ADA E YONATH

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
    Miri Krupkin
    Weizmann Institute of Science, Rehovot 76100, Israel
    Philos Trans R Soc Lond B Biol Sci 366:2972-8. 2011
  2. doi request reprint X-ray crystallography at the heart of life science
    Ada Yonath
    Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Struct Biol 21:622-6. 2011
  3. ncbi request reprint Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture)
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    Angew Chem Int Ed Engl 49:4341-54. 2010
  4. pmc Large facilities and the evolving ribosome, the cellular machine for genetic-code translation
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    J R Soc Interface 6:S575-85. 2009
  5. pmc 23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22
    Rita Berisio
    Department for Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Antimicrob Agents Chemother 50:3816-23. 2006
  6. ncbi request reprint Ribosomal crystallography: peptide bond formation, chaperone assistance and antibiotics activity
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    Mol Cells 20:1-16. 2005
  7. ncbi request reprint Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, Rehovot, Israel
    Annu Rev Biochem 74:649-79. 2005
  8. ncbi request reprint The search and its outcome: high-resolution structures of ribosomal particles from mesophilic, thermophilic, and halophilic bacteria at various functional states
    Ada Yonath
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Annu Rev Biophys Biomol Struct 31:257-73. 2002
  9. ncbi request reprint Ribosomal crystallography: initiation, peptide bond formation, and amino acid polymerization are hampered by antibiotics
    Ada Yonath
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Annu Rev Microbiol 58:233-51. 2004
  10. ncbi request reprint Structural insight into functional aspects of ribosomal RNA targeting
    Ada Yonath
    Dept of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Chembiochem 4:1008-17. 2003

Collaborators

  • Tamar Auerbach-Nevo
  • Francois Franceschi
  • Alexander S Mankin
  • Erik C Bottger
  • Manfred S Weiss
  • Anat Bashan
  • Chen Davidovich
  • Tamar Auerbach
  • Ilana Agmon
  • Raz Zarivach
  • Rita Berisio
  • Ella Zimmerman
  • David Baram
  • Joerg Harms
  • Frank Schluenzen
  • Itai Wekselman
  • Heike Bartels
  • Maggie Kessler
  • Matthew J Belousoff
  • Harly A S Hansen
  • Maya Amit
  • Miri Krupkin
  • Matthew Belousoff
  • Efrat Ben-Zeev
  • Assa Sittner
  • Erez Pyetan
  • Moshe Peretz
  • Paola Fucini
  • Miriam Eisenstein
  • Menachem Shoham
  • Marta Pioletti
  • Hua Tang
  • Donna Matzov
  • Markus Metz
  • Rinat Kalaora
  • Kenji Arakawa
  • Lin Rozenszajn
  • Ofir Sade-Falk
  • Liqun Xiong
  • Haruyasu Kinashi
  • Inbal Mermershtain
  • Dorota Klepacki
  • Yaron Caspi
  • Tal Shapira
  • Leena Taha
  • Haim Rozenberg
  • Rachel D Yaggie
  • Richard R Gontarek
  • Natascia Corti
  • Peter Pfister
  • Inbal Greenberg
  • Daniel Wilson
  • Elizaveta Kossoy
  • Alexander Kosmidis
  • Katherine Dickman
  • Nan Wu
  • Karen Jakes

