Y Zick

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint Role of galectin-8 as a modulator of cell adhesion and cell growth
    Yehiel Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycoconj J 19:517-26. 2004
  2. ncbi request reprint Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance
    Y Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Soc Trans 32:812-6. 2004
  3. ncbi request reprint Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance
    Yehiel Zick
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Sci STKE 2005:pe4. 2005
  4. ncbi request reprint Role of Ser/Thr kinases in the uncoupling of insulin signaling
    Y Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Obes Relat Metab Disord 27:S56-60. 2003
  5. ncbi request reprint Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins
    Y F Liu
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:14459-65. 2001
  6. ncbi request reprint Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function
    K Paz
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 274:28816-22. 1999
  7. ncbi request reprint Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
    Y R Hadari
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel weizmann ac il
    J Cell Sci 113:2385-97. 2000
  8. ncbi request reprint Galectin-8 functions as a matricellular modulator of cell adhesion
    Y Levy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:31285-95. 2001
  9. ncbi request reprint Annexin II is a novel player in insulin signal transduction. Possible association between annexin II phosphorylation and insulin receptor internalization
    Y Biener
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 271:29489-96. 1996
  10. ncbi request reprint Galectin-8. A new rat lectin, related to galectin-4
    Y R Hadari
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 270:3447-53. 1995

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Role of galectin-8 as a modulator of cell adhesion and cell growth
    Yehiel Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycoconj J 19:517-26. 2004
    ..Hence, galectin-8 may modulate cell-matrix interactions and regulate cellular functions in a variety of physiological and pathological conditions...
  2. ncbi request reprint Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance
    Y Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Soc Trans 32:812-6. 2004
    ....
  3. ncbi request reprint Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance
    Yehiel Zick
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Sci STKE 2005:pe4. 2005
    ..Identification of the specific kinases involved in such insulin resistance pathways can help lead to the rational design of novel therapeutic agents for treating insulin resistance and type 2 diabetes...
  4. ncbi request reprint Role of Ser/Thr kinases in the uncoupling of insulin signaling
    Y Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Obes Relat Metab Disord 27:S56-60. 2003
    ..This article focuses on the cardinal role of Ser/Thr protein kinases, which phosphorylate insulin receptor substrates, as key players in the uncoupling of insulin signaling and the induction of an insulin resistance state...
  5. ncbi request reprint Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins
    Y F Liu
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:14459-65. 2001
    ..These findings implicate PKCzeta as a key element in a multistep negative feedback control mechanism of IRS-1 functions...
  6. ncbi request reprint Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function
    K Paz
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 274:28816-22. 1999
    ..These findings implicate PKB as a positive regulator of IRS-1 functions...
  7. ncbi request reprint Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
    Y R Hadari
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel weizmann ac il
    J Cell Sci 113:2385-97. 2000
    ..Binding of galectin-8 modulates integrin interactions with the extracellular matrix and thus regulates cell adhesion and cell survival...
  8. ncbi request reprint Galectin-8 functions as a matricellular modulator of cell adhesion
    Y Levy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:31285-95. 2001
    ..Because of its dual effects on the adhesive properties of the cells and its association with fibronectin, galectin-8 might be considered a novel type of matricellular protein...
  9. ncbi request reprint Annexin II is a novel player in insulin signal transduction. Possible association between annexin II phosphorylation and insulin receptor internalization
    Y Biener
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 271:29489-96. 1996
    ..Hence, Tyr phosphorylation of annexin II could be part of the internalization and sorting mechanism of the insulin receptor...
  10. ncbi request reprint Galectin-8. A new rat lectin, related to galectin-4
    Y R Hadari
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 270:3447-53. 1995
    ..Together with galectin-4, galectin-8 therefore represents a subfamily of galectins consisting of a tandem repeat of structurally different carbohydrate recognition domains within a single polypeptide chain...
  11. ncbi request reprint Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin
    Yifat Levy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:14533-42. 2003
    ..They further suggest that downstream effectors of PI3K, including PKB and p70 S6 kinase, in part mediate cell adhesion, spreading, and microspike formation induced by galectin-8...
  12. ncbi request reprint Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region
    H Voliovitch
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 270:18083-7. 1995
    ..This could account for the fact that partial deletion of the PH domain selectively impairs the in vivo interactions between the insulin receptor and IRS-1, whereas their in vitro interactions remain unaffected...
  13. doi request reprint Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets
    A Beck
    Department of Molecular Cell Biology, Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Israel
    Diabetologia 56:1317-26. 2013
    ..Pro-inflammatory cytokines induce death of beta cells and hamper engraftment of transplanted islet mass. Our aim was to reveal novel genes involved in this process, as a platform for innovative therapeutic approaches...
  14. doi request reprint Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression
    M Alberstein
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    J Viral Hepat 19:65-71. 2012
    ....
  15. doi request reprint An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells
    A Beck
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Diabetologia 54:2845-55. 2011
    ..Pro-inflammatory cytokines induce death of pancreatic beta cells, leading to the development of type 1 diabetes. We sought to identify novel players and the underlying mechanisms involved in this process...
