Marcello Arca

Summary

Country: Italy

Publications

  1. ncbi The common mutations in the lipoprotein lipase gene in Italy: effects on plasma lipids and angiographically assessed coronary atherosclerosis
    M Arca
    Istituto di Terapia Medica Sistematica, Universita di Roma, La Sapienza, Italy
    Clin Genet 58:369-74. 2000
  2. ncbi Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy
    Marcello Arca
    Department of Clinical and Applied Medical Therapy, University La Sapienza, 00161 Rome, Italy
    Free Radic Biol Med 42:698-705. 2007
  3. pmc Treating statin-intolerant patients
    Marcello Arca
    Atherosclerosis Unit, Department of Internal Medicine and Allied Medical Specialities, Sapienza University of Rome, Rome, Italy
    Diabetes Metab Syndr Obes 4:155-66. 2011
  4. doi Metabolic consequences of adipose triglyceride lipase deficiency in humans: an in vivo study in patients with neutral lipid storage disease with myopathy
    Andrea Natali
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 98:E1540-8. 2013
  5. doi The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism
    Marcello Arca
    Dipartimento di Medicina, Interna e Specialità Mediche Sapienza Università di Roma, Rome, Italy
    Curr Opin Lipidol 24:313-20. 2013
  6. ncbi Mechanisms of diabetic dyslipidemia: relevance for atherogenesis
    Marcello Arca
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Università di Roma Viale del Policlinico, 155 00161 Rome, Italy
    Curr Vasc Pharmacol 10:684-6. 2012
  7. ncbi Management of statin-intolerant patient
    M Arca
    Atherosclerosis Unit, Department of Internal Medicine and Allied Medical Specialities, La Sapienza University, Rome, Italy
    Panminerva Med 54:105-18. 2012
  8. pmc Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD
    Marco G Baroni
    Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Italy
    BMC Med Genet 4:8. 2003
  9. ncbi Usefulness of atherogenic dyslipidemia for predicting cardiovascular risk in patients with angiographically defined coronary artery disease
    Marcello Arca
    Department of Clinical and Medical Therapy, Unit of Medical Therapy, Io Medical School, La Sapienza University of Rome, Rome, Italy
    Am J Cardiol 100:1511-6. 2007
  10. ncbi Comparison of atorvastatin versus fenofibrate in reaching lipid targets and influencing biomarkers of endothelial damage in patients with familial combined hyperlipidemia
    Marcello Arca
    Unit of Medical Therapy, Department of Clinical and Medical Therapy, University La Sapienza, Rome, Italy
    Metabolism 56:1534-41. 2007

Detail Information

Publications46

  1. ncbi The common mutations in the lipoprotein lipase gene in Italy: effects on plasma lipids and angiographically assessed coronary atherosclerosis
    M Arca
    Istituto di Terapia Medica Sistematica, Universita di Roma, La Sapienza, Italy
    Clin Genet 58:369-74. 2000
    ..None of LPL variants was a significant predictor of angiographically assessed coronary atherosclerosis. At most, the risk was borderline, increased in N291S carriers and possibly decreased in S447X carriers...
  2. ncbi Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy
    Marcello Arca
    Department of Clinical and Applied Medical Therapy, University La Sapienza, 00161 Rome, Italy
    Free Radic Biol Med 42:698-705. 2007
    ..More research work is needed to understand the clinical meaning of these findings, which may help to understand the role of oxidative stress in FCHL and lipid-lowering therapy...
  3. pmc Treating statin-intolerant patients
    Marcello Arca
    Atherosclerosis Unit, Department of Internal Medicine and Allied Medical Specialities, Sapienza University of Rome, Rome, Italy
    Diabetes Metab Syndr Obes 4:155-66. 2011
    ..However, the cardiovascular benefit of these strategies has not been well established, so their use has to be guided by a careful clinical assessment of each patient...
  4. doi Metabolic consequences of adipose triglyceride lipase deficiency in humans: an in vivo study in patients with neutral lipid storage disease with myopathy
    Andrea Natali
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 98:E1540-8. 2013
    ..The role of adipose triglyceride lipase (ATGL) in intermediate substrates metabolism has not been fully elucidated in humans...
