G Bassotti

Summary

Country: Italy

Publications

  1. ncbi request reprint Enteric glial cells and their role in gastrointestinal motor abnormalities: introducing the neuro-gliopathies
    Gabrio Bassotti
    World J Gastroenterol 13:4035-41. 2007
  2. ncbi request reprint Low-amplitude propagated contractile waves: a relevant propulsive mechanism of human colon
    G Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    Dig Liver Dis 33:36-40. 2001
  3. ncbi request reprint Twenty-four hour recordings of colonic motility in patients with diverticular disease: evidence for abnormal motility and propulsive activity
    G Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy
    Dis Colon Rectum 44:1814-20. 2001
  4. ncbi request reprint Normal aspects of colorectal motility and abnormalities in slow transit constipation
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Dept of Clinical and Experimental Medicine, University of Perugia Medical School, Strada del Cimitero 2 a, 06131 San Marco, Perugia, Italy
    World J Gastroenterol 11:2691-6. 2005
  5. ncbi request reprint Slow transit constipation: a functional disorder becomes an enteric neuropathy
    Gabrio Bassotti
    World J Gastroenterol 12:4609-13. 2006
  6. pmc TOPOIIalpha and HER-2/neu overexpression/amplification in Barrett's oesophagus, dysplasia and adenocarcinoma
    Elisa Rossi
    2nd Department of Pathology, University of Brescia Spedali Civili, Brescia, Italy
    Histopathology 57:81-9. 2010
  7. doi request reprint A practical approach to diagnosis and management of functional constipation in adults
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Intern Emerg Med 8:275-82. 2013
  8. doi request reprint Understanding constipation treatment: do we need to strain to obtain better results?
    Gabrio Bassotti
    Professor, Clinica di Gastroenterologia ed Epatologia, Ospedale Santa Maria della Misericordia, Piazzale Menghini, 1, 06156 San Sisto Perugia, Italy 39 075 584 7570
    Expert Opin Drug Metab Toxicol 9:387-9. 2013
  9. ncbi request reprint The role of colonic mast cells and myenteric plexitis in patients with diverticular disease
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Int J Colorectal Dis 28:267-72. 2013
  10. doi request reprint Colonic diverticular disease: abnormalities of neuromuscular function
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dig Dis 30:24-8. 2012

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Enteric glial cells and their role in gastrointestinal motor abnormalities: introducing the neuro-gliopathies
    Gabrio Bassotti
    World J Gastroenterol 13:4035-41. 2007
    ....
  2. ncbi request reprint Low-amplitude propagated contractile waves: a relevant propulsive mechanism of human colon
    G Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    Dig Liver Dis 33:36-40. 2001
    ..By contrast, information on less vigorous propulsive contractions is still lacking...
  3. ncbi request reprint Twenty-four hour recordings of colonic motility in patients with diverticular disease: evidence for abnormal motility and propulsive activity
    G Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy
    Dis Colon Rectum 44:1814-20. 2001
    ..CONCLUSIONS: We concluded that patients with diverticular disease of the colon have abnormal motor and propulsive activities of the large bowel, which are confined to the affected segments...
  4. ncbi request reprint Normal aspects of colorectal motility and abnormalities in slow transit constipation
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Dept of Clinical and Experimental Medicine, University of Perugia Medical School, Strada del Cimitero 2 a, 06131 San Marco, Perugia, Italy
    World J Gastroenterol 11:2691-6. 2005
    ..These data have helped in elucidating, although only in part, some pathophysiological mechanisms of chronic constipation, and especially of the STC subtype...
  5. ncbi request reprint Slow transit constipation: a functional disorder becomes an enteric neuropathy
    Gabrio Bassotti
    World J Gastroenterol 12:4609-13. 2006
    ..In the present article we will discuss these evidences, and will try to put them in relation with the abnormal motor function of the large bowel documented in this pathological condition...