  16. ncbi request reprint Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers
    Y R Hadari
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 267:17483-6. 1992
    ..The recruitment of the holoenzyme may also involve its enzymatic activation and thus constitute an important step in the transduction of insulin signals...
  17. pmc Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance
    Yan Fang Liu
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 24:9668-81. 2004
    ....
  18. ncbi request reprint Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
    Avia Herschkovitz
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Faculty of Agricultural, Food, and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    J Biol Chem 282:18018-27. 2007
    ..These findings suggest that insulin-stimulated IRS kinases such as PKCzeta overlap with IRS kinases triggered by inducers of insulin resistance, such as IKKbeta, to phosphorylate IRS-1 on common Ser sites...
  19. doi request reprint Phosphorylation of IRS proteins, insulin action, and insulin resistance
    Sigalit Boura-Halfon
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100 Israel
    Am J Physiol Endocrinol Metab 296:E581-91. 2009
    ..Finally, its implications on insulin signaling, insulin resistance and type 2 diabetes, an emerging epidemic of the 21st century are outlined...
  20. ncbi request reprint Extracellular matrix proteins modulate endocytosis of the insulin receptor
    Sigalit Boura-Halfon
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:16397-404. 2003
    ....
  21. ncbi request reprint Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8
    Rinat Arbel-Goren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 280:19105-14. 2005
    ..These effects of the lectin depended upon protein-sugar interactions and were induced when galectin-8 was present as a soluble ligand or when it was overexpressed in cells...
  22. ncbi request reprint It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin
    Yifat Levy
    Department of Chemical Services, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 16:463-76. 2006
    ..These results provide evidence that cooperative interactions between the two CRDs and the "hinge" domain are required for the proper functioning of galectin-8...
  23. ncbi request reprint Molecular basis of insulin action
    Yehiel Zick
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Novartis Found Symp 262:36-50; disucssion 50-5, 265-8. 2004
    ..Then, impairments in insulin signalling pathways and new paradigms regarding the molecular basis of insulin and IGF-1 resistance will be analysed...
  24. pmc Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress
    Diana Gurevitch
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Diabetes 59:2188-97. 2010
    ..Here, we examined the role of Ser phosphorylation of IRS-2 in mediating the inhibitory effects of proinflammatory cytokines and cellular stress on beta-cell function...
  25. doi request reprint Serine kinases of insulin receptor substrate proteins
    Sigalit Boura-Halfon
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Vitam Horm 80:313-49. 2009
    ..Finally, its implications on insulin/IGF-1 signaling, insulin/IGF-1 resistance and diabetes, an emerging epidemic of the twenty-first century are outlined...
  26. ncbi request reprint Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins
    Rina Hemi
    Institute of Endocrinology, Sheba Medical Center, Tel Hashomer 52601, Israel
    J Biol Chem 277:8961-9. 2002
    ..Stress-dependent transactivation of ErbB2/ErbB3 receptors triggers a PI3K cascade that induces serine phosphorylation of IRS proteins culminating in insulin resistance...
  27. doi request reprint Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?
    Michael H Shanik
    Division of Endocrinology, North Shore Long Island Jewish Health System, Lake Success, New York, USA
    Diabetes Care 31:S262-8. 2008
    ..5) Many patients with insulinoma who have elevated basal levels of insulin have reduced (but not absent) responsiveness to administered insulin. In summary, hyperinsulinemia is often both a result and a driver of insulin resistance...
  28. ncbi request reprint Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases
    Yechiel Levkovitz
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Campus, Petah Tiqva, Israel
    Mol Cell Neurosci 36:305-12. 2007
    ..These results implicate selected SSRIs as inhibitors of insulin signaling and as potential inducers of cellular insulin resistance...
  29. ncbi request reprint CD44 involvement in autoimmune inflammations: the lesson to be learned from CD44-targeting by antibody or from knockout mice
    David Naor
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Ann N Y Acad Sci 1110:233-47. 2007
    ..The mechanisms that stand behind these findings are discussed...
  30. ncbi request reprint The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation
    Lora Eshkar Sebban
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 179:1225-35. 2007
    ....
  31. ncbi request reprint Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting
    Nathalie Nagy
    Laboratory of Pathology, Cliniques Universitaires de Bruxelles, Hopital Erasme, Brussels, Belgium
    Cancer 97:1849-58. 2003
    ..The current study analyzed the prognostic values contributed by galectin-1, galectin-3, galectin-4, and galectin-8 in cases of colon carcinoma...
  32. ncbi request reprint Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas
    Klaus Kayser
    UICC Telepathology Consultation Center, Institute of Pathology, Charite, Humboldt University, Berlin, Germany
    Pathol Res Pract 199:589-98. 2003
    ..These results contribute to the definition of biochemical characteristics in hamartomas and can be useful for distinguishing them from chronic degenerative disorders...
  33. ncbi request reprint Expression and putative role of lactoseries carbohydrates present on NCAM in the rat primary olfactory pathway
    Melonie Joanne Storan
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    J Comp Neurol 475:289-302. 2004
    ....