Research Topics
Species | S ArdizzoneSummaryCountry: Italy Publications
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Publications
Comparative tolerability of therapies for ulcerative colitisSandro Ardizzone
Department of Gastroenterology, L Sacco University Hospital, Milan, Italy
Drug Saf 25:561-82. 2002..The broadening of the drug regimen available to the clinician has advanced our knowledge about the disease, and further development of more effective, less toxic agents can be anticipated in the future...
Extraintestinal manifestations of inflammatory bowel diseaseS Ardizzone
Chair of Gastroenterology, L Sacco University Hospital, Milan, Italy
Dig Liver Dis 40:S253-9. 2008..Early recognition of these extraintestinal manifestations should help guide therapy that will reduce overall morbidity in affected patients. This paper reviews the diagnosis, therapy and management of the more common EIMs...- Immunosuppressive and biologic therapy for ulcerative colitisSandro Ardizzone
Cattedra e Divisione di Gatroenterologia, ed Endoscopia Digestiva, Azienda, Ospedaliera L Sacco, Polo Universitario, Italy Gastroenterology Oncology Surgery, Via GB Grassi, Milan 20157, Italy 39 02 3904 2486 39 02 3904 2232
Expert Opin Emerg Drugs 17:449-67. 2012..Keeping in mind this potentially new therapeutic scenario, there are some critical areas in which early and more diffuse use of conventional and emerging new immunomodulators is advocated... - Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel diseaseS Ardizzone
Department of Gastroenterology L Sacco University Hospital, University of Milan, Milan, Italy
Inflamm Bowel Dis 13:516-23. 2007.... - Is it possible to modify the clinical course of Crohn's disease?Sandro Ardizzone
Inflammatory Bowel Disease Unit, L Sacco University Hospital, Milan, Italy
Nat Clin Pract Gastroenterol Hepatol 5:428-9. 2008 - Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's diseaseSandro Ardizzone
Cattedra di Gastroenterologia, Azienda Ospedaliera L Sacco, Polo Universitario, Via G B Grassi, 74, 20157 Milan, Italy
Gastroenterology 127:730-40. 2004..We aimed to compare the efficacy and safety of azathioprine and mesalamine in the prevention of clinical and surgical relapse in patients who have undergone conservative surgery for Crohn's disease... 
Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitisS Ardizzone
Cattedra di Gastroenterologia, Azienda Ospedaliera L Sacco, Polo Universitario, Via G B Grassi 74, 20157 Milano, Italy
Gut 55:47-53. 2006..There are limited evidence based data concerning the use of azathioprine in ulcerative colitis. We aimed to compare the efficacy of azathioprine and oral 5-aminosalicylic acid in inducing remission of steroid dependent ulcerative colitis...- Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro studyS Ardizzone
Gastroenterology Unit, Department of Clinical Science, L Sacco University Hospital, Milano, Italy
Int J Immunopathol Pharmacol 22:63-71. 2009..The observation that the effect of this modulation was different in CD compared to UC patients provides an interesting area of research into the pathogenesis and treatment of these inflammatory conditions... - Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitisSandro Ardizzone
Department of Clinical Science, Gastroenterology Unit, L Sacco University Hospital, Milan, Italy
Clin Gastroenterol Hepatol 9:483-489.e3. 2011..We evaluated whether early clinical and endoscopic responses to this therapy are associated with late outcomes in UC... - Imaging of perianal Crohn's diseaseS Ardizzone
Department of Clinical Science, L Sacco University Hospital, Milan, Italy
Dig Liver Dis 39:970-8. 2007..For transcutaneous perianal ultrasound too, good preliminary data have been reported. This paper reviews the available data on imaging methods for the management of perianal Crohn's disease... - Autoantibody profile during short-term infliximab treatment for Crohn's disease: a prospective cohort studyF Atzeni
Rheumatology Unit, L Sacco University Hospital, Milan, Italy
Aliment Pharmacol Ther 22:453-61. 2005..The potential clinical implications of autoimmunity during treatment with infliximab are unclear... - Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's diseaseA Cassinotti
Department of Clinical Science, L Sacco University Hospital, Via G B Grassi 74, 20157 Milan, Italy
Gut 57:211-7. 2008..We investigated the safety and efficacy of HSCT with unselected peripheral blood stem cells (PBSCs) in moderate-severe refractory Crohn's disease... - Use of colonoscopy in the management of patients with Crohn's disease: appropriateness and diagnostic yieldG Manes
Department of Gastroenterology, L Sacco University Hospital, Via G B Grassi 74, 20157 Milan, Italy
