Luigi Francesco Agnati

Summary

Country: Italy

Publications

  1. pmc The neurobiology of imagination: possible role of interaction-dominant dynamics and default mode network
    Luigi F Agnati
    IRCCS San Camillo, Venice, Italy
    Front Psychol 4:296. 2013
  2. ncbi request reprint A new interpretative paradigm for Conformational Protein Diseases
    Luigi Francesco Agnati
    IRCCS San Camillo, Lido Venezia, Italy
    Curr Protein Pept Sci 14:141-60. 2013
  3. doi request reprint Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism
    Luigi F Agnati
    IRCCS San Camillo, Lido VE, Italy
    Brain Res 1476:38-57. 2012
  4. doi request reprint Neuronal correlates to consciousness. The "Hall of Mirrors" metaphor describing consciousness as an epiphenomenon of multiple dynamic mosaics of cortical functional modules
    Luigi Francesco Agnati
    Fondazione IRCCS San Camillo, Venezia Lido, Italy
    Brain Res 1476:3-21. 2012
  5. doi request reprint Aspects on the integrative actions of the brain from neural networks to "brain-body medicine"
    L F Agnati
    IRCCS San Camillo, Lido Venezia, Italy
    J Recept Signal Transduct Res 32:163-80. 2012
  6. ncbi request reprint A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's disease
    L F Agnati
    Department of Biomedical Sciences, University of Modena and IRCCS Lido, Venezia, Italy
    Curr Alzheimer Res 7:307-22. 2010
  7. doi request reprint On the key role played by altered protein conformation in Parkinson's disease
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
    J Neural Transm 115:1285-99. 2008
  8. ncbi request reprint Understanding neuronal molecular networks builds on neuronal cellular network architecture
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Brain Res Rev 58:379-99. 2008
  9. ncbi request reprint Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domains
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
    Brain Res Rev 58:459-74. 2008
  10. ncbi request reprint Role of cooperativity in protein folding and protein mosaic assemblage relevance for protein conformational diseases
    L F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Curr Protein Pept Sci 8:460-70. 2007

