Roberta Bernini

Summary

Country: Italy

Publications

  1. ncbi request reprint Naturally occurring hydroxytyrosol: synthesis and anticancer potential
    R Bernini
    Universita degli Studi della Tuscia, Dipartimento di Scienze e Tecnologie per l Agricoltura, le foreste, la natura e l energia, Viterbo, Italy
    Curr Med Chem 20:655-70. 2013
  2. doi request reprint A convenient and safe O-methylation of flavonoids with dimethyl carbonate (DMC)
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Molecules 16:1418-25. 2011
  3. doi request reprint Chemoselective C-4 aerobic oxidation of catechin derivatives catalyzed by the Trametes villosa laccase/1-hydroxybenzotriazole system: synthetic and mechanistic aspects
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Università degli Studi della Tuscia, Viterbo, Italy
    J Org Chem 76:820-32. 2011
  4. doi request reprint Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Eur J Med Chem 46:439-46. 2011
  5. doi request reprint New lipophilic piceatannol derivatives exhibiting antioxidant activity prepared by aromatic hydroxylation with 2-iodoxybenzoic acid (IBX)
    Roberta Bernini
    Agrobiology and Agrochemistry Department, University of Tuscia, Viterbo, Italy
    Molecules 14:4669-81. 2009
  6. doi request reprint A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Bioorg Med Chem 17:5676-82. 2009
  7. doi request reprint A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role of the catechol moiety on the toxicity of lignans
    Roberta Bernini
    Department of Agrobiology and Agrochemistry, University of Tuscia, 01100, Viterbo, Italy
    Org Biomol Chem 7:2367-77. 2009
  8. doi request reprint Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    J Agric Food Chem 56:8897-904. 2008
  9. doi request reprint Alkynylation of aryl halides with perfluoro-tagged palladium nanoparticles immobilized on silica gel under aerobic, copper- and phosphine-free conditions in water
    Roberta Bernini
    Dipartimento A B A C, Universita della Tuscia e Consorzio Universitario La Chimica per l Ambiente, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Org Biomol Chem 7:2270-3. 2009
  10. doi request reprint Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters
    Roberta Bernini
    Department of Agriculture, Forests, Nature and Energy DAFNE, University of Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    J Agric Food Chem 60:7408-16. 2012

Detail Information

Publications11

  1. ncbi request reprint Naturally occurring hydroxytyrosol: synthesis and anticancer potential
    R Bernini
    Universita degli Studi della Tuscia, Dipartimento di Scienze e Tecnologie per l Agricoltura, le foreste, la natura e l energia, Viterbo, Italy
    Curr Med Chem 20:655-70. 2013
    ....
  2. doi request reprint A convenient and safe O-methylation of flavonoids with dimethyl carbonate (DMC)
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Molecules 16:1418-25. 2011
    ..This methylation protocol avoids the use of hazardous and high toxic reagents (diazomethane, dimethyl sulfate, methyl iodide)...
  3. doi request reprint Chemoselective C-4 aerobic oxidation of catechin derivatives catalyzed by the Trametes villosa laccase/1-hydroxybenzotriazole system: synthetic and mechanistic aspects
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Università degli Studi della Tuscia, Viterbo, Italy
    J Org Chem 76:820-32. 2011
    ....
  4. doi request reprint Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Eur J Med Chem 46:439-46. 2011
    ..These data suggest that the novel ester might exert a more effective antitumour activity than hydroxytyrosol and α-lipoic acid...
  5. doi request reprint New lipophilic piceatannol derivatives exhibiting antioxidant activity prepared by aromatic hydroxylation with 2-iodoxybenzoic acid (IBX)
    Roberta Bernini
    Agrobiology and Agrochemistry Department, University of Tuscia, Viterbo, Italy
    Molecules 14:4669-81. 2009
    ..The new compounds showed antioxidant activity and seemed promising for possible applications as multifunctional emulsifiers in food, cosmetic and pharmaceutical fields...
  6. doi request reprint A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Bioorg Med Chem 17:5676-82. 2009
    ..The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules...
  7. doi request reprint A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role of the catechol moiety on the toxicity of lignans
    Roberta Bernini
    Department of Agrobiology and Agrochemistry, University of Tuscia, 01100, Viterbo, Italy
    Org Biomol Chem 7:2367-77. 2009
    ..Thus, despite the in vitro antioxidant activity usually described for catechol derivatives, our results show for the first time the generation of a clastogenic potential, highly indicative of a long-term genetic and cancer risk...
  8. doi request reprint Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol
    Roberta Bernini
    Dipartimento di Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    J Agric Food Chem 56:8897-904. 2008
    ....
  9. doi request reprint Alkynylation of aryl halides with perfluoro-tagged palladium nanoparticles immobilized on silica gel under aerobic, copper- and phosphine-free conditions in water
    Roberta Bernini
    Dipartimento A B A C, Universita della Tuscia e Consorzio Universitario La Chimica per l Ambiente, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Org Biomol Chem 7:2270-3. 2009
    ....
  10. doi request reprint Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters
    Roberta Bernini
    Department of Agriculture, Forests, Nature and Energy DAFNE, University of Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    J Agric Food Chem 60:7408-16. 2012
    ..Less evident positive effects have been detected in whole cells experiments. Cytotoxicity experiments, using MTT assay, on a representative set of compounds evidenced no influence in cell survival. ..
  11. doi request reprint 2-Arylhydroxytyrosol derivatives via Suzuki-Miyaura cross-coupling
    Roberta Bernini
    Dipartimento A B A C, Universita degli Studi della Tuscia, Via S Camillo de Lellis, 01100 Viterbo, Italy
    Org Lett 10:3457-60. 2008
    ..A remarkable halide effect has been observed. 2-Iodo- and 2-bromohydroxytyrosol derivatives have been found to be ineffective cross-coupling partners in many cases. The acetonide and carbonate protecting groups can be readily removed...