Alfonso Baldi

Summary

Country: Italy

Publications

  1. ncbi request reprint Analysis of cell cycle regulator proteins in encapsulated thymomas
    Alfonso Baldi
    Department of Thoracic Surgery, Tor Vergata University, Rome, Italy
    Clin Cancer Res 11:5078-83. 2005
  2. doi request reprint The serine protease HtrA1 is a novel prognostic factor for human mesothelioma
    Alfonso Baldi
    Department of Biochemistry and Biophysics, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Pharmacogenomics 9:1069-77. 2008
  3. ncbi request reprint Intraoral lymphoepithelial carcinoma of the minor salivary glands
    Dardo Menditti
    Department of Dentistry, Orthodontics and Oral Surgery, Second University of Naples, Italy
    In Vivo 26:1087-9. 2012
  4. pmc Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    J Transl Med 9:221. 2011
  5. pmc Adjuvant electrochemotherapy in veterinary patients: a model for the planning of future therapies in humans
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 28:114. 2009
  6. pmc Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer
    Pietro G Signorile
    Fondazione Italiana Endometriosi, Rome, Italy
    J Exp Clin Cancer Res 28:49. 2009
  7. pmc Oral benign fibrous histiocytoma: two case reports
    Dardo Menditti
    Dipartimento di Scienze Odontostomatologiche, Seconda Universita di Napoli, 80138 Napoli, Italia
    Cases J 2:9343. 2009
  8. pmc Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse
    Paola Aulino
    Department of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, Italy
    BMC Cancer 10:363. 2010
  9. ncbi request reprint Oral angioleiomyoma: a rare pathological entity
    Dardo Menditti
    Department of Biochemistry, Second University of Naples, 80138, Napoli, Italy
    In Vivo 26:161-3. 2012
  10. ncbi request reprint Skin phototype and local trauma in the onset of balanitis xerotica obliterans (BXO) in circumcised patients
    Massimo Villa
    Department of Surgery, Tor Vergata University, Rome, Italy
    In Vivo 26:143-6. 2012

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Analysis of cell cycle regulator proteins in encapsulated thymomas
    Alfonso Baldi
    Department of Thoracic Surgery, Tor Vergata University, Rome, Italy
    Clin Cancer Res 11:5078-83. 2005
    ..In this study, three components of the cell cycle machinery (i.e., p21, p27 and p53) were examined in a series of well-characterized encapsulated thymoma specimens to analyze coregulation and influence on recurrence and survival...
  2. doi request reprint The serine protease HtrA1 is a novel prognostic factor for human mesothelioma
    Alfonso Baldi
    Department of Biochemistry and Biophysics, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Pharmacogenomics 9:1069-77. 2008
    ..The objective of our study was to analyze the potential prognostic value of the expression of the serine protease HtrA1 and of EGFR in 70 malignant mesotheliomas...
  3. ncbi request reprint Intraoral lymphoepithelial carcinoma of the minor salivary glands
    Dardo Menditti
    Department of Dentistry, Orthodontics and Oral Surgery, Second University of Naples, Italy
    In Vivo 26:1087-9. 2012
    ..The tumour was described at the clinical and instrumental level; moreover, its histopathological phenotype was defined. Finally, the problems of differential diagnosis and the most appropriate therapeutic approaches are discussed...
  4. pmc Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    J Transl Med 9:221. 2011
    ..In this study pet with spontaneously occurring cancer proven refractory to conventional chemotherapy have been recruited in a compassionate study...
  5. pmc Adjuvant electrochemotherapy in veterinary patients: a model for the planning of future therapies in humans
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 28:114. 2009
    ..This review summarizes the recent progresses in preclinical oncology and their possible transfer to humans...
  6. pmc Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer
    Pietro G Signorile
    Fondazione Italiana Endometriosi, Rome, Italy
    J Exp Clin Cancer Res 28:49. 2009
    ..Our objective was to test the validity of the theory of müllerianosis for endometriosis, that is the misplacing of primitive endometrial tissue along the migratory pathway of foetal organogenesis..
  7. pmc Oral benign fibrous histiocytoma: two case reports
    Dardo Menditti
    Dipartimento di Scienze Odontostomatologiche, Seconda Universita di Napoli, 80138 Napoli, Italia
    Cases J 2:9343. 2009
    ..The clinical and histological features of the lesion are reported. Finally, a literature revision of this pathology at the level of the oral cavity is reported...