  6. pmc TOPOIIalpha and HER-2/neu overexpression/amplification in Barrett's oesophagus, dysplasia and adenocarcinoma
    Elisa Rossi
    2nd Department of Pathology, University of Brescia Spedali Civili, Brescia, Italy
    Histopathology 57:81-9. 2010
    ..The aim was to investigate gene amplification and protein overexpression of TopoIIalpha and Her-2/neu in non-dysplastic BO, dysplastic BO, Barrett ADC, and chromosome 17 aneusomy...
  7. doi request reprint A practical approach to diagnosis and management of functional constipation in adults
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Intern Emerg Med 8:275-82. 2013
    ..This review will analyse the clinical and diagnostic aspects of chronic constipation in adult patients, with emphasis on recent therapeutic approaches...
  8. doi request reprint Understanding constipation treatment: do we need to strain to obtain better results?
    Gabrio Bassotti
    Professor, Clinica di Gastroenterologia ed Epatologia, Ospedale Santa Maria della Misericordia, Piazzale Menghini, 1, 06156 San Sisto Perugia, Italy 39 075 584 7570
    Expert Opin Drug Metab Toxicol 9:387-9. 2013
    ..As for many other pathological issues, understanding the pathophysiological grounds of the condition to face greatly simplifies and accurately individuates the problem, to target the problem and help in reaching the therapeutic goal...
  9. ncbi request reprint The role of colonic mast cells and myenteric plexitis in patients with diverticular disease
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Int J Colorectal Dis 28:267-72. 2013
    ..Gut mast cells represent an important cell population involved in intestinal homeostasis and inflammatory processes. However, their possible role has not to date been investigated in colonic diverticular disease...
  10. doi request reprint Colonic diverticular disease: abnormalities of neuromuscular function
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dig Dis 30:24-8. 2012
    ..The latter may have a role of paramount importance in the development of visceral hypersensitivity, responsible for abdominal pain in a subset of patients...
  11. ncbi request reprint Evaluating slow-transit constipation in patients using laxatives: a better approach or do we need improved patient selection?
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Santa Maria della Misericordia Hospital, 1, 06156 San Sisto Perugia, Italy
    Expert Rev Gastroenterol Hepatol 6:145-7. 2012
    ..Thus, the use of laxatives seems to influence the clinical aspects of patients with slow-transit constipation, and this should be considered when evaluating these participants...
  12. doi request reprint An assessment of enteric nervous system and estroprogestinic receptors in obstructed defecation associated with rectal intussusception
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Neurogastroenterol Motil 24:e155-61. 2012
    ..We investigated ENS abnormalities in patients with OD, undergoing surgery, together with the presence of estrogen (α and β) and progesterone receptors, and compare the results with those obtained in controls...
  13. ncbi request reprint Short-segment jejunal carcinoma mimicking multiple lesions of the small bowel at capsule endoscopy
    G Bassotti
    Gastroenterology and Hepatology Section, University of Perugia Medical School, Perugia, Italy
    Endoscopy 39:E153. 2007
  14. ncbi request reprint Colonic propulsive and postprandial motor activity in patients with ulcerative colitis in remission
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, 06100 Perugia, Italy
    Eur J Gastroenterol Hepatol 18:507-10. 2006
    ..Recent evidence suggests that the propulsive activity is highly increased during the active phase of the disease, probably contributing to the diarrhoea. However, data are even scarcer in the quiescent phase of the disease...
  15. ncbi request reprint Treatment with botulinum toxin of octo-nonagerians with oesophageal achalasia: a two-year follow-up study
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Aliment Pharmacol Ther 23:1615-9. 2006
    ..Treatment of oesophageal achalasia with intrasphincteric injections of botulinum toxin has proved to be a successful alternative treatment modality. However, little is known about its long-term effects in very old patients...
  16. pmc Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, Padiglione W, 06100 Perugia, Italy
    J Clin Pathol 58:973-7. 2005
    ..However, little is known about the basic mechanism that may underlie abnormal colon motility in diverticulosis...