Detail Information

Publications34

  1. pmc A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
    Miri Krupkin
    Weizmann Institute of Science, Rehovot 76100, Israel
    Philos Trans R Soc Lond B Biol Sci 366:2972-8. 2011
    ..This 'proto-ribosome' could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the 'pre-proto-ribosome', which was adapted for producing proteins...
  2. doi request reprint X-ray crystallography at the heart of life science
    Ada Yonath
    Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Struct Biol 21:622-6. 2011
    ..This remarkable advance yielded numerous new insights into intricate functional aspects. Owing to space limitation this article focuses on selected studies performed recently and highlights some recent exciting developments...
  3. ncbi request reprint Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture)
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    Angew Chem Int Ed Engl 49:4341-54. 2010
    ....
  4. pmc Large facilities and the evolving ribosome, the cellular machine for genetic-code translation
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    J R Soc Interface 6:S575-85. 2009
    ....
  5. pmc 23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22
    Rita Berisio
    Department for Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Antimicrob Agents Chemother 50:3816-23. 2006
    ..Such deletions may also lead to notable differences in the tunnel outline, as well as to an increase of its diameter to a size, allowing the progression of the nascent chain...
  6. ncbi request reprint Ribosomal crystallography: peptide bond formation, chaperone assistance and antibiotics activity
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    Mol Cells 20:1-16. 2005
    ....
  7. ncbi request reprint Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation
    Ada Yonath
    Department of Structural Biology, Weizmann Institute, Rehovot, Israel
    Annu Rev Biochem 74:649-79. 2005
    ..The observed variability in antibiotic binding and inhibitory modes justifies expectations for structurally based improved properties of existing compounds as well as for the discovery of novel drug classes...
  8. ncbi request reprint The search and its outcome: high-resolution structures of ribosomal particles from mesophilic, thermophilic, and halophilic bacteria at various functional states
    Ada Yonath
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Annu Rev Biophys Biomol Struct 31:257-73. 2002
    ..In unbound subunits, the features creating intersubunit bridges within associated ribosomes lie on the interface surface, and the features that bind factors and substrates reach toward the binding site only when conditions are ripe...
  9. ncbi request reprint Ribosomal crystallography: initiation, peptide bond formation, and amino acid polymerization are hampered by antibiotics
    Ada Yonath
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Annu Rev Microbiol 58:233-51. 2004
    ..By connecting the PTC, the decoding center, and the tRNA entrance and exit regions, the symmetry-related region can transfer intraribosomal signals, guaranteeing smooth processivity of amino acid polymerization...
  10. ncbi request reprint Structural insight into functional aspects of ribosomal RNA targeting
    Ada Yonath
    Dept of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Chembiochem 4:1008-17. 2003
  11. ncbi request reprint High-resolution structures of large ribosomal subunits from mesophilic eubacteria and halophilic archaea at various functional States
    Ada Yonath
    Department of Structural Biology, Weizmann Inst of Science, Rehovot, 76100 Israel
    Curr Protein Pept Sci 3:67-78. 2002
    ....
  12. ncbi request reprint Initiation and inhibition of protein biosynthesis studies at high resolution
    Raz Zarivach
    Dept Structural Biology, Weizmann Inst of Science, Rehovot, 76100 Israel
    Curr Protein Pept Sci 3:55-65. 2002
    ..In addition, although the decoding center is formed of RNA, proteins seem to serve ancillary functions such as stabilizing ist required conformation and assisting the directionality of the translocation...
  13. pmc Structural basis for cross-resistance to ribosomal PTC antibiotics
    Chen Davidovich
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 105:20665-70. 2008
    ....
  14. ncbi request reprint Ribosomal crystallography: peptide bond formation and its inhibition
    Anat Bashan
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Biopolymers 70:19-41. 2003
    ..This tunnel, assumed to be a passive path for the growing chains, was found to be involved dynamically in gating and discrimination...
  15. ncbi request reprint Ribosomal antibiotics: structural basis for resistance, synergism and selectivity
    Tamar Auerbach
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Trends Biotechnol 22:570-6. 2004
    ..The observed variability in binding modes justifies expectations for structural design of improved antibiotic properties...
  16. ncbi request reprint Ribosomal tolerance and peptide bond formation
    Ada Yonath
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Biol Chem 384:1411-9. 2003
    ....
  17. pmc Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action
    David Baram
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 102:12017-22. 2005
    ....
  18. ncbi request reprint Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression
    Anat Bashan
    Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    Mol Cell 11:91-102. 2003
    ..Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism...
  19. pmc Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