  8. pmc Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse
    Paola Aulino
    Department of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, Italy
    BMC Cancer 10:363. 2010
    ..As part of the search for novel clinical and basic research applications for this experimental model, we characterized novel cellular and molecular features of C26-bearing mice...
  9. ncbi request reprint Oral angioleiomyoma: a rare pathological entity
    Dardo Menditti
    Department of Biochemistry, Second University of Naples, 80138, Napoli, Italy
    In Vivo 26:161-3. 2012
    ..The surgical wound healed in one week with normal scarring. Finally, the problems of differential diagnosis with other tumours of the oral cavity and the most appropriate therapeutic procedures are discussed...
  10. ncbi request reprint Skin phototype and local trauma in the onset of balanitis xerotica obliterans (BXO) in circumcised patients
    Massimo Villa
    Department of Surgery, Tor Vergata University, Rome, Italy
    In Vivo 26:143-6. 2012
    ..Moreover, the data produced suggest should the advantages of repeated MRF be weighed against the increased risk of developing BXO, which in turn may increase complication rate of circumcision surgery...
  11. ncbi request reprint Embryonal rhabdomyosarcoma of the tongue in old age
    Alfonso Baldi
    Department of Biochemistry F Cedrangolo, Second University of Naples, 80138 Naples, Italy
    Oral Oncol 40:450-2. 2004
    ..TUNEL analysis showed that apoptosis was present in 10% of the cells, thus suggesting that an high number of apoptotic cells may represent an indicator of good prognosis for this malignancy...
  12. ncbi request reprint Analysis of APAF-1 expression in human cutaneous melanoma progression
    Alfonso Baldi
    Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    Exp Dermatol 13:93-7. 2004
    ..We conclude that loss of APAF-1 expression can be considered as an indicator of malignant transformation in melanoma...
  13. ncbi request reprint Pleomorphic adenoma of cervical heterotopic salivary glands
    A Baldi
    Dept of Biochemistry and Biophysics F Cedrangolo, Second University of Naples, Italy
    J Exp Clin Cancer Res 22:645-7. 2003
    ..The characteristics of salivary heterotipias of the neck, and their diagnostic difficulties and histogenetic problems are reviewed...
  14. ncbi request reprint Cystic nephroma: report of a case and review of the literature
    Alfonso Baldi
    Department of Biochemistry, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    In Vivo 21:895-6. 2007
    ..The histopathological differential diagnosis and immunohistochemical features that are potentially useful for refining this tumor are discussed...
  15. pmc Dermoid cyst of the mandibula: a case report
    Dardo Menditti
    Dipartimento di Biochimica, Sezione di Anatomia Patologica, Seconda Universita di Napoli, Italia
    Cases J 1:260. 2008
    ..abstract:..
  16. ncbi request reprint Cystitis glanduralis complicating an eosinophilic cystitis: a case report
    Alfonso Baldi
    Department of Biochemistry and Biophysic F Cedrangolo, Section of Pathology, Second University of Naples, Italy
    In Vivo 17:651-3. 2003
    ..The patient was treated with transurethral resection of the lesion and a combination of corticosteroids and anthistaminics for three months. He is disease-free at 24 months of follow-up...
  17. pmc Malignant melanoma associated with a blue naevus: a case report
    Pasquale Mellone
    Department of Biochemistry, Sect, Pathology, Second University of Naples, Naples, Italy
    Cases J 1:433. 2008
    ..abstract:..
  18. pmc Definition of an automated Content-Based Image Retrieval (CBIR) system for the comparison of dermoscopic images of pigmented skin lesions
    Alfonso Baldi
    Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy
    Biomed Eng Online 8:18. 2009
    ..To overcome the limits of current state of art text-based access methods, we have developed a novel content-based search engine for dermoscopic images to support clinical decision making...
  19. ncbi request reprint Endometriosis: pathogenesis, diagnosis, therapy and association with cancer (review)
    Alfonso Baldi
    Fondazione Italiana Endometriosi, Rome, Italy
    Oncol Rep 19:843-6. 2008
    ..The risk for cancer among women with endometriosis will be analyzed in light of the most recent epidemiological and functional studies focused on this disease...