Dig Liver Dis 41:653-8. 2009..In the present study we evaluate the clinical impact of performing colonoscopy in Crohn's disease patients... - Prevalence, detection rate and outcome of cytomegalovirus infection in ulcerative colitis patients requiring colonic resectionG Maconi
Department of Gastroenterology, L Sacco University Hospital, Via G B Grassi, 74, 20157 Milan, Italy
Dig Liver Dis 37:418-23. 2005.... - Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: a randomised, investigator-blind studyS Ardizzone
L Sacco University Hospital, Via G B Grassi 74, 20157 Milan, Italy
Dig Liver Dis 35:619-27. 2003..The aim of this study was to evaluate the efficacy and safety of methotrexate in comparison with azathioprine, and to establish whether methotrexate has a shorter onset of action in this setting... - Review article: the management of steroid dependency in ulcerative colitisG Bianchi Porro
Department of Clinical Science, Chair of Gastroenterology, L Sacco University Hospital, Milan, Italy
Aliment Pharmacol Ther 26:779-94. 2007.... - Appropriateness of immunosuppressive drugs in inflammatory bowel diseases assessed by RAND method: Italian Group for IBD (IG-IBD) position statementR Caprilli
Promoter Centre, GI Unit, Department of Clinical Science, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
Dig Liver Dis 37:407-17. 2005..Despite the explosion of biological therapies, the old immunosuppressants continue to play a pivotal role in the management of inflammatory bowel diseases... - Infliximab in treatment of Crohn's disease: the Milan experienceS Ardizzone
Gastrointestinal Unit, L. Sacco University Hospital, Milan, Italy
Dig Liver Dis 34:411-8. 2002..CONCLUSION: The present experience with infliximab in clinical practice confirms its efficacy, in particular in inflammatory/refractory Crohn's disease and its safety, at least, in short-term follow-up... - Infliximab-induced lupus in Crohn's disease: a case reportP Sarzi-Puttini
Rheumatology Unit, L Sacco University Hospital, Milan, Italy
Dig Liver Dis 35:814-7. 2003..This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus... - Maintenance treatment with azathioprine in ulcerative colitis: outcome and predictive factors after drug withdrawalAndrea Cassinotti
Department of Clinical Sciences, Gastroenterology Unit, Luigi Sacco University Hospital, Milano, Italy
Am J Gastroenterol 104:2760-7. 2009..Whether the duration of maintenance treatment with azathioprine (AZA) affects the outcome of ulcerative colitis (UC) is unclear. We investigated clinical outcomes and any predictive factors after withdrawal of AZA in UC... - Inflammatory bowel disease: new insights into pathogenesis and treatmentS Ardizzone
L. Sacco University Hospital, Milan, Italy
J Intern Med 252:475-96. 2002.... - Perianal Crohn's disease: overviewS Ardizzone
Department of Clinical Science, L. Sacco University Hospital, Milan, Italy
Dig Liver Dis 39:957-8. 2007 - Is interferon-alpha therapy safe and effective for patients with chronic hepatitis C and inflammatory bowel disease? A case-control studyS Bargiggia
Academic Department of Gastroenterology, L Sacco University Hospital, Milan, Italy
Aliment Pharmacol Ther 22:209-15. 2005..Limited data are available as to the safety and efficacy of alpha-interferon therapy for chronic active hepatitis C in patients with concomitant inflammatory bowel disease... - Small bowel stenosis in Crohn's disease: clinical, biochemical and ultrasonographic evaluation of histological featuresG Maconi
Department of Gastroenterology, L Sacco University Hospital, Milan, Italy
Aliment Pharmacol Ther 18:749-56. 2003..To establish whether intestinal ultrasound, clinical or biochemical indices of activity can assess histological features of ileal stenosis in Crohn's disease... - Frequency of NOD2/CARD15 variants in both sporadic and familial cases of Crohn's disease across Italy. An Italian Group for Inflammatory Bowel Disease StudyV Annese
Department of General and Specialist Medicine, Unit of Gastroenterology, CSS IRCCS Hospital, Viale Cappuccini, 1, 71013 San Giovanni Rotondo, Italy
Dig Liver Dis 36:121-4. 2004..Three variants of the NOD2/CARD15 gene are strongly associated with susceptibility to Crohn's disease; however, striking racial and geographic differences of their frequency have been described... - Appropriateness and diagnostic yield of colonoscopy in the management of patients with ulcerative colitis: a prospective study in an open access endoscopy serviceGianpiero Manes
Department of Clinical Science, Chair and Department of Gastroenterology, L Sacco University Hospital, Milano, Italy
Inflamm Bowel Dis 14:1133-8. 2008..Colonoscopy is frequently performed in ulcerative colitis (UC), but its benefit in the management of the disease is a matter of debate. The objective was to determine the clinical impact of colonoscopy in UC... - An analysis of the factors associated with the development of complications in patients undergoing precut sphincterotomy: a prospective, controlled, randomized, multicenter studyGianpiero Manes