Collaborators

Detail Information

Publications46

  1. pmc The neurobiology of imagination: possible role of interaction-dominant dynamics and default mode network
    Luigi F Agnati
    IRCCS San Camillo, Venice, Italy
    Front Psychol 4:296. 2013
    ....
  2. ncbi request reprint A new interpretative paradigm for Conformational Protein Diseases
    Luigi Francesco Agnati
    IRCCS San Camillo, Lido Venezia, Italy
    Curr Protein Pept Sci 14:141-60. 2013
    ..Against this background an original interpretative paradigm for CPDs will be given in the frame of the previously proposed Red Queen Theory of Aging...
  3. doi request reprint Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism
    Luigi F Agnati
    IRCCS San Camillo, Lido VE, Italy
    Brain Res 1476:38-57. 2012
    ..A selection of illustrative examples of each of these mental states is presented as they appear in the pages of the European literature. This article is part of a Special Issue entitled: Brain Integration...
  4. doi request reprint Neuronal correlates to consciousness. The "Hall of Mirrors" metaphor describing consciousness as an epiphenomenon of multiple dynamic mosaics of cortical functional modules
    Luigi Francesco Agnati
    Fondazione IRCCS San Camillo, Venezia Lido, Italy
    Brain Res 1476:3-21. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  5. doi request reprint Aspects on the integrative actions of the brain from neural networks to "brain-body medicine"
    L F Agnati
    IRCCS San Camillo, Lido Venezia, Italy
    J Recept Signal Transduct Res 32:163-80. 2012
    ..These highly interconnected regions operate as specialized interfaces between the brain and the body integrating brain-borne and body-borne neural and humoral signals...
  6. ncbi request reprint A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's disease
    L F Agnati
    Department of Biomedical Sciences, University of Modena and IRCCS Lido, Venezia, Italy
    Curr Alzheimer Res 7:307-22. 2010
    ..The results of the present simulation is compatible with the proposal that mutated mitochondrial agents behave as though they were infectious particles migrating through a continuum of interconnected cells...
  7. doi request reprint On the key role played by altered protein conformation in Parkinson's disease
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
    J Neural Transm 115:1285-99. 2008
    ..This datum is in agreement with the observation that these two proteins synergistically promote polymerisation of each other into amyloid fibrils, favouring the formation of Lewy bodies...
  8. ncbi request reprint Understanding neuronal molecular networks builds on neuronal cellular network architecture
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Brain Res Rev 58:379-99. 2008
    ..Thus, by means of a computer assisted analysis the presence of disorder sequences in the main streams of the molecular networks that have beta2AR and EGFR as input proteins leading to MAP kinase activation has been evaluated...
  9. ncbi request reprint Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domains
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
    Brain Res Rev 58:459-74. 2008
    ....
  10. ncbi request reprint Role of cooperativity in protein folding and protein mosaic assemblage relevance for protein conformational diseases
    L F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Curr Protein Pept Sci 8:460-70. 2007
    ..Such aggregates cause pathological changes in the GMN structure and function leading to neurodegenerative diseases such as Alzheimer's disease. Thus, a novel view of the so called Protein Conformational Diseases (PCD) is proposed...
  11. ncbi request reprint Possible relevance of receptor-receptor interactions between viral- and host-coded receptors for viral-induced disease
    Luigi F Agnati
    Section of Physiology and 2Section of Pharmacology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    ScientificWorldJournal 7:1073-81. 2007
    ..The prevention of viral receptor-induced changes in host receptor networks may give rise to novel antiviral drugs that counteract viral-induced disease...
  12. ncbi request reprint Does the human brain have unique genetically determined networks coding logical and ethical principles and aesthetics? From Plato to novel mirror networks
    Luigi Francesco Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 141100 Modena, Italy
    Brain Res Rev 55:68-77. 2007
    ..On these grounds it is suggested that neurobiological findings can give important contributions to the philosophical debate on innatism by putting forward possible explanatory models and heuristic hypotheses...
  13. doi request reprint Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein
    L F Agnati
    Department of Biomedical Sciences, University of Modena, Via Campi 287, 41100 Modena, Italy
    J Neural Transm 116:953-74. 2009
    ..The paper presents findings supporting the concept that such key-signals in instances such as ageing may favour neurodegenerative processes in an attempt of maximizing neuronal plasticity...
  14. doi request reprint Implications of the 'Energide' concept for communication and information handling in the central nervous system
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi, 287, 41100 Modena, Italy
    J Neural Transm 116:1037-52. 2009
    ..Finally, relevances of the Energide concept for the information handling in the central nervous system are discussed especially in relation to the inter-Energide exchange of information...
  15. pmc Theoretical considerations on the topological organization of receptor mosaics
