STEPHEN WEINER

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint Structural biology. Choosing the crystallization path less traveled
    S Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 309:1027-8. 2005
  2. ncbi request reprint Biomineralization. At the cutting edge
    Steve Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 298:375-6. 2002
  3. ncbi request reprint Biologically formed amorphous calcium carbonate
    Steve Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Connect Tissue Res 44:214-8. 2003
  4. doi request reprint Biomineralization: a structural perspective
    STEPHEN WEINER
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 163:229-34. 2008
  5. ncbi request reprint Structural characterization of modern and fossilized charcoal produced in natural fires as determined by using electron energy loss spectroscopy
    Ilit Cohen-Ofri
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 13:2306-10. 2007
  6. pmc Radiocarbon dating of charcoal and bone collagen associated with early pottery at Yuchanyan Cave, Hunan Province, China
    Elisabetta Boaretto
    Department of Land of Israel Studies, Bar Ilan University, 52900 Ramat Gan, Israel
    Proc Natl Acad Sci U S A 106:9595-600. 2009
  7. ncbi request reprint Structure and mechanical properties of the soft zone separating bulk dentin and enamel in crowns of human teeth: insight into tooth function
    Paul Zaslansky
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    J Struct Biol 153:188-99. 2006
  8. doi request reprint Forming nacreous layer of the shells of the bivalves Atrina rigida and Pinctada margaritifera: an environmental- and cryo-scanning electron microscopy study
    Fabio Nudelman
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 162:290-300. 2008
  9. ncbi request reprint Mollusk shell formation: a source of new concepts for understanding biomineralization processes
    Lia Addadi
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 12:980-7. 2006
  10. pmc Relatively well preserved DNA is present in the crystal aggregates of fossil bones
    Michal Salamon
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 102:13783-8. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Structural biology. Choosing the crystallization path less traveled
    S Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 309:1027-8. 2005
  2. ncbi request reprint Biomineralization. At the cutting edge
    Steve Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 298:375-6. 2002
  3. ncbi request reprint Biologically formed amorphous calcium carbonate
    Steve Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Connect Tissue Res 44:214-8. 2003
    ..We also suspect that ACC fulfils many different functions, including as a transient precursor phase during the formation of crystalline calcium carbonate...
  4. doi request reprint Biomineralization: a structural perspective
    STEPHEN WEINER
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 163:229-34. 2008
    ..Structure is thus in many respects the foundation upon which the field of biomineralization rests...
  5. ncbi request reprint Structural characterization of modern and fossilized charcoal produced in natural fires as determined by using electron energy loss spectroscopy
    Ilit Cohen-Ofri
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 13:2306-10. 2007
    ..The few graphite-like microcrystallites found in fossilized charcoal were composed of onion-like structures that are probably less prone to oxidation owing to their rounded structures...
  6. pmc Radiocarbon dating of charcoal and bone collagen associated with early pottery at Yuchanyan Cave, Hunan Province, China
    Elisabetta Boaretto
    Department of Land of Israel Studies, Bar Ilan University, 52900 Ramat Gan, Israel
    Proc Natl Acad Sci U S A 106:9595-600. 2009
    ..Charcoal and bone collagen samples located above and below one of the fragments produced dates of around 18,000. These ceramic potsherds therefore provide some of the earliest evidence for pottery making in China...
  7. ncbi request reprint Structure and mechanical properties of the soft zone separating bulk dentin and enamel in crowns of human teeth: insight into tooth function
    Paul Zaslansky
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    J Struct Biol 153:188-99. 2006
    ..Our results support and expand upon the hypothesis that the durability of the whole tooth relies upon a bucco-lingual asymmetric matching of stiffness by means of an interphase: a cushioning soft layer between enamel and bulk dentin...
  8. doi request reprint Forming nacreous layer of the shells of the bivalves Atrina rigida and Pinctada margaritifera: an environmental- and cryo-scanning electron microscopy study
    Fabio Nudelman
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 162:290-300. 2008
    ..As the tablets grow, the silk-fibroin is pushed aside and becomes sandwiched between the mineral and the chitin layer...
  9. ncbi request reprint Mollusk shell formation: a source of new concepts for understanding biomineralization processes
    Lia Addadi
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 12:980-7. 2006
    ..All this takes place in a highly structured chitinous framework. Here we present ideas on how these disparate components work together to produce the highly structured pearly nacreous layer of the mollusk shell...
  10. pmc Relatively well preserved DNA is present in the crystal aggregates of fossil bones
    Michal Salamon
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 102:13783-8. 2005
    ..This counterintuitive approach to extracting relatively well preserved DNA from bones significantly improves the chances of obtaining authentic ancient DNA sequences, especially from human bones...
  11. ncbi request reprint Phase shifting speckle interferometry for determination of strain and Young's modulus of mineralized biological materials: a study of tooth dentin compression in water
    Paul Zaslansky
    Weizmann Institute of Science, Department of Structural Biology, Rehovot, Israel 76100
    J Biomed Opt 10:024020. 2005
    ..0 GPa. Our approach can be used to map deformations on irregular surfaces, and measure strain on wet samples of varying sizes. This can be extended to the study of other biological materials including bone and synthetic biomaterials...
  12. doi request reprint Enamel dictates whole tooth deformation: a finite element model study validated by a metrology method
    Meir M Barak
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    J Struct Biol 168:511-20. 2009
    ..We conclude that for the most part, that enamel and not dentin dictates the mechanical behavior of the whole tooth...
  13. pmc Structure-function relations of primate lower incisors: a study of the deformation of Macaca mulatta dentition using electronic speckle pattern interferometry (ESPI)
    Netta Lev Tov Chattah
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    J Anat 218:87-95. 2011
