Itai Yanai

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel and Bioinformatics Unit, Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
    OMICS 8:15-24. 2004
  2. pmc The society of genes: networks of functional links between genes from comparative genomics
    Itai Yanai
    Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Genome Biol 3:research0064. 2002
  3. pmc The integrated world of functional genomics
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Genome Biol 4:301. 2003
  4. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
  5. pmc Widespread ectopic expression of olfactory receptor genes
    Ester Feldmesser
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 7:121. 2006
  6. ncbi Similar gene expression profiles do not imply similar tissue functions
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Trends Genet 22:132-8. 2006
  7. pmc Evolution of gene fusions: horizontal transfer versus independent events
    Itai Yanai
    Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Genome Biol 3:research0024. 2002
  8. ncbi GeneAnnot: comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes
    Vered Chalifa-Caspi
    Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
    Bioinformatics 20:1457-8. 2004
  9. ncbi Identifying functional links between genes using conserved chromosomal proximity
    Itai Yanai
    Bioinformatics Graduate Program and Dept of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Trends Genet 18:176-9. 2002
  10. ncbi Rewiring of the yeast transcriptional network through the evolution of motif usage
    Jan Ihmels
    Department of Molecular Genetics and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
    Science 309:938-40. 2005

Detail Information

Publications16

  1. ncbi Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel and Bioinformatics Unit, Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
    OMICS 8:15-24. 2004
    ..A disturbing corollary of these findings is that knowledge of where the gene is expressed may not carry information about its function...
  2. pmc The society of genes: networks of functional links between genes from comparative genomics
    Itai Yanai
    Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Genome Biol 3:research0064. 2002
    ..We have previously generated the links according to each of these methods individually for 43 known microbial genomes. Here we combine these results to construct networks of functional associations...
  3. pmc The integrated world of functional genomics
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Genome Biol 4:301. 2003
  4. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
    ..Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of expression...
  5. pmc Widespread ectopic expression of olfactory receptor genes
    Ester Feldmesser
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 7:121. 2006
    ..The present study systematically explores the expression patterns of OR genes in a large number of tissues and assesses the potential functional implication of such ectopic expression...
  6. ncbi Similar gene expression profiles do not imply similar tissue functions
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Trends Genet 22:132-8. 2006
    ..Ectopic expression is possibly explained as expression leakage, caused by spreading of chromatin modifications or the transcription apparatus into neighboring genes...
  7. pmc Evolution of gene fusions: horizontal transfer versus independent events
    Itai Yanai
    Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Genome Biol 3:research0024. 2002
    ..Gene fusions can be used as tools for functional prediction and also as evolutionary markers. Fused genes often show a scattered phyletic distribution, which suggests a role for processes other than vertical inheritance in their evolution...
  8. ncbi GeneAnnot: comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes
    Vered Chalifa-Caspi
    Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
    Bioinformatics 20:1457-8. 2004
    ..Moreover, a gene is often represented by more than one probeset, and analyzing probe matches at the mRNA level can help one deduce whether these probesets are derived from the same or different splice variants...
  9. ncbi Identifying functional links between genes using conserved chromosomal proximity
    Itai Yanai
    Bioinformatics Graduate Program and Dept of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Trends Genet 18:176-9. 2002
    ..Of the pairs annotated in the KEGG database, 80% are in the same biological pathway in KEGG...
  10. ncbi Rewiring of the yeast transcriptional network through the evolution of motif usage
    Jan Ihmels
    Department of Molecular Genetics and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
    Science 309:938-40. 2005
    ..Our results shed new light on the genetic mechanisms underlying the large-scale evolution of transcriptional networks...
  11. ncbi Modular genes with metazoan-specific domains have increased tissue specificity
    Inbar Cohen-Gihon
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Genet 21:210-3. 2005
    ..Our analyses suggest that highly modular gene products have been recruited for tissue-specific functions that are required in complex organisms...
  12. ncbi Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms
    Naama M Kopelman
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Nat Genet 37:588-9. 2005
    ..A cross-organism analysis suggests that selection for genome-wide genic proliferation might be interchangeably met by either evolutionary mechanism...
  13. pmc An avidin-like domain that does not bind biotin is adopted for oligomerization by the extracellular mosaic protein fibropellin
    Itai Yanai
    Biomedical Engineering Department, 44 Cummington Street, Boston University, Boston, MA 02215, USA
    Protein Sci 14:417-23. 2005
    ..Finally, based upon the oligomerization of the avidin-like domain, we propose a model for the overall structure of the apical lamina...
  14. pmc Predictome: a database of putative functional links between proteins
    Joseph C Mellor
    Bioinformatics Graduate Program and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Nucleic Acids Res 30:306-9. 2002
    ..As a repository for such data, Predictome is an ongoing resource for the community, providing functional relationships among proteins as new genomic data emerges. Predictome is available at http://predictome.bu.edu...
  15. ncbi GeneAnnot: interfacing GeneCards with high-throughput gene expression compendia
    Vered Chalifa-Caspi
    Bioinformatics Support Unit, Life Sciences Dept, Ben Gurion University of the Negev, Beer Sheva, Israel
    Brief Bioinform 4:349-60. 2003
    ....
  16. pmc Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression
    Itai Yanai
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Syst Biol 4:163. 2008
    ..The coupling of asynchronous and topologically distinct modules may be a general principle of module assembly that functions to potentiate genetic switches...