Eyal D Schejter

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila
    Jennifer A Zallen
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 156:689-701. 2002
  2. pmc Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling
    S Ben-Yaacov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 152:1-13. 2001
  3. pmc Born to run: creating the muscle fiber
    Eyal D Schejter
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Curr Opin Cell Biol 22:566-74. 2010
  4. pmc Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery
    Shaul Yogev
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Biol 8:. 2010
  5. pmc The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion
    Boaz Gildor
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    EMBO Rep 10:1043-50. 2009
  6. doi request reprint Apical secretion in epithelial tubes of the Drosophila embryo is directed by the Formin-family protein Diaphanous
    R ada Massarwa
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Dev Cell 16:877-88. 2009
  7. doi request reprint The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release
    Shay Rotkopf
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Development 138:2729-39. 2011
  8. ncbi request reprint Conserved interactions with cytoskeletal but not signaling elements are an essential aspect of Drosophila WASp function
    Tamar Tal
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Biol 243:260-71. 2002
  9. doi request reprint Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette
    Tal Rousso
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 137:3427-37. 2010
  10. doi request reprint Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts
    Boaz Gildor
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 139:4040-50. 2012

Collaborators

Detail Information

Publications25

  1. pmc SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila
    Jennifer A Zallen
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 156:689-701. 2002
    ....
  2. pmc Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling
    S Ben-Yaacov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 152:1-13. 2001
    ..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway...
  3. pmc Born to run: creating the muscle fiber
    Eyal D Schejter
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Curr Opin Cell Biol 22:566-74. 2010
    ..We address these processes by highlighting recent findings from the Drosophila model system...
  4. pmc Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery
    Shaul Yogev
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Biol 8:. 2010
    ..Following this trafficking step, secretion from the axons is regulated in a manner similar to secretion from cell bodies. These findings uncover a role for the ER in trafficking proteins from the neuronal cell body to axon terminus...
  5. pmc The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion
    Boaz Gildor
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    EMBO Rep 10:1043-50. 2009
    ..This observation further suggests that actin-filament accumulation at the fusion sites might not depend on Arp2/3 activity altogether...
  6. doi request reprint Apical secretion in epithelial tubes of the Drosophila embryo is directed by the Formin-family protein Diaphanous
    R ada Massarwa
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Dev Cell 16:877-88. 2009
    ..This mechanism allows efficient utilization of the entire apical membrane for secretion...
  7. doi request reprint The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release
    Shay Rotkopf
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Development 138:2729-39. 2011
    ..A requirement for WASp-based activity in somatic support cells therefore appears to be a universal feature of spermatogenesis...
  8. ncbi request reprint Conserved interactions with cytoskeletal but not signaling elements are an essential aspect of Drosophila WASp function
    Tamar Tal
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Biol 243:260-71. 2002
    ..In contrast, we find that association with the key signaling molecules CDC42 and PIP2 is not an essential requirement, implying that activation of Wsp function in vivo depends on additional or alternative signaling pathways...
  9. doi request reprint Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette
    Tal Rousso
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 137:3427-37. 2010
    ..Diversification of the Egfr signaling pathway appears to have coupled gene duplication events with modulation of the biochemical properties and subcellular localization patterns of Rhomboid proteases and their substrates...
  10. doi request reprint Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts
    Boaz Gildor
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 139:4040-50. 2012
    ..The ensuing induction of proteins required for fusion enables myoblasts to fuse with the myotubes and give rise to subsequent muscle fiber growth...
  11. ncbi request reprint Making muscles: Arp, two, three
    Boaz Gildor
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Fly (Austin) 4:145-8. 2010
    ..Our approach also allows us to assess the involvement of the Arp2/3 machinery in formation of a distinct, fusion-associated actin structure...
  12. ncbi request reprint WIP/WASp-based actin-polymerization machinery is essential for myoblast fusion in Drosophila
    R ada Massarwa
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Dev Cell 12:557-69. 2007
    ..These observations identify cellular and developmental roles for the WASp-Arp2/3 pathway, and provide a link between force-generating actin polymerization and cell fusion...
  13. pmc The actin regulator N-WASp is required for muscle-cell fusion in mice
    Yael Gruenbaum-Cohen
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 109:11211-6. 2012
    ..WASp-family elements appear therefore to act as universal mediators of the myogenic cell-cell fusion mechanism underlying formation of functional muscle fibers, in both vertebrate and invertebrate species...
  14. pmc Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases
    Shaul Yogev
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 27:1219-30. 2008
    ..These observations identify changes in intracellular compartment localization of Rho proteins as a basis for signal attenuation, in tissues where EGFR activation must be highly restricted in space and time...
  15. doi request reprint Creating gradients by morphogen shuttling
    Ben Zion Shilo
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Genet 29:339-47. 2013
    ....
  16. ncbi request reprint Self-organized shuttling: generating sharp dorsoventral polarity in the early Drosophila embryo
    Michal Haskel-Ittah
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Cell 150:1016-28. 2012
    ..Shuttling may represent a general paradigm for patterning early embryos...
  17. ncbi request reprint Versatility of EGF receptor ligand processing in insects
    Shaul Yogev
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Dev Biol 357:17-20. 2011
    ....
  18. ncbi request reprint Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways
    Efrat Assa-Kunik
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 134:1161-9. 2007
    ....
  19. pmc Directing exocrine secretory vesicles to the apical membrane by actin cables generated by the formin mDia1
    Erez Geron
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 110:10652-7. 2013
    ..Together with previous results that identified a role for Diaphanous in apical secretion in tubular organs of Drosophila, the role of Diaphanous formins at the final stages of secretion appears to be highly conserved. ..
  20. doi request reprint Sequential activation of ETS proteins provides a sustained transcriptional response to EGFR signaling
    Arkadi Shwartz
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 140:2746-54. 2013
    ..Pulse-chase experiments indicate that PntP1 is stable for several hours in the eye disc. Sequential ETS-protein recruitment therefore allows sustained induction of target genes, beyond the transient activation of EGFR...
  21. ncbi request reprint Actin organization in the early Drosophila embryo
    Eyal D Schejter
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Novartis Found Symp 269:127-38; discussion 138-43, 223-30. 2005
    ..We have determined that sponge encodes a Drosophila homologue of the evolutionarily-conserved CDM (DOCK180) protein family...
  22. pmc Regulation of developmental intercellular signalling by intracellular trafficking
    Ben Zion Shilo
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 30:3516-26. 2011
    ..We will then turn to the signal-receiving cell, and discuss mechanisms by which endocytosis can affect the spatial features of the signal, and the compartmentalization of components downstream to the receptor...
  23. ncbi request reprint Modular tubes: common principles of renal development
    Eyal D Schejter
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Biol 13:R511-3. 2003
    ..Key features of this unusual manner of specifying functional units within a tubular organ have now been found to be similarly employed during development of the insect renal system...
  24. doi request reprint Orienting the direction of EGFR activation
    Ben Zion Shilo
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 23:449-50. 2012
    ..In this issue of Developmental Cell, Peng et al. (2012) demonstrate that a bias in the directionality of protrusions emanating from cells secreting the EGFR ligand Spitz leads to asymmetric activation of the pathway...