  20. pmc Mediastinal hibernoma: a case report
    A Baldi
    Department of Biochemistry and Biophysic F Cedrangolo, Section of Pathology, Second University of Naples, Naples 80128, Italy
    J Clin Pathol 57:993-4. 2004
    ..A recent clinicopathological study of 170 cases from the Armed Forces Institute of Pathology confirmed the exceptionality of the intrathoracic location. This report describes a very rare case of mediastinal hibernoma in a young man...
  21. ncbi request reprint Echinococcal cysts with primary cutaneous localization
    A Baldi
    Department of Biochemistry and Biophysics F Cedrangolo, Section of Anatomic Pathology, Second University of Naples, Italy
    Br J Dermatol 147:807. 2002
  22. doi request reprint Amprenavir inhibits the migration in human hepatocarcinoma cell and the growth of xenografts
    Vincenzo Esposito
    Third Division of Infection Diseases, AORN dei Colli, Naples, Italy
    J Cell Physiol 228:640-5. 2013
    ..In summary these findings suggest novel anti-neoplastic action of Amprenavir on liver cancer showing the possibility of novel combination therapies...
  23. doi request reprint Preclinical models in electrochemotherapy: the role of veterinary patients
    Enrico Pierluigi Spugnini
    SAFU Department, Regina Elena Cancer Institute, Via delle Messi d Oro 156, Rome 00158, Italy
    Future Oncol 8:829-37. 2012
    ..This review summarizes the state of the art in veterinary oncology as a preclinical model...
  24. ncbi request reprint Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma
    Vincenzo Esposito
    Third Division Cotugno Hospital, Naples, Italy
    Clin Cancer Res 12:2634-9. 2006
    ..We aimed to evaluate the antineoplastic potential activities of the protease inhibitor indinavir (Crixivan) in in vitro and in vivo hepatocarcinoma models...
  25. pmc Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability
    Alessandra Verdina
    Laboratory D, Dept for Development of Therapeutic Programs, CRS, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158, Rome, Italy
    J Transl Med 6:27. 2008
    ..These results suggest that the association of piroxicam and CDDP specifically triggers cell cycle regulation and apoptosis in different mesothelioma cell lines and may hold promise in the treatment of mesothelioma...
  26. pmc Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma
    Alfonso Baldi
    Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy
    PLoS ONE 6:e23569. 2011
    ..We have previously shown in vivo that piroxicam/cisplatin combined treatment in MM, specifically acts on cell cycle regulation triggering apoptosis, with survival increase...
  27. pmc Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: preclinical data for the standardization of this treatment in pets and humans
    Enrico P Spugnini
    S A F U, Department, Regina Elena Cancer Institute, Rome, Italy
    J Transl Med 5:48. 2007
    ..Further studies on this topic are warranted in companion animals with spontaneous tumors to identify new molecular targets for electrochemotherapy and to the develop new therapeutical protocols to be translated to humans...
  28. ncbi request reprint The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways
    Michele Caraglia
    Experimental Pharmacology Unit, Experimental Oncology Department, National Cancer Institute Fondazione G Pascale, Naples, Italy
    Int J Cancer 121:2317-30. 2007
    ....
  29. doi request reprint Functional and pharmacodynamic evaluation of metronomic cyclophosphamide and docetaxel regimen in castration-resistant prostate cancer
    Irene Cardillo
    SAFU Department, Regina Elena National Cancer Institute, Via E Chianesi 53, Rome, Italy
    Future Oncol 9:1375-88. 2013
    ..Mice were treated with a combination of CYC (50 mg/kg/day) and docetaxel (10-30 mg/kg/week) or with docetaxel alone. Docetaxel plasma levels were analyzed in patients receiving the drug alone or combined with CYC...
  30. ncbi request reprint Pkn is a novel partner of cyclin T2a in muscle differentiation
    Giuliano Cottone
    Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 207:232-7. 2006
    ..Taken together, our data strengthen the hypothesis that Cyclin T2a plays a role in muscle differentiation, and propose PKNalpha as a novel partner of Cyclin T2a in this process...
  31. ncbi request reprint R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation
    Michele Caraglia
    Experimental Pharmacology Unit, National Cancer Institute of Naples Fondazione G Pascale, Naples, Italy
    J Cell Physiol 211:533-43. 2007
    ....
  32. ncbi request reprint Analysis of HtrA1 serine protease expression in human lung cancer
    Vincenzo Esposito
    Third Division, Cotugno Hospital, Naples, Italy
    Anticancer Res 26:3455-9. 2006
    ..Our data suggest that HtrA1 may be involved in lung cancer progression by targeting several molecular pathways...