  17. pmc The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation
    G Bassotti
    Clinica di Gastroenterologia ed Epatologia, Via Enrico Dal Pozzo, Padiglione W, 06100 Perugia, Italy
    Gut 55:41-6. 2006
    ..As motor abnormalities are thought to play an important pathogenetic role, studies have been performed on the colonic neuroenteric system, which rules the motor aspects of the viscus...
  18. ncbi request reprint Alterations in colonic motility and relationship to pain in colonic diverticulosis
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Clin Gastroenterol Hepatol 3:248-53. 2005
    ....
  19. ncbi request reprint Case report: colonic manometry reveals abnormal propulsive behaviour after anterior resection of the rectum
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, Azienda Ospedaliera and University of Perugia, Italy
    Dig Liver Dis 37:124-8. 2005
    ..High-amplitude simultaneous contractions were also observed. We feel that the surgical resection of a potential physiological brake may be responsible for these observations...
  20. ncbi request reprint Enteric neuropathology of the terminal ileum in patients with intractable slow-transit constipation
    Gabrio Bassotti
    Department of Clinical and Experimental Medicine, Clinic of Gastroenterology and Hepatology, University of Perugia, Via Enrico Dal Pozzo, Padiglione W, 06100 Perugia, Italy
    Hum Pathol 37:1252-8. 2006
    ....
  21. ncbi request reprint Comparison of three methods to assess enteric neuronal apoptosis in patients with slow transit constipation
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Apoptosis 12:329-32. 2007
    ..Some recent evidence suggests that increased apoptotic phenomena in the colonic enteric neurons may play a role. However, the best method to assess these phenomena has not been evaluated...
  22. doi request reprint Increase of colonic mast cells in obstructed defecation and their relationship with enteric glia
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dig Dis Sci 57:65-71. 2012
    ..Mast cells are involved in visceral hypersensitivity and motor activity of the gastrointestinal tract. However, there is almost no information concerning mast cells in constipated patients...
  23. doi request reprint Beyond hematoxylin and eosin: the importance of immunohistochemical techniques for evaluating surgically resected constipated patients
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Tech Coloproctol 15:371-5. 2011
    ..By employing some simple and widely available immunohistochemical methods, discussed in this review, it is possible to gather data that may help in explaining the pathophysiological basis of constipation in these patients...
  24. doi request reprint Colonic mast cells in controls and slow transit constipation patients
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Piazza Menghini 1, San Sisto Perugia, Italy
    Aliment Pharmacol Ther 34:92-9. 2011
    ..However, most data are only available for clinical conditions characterised by diarrhoea, where MC have chiefly investigated in the mucosal layer of the colon and there is almost no information concerning constipation...
  25. ncbi request reprint Painful constipation: a neglected entity?
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Brescia, Italy
    Rev Esp Enferm Dig 103:25-8. 2011
    ..The present article reviews the current knowledge about painful constipation, trying to put together the scarce data available, and to frame it in the more general context of chronic constipation...
  26. doi request reprint Can "functional" constipation be considered as a form of enteric neuro-gliopathy?
    Gabrio Bassotti
    Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology Section, University of Perugia, Italy
    Glia 59:345-50. 2011
    ..In this article we will discuss these evidences, and will try to consider constipation no more as a simple functional or idiopathic disorder but as a form of enteric neuro-gliopathy...
  27. ncbi request reprint Enteric glial cells: new players in gastrointestinal motility?
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Lab Invest 87:628-32. 2007
    ..Thus, as also shown by recent evidence in both experimental animal models, and in some human diseases, alterations of enteric glial cells might have some role in the development of intestinal motor abnormalities...
  28. ncbi request reprint Apoptotic phenomena are not a major cause of enteric neuronal loss in constipated patients with dementia
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Neuropathology 27:67-72. 2007
    ....
  29. ncbi request reprint Colonic neuropathological aspects in patients with intractable constipation due to obstructed defecation
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Mod Pathol 20:367-74. 2007
    ..These findings might explain some of the pathophysiological abnormalities, and help to better understand this condition...