    Agnati Luigi Francesco
    Department Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS Lido, Venezia, Italy
    Curr Protein Pept Sci 10:559-69. 2009
    ..Thus, just as in any network, the receptor operating as a hub is the one that in the molecular network formed by the receptors has the highest number of inputs...
  16. doi request reprint Receptor-receptor interactions: A novel concept in brain integration
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and IRCCS San Camillo, Lido Venezia, Italy
    Prog Neurobiol 90:157-75. 2010
    ..Finally, the hypothesis is introduced on the existence of check-points along the amino acid pathways connecting allosteric and orthosteric binding sites of a receptor and their potential importance for drug development...
  17. ncbi request reprint Understanding wiring and volume transmission
    Luigi F Agnati
    IRCCS San Camillo Venezia, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, Modena, Italy
    Brain Res Rev 64:137-59. 2010
    ....
  18. pmc On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers
    Luigi F Agnati
    IRCCS San Camillo, Lido Venezia, Italy
    J Recept Signal Transduct Res 30:287-303. 2010
    ..Therefore, the theoretical implications of the GPCR oligomerization will be briefly discussed together with possible implications of this phenomenon especially for new strategies in drug development...
  19. doi request reprint An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors
    Luigi F Agnati
    IRCCS San Camillo, Lido Venezia, Italy
    J Recept Signal Transduct Res 30:355-69. 2010
    ..It is interesting to note that in some instances accordance has been found between the bioinformatics indications and the available experimental data...
  20. doi request reprint Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms
    Luigi Francesco Agnati
    IRCCS San Camillo, Lido VE, Italy
    J Recept Signal Transduct Res 31:315-31. 2011
    ..We believe that almost all the biochemical knowledge presently available on GPCRs can be used in the development of these new pharmacological approaches...
  21. ncbi request reprint One century of progress in neuroscience founded on Golgi and Cajal's outstanding experimental and theoretical contributions
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Brain Res Rev 55:167-89. 2007
    ..In fact, it has been proposed that a network of fibrils enmeshes the entire CNS forming a global molecular network (GMN) superimposed on the cellular networks...
  22. ncbi request reprint Allosteric modulation of dopamine D2 receptors by homocysteine
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
    J Proteome Res 5:3077-83. 2006
    ..The present results could have implications for Parkinson's disease...
  23. ncbi request reprint Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease
    L F Agnati
    Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, Modena, Italy
    J Neural Transm 114:21-31. 2007
    ....
  24. ncbi request reprint Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease
    Luigi F Agnati
    Department of Biomedial Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Brain Res Bull 64:155-64. 2004
    ..These results open new therapeutic avenues in early events in Parkinson's disease...
  25. ncbi request reprint Energy gradients for VT-signal migration in the CNS: studies on melanocortin receptors, mitochondrial uncoupling proteins and food intake
    L F Agnati
    Section of Physiology, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy
    J Endocrinol Invest 27:23-34. 2004
    ..g., in the arcuate nucleus representing signals relevant to energy homeostasis). Thus, WT and VT are both modulated by peptidergic signals that affect thermal gradients...
  26. ncbi request reprint Energy gradients for the homeostatic control of brain ECF composition and for VT signal migration: introduction of the tide hypothesis
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Neural Transm 112:45-63. 2005
    ..These fluid push-pull movements favor both the migration of signals and the extra-cellular fluid renewal, especially in the cerebral cortex...
  27. ncbi request reprint Studies on homocysteine plasma levels in Alzheimer's patients. Relevance for neurodegeneration
    L F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena
    J Neural Transm 112:163-9. 2005
    ....
  28. ncbi request reprint How receptor mosaics decode transmitter signals. Possible relevance of cooperativity
    Luigi F Agnati
    Department of Biomedical Sciences, 41100 Modena, Italy
    Trends Biochem Sci 30:188-93. 2005
    ..Thus, the binding of the ligand at one receptor alters the likelihood of the same ligand binding at the next site, in the case of RMs, formed by identical receptors and/or by iso-receptors (receptors that bind the same ligand)...
  29. ncbi request reprint How proteins come together in the plasma membrane and function in macromolecular assemblies: focus on receptor mosaics
    Luigi F Agnati
    Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Mol Neurosci 26:133-54. 2005
    ..The oscillation in the intensity of the dipole caused by the action potentials opens the possibility of an interaction among dipoles by electromagnetic waves...
  30. ncbi request reprint Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases
    Luigi Francesco Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Neuromolecular Med 7:61-78. 2005
    ....
  31. ncbi request reprint Volume transmission and wiring transmission from cellular to molecular networks: history and perspectives
    L F Agnati