  33. doi request reprint Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells
    Daniela Stoppoloni
    Department for the Development of Therapeutic Programs, Regina Elena Cancer Institute, Rome, Italy
    J Thorac Oncol 6:583-91. 2011
    ..The aim of this study was to investigate the expression and biological activity of aromatase (CYP19A1) in malignant mesothelioma (MM)...
  34. doi request reprint Helicobacter pylori heat shock protein B (HspB) localizes in vivo in the gastric mucosa and MALT lymphoma
    Antonio De Luca
    Department of Medicine and Public Health, Second University of Naples, Naples, Italy
    J Cell Physiol 216:78-82. 2008
    ..In conclusion, our observations suggest a possible involvement of HspB in the pathogenesis of H. pylori-related pathologies such as gastritis, ulcer and gastric cancer...
  35. doi request reprint Role of FAP48 in HIV-associated lipodystrophy
    Vincenzo Esposito
    Third Division Cotugno Hospital, Naples, Italy
    J Cell Biochem 113:3446-54. 2012
    ..In conclusion, this molecule could be a potential target for novel therapeutic approaches to the HAART related lipodystrophy in HIV patients...
  36. pmc Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 27:58. 2008
    ..All the patients responded to the treatment and are still in remission at different times. Electrochemotherapy appears as a safe and efficacious modality for the treatment of TVT and warrants further investigations...
  37. pmc Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target
    Stefania Crispi
    Gene Expression Core, Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics, Naples, Italy
    PLoS ONE 4:e7016. 2009
    ....
  38. doi request reprint Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells
    Monica Marra
    Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
    Int J Cancer 125:2004-13. 2009
    ..In the same experimental conditions, CYR61 protein downregulation potentiated the inactivation of the Ras-dependent proliferation pathway and cell cycle inhibitors p21 and p27 expression...
  39. ncbi request reprint Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    Front Biosci (Elite Ed) 5:974-81. 2013
    ..The identification of effective combination coupled with the development of novel equipments and electrodes will be instrumental in planning the translation of these results to humans as per correct laboratory-clinical interface...
  40. pmc Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: preliminary observations
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 27:6. 2008
    ..The combination showed remarkable efficacy at controlling the malignant effusion secondary to MM in our patients and warrants further investigations...
  41. pmc Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Via delle Messi d Oro 156, Rome 00158, Italy
    J Transl Med 9:125. 2011
    ..In this study we evaluated whether electroporation could increase the delivery of antisense oligodeoxynucleotides against bcl-2 (G3139) as well as the efficacy of combination chemotherapy in human melanoma xenografts...
  42. pmc Synergistic effect of gefitinib and rofecoxib in mesothelioma cells
    Daniela Stoppoloni
    Department for the Development of Therapeutic Programs, Laboratory D, Centro Ricerca Sperimentale, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Mol Cancer 9:27. 2010
    ..Combination of COX-2 and EGFR inhibitors, therefore, could be an effective strategy for reducing cell growth in those lines expressing the two molecular markers...
  43. pmc Identification of genes down-regulated during lung cancer progression: a cDNA array study
    Mara Campioni
    Department of Biochemistry and Biophysics F, Cedrangolo, Section of Pathology, Second University of Naples, Naples, Italy
    J Exp Clin Cancer Res 27:38. 2008
    ..Lung cancer remains a major health challenge in the world. Survival for patients with stage I disease ranges between 40-70%. This suggests that a significant proportion of patients with stage I NSCLC may actually be under-staged...
  44. ncbi request reprint Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 22:47-9. 2008
    ..The dog is still in complete remission after 18 months. Electrochemotherapy is a safe and efficacious adjuvant therapy for ASGC and warrants further investigation in order to standardize its protocols...
  45. ncbi request reprint Electrochemotherapy-induced radiation recall in a cat
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 22:751-3. 2008
    ..Electrochemotherapy (ECT) should be used with caution in previously irradiated areas. Further studies are warranted in this field due to its potential as a rescue for relapsing tumors...
  46. doi request reprint Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis
    Daniela Stoppoloni
    Laboratory D, Department for the Development of Therapeutic Programs, Centro Ricerca Sperimentale, Regina Elena Cancer Institute, Rome, Italy
    Cancer 113:2761-9. 2008
    ..The human embryonic lethal abnormal vision (ELAV)-like protein HuR is a messenger RNA (mRNA)-binding protein that controls the stability of certain transcripts, including cyclooxygenase2 (COX-2)...