  30. ncbi request reprint Colonic motility studies in severe chronic constipation: an organic approach to a functional problem
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Medical School, Perugia, Italy
    Tech Coloproctol 8:147-50. 2004
    ..This article focuses on the current diagnostic approach to chronic constipation, with an emphasis on the possible role of colonic manometry to help better choose those patients that may benefit from surgery...
  31. ncbi request reprint Pseudo-pseudo-obstruction
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, San Marco, Italy
    Eur J Gastroenterol Hepatol 16:1039-41. 2004
    ..We present here a case in which such a diagnosis was suspected, but a thorough in-depth evaluation revealed that the symptoms were due to a treatable cause--abdominopelvic adhesions...
  32. ncbi request reprint Colonic propulsive impairment in intractable slow-transit constipation
    Gabrio Bassotti
    Gastroenterolgy and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy
    Arch Surg 138:1302-4. 2003
    ..An overall impairment of colonic propulsive activity may represent a major disease mechanism...
  33. pmc Biofeedback for pelvic floor dysfunction in constipation
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, 06100 Perugia, Italy
    BMJ 328:393-6. 2004
  34. ncbi request reprint Symptomatic reversible duodenal compression due to iatrogenic retroperitoneal hematoma
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical, and Experimental Medicine, University of Perugia, Perugia, Italy
    Dig Liver Dis 36:78-81. 2004
    ..We describe a case of reversible symptomatic duodenal compression caused by a retroperitoneal hematoma after ingestion of sertraline and nimesulide...
  35. ncbi request reprint Of tubes and men: studying manometrically the effects of laxatives on colonic motility
    G Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    Eur J Gastroenterol Hepatol 13:631-3. 2001
    ....
  36. ncbi request reprint An extended assessment of bowel habits in a general population
    Gabrio Bassotti
    Sezione di Gastroenterologia ed Epatologia, Dipartamento di Medicina Clinica e Sperimentale, Universita di Perugia, Strada del Cimitero 2 a, 06131 San Marco, Perugia, Italy
    World J Gastroenterol 10:713-6. 2004
    ..The aim of this prospective study was to objectively assess the bowel habits and related aspects in a large sample drawn from the general population...
  37. ncbi request reprint Pathophysiological aspects of diverticular disease of colon and role of large bowel motility
    Gabrio Bassotti
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Italy
    World J Gastroenterol 9:2140-2. 2003
    ..The present review considers the pathophysiology of colonic diverticular disease, with a special emphasis on factors related to abnormal colonic motility...
  38. ncbi request reprint Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures
    G Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia School of Medicine, Italy
    Dig Liver Dis 32:699-702. 2000
    ..Interest has, therefore, recently increased in "chemical sphincterotomy" by using topical glyceryl trinitrate ointment. Unfortunately, there is, to date, no specific pharmaceutical preparation of such compound...
  39. ncbi request reprint Are colonic regular contractile frequency patterns in slow transit constipation a relevant pathophysiological phenomenon?
    G Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, 06131 San Marco Perugia, Italy
    Dig Liver Dis 35:552-6. 2003
    ..Pathogenesis of slow transit constipation still remains elusive. Some studies have shown several colonic motor abnormalities; however, it is not easy to understand the relative importance of the single ones...
  40. ncbi request reprint Toward a definition of colonic inertia
    Gabrio Bassotti
    Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    World J Gastroenterol 10:2465-7. 2004
    ..In this paper these concepts are reviewed and a more stringent definition of colonic inertia is proposed...
  41. ncbi request reprint Empirical antibiotic treatment with piperacillin-tazobactam in patients with microbiologically-documented biliary tract infections
    Gabrio Bassotti
    Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Strada del Cimitero, 2 A, San Marco 06131 Perugia, Italy
    World J Gastroenterol 10:2281-3. 2004
    ....