  5. doi The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism
    Marcello Arca
    Dipartimento di Medicina, Interna e Specialità Mediche Sapienza Università di Roma, Rome, Italy
    Curr Opin Lipidol 24:313-20. 2013
    ..In this review, we discuss the recent developments in understanding the specific role in metabolic processes of the liver-derived ANGPTL3...
  6. ncbi Mechanisms of diabetic dyslipidemia: relevance for atherogenesis
    Marcello Arca
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Università di Roma Viale del Policlinico, 155 00161 Rome, Italy
    Curr Vasc Pharmacol 10:684-6. 2012
    ..The consequences of atherogenic dyslipidemia on mechanisms of atherogenesis will be also reviewed...
  7. ncbi Management of statin-intolerant patient
    M Arca
    Atherosclerosis Unit, Department of Internal Medicine and Allied Medical Specialities, La Sapienza University, Rome, Italy
    Panminerva Med 54:105-18. 2012
    ..However, the cardiovascular benefit of these approaches has not been established, so that their use has to be employed after a careful clinical assessment of each patient...
  8. pmc Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD
    Marco G Baroni
    Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Italy
    BMC Med Genet 4:8. 2003
    ..Furthermore, an 8 years prospective analysis of clinical cardiovascular events was related to the various genetic markers...
  9. ncbi Usefulness of atherogenic dyslipidemia for predicting cardiovascular risk in patients with angiographically defined coronary artery disease
    Marcello Arca
    Department of Clinical and Medical Therapy, Unit of Medical Therapy, Io Medical School, La Sapienza University of Rome, Rome, Italy
    Am J Cardiol 100:1511-6. 2007
    ..21, p = 0.008). In conclusion, these data provide evidence that atherogenic dyslipidemia is an independent predictor of cardiovascular risk in patients with CAD, even stronger than isolated high triglycerides or low HDL cholesterol...
  10. ncbi Comparison of atorvastatin versus fenofibrate in reaching lipid targets and influencing biomarkers of endothelial damage in patients with familial combined hyperlipidemia
    Marcello Arca
    Unit of Medical Therapy, Department of Clinical and Medical Therapy, University La Sapienza, Rome, Italy
    Metabolism 56:1534-41. 2007
    ....
  11. ncbi Atorvastatin efficacy in the prevention of cardiovascular events in patients with diabetes mellitus and/or metabolic syndrome
    Marcello Arca
    Department of Clinical and Therapeutic Medicine, La Sapienza University of Rome, Rome, Italy
    Drugs 67:43-54. 2007
    ....
  12. ncbi Atorvastatin efficacy in the primary and secondary prevention of cardiovascular events
    Marcello Arca
    Department of Clinical and Therapeutic Medicine, La Sapienza University of Rome, Rome, Italy
    Drugs 67:29-42. 2007
    ....
  13. ncbi PON1 L55M polymorphism is not a predictor of coronary atherosclerosis either alone or in combination with Q192R polymorphism in an Italian population
    M Arca
    Universita degli Studi di Roma La Sapienza, Rome, Italy
    Eur J Clin Invest 32:9-15. 2002
    ..The present study evaluated the role of the PON1 L55M polymorphism independently and in conjunction with the Q192R polymorphism on the risk of coronary atherosclerosis in an Italian population...
  14. ncbi Atorvastatin: a safety and tolerability profile
    Marcello Arca
    Department of Clinical and Therapeutic Medicine, La Sapienza University of Rome, Rome, Italy
    Drugs 67:63-9. 2007
    ..Thus, atorvastatin is a safe and well tolerated statin for use in a wide range of patients...
  15. ncbi Lack of association of the common TaqIB polymorphism in the cholesteryl ester transfer protein gene with angiographically assessed coronary atherosclerosis
    M Arca
    Istituto di Terapia Medica Sistematica, Universita degli Studi di Roma La Sapienza, Italy
    Clin Genet 60:374-80. 2001
    ..Our findings do not support the hypothesis that a genetic variant resulting in lowered CETP activity is associated with reduced risk of coronary atherosclerosis...
