Research Topics
| Itai YanaiSummaryAffiliation: Weizmann Institute of Science Country: Israel Publications
| Collaborators
|
Detail Information
Publications
Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription controlItai Yanai
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel and Bioinformatics Unit, Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
OMICS 8:15-24. 2004..A disturbing corollary of these findings is that knowledge of where the gene is expressed may not carry information about its function...
The society of genes: networks of functional links between genes from comparative genomicsItai Yanai
Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Genome Biol 3:research0064. 2002..We have previously generated the links according to each of these methods individually for 43 known microbial genomes. Here we combine these results to construct networks of functional associations...- The integrated world of functional genomicsItai Yanai
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
Genome Biol 4:301. 2003 - Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specificationItai Yanai
Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
Bioinformatics 21:650-9. 2005..AVAILABILITY: All data and analyses are publically available at the GeneNote website, http://genecards.weizmann.ac.il/genenote/ and, GEO accession GSE803. CONTACT: SUPPLEMENTARY INFORMATION: Four tables available at the above site... - Widespread ectopic expression of olfactory receptor genesEster Feldmesser
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
BMC Genomics 7:121. 2006..The present study systematically explores the expression patterns of OR genes in a large number of tissues and assesses the potential functional implication of such ectopic expression... - Similar gene expression profiles do not imply similar tissue functionsItai Yanai
Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Trends Genet 22:132-8. 2006..Ectopic expression is possibly explained as expression leakage, caused by spreading of chromatin modifications or the transcription apparatus into neighboring genes... - Evolution of gene fusions: horizontal transfer versus independent eventsItai Yanai
Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Genome Biol 3:research0024. 2002.... - GeneAnnot: comprehensive two-way linking between oligonucleotide array probesets and GeneCards genesVered Chalifa-Caspi
Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
Bioinformatics 20:1457-8. 2004..AVAILABILITY: http://genecards.weizmann.ac.il/geneannot/ SUPPLEMENTARY INFORMATION: Program description and statistics http://genecards.weizmann.ac.il/geneannot/DOC/index.html.. - Identifying functional links between genes using conserved chromosomal proximityItai Yanai
Bioinformatics Graduate Program and Dept of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Trends Genet 18:176-9. 2002..Of the pairs annotated in the KEGG database, 80% are in the same biological pathway in KEGG... - Rewiring of the yeast transcriptional network through the evolution of motif usageJan Ihmels
Department of Molecular Genetics and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
Science 309:938-40. 2005..Our results shed new light on the genetic mechanisms underlying the large-scale evolution of transcriptional networks... - Modular genes with metazoan-specific domains have increased tissue specificityInbar Cohen-Gihon
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Trends Genet 21:210-3. 2005..Our analyses suggest that highly modular gene products have been recruited for tissue-specific functions that are required in complex organisms... - Alternative splicing and gene duplication are inversely correlated evolutionary mechanismsNaama M Kopelman
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Nat Genet 37:588-9. 2005..A cross-organism analysis suggests that selection for genome-wide genic proliferation might be interchangeably met by either evolutionary mechanism... - An avidin-like domain that does not bind biotin is adopted for oligomerization by the extracellular mosaic protein fibropellinItai Yanai
Biomedical Engineering Department, 44 Cummington Street, Boston University, Boston, MA 02215, USA
Protein Sci 14:417-23. 2005..Finally, based upon the oligomerization of the avidin-like domain, we propose a model for the overall structure of the apical lamina... - Predictome: a database of putative functional links between proteinsJoseph C Mellor
Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Nucleic Acids Res 30:306-9. 2002..As a repository for such data, Predictome is an ongoing resource for the community, providing functional relationships among proteins as new genomic data emerges. Predictome is available at http://predictome.bu.edu... - GeneAnnot: interfacing GeneCards with high-throughput gene expression compendiaVered Chalifa-Caspi
Bioinformatics Support Unit, Life Sciences Dept, Ben Gurion University of the Negev, Beer Sheva, Israel
Brief Bioinform 4:349-60. 2003.... - Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expressionItai Yanai
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Mol Syst Biol 4:163. 2008..The coupling of asynchronous and topologically distinct modules may be a general principle of module assembly that functions to potentiate genetic switches...