    Chen Davidovich
    Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 104:4291-6. 2007
    ..Likewise, pleuromutilin resistant mechanisms involve nucleotides residing in the environs of the binding pocket, consistent with their slow resistance-development rates...
  20. ncbi request reprint Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism
    Ilana Agmon
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    FEBS Lett 567:20-6. 2004
    ..The interactions of protein L2 tail with the symmetry-related region periphery explain its conservation and its contributions to nascent chain elongation...
  21. ncbi request reprint On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes. Derived on 20 October 2002 at the 28th FEBS Meeting in Istanbul
    Ilana Agmon
    Department of Structural Biology, The Weizmann Institute, Rehovot, Israel
    Eur J Biochem 270:2543-56. 2003
    ..We showed by crystallographic methods that this tunnel is capable of undergoing conformational oscillations and correlated the tunnel mobility with sequence discrimination, gating and intracellular regulation...
  22. ncbi request reprint From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects
    David Baram
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    FEBS Lett 579:948-54. 2005
    ..Remarkably, although antibiotics discrimination is determined by the identity of a single nucleotide, involved also in resistance, additional nucleotides dictate antibiotics effectiveness...
  23. ncbi request reprint A crevice adjoining the ribosome tunnel: hints for cotranslational folding
    Maya Amit
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    FEBS Lett 579:3207-13. 2005
    ..In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins...
  24. pmc The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
    Tamar Auerbach
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 107:1983-8. 2010
    ....
  25. ncbi request reprint On the interaction of colicin E3 with the ribosome
    Raz Zarivach
    Weizmann Institute of Science, Department of Structural Biology, Rehovot 76100, Israel
    Biochimie 84:447-54. 2002
    ..Furthermore, the model structure suggests that the inhibitory action of bound immunity is due to charge repulsion of this acidic protein by the negatively charged rRNA backbone..
  26. doi request reprint Ancient machinery embedded in the contemporary ribosome
    Matthew J Belousoff
    Department of Structural Biology, Weizmann Institute, 2 Herzl Street, Rehovot, 76100 Israel
    Biochem Soc Trans 38:422-7. 2010
    ..Efforts toward the structural definition of the early entity capable of genetic decoding involve the crystallization of the small ribosomal subunit of a bacterial organism harbouring a single functional rRNA operon...
  27. ncbi request reprint Reproducible growth of well diffracting ribosomal crystals
    Tamar Auerbach-Nevo
    Department of Structural Biology, Weizmann Institute of Science, Israel
    Acta Crystallogr D Biol Crystallogr 61:713-9. 2005
    ..The functional state that is most suitable to yield quality crystals was identified as that of the polysome and it was found that this fraction reproducibly yielded crystals of superior properties...
  28. doi request reprint Biological implications of the ribosome's stunning stereochemistry
    Ella Zimmerman
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Chembiochem 10:63-72. 2009
    ..The extreme flexibility of the nucleotides that facilitate peptide bond formation is being exploited to promote antibiotic selectivity and synergism, as well as to combat antibiotic resistance...
  29. doi request reprint Ribosome's mode of function: myths, facts and recent results
    Itai Wekselman
    Weizmann Inst of Science, Rehovot, 76100, Israel
    J Pept Sci 15:122-30. 2009
    ....
  30. doi request reprint Correlating ribosome function with high-resolution structures
    Anat Bashan
    Department of Structural Biology, Weizmann Institute, Rehovot, 76100, Israel
    Trends Microbiol 16:326-35. 2008
    ..The availability of these structures has also illuminated the action, selectivity, resistance and synergism of antibiotics that target ribosomes...
  31. ncbi request reprint Antibiotics targeting ribosomes: crystallographic studies
    Tamar Auerbach
    Dept of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
    Curr Drug Targets Infect Disord 2:169-86. 2002
    ....
  32. ncbi request reprint Prediction of the structure of the complex between the 30S ribosomal subunit and colicin E3 via weighted-geometric docking
    Efrat Ben-Zeev
    Weizmann Institute of Science, Department of Biological Chemistry, Rehovot, 76100 Israel
    J Biomol Struct Dyn 20:669-76. 2003
    ..In addition, it suggests that bound acidic immunity protein inhibits the enzymatic activity of colicin E3 by electrostatic repulsion of the negatively charged substrate...
  33. doi request reprint The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery
    Chen Davidovich
    The Department of Structural Biology, Weizmann Institute, Rehovot, Israel
    Res Microbiol 160:487-92. 2009
    ..This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization...
  34. ncbi request reprint Symmetry at the active site of the ribosome: structural and functional implications
    Ilana Agmon
    Department of Structural Biology, The Weizmann Institute, 76100 Rehovot, Israel
    Biol Chem 386:833-44. 2005
    ..The positional catalysis exerted by the ribosome places the reactants in stereochemistry close to the intermediate state and facilitates the catalytic contribution of the P-site tRNA 2'-hydroxyl...