  16. doi Functional rs20417 SNP (-765G>C) of cyclooxygenase-2 gene does not predict the risk of recurrence of ischemic events in coronary patients: results of a 7-year prospective study
    Anna Montali
    Department of Clinical and Medical Therapy, Atherosclerosis Unit, Lipid Clinic Center of La Sapienza University of Rome, Rome, Italy
    Cardiology 115:236-42. 2010
    ..Conclusions: These results suggest that the functional G-765C variant in the COX-2 gene is not a significant predictor of the recurrence of ischemic events in coronary patients...
  17. doi C242T polymorphism of NADPH oxidase p22phox and recurrence of cardiovascular events in coronary artery disease
    Marcello Arca
    Department of Clinical and Medical Therapy, Unit of Medical Therapy, La Sapienza University, Rome, Italy
    Arterioscler Thromb Vasc Biol 28:752-7. 2008
    ..The common C242T polymorphism in the gene for the p22phox subunit of NADPH oxidase has been reported to be negatively associated with oxidative stress, but whether it confers prognostic information is not yet clear...
  18. doi Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia
    Luisa Nanni
    Department of Clinical and Medical Therapy, Unit of Atherosclerosis, University of Rome La Sapienza, Italy
    Atherosclerosis 213:206-11. 2010
    ..This study was designed to evaluate whether selected PNPLA2 variants may influence the susceptibility to FCHL or its lipid-related traits...
  19. doi Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization
    Ilenia Minicocci
    Department of Internal Medicine and Medical Specialties, Atherosclerosis Unit, Sapienza University of Rome, 00161 Rome, Italy
    J Clin Endocrinol Metab 97:E1266-75. 2012
    ..Familial combined hypolipidemia causes a global reduction of plasma lipoproteins. Its clinical correlates and metabolic implications have not been well defined...
  20. ncbi Detection of familial hypercholesterolemia in a cohort of children with hypercholesterolemia: results of a family and DNA-based screening
    Filomena Campagna
    Department of Clinical and Applied Medical Therapy, Unit of Medical Therapy, University of Rome La Sapienza, Rome, Italy
    Atherosclerosis 196:356-64. 2008
    ..9 mmol/L was the best cut off value for diagnosing FH in these children, showing 79% sensitivity and 71.0% specificity. We propose the use of a LDL-C cut off level associated with a family study to identify FH among HC children...
  21. ncbi The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age <or=50 years)
    Emanuela Filippi
    Department of Clinical Sciences, Division of Endocrinology, Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy
    J Mol Med (Berl) 83:711-9. 2005
    ....
  22. pmc Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis
    Ilenia Minicocci
    Departments of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy
    J Lipid Res 54:3481-90. 2013
    ..Furthermore, our analysis confirmed that FHBL2 is not associated with adverse clinical sequelae. The possibility that FHBL2 confers lower risk of diabetes and cardiovascular disease warrants more detailed investigation. ..
  23. ncbi Atorvastatin: its clinical role in cerebrovascular prevention
    Achille Gaspardone
    Cardiology Department, Ospedale S Eugenio, Rome, Italy
    Drugs 67:55-62. 2007
    ....
  24. ncbi Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperli
    Filomena Campagna
    Dipartimento di Terapia Medica, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Metabolism 51:1298-305. 2002
    ..Conversely, genetic variants in the IRS-1, FABP-2, and the beta3-AR gene appear not to have a major role as modifier genes in FCHL...
  25. ncbi The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients
    D Ombres
    Istituto di Terapia Medica Sistematica, II Cattedra di Cardiologia and Istituto di Chirurgia del Cuore e dei Grossi Vasi, Universita di Roma La Sapienza, Italy
    Arterioscler Thromb Vasc Biol 18:1611-6. 1998
    ..However, it did confirm that the PON1 low-activity allele is associated with a less atherogenic lipid profile...