Department of Gastroenterology, University Hospital L Sacco, Via G B Grassi 74, Milano 20157, Italy
Am J Gastroenterol 104:2412-7. 2009..We evaluated the role of the timing of precut in determining the development of complications and with respect to the other factors involved... - Over-the-catheter precut to gain access to the biliary duct during ERCP rendezvousGianpiero Manes
Department of Gastroenterology, L Sacco University Hospital, Via G B Grassi 74, 20157 Milano, Italy
Surg Endosc 22:2323-5. 2008..Moreover, rendezvous performed in the typical manner needs the use of several costly accessories. We herein describe a simpler and cheaper method to gain access to the biliary duct at rendezvous... - Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter studyGianpiero Manes
Department of Gastroenterology, University Hospital L Sacco, Milano, Italy
Gastrointest Endosc 65:982-7. 2007..This study's aim was to evaluate whether gabexate mesylate administered after ERCP reduces the incidence of pancreatitis... - Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel diseaseMario Cottone
University of Palermo, Palermo, Italy
Clin Gastroenterol Hepatol 9:30-5. 2011..Few data are available on effects of biologic therapies in patients more than 65 years old with inflammatory bowel disease (IBD). We evaluated the risk and benefits of therapy with tumor necrosis factor (TNF) inhibitors in these patients... - Editor's quiz: Sigmoid stricture in a 39-year-old femaleS Greco
Department of Clinical Sciences, Department of Gastroenterology, L. Sacco University Hospital, Via G.B. Grassi, 74, 20157 Milano, Italy
Gut 56:1247, 1256. 2007 - Prospective study of long-term results and prognostic factors after conservative surgery for small bowel Crohn's diseaseGianluca M Sampietro
Department of Surgery, Gastroenterology and Oncology, II Division of Surgery, Luigi Sacco University Hospital, Milano, Italy
Clin Gastroenterol Hepatol 7:183-91; quiz 125. 2009..We prospectively evaluated safety and long-term efficacy of conservative surgery for patients with complicated CD... - Perianal fistulae following infliximab treatment: clinical and endosonographic outcomeSandro Ardizzone
Cattedra di Gastroenterologia, Azienda Ospedaliera - Polo Universitario L. Sacco, , Via G.B. Grassi, 74 20157 Milano, Italy
Inflamm Bowel Dis 10:91-6. 2004..Despite closure, most fistula tracts are still detectable at AE. Persistence of the internal tract is a condition at higher risk of fistula recurrence... - A prospective, longitudinal study of nonconventional strictureplasty in Crohn's diseaseGianluca M Sampietro
Department of Surgery, II Division of General Surgery, , Ospedale Luigi Sacco, Milan, Italy
J Am Coll Surg 199:8-20; discussion 20-2. 2004..Considering the unpredictability of the clinical course of CD and the lifetime need for surgical procedures, NCSP, together with minimal resection and classic SP repertoire, should be considered first-line treatment in complicated CD... - Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control studyFabrizio Parente
Gastrointestinal Unit, A Manzoni Hospital, Lecco, and the Gastroenterology Unit, L Sacco University Hospital, Milan, Italy
Hepatology 45:1267-74. 2007..Site of disease at diagnosis, lifetime surgery, extent of ileal resections, number of clinical recurrences, TPN, and the frequency and duration of hospitalizations are independently associated with GD... - New onset of atrial fibrillation after introduction of azathioprine in ulcerative colitis: case report and review of the literatureAndrea Cassinotti
Department of Clinical Science, Gastroenterology Unit, L Sacco University Hospital, Via G B Grassi 74, 20157, Milan, Italy
Eur J Clin Pharmacol 63:875-8. 2007.... - Prevalence and clinical significance of sonographic detection of enlarged regional lymph nodes in Crohn's diseaseGiovanni Maconi
Department of Gastroenterology, L Sacco University Hospital, Via G B Grassi 74, IT 20157 Milan, Italy
Scand J Gastroenterol 40:1328-33. 2005.... - CARD15 gene variants and risk of reoperation in Crohn's disease patientsGiovanni Maconi
Department of Clinical Sciences, L Sacco University Hospital, Via G B Grassi, 74, Milan 20157, Italy
Am J Gastroenterol 104:2483-91. 2009..However, data regarding the association between these variants and the need for reoperation are very few and conflicting. This study evaluated the risk factors of reoperation, including CARD15 gene variants... - Association of NOD2/CARD15 mutations on Crohn's disease phenotype in an Italian populationVera Bianchi
Department of Biology and Genetics for Medical Sciences, University of Milan, Italy
Eur J Gastroenterol Hepatol 19:217-23. 2007..To confirm the prevalence of NOD2/CARD15 mutations in Italian inflammatory bowel disease patients and to define the role of the different mutations on Crohn's disease phenotype... - Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single centerStefano Bargiggia
