Israel Schechter

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi Mapping of the active site of proteases in the 1960s and rational design of inhibitors/drugs in the 1990s
    I Schechter
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Protein Pept Sci 6:501-12. 2005
  2. ncbi Inhibitors can activate proteases to catalyze the synthesis and hydrolysis of peptides
    Israel Schechter
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 45:14567-72. 2006
  3. doi Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s)
    Israel Schechter
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Biol Chem 389:313-20. 2008
  4. ncbi A new sono-electrochemical method for enhanced detoxification of hydrophilic chloroorganic pollutants in water
    Yakov Yasman
    Department of Chemistry, The Grand Water Research Institute, Technion Israel Institute of Technology, Technion City, Haifa 32000
    Ultrason Sonochem 11:365-72. 2004

Collaborators

  • Yakov Yasman
  • Noah Galil
  • Valery Bulatov
  • Vladimir V Gridin
  • Sabina Agur
  • Robert Armon

Detail Information

Publications4

  1. ncbi Mapping of the active site of proteases in the 1960s and rational design of inhibitors/drugs in the 1990s
    I Schechter
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Protein Pept Sci 6:501-12. 2005
    ..This model is still in use in basic research to evaluate enzyme activity, and in pharmaceutical research for the development of inhibitors/drugs...
  2. ncbi Inhibitors can activate proteases to catalyze the synthesis and hydrolysis of peptides
    Israel Schechter
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 45:14567-72. 2006
    ..Thus, the binding energy of formation of the enzyme-inhibitor complex can be utilized to catalyze the synthesis of peptide bonds in the absence of an exogenous energy source (e.g., ATP)...
  3. doi Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s)
    Israel Schechter
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Biol Chem 389:313-20. 2008
    ..Nevertheless, as both BACE 1 and cathepsin D show poor activity towards the WT beta-site sequence, it is necessary to continue the search for additional beta-secretase candidate(s)...
  4. ncbi A new sono-electrochemical method for enhanced detoxification of hydrophilic chloroorganic pollutants in water
    Yakov Yasman
    Department of Chemistry, The Grand Water Research Institute, Technion Israel Institute of Technology, Technion City, Haifa 32000
    Ultrason Sonochem 11:365-72. 2004
    ..These findings indicate that SEF process may be an effective method for detoxification of environmental water...