  26. ncbi Autosomal recessive hypercholesterolemia in Spanish kindred due to a large deletion in the ARH gene
    Fabiana Quagliarini
    Department of Clinical and Medical Therapy, Unit of Medical Therapy, Sapienza University of Rome, Policlinico Umberto, I Viale del Policlinico 155, 00161 Rome, Italy
    Mol Genet Metab 92:243-8. 2007
    ..No protein product was detected in affected individuals by immunoblot analysis. This novel mutation adds new support to the molecular heterogeneity of ARH in the Mediterranean basin...
  27. ncbi Congenital analbuminemia attributable to compound heterozygosity for novel mutations in the albumin gene
    Filomena Campagna
    Department of Clinical and Applied Medical Therapy, University of Rome, La Sapienza, Italy
    Clin Chem 51:1256-8. 2005
  28. doi The relationship between metabolic syndrome, its components, and the whole-body atherosclerotic disease burden as measured by computed tomography angiography
    Giovanni Pigna
    Department of Medicine and Medical Specialities, Unit of Atherosclerosis, Sapienza University of Rome, Rome, Italy
    Atherosclerosis 215:417-20. 2011
    ..Quantify the whole-body atherosclerotic disease in asymptomatic subjects with and without metabolic syndrome (MetS) and to assess the contribution of the syndrome and its components to the atherosclerotic burden...
  29. ncbi The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity
    Raffaella Buzzetti
    Endocrinology, Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy
    Eur J Hum Genet 12:1050-4. 2004
    ..Our observations substantially extend previous findings and demonstrated that X12Ala variant is significantly associated with greater insulin sensitivity...
  30. doi Novel mutations in the adipose triglyceride lipase gene causing neutral lipid storage disease with myopathy
    Filomena Campagna
    Department of Clinical and Therapeutic Medicine, Universita di Roma La Sapienza, 00161 Rome, Italy
    Biochem Biophys Res Commun 377:843-6. 2008
    ..L255X and p.I212X, respectively). These mutations predict a truncated PNPLA2 protein lacking the C-terminal hydrophobic domain. These findings indicate that NLSDM is rare, but genetically heterogeneous...
  31. ncbi 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques
    Alessio Annovazzi
    Nuclear Medicine, 2nd Faculty of Medicine, University La Sapienza, Rome, Italy
    Eur J Nucl Med Mol Imaging 33:117-26. 2006
    ....
  32. ncbi Angiotensin-converting enzyme gene polymorphism is not associated with coronary atherosclerosis and myocardial infarction in a sample of Italian patients
    M Arca
    Istituto di Terapia Medica Sistematica, Universita di Roma La Sapienza, Italy
    Eur J Clin Invest 28:485-90. 1998
    ..However, the relationships between ACE genotypes, the development of coronary atherosclerosis and the occurrence of major coronary events are still controversial...
  33. ncbi Association of the human adiponectin gene and insulin resistance
    Emanuela Filippi
    1Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Rome, Italy
    Eur J Hum Genet 12:199-205. 2004
    ..In particular, among leaner individuals, the adiponectin gene appears to determine an increased risk to develop insulin resistance...
  34. ncbi A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease
    M G Baroni
    Istituto di II Clinica Medica, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy
    Arterioscler Thromb Vasc Biol 19:2975-80. 1999
    ..Besides the increased frequency of diabetes, carriers showed a more atherogenic lipid profile, suggesting a potential role of the IRS-1 gene in the pathogenesis of lipid abnormalities associated with CAD...
  35. ncbi The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance
    M G Baroni
    Department of Clinical Science, Division of Endocrinology, University of Rome La Sapienza, Rome, Italy
    Diabetologia 44:367-72. 2001
    ..By investigating the relation between this IRS-1 mutation, measures of obesity and metabolic parameters, we explored the possible influence of this mutation on body fat distribution and insulin resistance...
  36. doi Subclinical atherosclerosis in systemic lupus erythematosus and antiphospholipid syndrome: focus on β2GPI-specific T cell response
    Fabrizio Conti
    From the Rheumatology Unit F C, F R S, C A, F C, E M, G V, Atherosclerosis Unit A M, M A, and Internal Medicine D M P, Department of Internal Medicine and Medical Specialties and Department of Experimental Medicine A C, M S, Sapienza University of Rome, Rome, Italy and Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy B B, E P, R R
    Arterioscler Thromb Vasc Biol 34:661-8. 2014
    ..We evaluated early atherosclerosis in patients with SLE and APS and investigated T cell reactivity to β2GPI and its relationship with atherosclerotic process...