  42. ncbi request reprint Abnormal colonic propagated activity in patients with slow transit constipation and constipation-predominant irritable bowel syndrome
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Digestion 68:178-83. 2003
    ..The pathophysiological basis of constipation is still unclear, and the role of colonic dysfunction is debated, especially in irritable bowel syndrome. Objective data are quite scarce, especially concerning colonic propulsive activity...
  43. ncbi request reprint Twenty-four-hour manometric study of colonic propulsive activity in patients with diarrhea due to inflammatory (ulcerative colitis) and non-inflammatory (irritable bowel syndrome) conditions
    Gabrio Bassotti
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Via Enrico Dal Pozzo, Padiglione W, Perugia, Italy
    Int J Colorectal Dis 19:493-7. 2004
    ..Little is known concerning colonic motility and almost nothing is known concerning propulsive activity in pathological conditions characterized by diarrhea of both inflammatory and non-inflammatory origin...
  44. ncbi request reprint Review article: pharmacological options in achalasia
    G Bassotti
    Gastrointestinal Motility Laboratory, GI and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia School of Medicine, Italy
    Aliment Pharmacol Ther 13:1391-6. 1999
    ....
  45. ncbi request reprint Intestinal manometry: value and limitations
    G Bassotti
    Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy
    Diabetes Nutr Metab 17:33-7. 2004
  46. pmc Manometric investigation of anorectal function in early and late stage Parkinson's disease
    G Bassotti
    Laboratorio di Motilità Intestinale, Sezione di Gastroenterologia ed Epatologia, Via Enrico Dal Pozzo, 06100 Perugia, Italy
    J Neurol Neurosurg Psychiatry 68:768-70. 2000
    ..In conclusion, defecatory dysfunction is frequent in Parkinson's disease, it is not confined to late stage patients, and it is found early in the course of the disease. This has potential implications for a targeted therapeutic approach...
  47. ncbi request reprint Chromosomal study of enteric glial cells and neurons by fluorescence in situ hybridization in slow transit constipation
    E Rossi
    Second Department of Pathology, Spedali Civili, Brescia, Italy
    Neurogastroenterol Motil 19:578-84. 2007
    ..No other abnormalities were found for the remaining probes, and no abnormalities were found in controls. We concluded that in a subgroup of patients with slow transit constipation a genetic basis may be present...
  48. ncbi request reprint Enteric nervous system abnormalities in inflammatory bowel diseases
    V Villanacci
    2nd Department of Pathology, Spedali Civili and University of Brescia, Brescia, Italy
    Neurogastroenterol Motil 20:1009-16. 2008
    ..The study confirms the presence of abnormalities of the different cells of the ENS in IBD. The presence of lesions in samples from uninvolved areas, such as a reduction of enteroglia, supports a pathogenetic role of the ENS...
  49. ncbi request reprint Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system
    V Villanacci
    II Department of Pathology, Spedali Civili and University of Brescia, Brescia, Italy
    Neurogastroenterol Motil 20:206-12. 2008
    ..In conclusion, Rai is expressed in the human gut, especially in the enteric glial cells. We conclude that Rai may provide an additional marker for this cell type...
  50. ncbi request reprint COX-2, CDX2, and CDC2 immunohistochemical assessment for dysplasia-carcinoma progression in Barrett's esophagus
    V Villanacci
    2nd Department of Pathology, Spedali Civili, University of Brescia, Italy
    Dig Liver Dis 39:305-11. 2007
    ..Immunohistochemical changes associated with development of cancer in Barrett's esophagus offer potential areas of intervention to prevent and manage esophageal cancer...
  51. doi request reprint Colonic lymphoid follicles and NOD2/CARD15 mutational status in Crohn's disease
    R Nascimbeni
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Br J Surg 96:655-62. 2009
    ..This study analysed variations of colonic lymphoid follicles (CLFs) according to the nucleotide-binding oligomerization domain 2 (NOD2) and caspase recruitment domain-containing protein 15 (CARD15) gene in patients with Crohn's disease...
  52. doi request reprint A simplified method for anal ultrasonography: assessment of patient satisfaction and the simplicity of the procedure
    D Castellani
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Tech Coloproctol 12:207-9. 2008
    ....