  47. doi request reprint The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein
    Mara Campioni
    Department of Biochemistry, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Mol Cancer Res 8:1248-60. 2010
    ..Considering that HtrA1 levels are significantly increased during embryogenesis, we speculate that one of the targets of HtrA1 activity during fetal development is the TSC2-TSC1 pathway...
  48. ncbi request reprint Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 21:819-22. 2007
    ..Electrochemotherapy is well tolerated and has effectiveness against incompletely excised sarcomas in companion animals. Further investigations are warranted to improve the currently available protocols...
  49. ncbi request reprint Ferritin contributes to melanoma progression by modulating cell growth and sensitivity to oxidative stress
    Alfonso Baldi
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 11:3175-83. 2005
    ..Here, we attempted to characterize the role of ferritin in the biology of human melanoma and in the progression of this disease...
  50. ncbi request reprint Adjuvant carboplatin for the treatment of intestinal carcinoid in a dog
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 22:759-61. 2008
    ..This report represents the first description of long-term control of intestinal carcinoid in the dog and the first of adjuvant chemotherapy for this rare and aggressive neoplasm...
  51. doi request reprint Antiproliferative effect of Aurora kinase targeting in mesothelioma
    Stefania Crispi
    Gene Expression Core Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics, CNR, Naples, Italy
    Lung Cancer 70:271-9. 2010
    ..Our findings support a role of Aurora kinase in mesothelioma and the possibility of using Aurora kinase inhibitors in therapeutic modalities...
  52. ncbi request reprint Long-term disease-free survival of patients with radically resected thymomas: relevance of cell-cycle protein expression
    Tommaso Claudio Mineo
    Department of Thoracic Surgery, Tor Vergata University, Rome, Italy
    Cancer 104:2063-71. 2005
    ....
  53. ncbi request reprint Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance
    Mara Campioni
    Department of Biochemistry and Biophysic F Cedrangolo, Section of Pathology, Second University of Naples, Italy
    Exp Dermatol 14:811-8. 2005
    ..Moreover, the most recent findings about the involvement of this molecule in melanoma progression and chemoresistance, as well as the clinico-pathological relevance of these findings in the treatment of this deadly disease, are reported...
  54. ncbi request reprint Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure
    Antonio Abbate
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Am Coll Cardiol 41:753-60. 2003
    ....
  55. pmc High Erk-1 activation and Gadd45a expression as prognostic markers in high risk pediatric haemolymphoproliferative diseases
    Velia D'Angelo
    Pediatric Oncology Service, Pediatric Department, F Fede, II University of Naples, Naples, Italy
    J Exp Clin Cancer Res 28:39. 2009
    ..These results demonstrate an involvement of these proteins in survival of blast cells and, consequently, on relapse percentages of the different subgroups of patients...
  56. ncbi request reprint Leiomyosarcoma of the scrotum arising from the dartos muscle: a rare clinicopathological entity
    Paolo Persichetti
    Department of Plastic and Reconstructive Surgery, Campus Biomedico University, Rome, Italy
    In Vivo 18:553-4. 2004
    ..The patient was treated by a wide surgical excision and no recurrence has been recognized 36 months later. A review of the literature is presented, summarizing the principal clinical and morphological characteristics of this rare tumor...
  57. doi request reprint Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects
    Stefania Crispi
    Gene Expression and Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics A B T CNR, Naples, Italy
    J Cell Physiol 228:1927-34. 2013
    ..These data support the theory that embryological defects could be responsible of the endometriosis generation...
  58. doi request reprint In vitro model of stromal and epithelial immortalized endometriotic cells
    Mariarosaria Boccellino
    Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
    J Cell Biochem 113:1292-301. 2012
    ..In conclusion, these cells are potentially useful as an experimental model to investigate endometriosis biology...
  59. pmc Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    J Transl Med 9:152. 2011
    ..In this article we evaluate the capability of ECT to allow the use of cisplatin despite its high toxicity in a spontaneous feline model of soft tissue sarcoma...
  60. ncbi request reprint Electrochemotherapy for the treatment of squamous cell carcinoma in cats: a preliminary report
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Vet J 179:117-20. 2009
    ..Seven of the cats (77.7%) had a complete response lasting up to 3 years. ECT seems to be a safe and effective option for the treatment of feline sun-induced squamous cell carcinomas and warrants further investigation...