  37. ncbi Human resistin gene, obesity, and type 2 diabetes: mutation analysis and population study
    Federica Sentinelli
    Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Rome, Italy
    Diabetes 51:860-2. 2002
    ..In conclusion, our data suggest that genetic defects of the resistin gene are unlikely to play a role in the etiology of these common disorders in our population...
  38. doi Comparison between an empirically derived model and the EuroSCORE system in the evaluation of hospital performance: the example of the Italian CABG Outcome Project
    Paola D'Errigo
    National Centre of Epidemiology, Surveillance and Health Promotion Istituto Superiore di Sanità, Rome, Italy
    Eur J Cardiothorac Surg 33:325-33. 2008
    ..To compare the risk-adjustment model empirically derived from the 'Italian CABG Outcome Project' with that of the additive and logistic EuroSCORE in terms of accuracy, predictive power and ability to rank hospital performances...
  39. doi Clinical and genetic characterization of Chanarin-Dorfman syndrome
    Claudio Bruno
    Muscular and Neurodegenerative Disease Unit, Giannina Gaslini Institute, University of Genova, Genova, Italy
    Biochem Biophys Res Commun 369:1125-8. 2008
    ..Molecular analysis identified five mutations, three of which are novel. These findings expand the clinical and mutational spectrum and underline the genetic heterogeneity of this disease...
  40. ncbi Autosomal recessive hypercholesterolemia (ARH) and homozygous familial hypercholesterolemia (FH): a phenotypic comparison
    Livia Pisciotta
    Department of Internal Medicine, University of Genoa, Vaile Benedetto XV 6, I 16132 Genoa, Italy
    Atherosclerosis 188:398-405. 2006
    ..In conclusion the clinical phenotype of ARH is milder than that of receptor-negative HoFH and resembles that observed in receptor-defective HoFH...
  41. ncbi A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
    Francesco Cipollone
    G d Annunzio University of Chieti and G d Annunzio University Foundation, Chieti, Italy
    JAMA 291:2221-8. 2004
    ..Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear...
  42. ncbi The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, 20133 Milan, Italy
    Arterioscler Thromb Vasc Biol 25:1972-8. 2005
    ..To better understand the role of lecithin:cholesterol acyltransferase (LCAT) in lipoprotein metabolism through the genetic and biochemical characterization of families carrying mutations in the LCAT gene...
  43. ncbi Treatment of severe hypercholesterolemia with atorvastatin in congenital analbuminemia
    Maria Del Ben
    Am J Med 117:803-4. 2004
  44. ncbi Interleukin-1 gene cluster polymorphisms and risk of coronary artery disease
    Branislav Vohnout
    Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Consorzio Mario Negri Sud, Via Nazionale 1, 66030 Santa Maria Imbaro, Italy
    Haematologica 88:54-60. 2003
    ..Several genetic polymorphisms have been described in the genes of the IL-1 cluster and associations with coronary artery disease (CAD) have been reported, although with contrasting results...
  45. ncbi Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis
    Marcello Arca
    Department of Medical Therapy, University of Rome La Sapienza, Italy
    Lancet 359:841-7. 2002
    ..Our aim was to ascertain why ARH is more common on Sardinia than elsewhere...
  46. ncbi Adaptor protein ARH is recruited to the plasma membrane by low density lipoprotein (LDL) binding and modulates endocytosis of the LDL/LDL receptor complex in hepatocytes
    Maria Isabella Sirinian
    Department of Clinical and Applied Medical Therapy, University of Rome La Sapienza, Italy
    J Biol Chem 280:38416-23. 2005
    ..We suggest that ARH is an endocytic sorting adaptor that actively participates in the internalization of the LDL-LDLR complex, possibly enhancing the efficiency of its packaging into the endocytic vesicles...