca2+ overload" hypothesis in AD pathogenesis is here discussed and reformulated...
  14. ncbi request reprint Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients
    Davide Seripa
    Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
    Neurobiol Aging 26:455-64. 2005
    ....
  15. ncbi request reprint Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease
    Claudia Günther
    Department of Human Genetics, University Hospital Hamburg Eppendorf, Butenfeld 42, 22529 Hamburg, Germany
    Neurosci Lett 369:219-23. 2004
    ..The findings suggest that a TFAM haplotype containing rs1937 G (for S12) may be a moderate risk factor for AD...
  16. ncbi request reprint Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementia
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Dement Geriatr Cogn Disord 18:189-96. 2004
    ..Our results demonstrate that possession of at least one LMW apo(a) isoform is significantly associated with dementia and specifically offer new evidence of a strong association between the lipoprotein system and post-stroke dementia...
  17. ncbi request reprint Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease
    Catia Scassellati
    Genetics Unit, I R C C S Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurosci Lett 356:119-22. 2004
    ..Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD...
  18. doi request reprint Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurosci Lett 434:304-9. 2008
    ..This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve...
  19. ncbi request reprint Apolipoprotein(a) null phenotype is related to a delayed age at onset of Alzheimer's disease
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
    Neurosci Lett 357:45-8. 2004
    ..We conclude that the expression of at least one apo(a) isoform may interact with other pathogenic mechanisms involved in controlling the age at onset of AD...
  20. ncbi request reprint Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  21. doi request reprint Exosomes: the Trojan horses of neurodegeneration
    Roberta Ghidoni
    Med Hypotheses 70:1226-7. 2008
  22. ncbi request reprint Tau missing from CSF: a case report
    Antonella Alberici
    J Neurol 254:107-9. 2007
  23. ncbi request reprint Resting EEG sources correlate with attentional span in mild cognitive impairment and Alzheimer's disease
    Claudio Babiloni
    Dip Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Eur J Neurosci 25:3742-57. 2007
    ..05). These results suggest that cortical sources of resting delta and alpha rhythms correlate with neuropsychological measures of immediate memory based on focused attention in the continuum of MCI and AD subjects...
  24. ncbi request reprint Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents beta-amyloid neurotoxicity
    Daniela Uberti
    Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, Italy
    Neuropsychopharmacology 32:872-80. 2007
    ..Thus, these findings may give intracellular TRAIL pathway a role in AD pathophysiology, making DR5 receptor a possible candidate as a pharmacological target...
  25. ncbi request reprint Free copper and resting temporal EEG rhythms correlate across healthy, mild cognitive impairment, and Alzheimer's disease subjects
    Claudio Babiloni
    Dip Fisiologia Umana e Farmacologia, Univ La Sapienza, Rome, Italy
    Clin Neurophysiol 118:1244-60. 2007
    ....
  26. ncbi request reprint Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels
    Giancarlo Zatti
    Department of Biomedical Sciences, University of Padua, Italy
    Cell Calcium 39:539-50. 2006
    ..Taken as a whole, our findings, while confirming the capability of presenilins to modify Ca(2+) homeostasis, suggest a re-evaluation of the "Ca(2+) overload" hypothesis in AD and a new working hypothesis is presented...
  27. ncbi request reprint Frontal white matter volume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease
    Claudio Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, University La Sapienza, Rome, Italy
    Clin Neurophysiol 117:1113-29. 2006
    ..Am J Neuroradiol. 2003 24(3):481-487]. In this study, we tested the hypothesis that such a relationship does exist not only in AD patients but also across the continuum of subjects with mild cognitive impairment (MCI) and AD...
  28. ncbi request reprint Fronto-parietal coupling of brain rhythms in mild cognitive impairment: a multicentric EEG study
    Claudio Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Brain Res Bull 69:63-73. 2006
    ..Future longitudinal research should evaluate whether the present EEG approach is able to predict the cognitive decline in individual MCI subjects...
  29. ncbi request reprint The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores
    Giancarlo Zatti
    Department of Biomedical Sciences, University of Padova, Italy
    Neurobiol Dis 15:269-78. 2004
    ..No significant difference was however found in CCE between FAD and control fibroblasts. Similar results were obtained in two cell lines (HEK293 and HeLa) stably or transiently expressing the PS2 M239I mutation...
  30. ncbi request reprint Mapping distributed sources of cortical rhythms in mild Alzheimer's disease. A multicentric EEG study
    Claudio Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Sezione di EEG ad Alta Risoluzione, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Neuroimage 22:57-67. 2004
    ..Future studies should evaluate the clinical usefulness of this approach in early differential diagnosis, disease staging, and therapy monitoring...
  31. ncbi request reprint Abnormal fronto-parietal coupling of brain rhythms in mild Alzheimer's disease: a multicentric EEG study
    Claudio Babiloni
    Dip Fisiologia Umana e Farmacologia, University La Sapienza Rome, Italy
    Eur J Neurosci 19:2583-90. 2004
    ..These results suggest that mild AD is characterized by an abnormal fronto-parietal coupling of the dominant human cortical rhythm at 8-10.5 Hz...
  32. ncbi request reprint The heterogeneity and natural history of mild cognitive impairment
    Giovanni B Frisoni
    Arch Neurol 62:163; author reply 163-4. 2005
  33. ncbi request reprint Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: a multicentric study
    Claudio Babiloni
    Dip Fisiologia Umana e Farmacologia, Univ La Sapienza Rome, Italy
    Neuroimage 29:948-64. 2006
    ..e., cortical delta and alpha rhythmicity) in MCI and AD subjects, prompting future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects...
  34. ncbi request reprint Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia
    Enzo Emanuele
    Molecular Medicine Laboratory, University of Pavia, IRCCS San Matteo Hospital, Pavia, Italy
    Arch Neurol 62:1734-6. 2005
    ..In addition, administration of sRAGE has been shown to reduce development of cerebral beta-amyloidosis in an Alzheimer disease mouse model...
  35. ncbi request reprint Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: a multicentric electroencephalogram study
    Claudio Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Universita La Sapienza, Rome, Italy
    Ann Neurol 59:323-34. 2006
    ..The present multicentric EEG study tested the hypothesis that presence of epsilon4 affects sources of resting EEG rhythms in both MCI and AD subjects...
  36. ncbi request reprint Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study
    Claudio Babiloni
    Dip Fisiologia Umana e Farmacologia, Univ La Sapienza Rome, Italy
    Clin Neurophysiol 117:252-68. 2006
    ..change across normal elderly (Nold), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects as a function of the global cognitive level...
  37. ncbi request reprint Alzheimer disease-associated cystatin C variant undergoes impaired secretion
    Luisa Benussi
    Neurobiology Lab, IRCCS Centro San Giovanni di Dio, Italy
    Neurobiol Dis 13:15-21. 2003
    ..In the brain, the reduced level of CysC may represent the molecular factor responsible for the increased risk of Alzheimer disease...
  38. ncbi request reprint Individual analysis of EEG frequency and band power in mild Alzheimer's disease
    Davide V Moretti
    Dipartimento Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Clin Neurophysiol 115:299-308. 2004
    ..This EEG study investigates the role of the cholinergic system, cortico-cortical connections, and sub-cortical white matter on the relationship between individual EEG frequencies and their relative power bands...