  53. ncbi request reprint Ischaemia: a pathogenetic clue in diversion colitis?
    V Villanacci
    2nd Pathology Department, Spedali Civili, Brescia, Italy
    Colorectal Dis 9:601-5. 2007
    ..Our aim is to look for signs of ischaemia in a group of patients developing colitis after diversion colostomy for various causes...
  54. ncbi request reprint Comparison of two different formulations of botulinum toxin A for the treatment of oesophageal achalasia. The Gismad Achalasia Study Group
    V Annese
    Divisione di Gastroenterologia, Ospedale C S S IRCSS, San Giovanni Rotondo, Italy
    Aliment Pharmacol Ther 13:1347-50. 1999
    ..Intrasphincteric injection of botulinum toxin has been reported as a safe and effective alternative treatment in oesophageal achalasia, especially in high-risk and elderly patients...
  55. ncbi request reprint Colonic lymphoid aggregates in slow transit constipation
    Vincenzo Villanacci
    2nd Pathology Department, Spedali Civili, Brescia, Italy
    Dig Dis Sci 52:321-3. 2007
    ..No differences were found concerning the other variables. The increase of colonic lymphoid aggregates found in severely constipated patients may represent a protective mucosal mechanism toward the chronic fecal stasis...
  56. ncbi request reprint One-year follow-up study on the effects of electrogalvanic stimulation in chronic idiopathic constipation with pelvic floor dyssynergia
    Giuseppe Chiarioni
    Gastrointestinal Rehabilitation Division, Valeggio sul Mincio Hospital, Azienda Ospedaliera, University of Verona, Verona, Italy
    Dis Colon Rectum 47:346-53. 2004
    ..The standard therapeutic approach for pelvic floor dyssynergia is biofeedback training, but long-term studies show that a significant percentage of patients remain symptomatic. Alternative or adjunctive therapeutic options are needed...
  57. ncbi request reprint Comparison of the Marsh-Oberhuber classification with a new grading system in identifying patients with latent celiac disease
    V Villanacci
    Department of Pathology, University of Brescia, Brescia, Italy
    Minerva Gastroenterol Dietol 56:371-5. 2010
    ..However, these descriptions are often unable to identify latent CD. The aim of this study was to evaluate whether the Marsh-Oberhuber classification and a recently proposed classification may help to identify patients with latent CD...
  58. ncbi request reprint Pharmacological treatment of irritable bowel syndrome: a critical assessment
    G Bassotti
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Italy
    Scand J Gastroenterol 38:1013-5. 2003
  59. ncbi request reprint Manometric assessment of idiopathic megarectum in constipated children
    Giuseppe Chiarioni
    Clinica di Gastroenterologia ed Epatologia Via Enrico Dal Pozzo, Padiglione W, Perugia 06100, Italy
    World J Gastroenterol 11:6027-30. 2005
    ..Data from this group were compared with those obtained in a similar group of children with recurrent abdominal pain...
  60. ncbi request reprint Targeted therapy with trastuzumab in dysplasia and adenocarcinoma arising in Barrett's esophagus: a translational approach
    V Villanacci
    Department of Pathology, University of Brescia, Spedali Civili, Brescia, Italy
    Minerva Gastroenterol Dietol 54:347-53. 2008
    ..The aim of this study was to evaluate the therapeutic role of the anti-HER2 monoclonal antibody, trastuzumab, in the management of ADC originating from HER2-positive Barrett's esophagus (BE)...
  61. ncbi request reprint Colonic regular contractile frequency patterns in irritable bowel syndrome: the 'spastic colon' revisited
    Gabrio Bassotti
    Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Eur J Gastroenterol Hepatol 16:613-7. 2004
    ..Among the various proposed mechanisms, colonic motility may play a role, at least in a subset of patients...
