Research Topics
Species | Luigi Francesco AgnatiSummaryCountry: Italy Publications
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Publications
Possible genetic and epigenetic links between human inner speech, schizophrenia and altruismLuigi F Agnati
IRCCS San Camillo, Lido VE, Italy
Brain Res 1476:38-57. 2012..A selection of illustrative examples of each of these mental states is presented as they appear in the pages of the European literature. This article is part of a Special Issue entitled: Brain Integration...- Neuronal correlates to consciousness. The "Hall of Mirrors" metaphor describing consciousness as an epiphenomenon of multiple dynamic mosaics of cortical functional modulesLuigi Francesco Agnati
Fondazione IRCCS San Camillo, Venezia Lido, Italy
Brain Res 1476:3-21. 2012..This article is part of a Special Issue entitled: Brain Integration... - Aspects on the integrative actions of the brain from neural networks to "brain-body medicine"L F Agnati
IRCCS San Camillo, Lido Venezia, Italy
J Recept Signal Transduct Res 32:163-80. 2012..These highly interconnected regions operate as specialized interfaces between the brain and the body integrating brain-borne and body-borne neural and humoral signals... 
Theoretical considerations on the topological organization of receptor mosaicsAgnati Luigi Francesco
Department Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS Lido, Venezia, Italy
Curr Protein Pept Sci 10:559-69. 2009..Thus, just as in any network, the receptor operating as a hub is the one that in the molecular network formed by the receptors has the highest number of inputs...- Understanding neuronal molecular networks builds on neuronal cellular network architectureLuigi F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Brain Res Rev 58:379-99. 2008..Thus, by means of a computer assisted analysis the presence of disorder sequences in the main streams of the molecular networks that have beta2AR and EGFR as input proteins leading to MAP kinase activation has been evaluated... 
Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domainsL F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
Brain Res Rev 58:459-74. 2008....- Role of cooperativity in protein folding and protein mosaic assemblage relevance for protein conformational diseasesL F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Curr Protein Pept Sci 8:460-70. 2007..Such aggregates cause pathological changes in the GMN structure and function leading to neurodegenerative diseases such as Alzheimer's disease. Thus, a novel view of the so called Protein Conformational Diseases (PCD) is proposed... - Possible relevance of receptor-receptor interactions between viral- and host-coded receptors for viral-induced diseaseLuigi F Agnati
Section of Physiology and 2Section of Pharmacology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
ScientificWorldJournal 7:1073-81. 2007..The prevention of viral receptor-induced changes in host receptor networks may give rise to novel antiviral drugs that counteract viral-induced disease... - Does the human brain have unique genetically determined networks coding logical and ethical principles and aesthetics? From Plato to novel mirror networksLuigi Francesco Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 141100 Modena, Italy
Brain Res Rev 55:68-77. 2007..On these grounds it is suggested that neurobiological findings can give important contributions to the philosophical debate on innatism by putting forward possible explanatory models and heuristic hypotheses... - One century of progress in neuroscience founded on Golgi and Cajal's outstanding experimental and theoretical contributionsLuigi F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
Brain Res Rev 55:167-89. 2007..In fact, it has been proposed that a network of fibrils enmeshes the entire CNS forming a global molecular network (GMN) superimposed on the cellular networks... - On the key role played by altered protein conformation in Parkinson's diseaseL F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
J Neural Transm 115:1285-99. 2008..This datum is in agreement with the observation that these two proteins synergistically promote polymerisation of each other into amyloid fibrils, favouring the formation of Lewy bodies... - Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synucleinL F Agnati
Department of Biomedical Sciences, University of Modena, Via Campi 287, 41100 Modena, Italy
J Neural Transm 116:953-74. 2009..The paper presents findings supporting the concept that such key-signals in instances such as ageing may favour neurodegenerative processes in an attempt of maximizing neuronal plasticity... - Implications of the 'Energide' concept for communication and information handling in the central nervous systemL F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi, 287, 41100 Modena, Italy