  61. ncbi request reprint Identification of genes down-regulated during melanoma progression: a cDNA array study
    Alfonso Baldi
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    Exp Dermatol 12:213-8. 2003
    ..In conclusion, comparative hybridization by means of cDNA arrays assisted in identifying a series of novel progression-associated changes in gene expression, confirming, at the same time, a number of previously described results...
  62. ncbi request reprint Increased apoptosis in remote non-infarcted myocardium in multivessel coronary disease
    Giuseppe G L Biondi-Zoccai
    Institute of Cardiology, Catholic University, Rome, Italy
    Int J Cardiol 94:105-10. 2004
    ..Our aim was to assess the role of post-infarction myocardial apoptosis and pro-apoptotic factor expression in the non-infarcted remote myocardium of subjects with multivessel coronary disease...
  63. ncbi request reprint Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma
    Enrico P Spugnini
    SAFU Department, CRS, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 12:6133-43. 2006
    ..The aim of the present study was to evaluate the effects of piroxicam, a widely used nonsteroidal anti-inflammatory drug, alone and in combination with cisplatin (CDDP), on cell growth of mesothelioma cells...
  64. ncbi request reprint Identification of protein-protein interactions of human HtrA1
    Mara Campioni
    Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy
    Front Biosci (Elite Ed) 3:1493-9. 2011
    ....
  65. ncbi request reprint Intraoperative versus postoperative electrochemotherapy in high grade soft tissue sarcomas: a preliminary study in a spontaneous feline model
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Via delle Messi d oro, 156, 00158, Rome, Italy
    Cancer Chemother Pharmacol 59:375-81. 2007
    ..The results suggest that ECT is a well tolerated and potentially useful addition to surgery in controlling high-grade sarcomas. On the basis of these results, additional evaluations are warranted in pets and in humans...
  66. ncbi request reprint Recurrent intrathoracic thymomas: potential prognostic importance of cell-cycle protein expression
    Tommaso C Mineo
    Department of Thoracic Surgery, Policlinico Tor Vergata University, Rome, Italy
    J Thorac Cardiovasc Surg 138:40-5. 2009
    ..Cell-cycle protein expression has proven useful in predicting outcome in a variety of neoplasms. We investigated its potential prognostic importance in recurrent intrathoracic thymomas...
  67. doi request reprint The value of occult disease in resection margin and lymph node after extrapleural pneumonectomy for malignant mesothelioma
    Tommaso Claudio Mineo
    Department of Thoracic Surgery, Policlinico Tor Vergata University, Rome, Italy
    Ann Thorac Surg 85:1740-6. 2008
    ..The purpose of this study was to examine the prognostic impact of occult disease after extrapleural pneumonectomy for malignant mesothelioma...
  68. ncbi request reprint Successful rescue of an apocrine gland carcinoma metastatic to the cervical lymph nodes by mitoxantrone coupled with trains of permeabilizing electrical pulses (electrochemotherapy)
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 22:51-3. 2008
    ..The dog is in complete remission after six months from his last treatment. Electrochemotherapy is a safe and efficacious therapy for metastatic carcinoma and warrants further investigation...
  69. ncbi request reprint Spontaneous intestinal melanoma in dogs
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 19:1051-4. 2005
    ..A spontaneous canine intestinal melanoma is described which, because of its local aggressive behavior and advanced stage, was not treatable with conventional strategies, thus being a potential candidate for investigational trials...
  70. ncbi request reprint Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Rome, Italy
    Anticancer Res 26:4585-9. 2006
    ..The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT)...
  71. ncbi request reprint Widespread myocardial inflammation and infarct-related artery patency
    Antonio Abbate
    Institute of Cardiology, Catholic University, Rome, Italy
    Circulation 110:46-50. 2004
    ....
  72. ncbi request reprint Characterization of tissue specific expression of Notch-1 in human tissues
    Alfonso Baldi
    Department of Biochemistry and Biophysics F Cedrangolo, Section of Pathologic Anatomy, Second University of Naples, Italy
    Biol Cell 96:303-11. 2004
    ....
  73. ncbi request reprint Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institut, Rome, Italy
    Vet J 178:291-3. 2008
    ..It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation...
  74. ncbi request reprint Distribution of the serine protease HtrA1 in normal human tissues
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Histochem Cytochem 51:1279-84. 2003
    ..This suggests a possible role for HtrA1 in the modulation of tissue activity in this organ. The various expression levels in human tissues indicate several possible roles for HtrA1 in different cell types...
