Roberta Bernini

Summary

Country: Italy

Publications

  1. ncbi Naturally occurring hydroxytyrosol: synthesis and anticancer potential
    R Bernini
    Universita degli Studi della Tuscia, Dipartimento di Scienze e Tecnologie per l Agricoltura, le foreste, la natura e l energia, Viterbo, Italy
    Curr Med Chem 20:655-70. 2013
  2. doi Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Eur J Med Chem 46:439-46. 2011
  3. doi A convenient and safe O-methylation of flavonoids with dimethyl carbonate (DMC)
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Molecules 16:1418-25. 2011
  4. doi Chemoselective C-4 aerobic oxidation of catechin derivatives catalyzed by the Trametes villosa laccase/1-hydroxybenzotriazole system: synthetic and mechanistic aspects
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Università degli Studi della Tuscia, Viterbo, Italy
    J Org Chem 76:820-32. 2011
  5. doi New lipophilic piceatannol derivatives exhibiting antioxidant activity prepared by aromatic hydroxylation with 2-iodoxybenzoic acid (IBX)
    Roberta Bernini
    Agrobiology and Agrochemistry Department, University of Tuscia, Viterbo, Italy
    Molecules 14:4669-81. 2009
  6. doi A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Bioorg Med Chem 17:5676-82. 2009
  7. doi A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role of the catechol moiety on the toxicity of lignans
    Roberta Bernini
    Department of Agrobiology and Agrochemistry, University of Tuscia, 01100, Viterbo, Italy
    Org Biomol Chem 7:2367-77. 2009
  8. doi Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    J Agric Food Chem 56:8897-904. 2008
  9. doi Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters
    Roberta Bernini
    Department of Agriculture, Forests, Nature and Energy DAFNE, University of Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    J Agric Food Chem 60:7408-16. 2012
  10. doi Alkynylation of aryl halides with perfluoro-tagged palladium nanoparticles immobilized on silica gel under aerobic, copper- and phosphine-free conditions in water
    Roberta Bernini
    Dipartimento A B A C, Universita della Tuscia e Consorzio Universitario La Chimica per l Ambiente, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Org Biomol Chem 7:2270-3. 2009

Collaborators

Detail Information

Publications12

  1. ncbi Naturally occurring hydroxytyrosol: synthesis and anticancer potential
    R Bernini
    Universita degli Studi della Tuscia, Dipartimento di Scienze e Tecnologie per l Agricoltura, le foreste, la natura e l energia, Viterbo, Italy
    Curr Med Chem 20:655-70. 2013
    ....
  2. doi Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Eur J Med Chem 46:439-46. 2011
    ..These data suggest that the novel ester might exert a more effective antitumour activity than hydroxytyrosol and α-lipoic acid...
  3. doi A convenient and safe O-methylation of flavonoids with dimethyl carbonate (DMC)
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Molecules 16:1418-25. 2011
    ..This methylation protocol avoids the use of hazardous and high toxic reagents (diazomethane, dimethyl sulfate, methyl iodide)...
  4. doi Chemoselective C-4 aerobic oxidation of catechin derivatives catalyzed by the Trametes villosa laccase/1-hydroxybenzotriazole system: synthetic and mechanistic aspects
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Università degli Studi della Tuscia, Viterbo, Italy
    J Org Chem 76:820-32. 2011
    ....
  5. doi New lipophilic piceatannol derivatives exhibiting antioxidant activity prepared by aromatic hydroxylation with 2-iodoxybenzoic acid (IBX)
    Roberta Bernini
    Agrobiology and Agrochemistry Department, University of Tuscia, Viterbo, Italy
    Molecules 14:4669-81. 2009
    ..The new compounds showed antioxidant activity and seemed promising for possible applications as multifunctional emulsifiers in food, cosmetic and pharmaceutical fields...
  6. doi A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Bioorg Med Chem 17:5676-82. 2009
    ..The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules...
  7. doi A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role of the catechol moiety on the toxicity of lignans
    Roberta Bernini
    Department of Agrobiology and Agrochemistry, University of Tuscia, 01100, Viterbo, Italy
    Org Biomol Chem 7:2367-77. 2009
    ..Thus, despite the in vitro antioxidant activity usually described for catechol derivatives, our results show for the first time the generation of a clastogenic potential, highly indicative of a long-term genetic and cancer risk...
  8. doi Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    J Agric Food Chem 56:8897-904. 2008
    ....
  9. doi Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters
    Roberta Bernini
    Department of Agriculture, Forests, Nature and Energy DAFNE, University of Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    J Agric Food Chem 60:7408-16. 2012
    ..Less evident positive effects have been detected in whole cells experiments. Cytotoxicity experiments, using MTT assay, on a representative set of compounds evidenced no influence in cell survival. ..
  10. doi Alkynylation of aryl halides with perfluoro-tagged palladium nanoparticles immobilized on silica gel under aerobic, copper- and phosphine-free conditions in water
    Roberta Bernini
    Dipartimento A B A C, Universita della Tuscia e Consorzio Universitario La Chimica per l Ambiente, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Org Biomol Chem 7:2270-3. 2009
    ....
  11. doi Novel phenotypes related to the breeding of purple-fruited tomatoes and effect of peel extracts on human cancer cell proliferation
    Andrea Mazzucato
    Department of Agriculture, Forests, Nature and Energy DAFNE, University of Tuscia, Via San Camillo de Lellis snc, 01100 Viterbo, Italy Electronic address
    Plant Physiol Biochem 72:125-33. 2013
    ....
  12. doi 2-Arylhydroxytyrosol derivatives via Suzuki-Miyaura cross-coupling
    Roberta Bernini
    Dipartimento A B A C, Universita degli Studi della Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Org Lett 10:3457-60. 2008
    ..A remarkable halide effect has been observed. 2-Iodo- and 2-bromohydroxytyrosol derivatives have been found to be ineffective cross-coupling partners in many cases. The acetonide and carbonate protecting groups can be readily removed...