J Neural Transm 116:1037-52. 2009..Finally, relevances of the Energide concept for the information handling in the central nervous system are discussed especially in relation to the inter-Energide exchange of information... - Receptor-receptor interactions: A novel concept in brain integrationLuigi F Agnati
Department of Biomedical Sciences, University of Modena and IRCCS San Camillo, Lido Venezia, Italy
Prog Neurobiol 90:157-75. 2010..Finally, the hypothesis is introduced on the existence of check-points along the amino acid pathways connecting allosteric and orthosteric binding sites of a receptor and their potential importance for drug development... - A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's diseaseL F Agnati
Department of Biomedical Sciences, University of Modena and IRCCS Lido, Venezia, Italy
Curr Alzheimer Res 7:307-22. 2010..The results of the present simulation is compatible with the proposal that mutated mitochondrial agents behave as though they were infectious particles migrating through a continuum of interconnected cells... - Understanding wiring and volume transmissionLuigi F Agnati
IRCCS San Camillo Venezia, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, Modena, Italy
Brain Res Rev 64:137-59. 2010.... - On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromersLuigi F Agnati
IRCCS San Camillo, Lido Venezia, Italy
J Recept Signal Transduct Res 30:287-303. 2010..Therefore, the theoretical implications of the GPCR oligomerization will be briefly discussed together with possible implications of this phenomenon especially for new strategies in drug development... - An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptorsLuigi F Agnati
IRCCS San Camillo, Lido Venezia, Italy
J Recept Signal Transduct Res 30:355-69. 2010..It is interesting to note that in some instances accordance has been found between the bioinformatics indications and the available experimental data... - Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanismsLuigi Francesco Agnati
IRCCS San Camillo, Lido VE, Italy
J Recept Signal Transduct Res 31:315-31. 2011..We believe that almost all the biochemical knowledge presently available on GPCRs can be used in the development of these new pharmacological approaches... - Allosteric modulation of dopamine D2 receptors by homocysteineLuigi F Agnati
Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
J Proteome Res 5:3077-83. 2006..The present results could have implications for Parkinson's disease... - Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's diseaseL F Agnati
Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, Modena, Italy
J Neural Transm 114:21-31. 2007.... - A boolean network modelling of receptor mosaics relevance of topology and cooperativityL F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS, Ospedale San Camillo, Venezia, Italy
J Neural Transm 114:77-92. 2007.... - Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's diseaseLuigi F Agnati
Department of Biomedial Sciences, University of Modena and Reggio Emilia, Modena, Italy
Brain Res Bull 64:155-64. 2004..These results open new therapeutic avenues in early events in Parkinson's disease... - Energy gradients for VT-signal migration in the CNS: studies on melanocortin receptors, mitochondrial uncoupling proteins and food intakeL F Agnati
Section of Physiology, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy
J Endocrinol Invest 27:23-34. 2004..g., in the arcuate nucleus representing signals relevant to energy homeostasis). Thus, WT and VT are both modulated by peptidergic signals that affect thermal gradients... - Energy gradients for the homeostatic control of brain ECF composition and for VT signal migration: introduction of the tide hypothesisL F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
J Neural Transm 112:45-63. 2005..These fluid push-pull movements favor both the migration of signals and the extra-cellular fluid renewal, especially in the cerebral cortex... - Studies on homocysteine plasma levels in Alzheimer's patients. Relevance for neurodegenerationL F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena
J Neural Transm 112:163-9. 2005.... - How receptor mosaics decode transmitter signals. Possible relevance of cooperativityLuigi F Agnati
Department of Biomedical Sciences, 41100 Modena, Italy
Trends Biochem Sci 30:188-93. 2005..Thus, the binding of the ligand at one receptor alters the likelihood of the same ligand binding at the next site, in the case of RMs, formed by identical receptors and/or by iso-receptors (receptors that bind the same ligand)... - How proteins come together in the plasma membrane and function in macromolecular assemblies: focus on receptor mosaicsLuigi F Agnati
Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Mol Neurosci 26:133-54. 2005..The oscillation in the intensity of the dipole caused by the action potentials opens the possibility of an interaction among dipoles by electromagnetic waves... - Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseasesLuigi Francesco Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
