Appendino G, Chianese G, Taglialatela Scafati O. Cannabinoids: occurrence and medicinal chemistry. Curr Med Chem. 2011;18:1085-99 pubmed
..sativa, the medicinal chemistry of cannabinoids, and their distribution in plants, highlighting the impact that research in these hot fields could have for modern medicinal chemistry and pharmacology. ..
Appendino G, Spagliardi P, Ballero M, Seu G. Macrocyclic diterpenoids from Euphorbia hyberna L. subsp. insularis and their reaction with oxyphilic reagents. Fitoterapia. 2002;73:576-82 pubmed
..Dehydration, isomerization of the exocyclic double and acyl rearrangement were, however, observed after reduction of the 9-keto group. ..
Appendino G, Bianchi F, Bader A, Campagnuolo C, Fattorusso E, Taglialatela Scafati O, et al
. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin. J Nat Prod. 2004;67:532-6 pubmed
..Despite a close structural similarity, compounds 2a and 2b induced apoptosis in Jurkat leukemia cells in mechanistically different ways. ..
Appendino G, Prosperini S, Valdivia C, Ballero M, Colombano G, Billington R, et al
. SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis. J Nat Prod. 2005;68:1213-7 pubmed
..Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties. ..
Appendino G, Maxia L, Bascope M, Houghton P, Sanchez Duffhues G, Munoz E, et al
. A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida. J Nat Prod. 2006;69:1101-4 pubmed
..This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances. ..
Appendino G, Pollastro F, Verotta L, Ballero M, Romano A, Wyrembek P, et al
. Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus. J Nat Prod. 2009;72:962-5 pubmed publisher
Appendino G, Ottino M, Marquez N, Bianchi F, Giana A, Ballero M, et al
. Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum. J Nat Prod. 2007;70:608-12 pubmed
..Arzanol inhibited HIV-1 replication in T cells and the release of pro-inflammatory cytokines in LPS-stimulated primary monocytes, qualifying as a novel plant-derived anti-inflammatory and antiviral chemotype worth further investigation. ..
Appendino G, Maxia L, Bettoni P, Locatelli M, Valdivia C, Ballero M, et al
. Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). J Nat Prod. 2006;69:251-4 pubmed
..Despite their close similarity, significant antibacterial activity was shown only by one of these compounds (3b, gallomyrtucommulone B), while the G3 hormone (4) was inactive...