  75. ncbi request reprint Prostate as sole unusual recurrence site of lymphoma in a dog
    Renato Assin
    Ambulatorio Veterinario Prati, Rome, Italy
    In Vivo 22:755-7. 2008
    ..Lymphoma rarely invades the prostate in the dog. To the best of our knowledge this is the first report of prostatic recurrence of lymphoma in a canine patient originally affected by intestinal lymphoma and treated with chemotherapy...
  76. ncbi request reprint Analysis of Fas (Apo-1/CD95) expression in non-small cell lung cancer
    Vincenzo Esposito
    Third Division of Infective Diseases, D Cotugno Hospital, Department of Cardiological, Respiratory and Thoracic Medical Sciences, Second University of Naples, Naples, Italy
    Anticancer Res 23:4901-5. 2003
    ..On the other hand, considering the role of the Fas-pathway in chemotherapy-induced apoptosis, further studies are required to analyze the potential value of Fas expression in predicting the response of NSCLC patients to chemotherapy...
  77. ncbi request reprint Use of flashlamp-pumped pulsed dye laser in the treatment of superficial vascular malformations and ulcerated hemangiomas
    Luigi Di Maio
    Department of Surgery, Section of Clinical Surgery, University of Chieti, Italy
    In Vivo 25:117-23. 2011
    ..Excellent ultimate outcome confirmed the clinical efficacy of the use of the pulsed dye laser in the treatment of dermal vascular malformations, which also appears to have good prospects in the management of hemangioma complication...
  78. ncbi request reprint Unicystic ameloblastoma of the mandible
    Dardo Menditti
    Department of Dentistry, Second University of Naples, 80138, Napoli, Italy
    In Vivo 25:125-7. 2011
    ..Finally, the problems of differential diagnosis with odontogenic or congenital cyst and the most appropriate therapeutic procedures are discussed...
  79. ncbi request reprint Female gender, myocardial remodeling and cardiac failure: are women protected from increased myocardiocyte apoptosis?
    Giuseppe G L Biondi-Zoccai
    Institute of Cardiology, Catholic University, Rome Italy
    Ital Heart J 5:498-504. 2004
    ....
  80. doi request reprint Positive bone marrow biopsy is associated with a decreased disease-free survival in patients with operable breast cancer
    Lucio Fortunato
    Department of Surgery, San Giovanni Addolorata Hospital, Rome, Italy
    Ann Surg Oncol 16:3010-9. 2009
    ..Bone marrow (BM) biopsy has been suggested as an independent prognostic factor in patients with breast cancer...
  81. ncbi request reprint Pulse-mediated chemotherapy enhances local control and survival in a spontaneous canine model of primary mucosal melanoma
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    Melanoma Res 16:23-7. 2006
    ..Further studies are needed to characterize this approach and to determine its suitability for head and neck mucosal melanoma...
  82. pmc Expression of apoptosis-related markers in malignant epithelial tumours of the lacrimal gland and their relation to clinical outcome
    Diego Strianese
    Department of Ophthalmology Orbital Section, University of Naples, Naples, Italy
    Br J Ophthalmol 91:1239-43. 2007
    ..To investigate the correlation between the expression of apoptosis-related markers and prognosis in malignant epithelial tumours of the lacrimal gland. Materials and..
  83. ncbi request reprint The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells
    Alfonso Baldi
    Laboratory C, CRS, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 21:6684-8. 2002
    ..These results suggest that down-regulation of PRSS11 and HtrA1 expression may represent an indicator of melanoma progression...
  84. ncbi request reprint Unusual problems in breast cancer and a rare lung cancer case. Case 1. Clinical complete response of breast cancer metastases after trastuzumab-based immunotherapy
    Giuseppe Tonini
    Università Campus Bio Medico, Rome, Italy and Regina Elena Cancer Institute, Rome, Italy
    J Clin Oncol 21:2215-6. 2003
  85. pmc HtrA serine proteases as potential therapeutic targets in cancer
    Jeremy Chien
    Department Biochemistry, Sect Pathology, Via L Armanni, 5, 80138 Naples, Italy
    Curr Cancer Drug Targets 9:451-68. 2009
    ..Finally, we will discuss the potential role of epigenetic therapy in targeting the expression and activation of HtrA serine proteases and the mechanisms by which these proteases enhance cytotoxic effect of conventional chemotherapy...
