Nathan Sharon

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi Fighting infectious diseases with inhibitors of microbial adhesion to host tissues
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Crit Rev Food Sci Nutr 42:267-72. 2002
  2. doi In memory of Roger W. Jeanloz, a pioneer glycobiologist (1917-2007)
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Glycobiology 18:206-8. 2008
  3. ncbi Lectins: carbohydrate-specific reagents and biological recognition molecules
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 282:2753-64. 2007
  4. ncbi Carbohydrates as future anti-adhesion drugs for infectious diseases
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Biochim Biophys Acta 1760:527-37. 2006
  5. ncbi A life with lectins
    N Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Cell Mol Life Sci 62:1057-62. 2005
  6. doi Lectins: past, present and future
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Biochem Soc Trans 36:1457-60. 2008
  7. ncbi History of lectins: from hemagglutinins to biological recognition molecules
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 14:53R-62R. 2004
  8. ncbi How proteins bind carbohydrates: lessons from legume lectins
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Agric Food Chem 50:6586-91. 2002
  9. ncbi Meet the multifunctional and sexy glycoforms of glycodelin
    Kfir Lapid
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 16:39R-45R. 2006
  10. ncbi Biases and complex patterns in the residues flanking protein N-glycosylation sites
    Shifra Ben-Dor
    Department of Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 14:95-101. 2004

Collaborators

  • Itzhak Ofek
  • E Crouch
  • C L Nilsson
  • Susann Teneberg
  • Ute Krengel
  • Haim Shmuely
  • Jun Hirabayashi
  • Doron Steinberg
  • Z Samra
  • Y Niv
  • Hany Sahly
  • Yoko Itakura
  • Albert M Wu
  • Kfir Lapid
  • Matthew J Duncan
  • Shifra Ben-Dor
  • Mark R Wormald
  • Ervin I Weiss
  • Eric Bonneil
  • Nivedita Mitra
  • Hansjörg Streicher
  • E L Weiss
  • Cecilia Svensson
  • Ora Burger
  • Ken Ichi Kasai
  • Zhangung Yang
  • June H Wu
  • Ming Sung Tsai
  • Junko Kominami
  • Sachiko Nakamura-Tsuruta
  • Anthony Herp
  • Michael S Cohen
  • Elena L Mann
  • Soman N Abraham
  • Avital Kozlovsky
  • Ron Lev-Dor
  • Halina Lis
  • Pierre Thibault
  • Nir Esterman
  • Eitan Rubin
  • N Martin Young
  • Mark Feldman
  • Ronit Bar Ness Greenstein
  • Avadhesha Surolia
  • Anders Kjellberg
  • Mina Tabak
  • R Lev-Dor
  • Ervin Weiss
  • Ishak Neeman
  • Frederick P Schwarz