  62. ncbi request reprint Antroduodenojejunal motor activity in untreated and treated celiac disease patients
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Gastroenterol Hepatol 23:e23-8. 2008
    ..Conclusions: Upper gut motor abnormalities are frequent in patients with celiac disease, even in those on a gluten-free diet. In the latter group, these abnormalities may suggest an incomplete adherence to the dietary regimen...
  63. ncbi request reprint An immunohistochemical study of the myenteric plexus in idiopathic achalasia
    Vincenzo Villanacci
    2nd Department of Pathology, Spedali Civili, Brescia, Italy
    J Clin Gastroenterol 44:407-10. 2010
    ..The pathophysiologic abnormalities may be the final result of several intermeshing mechanisms, and more than one single factor may cause the motor abnormalities...
  64. ncbi request reprint Role of T-helper type 2 cytokines in down-modulation of fas mRNA and receptor on the surface of activated CD4(+) T cells: molecular basis for the persistence of the allergic immune response
    F Spinozzi
    Laboratory of Allergology and Clinical Immunology, Department of Clinical and Experimental Medicine, Perugia, Italy
    FASEB J 12:1747-53. 1998
    ..T-helper type 2 cytokines (IL-4, IL-5, and GM-CSF) had a dose-dependent and specific inhibitory effect on Fas mRNA, suggesting a new fundamental biological role in the survival of inflammatory cells during allergen exposure...
  65. ncbi request reprint Gastrointestinal stromal tumors: usefulness of immunohistochemistry, flow cytometry and fluorescence in situ hybridization
    Maria Grazia Fontana
    First Department of Surgery, University of Brescia, Brescia, Italy
    J Gastroenterol Hepatol 22:1754-9. 2007
    ..This retrospective study evaluated a series of GIST by means of immunohistochemical techniques, flow cytometry and fluorescence in situ hybridization (FISH)...
  66. ncbi request reprint Diversion of the fecal stream resolves ulcerative colitis complicating chronic granulomatous disease in an adult patient
    Vincenzo Villanacci
    2nd Department of Pathology, Spedali Civili, University of Brescia, Brescia, Italy
    J Clin Gastroenterol 41:491-3. 2007
    ..The patient had a prompt improvement (continuing up to more than 5 y of follow-up) of the clinical picture after ileostomy and fecal diversion...
  67. ncbi request reprint A simplified method for anal ultrasonography: preliminary report
    Danilo Castellani
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Clin Gastroenterol 43:453-6. 2009
    ..Anal endosonography (AES) is able to reliably visualize and identify anal sphincter abnormalities. However, dedicated probes are quite expensive...
  68. ncbi request reprint Immunocytochemical assessment of p53 protein to detect malignancy in increased cell-yield brush cytology from the biliopancreatic tree
    Vincenzo Villanacci
    2nd Department of Pathology, Spedali Civili, University of Brescia, Brescia, Italy
    Dig Dis Sci 54:789-92. 2009
    ..Malignancies arising from the biliopancreatic tree are often diagnostic challenges for the gastroenterologist and the pathologist, especially when strictures without masses are present...
  69. ncbi request reprint Long-term study on the effects of visual biofeedback and muscle training as a therapeutic modality in pelvic floor dyssynergia and slow-transit constipation
    Edda Battaglia
    Servizio di Endoscopia e Motilità Intestinale, Cattedra di Medicina Interna, Dipartimento di Fisiopatologia Clinica, Universita di Torino, Torino, Italy
    Dis Colon Rectum 47:90-5. 2004
    ..This study was designed to assess in an objective way the medium- and long-term effects of biofeedback and muscle training in patients with pelvic floor dyssynergia and slow-transit constipation...
  70. ncbi request reprint Descending perineum syndrome: are abdominal hysterectomy and bowel habits linked?
    Filippo Pucciani
    Dipartimento di Area Critica Medico Chirurgica, Sezione di Clinica Chirurgica Generale e Discipline Chirurgiche, Unità di Colon Proctologia, Universita di Firenze, Firenze Careggi, Italy
    Dis Colon Rectum 48:2094-9. 2005
    ..This retrospective study evaluates the effect of abdominal hysterectomy on patients affected by descending perineum syndrome...
