Elazar Zelzer


Affiliation: Weizmann Institute of Science
Country: Israel


  1. Eyal S, Rubin S, Krief S, Levin L, Zelzer E. Common cellular origin and diverging developmental programs for different sesamoid bones. Development. 2019;146: pubmed publisher
    ..These findings highlight both common and divergent molecular and mechanical features of sesamoid bone development, which underscores their evolutionary plasticity. ..
  2. Felsenthal N, Rubin S, Stern T, Krief S, Pal D, Pryce B, et al. Development of migrating tendon-bone attachments involves replacement of progenitor populations. Development. 2018;145: pubmed publisher
    ..Moreover, they suggest that different cell populations may be considered for cell-based therapy of enthesis injuries. ..
  3. Blecher R, Heinemann Yerushalmi L, Assaraf E, Konstantin N, Chapman J, Cope T, et al. New functions for the proprioceptive system in skeletal biology. Philos Trans R Soc Lond B Biol Sci. 2018;373: pubmed publisher
    ..Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.This article is part of the Theo Murphy meeting issue 'Mechanics of development'. ..
  4. Rot C, Stern T, Blecher R, Friesem B, Zelzer E. A mechanical Jack-like Mechanism drives spontaneous fracture healing in neonatal mice. Dev Cell. 2014;31:159-70 pubmed publisher
    ..Finally, we show that muscle force is important in this process, as blocking muscle contraction disrupts growth plate formation, leading to premature callus ossification and failed reduction. ..
  5. Shwartz Y, Viukov S, Krief S, Zelzer E. Joint Development Involves a Continuous Influx of Gdf5-Positive Cells. Cell Rep. 2016;15:2577-87 pubmed publisher
    ..This work supports the influx model of joint development, which may apply to other organogenic processes. ..
  6. Blecher R, Krief S, Galili T, Biton I, Stern T, Assaraf E, et al. The Proprioceptive System Masterminds Spinal Alignment: Insight into the Mechanism of Scoliosis. Dev Cell. 2017;42:388-399.e3 pubmed publisher
    ..These findings uncover a central role for the proprioceptive system in maintaining spinal alignment. ..
  7. Eyal S, Blitz E, Shwartz Y, Akiyama H, Schweitzer R, Zelzer E. On the development of the patella. Development. 2015;142:1831-9 pubmed publisher
  8. Ben Shoham A, Rot C, Stern T, Krief S, Akiva A, Dadosh T, et al. Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology. Development. 2016;143:3933-3943 pubmed
    ..These data reveal the unique composition of the endothelium in developing bones and indicate that vascular patterning plays a role in determining bone shape by forming a template for deposition of bone matrix. ..
  9. Blecher R, Krief S, Galili T, Assaraf E, Stern T, Anekstein Y, et al. The Proprioceptive System Regulates Morphologic Restoration of Fractured Bones. Cell Rep. 2017;20:1775-1783 pubmed publisher
    ..These findings uncover a physiological role for proprioception in non-autonomous regulation of skeletal integrity. ..

More Information


  1. Felsenthal N, Zelzer E. Mechanical regulation of musculoskeletal system development. Development. 2017;144:4271-4283 pubmed publisher
    ..Here, we summarize the involvement of muscle-induced mechanical forces in the development of various vertebrate musculoskeletal components and their integration into one functional unit. ..
  2. Eshkar Oren I, Krief S, Ferrara N, Elliott A, Zelzer E. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development. 2015;142:672-80 pubmed publisher
    ..More broadly, we propose a double safety mechanism that restricts PCD to interdigital areas, as the genetic program of PCD provides the first layer and vascular patterning serves as the second. ..