    ..We suggest that these results demonstrate the importance of enamel cap morphology in directing deformation behavior; an ability stemming from the stiffness of the enamel cap overlying the more pliable dentin...
  14. doi request reprint Determining the elastic modulus of mouse cortical bone using electronic speckle pattern interferometry (ESPI) and micro computed tomography: a new approach for characterizing small-bone material properties
    Netta Lev Tov Chattah
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Bone 45:84-90. 2009
    ..We show that this method can be used to accurately and precisely measure the effective elastic modulus of mouse cortical bone...
  15. ncbi request reprint Mollusk shell formation: mapping the distribution of organic matrix components underlying a single aragonitic tablet in nacre
    Fabio Nudelman
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 153:176-87. 2006
    ..The observed differentiation in the distribution of matrix components and their functional groups shows that the different stages of single crystal growth are highly controlled by the matrix...
  16. doi request reprint Are tensile and compressive Young's moduli of compact bone different?
    Meir M Barak
    Department of Structural Biology, Weizmann Institute of Science, Israel
    J Mech Behav Biomed Mater 2:51-60. 2009
    ..It is also shown that within a relatively small bone specimen there are considerable variations in the modulus, presumably caused by structural inhomogeneities...
  17. pmc The grinding tip of the sea urchin tooth exhibits exquisite control over calcite crystal orientation and Mg distribution
    Yurong Ma
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 106:6048-53. 2009
    ..Clearly the formation of the tooth, and the tooth tip in particular, is amazingly well controlled. The improved understanding of these structural features could lead to the design of better mechanical grinding and cutting tools...
  18. pmc Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule
    Yael Politi
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 105:17362-6. 2008
    ..We propose that the amorphous-crystal transformation propagates in a tortuous path through preexisting 40- to 100-nm amorphous units, via a secondary nucleation mechanism...
  19. ncbi request reprint Biomineralization of limpet teeth: a cryo-TEM study of the organic matrix and the onset of mineral deposition
    Eli D Sone
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 158:428-44. 2007
    ..Crystal growth, on the other hand, is apparently not influenced by the matrix, in contrast to many other biomineralization systems...
  20. ncbi request reprint Local atomic order and infrared spectra of biogenic calcite
    Rachel Gueta
    Department of Structural Biology, Weizmann Institute of Science, Rehovoth 76100, Israel
    Angew Chem Int Ed Engl 46:291-4. 2007
  21. ncbi request reprint Asprich: A novel aspartic acid-rich protein family from the prismatic shell matrix of the bivalve Atrina rigida
    Bat Ami Gotliv
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Chembiochem 6:304-14. 2005
    ..Although we do not know, as yet, the function of these proteins, their generally conserved sequences do indicate that they might well fulfill basic functions in shell formation...
  22. ncbi request reprint Sea urchin spine calcite forms via a transient amorphous calcium carbonate phase
    Yael Politi
    Department of Structural Biology, 76100 Rehovot, Israel
    Science 306:1161-4. 2004
    ..Deposition of transient amorphous phases as a strategy for producing single crystals with complex morphology may have interesting implications for the development of sophisticated materials...
  23. ncbi request reprint Mollusc larval shell formation: amorphous calcium carbonate is a precursor phase for aragonite
    Ingrid Maria Weiss
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Exp Zool 293:478-91. 2002
    ..We conclude that ACC fulfills an important function in mollusc larval shell formation. It is conceivable that ACC may also be involved in adult shell formation...
  24. ncbi request reprint Spiers Memorial Lecture. Lessons from biomineralization: comparing the growth strategies of mollusc shell prismatic and nacreous layers in Atrina rigida
    Fabio Nudelman
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Faraday Discuss 136:9-25; discussion 107-23. 2007
    ..Comparing the mechanisms of growth of the nacreous and prismatic layers can help to understand the underlying strategies of formation of mineralized structures...
  25. pmc Mapping amorphous calcium phosphate transformation into crystalline mineral from the cell to the bone in zebrafish fin rays
    Julia Mahamid
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 107:6316-21. 2010
    ..The integration of the two techniques demonstrates that new mineral is delivered and deposited as packages of amorphous calcium phosphate nanospheres, which transform into platelets of crystalline apatite within the collagen matrix...
  26. pmc Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase
    Julia Mahamid
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 105:12748-53. 2008
    ..Based on these findings, we propose that this amorphous calcium phosphate phase may be a precursor phase that later transforms into the mature crystalline mineral...
  27. doi request reprint The stabilizing effect of silicate on biogenic and synthetic amorphous calcium carbonate
    Assaf Gal
    Weizmann Institute of Science, Department of Structural Biology, Rehovot 76100, Israel
    J Am Chem Soc 132:13208-11. 2010
    ..A mechanism of geometric frustration is suggested, whereby the presence of the tetrahedral silicate ion in the flat carbonate lattice prevents organization into crystalline polymorphs...

Research Grants19

  1. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 2003
    ..The results will improve understanding of the aging process of human osteonal bone, and will allow better evaluation of possible effects that treatments for osteoporosis may have on mechanical function of bone. ..
  2. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 1993
    ..The structural information from normal bones will be compared with that from bones suffering pathology, in order to identify any significant differences, and hopefully relate these to the manner in which the tissue malfunctions...
  3. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 1990
    ..Knowledge of the molecular organization of bone should form the basis for understanding its formation, its role during calcium homeostasis, its destruction during remodeling and its biomechanical functions as a structural support system...
  4. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 1999
    ..Detailed maps of microhardness, as well as local strain values using Moire fringes, will be produced and then related back to tooth structure. ..
  5. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 2007
    ..abstract_text> ..