  71. ncbi request reprint The enteric nervous system in chagasic and idiopathic megacolon
    Guido Iantorno
    Digestive Motility Section, Dr C B Udaondo Hospital, Buenos Aires, Argentina
    Am J Surg Pathol 31:460-8. 2007
    ..Patients with chagasic megacolon display important abnormalities of several components of the enteric nervous system. Similar alterations, although of lesser severity, may be found in patients with idiopathic megacolon...
  72. ncbi request reprint Audit of constipation in a gastroenterology referral center
    Guido Iantorno
    Unidad de Motilidad Digestiva, Hospital de Gastroenterologia Dr C Bonorino Udaondo, Buenos Aires, Argentina
    Dig Dis Sci 52:317-20. 2007
    ..Simple, physiologic testing is needed and useful for the diagnosis. This fact has therapeutic implications, especially because many such patients may benefit from biofeedback...
  73. ncbi request reprint Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Am J Gastroenterol 97:2454-9. 2002
    ..The immunosuppressive approach deserves further investigation in patients with severe gut motor abnormalities attributable to idiopathic myenteric ganglionitis...
  74. ncbi request reprint Colonic manometry: for children only? A typical case of paradoxical motility
    Gabrio Bassotti
    Am J Gastroenterol 98:949-50. 2003
  75. ncbi request reprint Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia
    Giuseppe Chiarioni
    Gastrointestinal Rehabilitation Division, Valeggio sul Mincio Hospital, Azienda Ospedaliera and University of Verona, Verona, Italy
    Gastroenterology 130:657-64. 2006
    ..The aim was to compare biofeedback to laxatives plus education...
  76. ncbi request reprint Botulinum toxin treatment of oesophageal achalasia in the old old and oldest old: a 1-year follow-up study
    Luca Dughera
    Department of Gastroenterology and Clinical Nutrition, University of Torino, Torino, Italy
    Drugs Aging 22:779-83. 2005
    ..This treatment seems particularly effective in elderly patients who are not candidates for more invasive procedures...
  77. ncbi request reprint Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis
    Edda Battaglia
    Department of Gastroenterology and Clinical Nutrition, University of Torino, Italy
    World J Gastroenterol 12:6172-7. 2006
    ..To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC)...
  78. ncbi request reprint Noncardiac chest pain of esophageal origin in patients with and without coronary artery disease
    Edda Battaglia
    Servizio di Endoscopia e Motilità Intestinale, Cattedra di Medicina Interna, Dipartimento di Fisiopatologia Clinica, Universita di Torino, Italy
    Hepatogastroenterology 52:792-5. 2005
    ..The purpose of this study was to assess the role of esophageal dysfunction in chest pain patients with and without coronary artery disease...
  79. ncbi request reprint Fluorescence in situ hybridization to evaluate dysplasia in Barrett's esophagus: a pilot study
    Renzo Cestari
    Digestive Endoscopy Unit, Department of Surgery, Spedali Civili, University of Brescia, Piazzale Spedali Civili 1, 25100 Brescia, Italy
    Cancer Lett 251:278-87. 2007
    ..Histological disagreement is frequent in the diagnosis and grading of dysplasia in Barrett's esophagus (BE)...
  80. ncbi request reprint Diagnostic value of serological assays in pediatric inflammatory bowel disorders
    Elsa Mainardi
    Department of Clinical Pathology, Ospedale Maggiore, Crema, Italy
    Digestion 75:210-4. 2007
    ....
  81. ncbi request reprint Randomized controlled trial of biofeedback
    Giuseppe Chiarioni
    Clin Gastroenterol Hepatol 5:1119; author reply 1119. 2007
  82. ncbi request reprint Non-surgical treatment of esophageal achalasia
    Vito Annese
    World J Gastroenterol 12:5763-6. 2006
    ..The present article reviews the non-surgical therapeutic options for achalasia...