Neuromolecular Med 7:61-78. 2005.... - The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathologyL F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS, Ospedale San Camillo, Venezia, Italy
J Neural Transm 114:3-19. 2007..The relevance of this new view of brain organization for a deeper understanding of some neurophysiological and neuropathological aspects of its function is briefly discussed... - Volume transmission and wiring transmission from cellular to molecular networks: history and perspectivesL F Agnati
Department of Biomedical Sciences, Section of Physiology, University of Modena, Modena, Italy
Acta Physiol (Oxf) 187:329-44. 2006..Thus, as an experimental part of the present paper a new approach to evaluate transmitter-receptor mismatches is given and evidence for inter-relationships between temperature micro-gradients and mismatches is provided... - On the existence of a global molecular network enmeshing the whole central nervous system: physiological and pathological implicationsL F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Curr Protein Pept Sci 7:3-15. 2006.... - Differential sensitivity of A2A and especially D2 receptor trafficking to cocaine compared with lipid rafts in cotransfected CHO cell lines. Novel actions of cocaine independent of the DA transporterSusanna Genedani
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
J Mol Neurosci 41:347-57. 2010..It is proposed that changes in D(2) and A(2A)-D(2) trafficking induced by allosteric actions of cocaine at D(2) receptors may contribute to the alterations of D(2) signaling found in cocaine abusers... - Receptor-receptor interactions, receptor mosaics, and basic principles of molecular network organization: possible implications for drug developmentLuigi F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy
J Mol Neurosci 26:193-208. 2005..These new data on G protein-coupled receptors and molecular network organization indicate possible new approaches for drug development... - Computer-assisted image analysis of caveolin-1 involvement in the internalization process of adenosine A2A-dopamine D2 receptor heterodimersSusanna Genedani
Section of Pharmacology, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Mol Neurosci 26:177-84. 2005.... - On the molecular basis of the receptor mosaic hypothesis of the engramLuigi F Agnati
Department of Biomedical Sciences, University of Modena, Modena, Italy
Cell Mol Neurobiol 24:501-16. 2004..Hence, this mechanism may play a role in learning processes where the input to a neuron is likely to remain constant for a while... - Introductory remarksLuigi F Agnati
Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Mol Neurosci 26:109-12. 2005 - Concluding remarksLuigi F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Mol Neurosci 26:299-302. 2005..Thus, Ra' operates as a modulator protein of Rb. 3. Ra' can still recognize its ligand and signal, but it allosterically affects its heteromeric partner Rb in a different way. Thus, Ra' operates as an unusual modulator of Rb... - New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cellsLuigi F Agnati
Department of Biomedical Sciences, Section of Physiology, University of Modena, Modena, Italy
J Histochem Cytochem 53:941-53. 2005.... - Receptor mosaics of neural and immune communication: possible implications for basal ganglia functionsLuigi F Agnati
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
Brain Res Rev 58:400-14. 2008..On the examples of receptor superfamilies expressed both in the neural and immune cells, our review paper aims to show some implications of receptor-receptor interactions for basal ganglia functions in health and disease... - A simple mathematical model of cooperativity in receptor mosaics based on the "symmetry rule"Luigi F Agnati
Department of Biomedical Sciences, University of Modena, Modena, Italy
Biosystems 80:165-73. 2005.... - Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptidesGiuseppina Leo
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Curr Alzheimer Res 4:305-13. 2007..These alterations in the neuroglial network morphology and function can, at least in part, explain the enhanced pain threshold observed in the Abeta intra-striatally injected animals... - Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamusCarla Torri
Department of Biomedical Sciences, Section of Physiology and Centro di Nutrizione Clinica e Malattie Metaboliche, University of Modena and Reggio Emilia, Via Campi 287, 41100, Modena, Italy
Peptides 23:1063-8. 2002..Altered hypothalamic transmission by POMC-derived peptides may contribute to the susceptibility of cafDIO rats to the weight promoting action of caf diet... - Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophreniaMartina Ballmaier
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Brescia University Medical School, Via Valsabbina 19, 25123 Brescia, Italy
Eur J Neurosci 15:1197-205. 2002..These results suggest a specific link between reelin-related neuronal pathology and dopamine involvement in the pathophysiology of psychotic disorders...