Detail Information

Publications26

  1. ncbi Fighting infectious diseases with inhibitors of microbial adhesion to host tissues
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Crit Rev Food Sci Nutr 42:267-72. 2002
    ..Together, these findings may lead to new therapeutic strategies that are in dire need because of the world-wide increase in antibiotic resistant bacteria...
  2. doi In memory of Roger W. Jeanloz, a pioneer glycobiologist (1917-2007)
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Glycobiology 18:206-8. 2008
  3. ncbi Lectins: carbohydrate-specific reagents and biological recognition molecules
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 282:2753-64. 2007
  4. ncbi Carbohydrates as future anti-adhesion drugs for infectious diseases
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Biochim Biophys Acta 1760:527-37. 2006
    ..All in all, however, there is little doubt that inhibitors of microbial lectins will in the near future join the arsenal of drugs for therapy of infectious diseases...
  5. ncbi A life with lectins
    N Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Cell Mol Life Sci 62:1057-62. 2005
  6. doi Lectins: past, present and future
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Biochem Soc Trans 36:1457-60. 2008
    ..The specialized functions of these lectins are discussed, as well as the potential medical applications of the knowledge gained. The review ends with speculations about future developments in lectin research and applications...
  7. ncbi History of lectins: from hemagglutinins to biological recognition molecules
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 14:53R-62R. 2004
    ..Here we present a brief account of 100-plus years of lectin research and show how these proteins have become the focus of intense interest for biologists and in particular for the glycobiologists among them...
  8. ncbi How proteins bind carbohydrates: lessons from legume lectins
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Agric Food Chem 50:6586-91. 2002
    ..Therefore, nature finds diverse solutions for the design of binding sites for structurally similar ligands, such as mono- or oligosaccharides. This diversity strongly suggests that lectins are products of convergent evolution...
  9. ncbi Meet the multifunctional and sexy glycoforms of glycodelin
    Kfir Lapid
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 16:39R-45R. 2006
    ..This review will focus on the involvement of the glycans in glycodelin activity and compare between the several glycoforms...
  10. ncbi Biases and complex patterns in the residues flanking protein N-glycosylation sites
    Shifra Ben-Dor
    Department of Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 14:95-101. 2004
    ....
  11. ncbi Differential affinities of Erythrina cristagalli lectin (ECL) toward monosaccharides and polyvalent mammalian structural units
    Albert M Wu
    Glyco Immunochemistry Research Laboratory, Institute of Molecular and Cellular Biology, Chang Gung University, Kwei San, Tao Yuan 333, Taiwan
    Glycoconj J 24:591-604. 2007
    ..These analyses should facilitate the understanding of the binding function of ECL...
  12. ncbi High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data
    Cecilia Svensson
    Department of Molecular Biotechnology and Center for Structural Biology, Chalmers University of Technology, P O Box 462, SE 405 30 Goteborg, Sweden
    J Mol Biol 321:69-83. 2002
    ....
  13. ncbi Inhibitory effect of a high-molecular-weight constituent of cranberry on adhesion of oral bacteria
    E L Weiss
    Department of Prosthodontics, School of Dental Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Crit Rev Food Sci Nutr 42:285-92. 2002
    ..A preliminary clinical trial showed that NDM reduces S. mutans counts in saliva. The antiadhesion activity of cranberry juice has a potential for altering the oral microbial flora resulting in improved oral hygiene...
  14. ncbi Anti-adhesion therapy of bacterial diseases: prospects and problems
    Itzhak Ofek
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    FEMS Immunol Med Microbiol 38:181-91. 2003
    ..Anti-adhesive drugs, once developed, may, therefore, serve as a new means to fight infectious diseases...
  15. ncbi Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice
    Ora Burger
    Sackler Faculty of Medicine, Tel Aviv University, Israel
    Crit Rev Food Sci Nutr 42:279-84. 2002
    ..pylori differ in their affinity to the cranberry juice constituent. Cranberry juice may also inhibit adhesion of bacteria to the stomach in vivo, and may prove useful for the prevention of stomach ulcer that is caused by H. pylori...
  16. ncbi A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite
    Ervin I Weiss
    Department of Prosthodontics, Faculty of Dentistry, Hebrew University Hadassah, Jerusalem, Israel
    FEMS Microbiol Lett 232:89-92. 2004
    ..The data suggest that the ability to reduce mutans streptococci counts in vivo is due to the anti-adhesion activity of the cranberry constituent...
  17. ncbi Recombinant plant lectins and their mutants
    Hansjörg Streicher
    Department of Chemistry, University of Konstanz, Konstanz D 78457, Germany
    Methods Enzymol 363:47-77. 2003
  18. ncbi Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry
    Haim Shmuely
    Helicobacter pylori Research Institute, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Diagn Microbiol Infect Dis 50:231-5. 2004
    ..There was no cross-resistance to the nondialysable material and metronidazole. These data suggest that a combination of antibiotics and a cranberry preparation may improve H. pylori eradication...
  19. ncbi Role of N-linked glycan in the unfolding pathway of Erythrina corallodendron lectin
    Nivedita Mitra
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
    Biochemistry 42:12208-16. 2003
    ..It therefore appears that while the covalently linked sugar does not contribute appreciably to the final folded structure of ECorL, it does alter its folding process in a significant manner...
  20. pmc Recognition of bacterial surface polysaccharides by lectins of the innate immune system and its contribution to defense against infection: the case of pulmonary pathogens
    Hany Sahly
    Institute of Immunology, Clinical Pathology and Molecular Medicine, Lademannbogen 61 63, 22339 Hamburg, Germany
    Infect Immun 76:1322-32. 2008
  21. ncbi Celebrating the golden anniversary of the discovery of bacillosamine, the diamino sugar of a Bacillus
    Nathan Sharon
    Glycobiology 17:1150-5. 2007
    ..Recently, there has been a burst of interest in Bac when it was found to be a link glycan in eubacterial glycoproteins. In this retrospective, I review the chance discovery of Bac, its structural determination and its biosynthesis...
  22. ncbi Systematic comparison of oligosaccharide specificity of Ricinus communis agglutinin I and Erythrina lectins: a search by frontal affinity chromatography
    Yoko Itakura
    Lectin Application and Analysis Team, Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 2, 1 1 1, Umezono, Tsukuba, Ibaraki 305 8568
    J Biochem 142:459-69. 2007
    ..Erythrina lectins can therefore serve as effective substitutes for RCA120, taking the above differences into consideration...
  23. ncbi The distinct binding specificities exhibited by enterobacterial type 1 fimbriae are determined by their fimbrial shafts
    Matthew J Duncan
    Molecular Genetics and Microbiology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 280:37707-16. 2005
    ..The capacity of type 1 fimbrial shafts to modulate the tissue tropism of different enterobacterial species represents a novel function for these highly organized structures...
  24. ncbi Letter to the Glyco-Forum: Karl Meyer, lysozyme, and penicilin
    Nathan Sharon
    Glycobiology 14:23G. 2004
  25. ncbi Probing genetic variation and glycoform distribution in lectins of the Erythrina genus by mass spectrometry
    Eric Bonneil
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    Arch Biochem Biophys 426:241-9. 2004
    ..A minor glycan heterogeneity was observed for most lectins examined except for that of ECafL and ECorL where an extra hexose residue was observed on the reducing GlcNAc residue of the heptasaccharide...
  26. ncbi Carbohydrates and glycoconjugates: progress in non-mammalian glycosylation, glycosyltransferases, invertebrate lectins and carbohydrate-carbohydrate interactions
    Mark R Wormald
    Curr Opin Struct Biol 14:591-2. 2004