Research Grants22

  1. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 1993
    ..Last, but not least, these studies are bound to contribute to the development of sophisticated crystallographic experimental methods...
  2. CRYSTALLOGRAPHIC STUDIES OF RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2004
    ..These, and further to come insights, should lead to improved therapeutic agents and allow structure based design of a new generation of more powerful, selective and efficient antibiotics. ..
  3. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 1992
    ..Last, but not least, these studies are bound to contribute to the development of sophisticated crystallographic experimental methods...
  4. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2009
    ..These studies have already illuminated principles of drug selectivity, and provided significant basic knowledge of possible pathways of drug resistance, hence paving the way to improve therapeutic properties. ..
  5. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 1990
    ..Last, but not least, our studies are bound to contribute to the development of sophisticated crystallographic experimental methods...
  6. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2007
    ..These studies have already illuminated principles of drug selectivity, and provided significant basic knowledge of possible pathways of drug resistance, hence paving the way to improve therapeutic properties. ..
  7. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2006
    ..These studies have already illuminated principles of drug selectivity, and provided significant basic knowledge of possible pathways of drug resistance, hence paving the way to improve therapeutic properties. ..
  8. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    ADA E YONATH; Fiscal Year: 2010
    ..These studies have already illuminated principles of drug selectivity, and provided significant basic knowledge of possible pathways of drug resistance, hence paving the way to improve therapeutic properties. ..
  9. CRYSTALLOGRAPHIC STUDIES OF RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2005
    ..These, and further to come insights, should lead to improved therapeutic agents and allow structure based design of a new generation of more powerful, selective and efficient antibiotics. ..
  10. CRYSTALLOGRAPHIC STUDIES OF RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2003
    ..These, and further to come insights, should lead to improved therapeutic agents and allow structure based design of a new generation of more powerful, selective and efficient antibiotics. ..
  11. CRYSTALLOGRAPHIC STUDIES OF RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2001
    ..cause misreading of mRNA codons by interacting with the small ribosomal subunit. Hence, detailed structural information should lead to a new generation of more powerful specific and efficient antibiotics. ..
  12. CRYSTALLOGRAPHIC STUDIES OF RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 2000
    ..cause misreading of mRNA codons by interacting with the small ribosomal subunit. Hence, detailed structural information should lead to a new generation of more powerful specific and efficient antibiotics. ..
  13. CRYSTALLOGRAPHIC STUDIES OF RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 1999
    ..cause misreading of mRNA codons by interacting with the small ribosomal subunit. Hence, detailed structural information should lead to a new generation of more powerful specific and efficient antibiotics. ..
  14. CRYSTALLOGRAPHIC STUDIES ON RIBOSOMAL PARTICLES
    Ada Yonath; Fiscal Year: 1991
    ..Last, but not least, these studies are bound to contribute to the development of sophisticated crystallographic experimental methods...