    Department of Biomedical Sciences, Section of Physiology, University of Modena, Modena, Italy
    Acta Physiol (Oxf) 187:329-44. 2006
    ..Thus, as an experimental part of the present paper a new approach to evaluate transmitter-receptor mismatches is given and evidence for inter-relationships between temperature micro-gradients and mismatches is provided...
  32. ncbi request reprint The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathology
    L F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS, Ospedale San Camillo, Venezia, Italy
    J Neural Transm 114:3-19. 2007
    ..The relevance of this new view of brain organization for a deeper understanding of some neurophysiological and neuropathological aspects of its function is briefly discussed...
  33. ncbi request reprint A boolean network modelling of receptor mosaics relevance of topology and cooperativity
    L F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS, Ospedale San Camillo, Venezia, Italy
    J Neural Transm 114:77-92. 2007
    ....
  34. ncbi request reprint On the existence of a global molecular network enmeshing the whole central nervous system: physiological and pathological implications
    L F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Curr Protein Pept Sci 7:3-15. 2006
    ....
  35. ncbi request reprint Differential sensitivity of A2A and especially D2 receptor trafficking to cocaine compared with lipid rafts in cotransfected CHO cell lines. Novel actions of cocaine independent of the DA transporter
    Susanna Genedani
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    J Mol Neurosci 41:347-57. 2010
    ..It is proposed that changes in D(2) and A(2A)-D(2) trafficking induced by allosteric actions of cocaine at D(2) receptors may contribute to the alterations of D(2) signaling found in cocaine abusers...
  36. ncbi request reprint Introductory remarks
    Luigi F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Mol Neurosci 26:109-12. 2005
  37. ncbi request reprint Computer-assisted image analysis of caveolin-1 involvement in the internalization process of adenosine A2A-dopamine D2 receptor heterodimers
    Susanna Genedani
    Section of Pharmacology, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Mol Neurosci 26:177-84. 2005
    ....
  38. ncbi request reprint Receptor-receptor interactions, receptor mosaics, and basic principles of molecular network organization: possible implications for drug development
    Luigi F Agnati
    Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
    J Mol Neurosci 26:193-208. 2005
    ..These new data on G protein-coupled receptors and molecular network organization indicate possible new approaches for drug development...
  39. ncbi request reprint On the molecular basis of the receptor mosaic hypothesis of the engram
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena, Modena, Italy
    Cell Mol Neurobiol 24:501-16. 2004
    ..Hence, this mechanism may play a role in learning processes where the input to a neuron is likely to remain constant for a while...
  40. ncbi request reprint New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cells
    Luigi F Agnati
    Department of Biomedical Sciences, Section of Physiology, University of Modena, Modena, Italy
    J Histochem Cytochem 53:941-53. 2005
    ....
  41. ncbi request reprint Receptor mosaics of neural and immune communication: possible implications for basal ganglia functions
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Brain Res Rev 58:400-14. 2008
    ..On the examples of receptor superfamilies expressed both in the neural and immune cells, our review paper aims to show some implications of receptor-receptor interactions for basal ganglia functions in health and disease...
  42. ncbi request reprint Concluding remarks
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Mol Neurosci 26:299-302. 2005
    ..Thus, Ra' operates as a modulator protein of Rb. 3. Ra' can still recognize its ligand and signal, but it allosterically affects its heteromeric partner Rb in a different way. Thus, Ra' operates as an unusual modulator of Rb...
  43. ncbi request reprint A simple mathematical model of cooperativity in receptor mosaics based on the "symmetry rule"
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena, Modena, Italy
    Biosystems 80:165-73. 2005
    ....
  44. ncbi request reprint Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptides
    Giuseppina Leo
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Curr Alzheimer Res 4:305-13. 2007
    ..These alterations in the neuroglial network morphology and function can, at least in part, explain the enhanced pain threshold observed in the Abeta intra-striatally injected animals...
  45. ncbi request reprint Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus
    Carla Torri
    Department of Biomedical Sciences, Section of Physiology and Centro di Nutrizione Clinica e Malattie Metaboliche, University of Modena and Reggio Emilia, Via Campi 287, 41100, Modena, Italy
    Peptides 23:1063-8. 2002
    ..Altered hypothalamic transmission by POMC-derived peptides may contribute to the susceptibility of cafDIO rats to the weight promoting action of caf diet...
  46. ncbi request reprint Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia
    Martina Ballmaier
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Brescia University Medical School, Via Valsabbina 19, 25123 Brescia, Italy
    Eur J Neurosci 15:1197-205. 2002
    ..These results suggest a specific link between reelin-related neuronal pathology and dopamine involvement in the pathophysiology of psychotic disorders...