  86. ncbi request reprint Cutaneus pseudolymphoma: a case report
    Emanuele Dragonetti
    Section of Dermatology, Rome American Hospital, Rome, Italy
    In Vivo 18:549-51. 2004
    ..Finally, the use of hydroxychloroquine sulfate is suggested for the therapy of pseudolymphoma cutis, especially when the causal factor is unknown...
  87. ncbi request reprint Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling
    Antonio Abbate
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Cell Physiol 193:145-53. 2002
    ....
  88. ncbi request reprint Clinical relevance of apoptosis in early and late post-infarction left ventricular remodeling
    Antonio Abbate
    Institute of Cardiology, Catholic University, Rome, Italy
    Ital Heart J 3:699-705. 2002
    ....
  89. ncbi request reprint Statins may potentiate bisphosphonates anticancer properties: a new pharmacological approach?
    Bruno Vincenzi
    Oncology Hematology Department, Campus Bio Medico University, Rome, Italy
    Med Hypotheses 61:98-101. 2003
    ....
  90. ncbi request reprint cDNA array technology in melanoma: an overview
    Alfonso Baldi
    Regina Elena Cancer Institute, CRS, Via delle Messi d oro, Rome, Italy
    J Cell Physiol 196:219-23. 2003
    ..This review discusses some recent findings obtained by means of cDNA arrays investigating the human melanoma...
  91. doi request reprint Role of apoptosis in pressure-overload cardiomyopathy
    Amedeo Anselmi
    Division of Cardiac Surgery, Department of Cardiovascular Medicine, Catholic University, Rome, Italy
    J Cardiovasc Med (Hagerstown) 9:227-32. 2008
    ..This review discusses the available experimental and clinical evidence with respect to the role played by myocardial apoptosis in pressure-overload cardiomyopathy...
  92. ncbi request reprint Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy
    Anna Severino
    Institute of Cardiology, Catholic University, Rome, Italy
    J Am Coll Cardiol 50:1029-37. 2007
    ..The aim of the study was to analyze the molecular mechanisms activated during postinfarction remodeling in human hearts...
  93. ncbi request reprint Human malignant mesothelioma: molecular mechanisms of pathogenesis and progression
    Enrico P Spugnini
    SAFU Department, Regina Elena National Cancer Institute, Rome, Italy
    Int J Biochem Cell Biol 38:2000-4. 2006
    ..Goal of this review article is to summarize the most recent advances in molecular pathogenesis of mesothelioma and discuss possible therapeutic implications of these findings...
  94. ncbi request reprint Effects of indinavir in a preliminary phase I study on dogs with stage III slenic hemangiosarcoma
    Enrico P Spugnini
    SAFU Department, Regina Elena Cancer Institute, Rome, Italy
    In Vivo 20:125-7. 2006
    ..The results suggest that Indinavir is potentially beneficial in dogs affected by microscopic residual disease...
  95. ncbi request reprint Biological agents involved in malignant mesothelioma: relevance as biomarkers or therapeutic targets
    Stefania Crispi
    Gene Expression Core Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics, CNR Naples Italy
    Curr Cancer Drug Targets 10:19-26. 2010
    ....
  96. ncbi request reprint Local control and distant metastasis after electrochemotherapy of a canine anal melanoma
    Enrico P Spugnini
    Centre of Biomedical Engineering Ivan Daskalov, Sofia, Bulgaria
    In Vivo 21:897-9. 2007
    ..Electrochemotherapy (ECT) is a safe palliative therapy for such neoplasm and warrants further investigations in dogs as well humans...
  97. ncbi request reprint Immunohistochemistry-detected microscopic tumor spread affects outcome in en-bloc resection for T3-chest wall lung cancer
    Tommaso C Mineo
    Thoracic Surgery Division, Tor Vergata University School of Medicine, Policlinico Tor Vergata University, Via Oxford 81, 00133 Rome, Italy
    Eur J Cardiothorac Surg 31:1120-4. 2007
    ..This study is aimed at analyzing the effect of immunohistochemistry-detected microscopic tumor spread on long-term survival after en-bloc lung and chest wall resection for T3-chest wall non-small cell lung cancer (NSCLC)...
  98. ncbi request reprint In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells
    Douglas M Noonan
    Tumor Progression Section, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, Genova, Italy
    J Cell Physiol 202:922-8. 2005
    ....