Gastrointestinal Unit, L. Sacco University Hospital, Milan, Italy
J Clin Gastroenterol 36:417-20. 2003..CONCLUSION: The prevalence of liver enlargement and liver steatosis was higher among IBD patients. The prevalence of gallstones was increased in CD patients only. This risk was related to age, female sex, and previous surgery... - Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD studyVito Annese
Gastroenterology Unit, CSS IRCCS Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy
Am J Gastroenterol 100:84-92. 2005..Three major variants of the CARD15 gene confer susceptibility to Crohn's disease (CD). Whether or not these variants correlate with specific clinical features of the disease is under evaluation... - Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn's disease: a prospective comparative studyGiovanni Maconi
Department of Gastroenterology, L. Sacco University Hospital, Milan, Italy
Am J Gastroenterol 98:1545-55. 2003..Comparable accuracy was found for US and CT. The combination of barium and US studies, or the sole use of US in more CD patients with more severe disease, can reliably detect most internal fistulae and abscesses... - Prevalence and clinical significance of sonographic evidence of mesenteric fat alterations in Crohn's diseaseGiovanni Maconi
Gastroenterology and Biostatistics, Department of Clinical Sciences, L Sacco University Hospital, Milan, Italy
Inflamm Bowel Dis 14:1555-61. 2008..This study assessed its sonographic prevalence, the correlation with the degree of clinical or biochemical activity of the disease, and its impact on disease outcome in CD patients... - Sympathetic overactivity in active ulcerative colitis: effects of clonidineRaffaello Furlan
Unità Sincopi e Disturbi della Postura, Medicina Interna II, Ospedale L Sacco, Universita di Milano, Via G B Grassi 74, 20157 Milano, Italy
Am J Physiol Regul Integr Comp Physiol 290:R224-32. 2006..An overall increase of sympathetic activity characterized active UC. Normalization of the autonomic profile by clonidine was accompanied by an improvement of the disease... - Transperineal ultrasound in the detection of perianal and rectovaginal fistulae in Crohn's diseaseGiovanni Maconi
Chair of Gastroenterology, Department of Clinical Sciences, L Sacco University Hospital, University of Milan, Italy
Am J Gastroenterol 102:2214-9. 2007..We investigated Crohn's disease perianal and rectovaginal fistulae using transperineal ultrasound and compared the findings with results of endoanal ultrasound as reference standard... - Ultrasonographic detection of toxic megacolon in inflammatory bowel diseasesGiovanni Maconi
Gastrointestinal Unit, L. Sacco University Hospital, University of Milan, Milan, Italy
Dig Dis Sci 49:138-42. 2004 - Monocyte-derived dendritic cells from Crohn patients show differential NOD2/CARD15-dependent immune responses to bacteriaValentina Salucci
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Inflamm Bowel Dis 14:812-8. 2008..NOD2 is an intracellular receptor of muramyl dipeptide (MDP), a component of peptidoglycan present in the cell wall of gram-positive (G+) and gram-negative (G-) bacteria... - Combined therapeutic approach: inflammatory bowel diseases and peripheral or axial arthritisFabiola Atzeni
Rheumatology Unit, L Sacco University Hospital, Milano, Italy
World J Gastroenterol 15:2469-71. 2009.... - Omega-3 free fatty acids for the maintenance of remission in Crohn disease: the EPIC Randomized Controlled TrialsBrian G Feagan
Robarts Clinical Trials, Robarts Research Institute, University of Western Ontario, 100 Perth Dr, London, ON, Canada N6A 5K8
JAMA 299:1690-7. 2008..Maintenance therapy for Crohn disease features the use of immunosuppressive drugs, which are associated with an increased risk of infection. Identification of safe and effective maintenance strategies is a priority... - Prevalence of pancreatic insufficiency in inflammatory bowel diseases. Assessment by fecal elastase-1Giovanni Maconi
Department of Clinical Sciences, L Sacco University Hospital, Via GB Grassi, 74, Milan, Italy
Dig Dis Sci 53:262-70. 2008..PI is reversible in most patients, and persistent PI is not associated with clinically active disease... - Erythroderma and toxic epidermal necrolysis caused by to 5-aminosalacylic acidEnrico Iemoli
Inflamm Bowel Dis 12:1007-8. 2006 - Biologic therapy for inflammatory bowel diseaseSandro Ardizzone
Chair of Gastroenterology, L. Sacco University Hospital, Milan, Italy
Drugs 65:2253-86. 2005..More controlled clinical trials are currently being conducted, exploring the safety and efficacy of old and new biologic agents, and the search certainly will open new and exciting perspectives on the development of therapies for IBD...