O Reiner

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint The unfolding story of two lissencephaly genes and brain development
    O Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Mol Neurobiol 20:143-56. 1999
  2. pmc PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing GABAergic Neurons
    Idit Livnat
    Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel
    Front Cell Neurosci 4:. 2010
  3. pmc Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon
    Michal Segal
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biol Open 1:220-31. 2012
  4. doi request reprint Mark/Par-1 marking the polarity of migrating neurons
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel
    Adv Exp Med Biol 800:97-111. 2014
  5. doi request reprint LIS1 functions in normal development and disease
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Electronic address
    Curr Opin Neurobiol 23:951-6. 2013
  6. doi request reprint Interkinetic nuclear movement in the ventricular zone of the cortex
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    J Mol Neurosci 46:516-26. 2012
  7. pmc HIV-1 Tat interacts with LIS1 protein
    Nicolas Epie
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    Retrovirology 2:6. 2005
  8. ncbi request reprint Similarities and differences between the Wnt and reelin pathways in the forming brain
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Mol Neurobiol 31:117-34. 2005
  9. ncbi request reprint DCX's phosphorylation by not just another kinase (JNK)
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Cell Cycle 3:747-51. 2004
  10. ncbi request reprint LIS1. let's interact sometimes... (part 1)
    O Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Neuron 28:633-6. 2000

Collaborators

Detail Information

Publications47

  1. ncbi request reprint The unfolding story of two lissencephaly genes and brain development
    O Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Mol Neurobiol 20:143-56. 1999
    ..Lissencephaly, a severe brain malformation, can be caused by mutations in one of two known genes: LIS1 and doublecortin (DCX). Recent in vitro and in vivo studies, report on possible functions for these gene products...
  2. pmc PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing GABAergic Neurons
    Idit Livnat
    Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel
    Front Cell Neurosci 4:. 2010
    ..We hypothesize that modulation of the Wnt pathway is the evolutionary conserved activity of the PAF-AH catalytic subunits...
  3. pmc Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon
    Michal Segal
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biol Open 1:220-31. 2012
    ..We propose that they may function primarily by inhibition of dynein-dependent resistance, which suggests that both dynein and kinesin motors may remain engaged with microtubules during bidirectional transport...
  4. doi request reprint Mark/Par-1 marking the polarity of migrating neurons
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel
    Adv Exp Med Biol 800:97-111. 2014
    ..Normal neuronal migration requires at least two of MARK/Par-1 substrates, DCX and tau. Overall, the positioning of MARK/Par-1 at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions. ..
  5. doi request reprint LIS1 functions in normal development and disease
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Electronic address
    Curr Opin Neurobiol 23:951-6. 2013
    ..LIS1-dynein interaction decreases the average velocity of the molecular motor in vitro, shows more complex effects in vivo, and may be of importance in high-load transport especially in neurons. ..
  6. doi request reprint Interkinetic nuclear movement in the ventricular zone of the cortex
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    J Mol Neurosci 46:516-26. 2012
    ....
  7. pmc HIV-1 Tat interacts with LIS1 protein
    Nicolas Epie
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    Retrovirology 2:6. 2005
    ..Tat-induced apoptosis of T-cells is attributed, in part, to the distortion of microtubules polymerization. LIS1 is a microtubule-associated protein that facilitates microtubule polymerization...
  8. ncbi request reprint Similarities and differences between the Wnt and reelin pathways in the forming brain
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Mol Neurobiol 31:117-34. 2005
    ..We propose that future studies directed at understanding of diversification will provide fruitful insights on mammalian brain formation...
  9. ncbi request reprint DCX's phosphorylation by not just another kinase (JNK)
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Cell Cycle 3:747-51. 2004
    ..The JNK pathway is linked to the reelin pathway, known to regulate cortical layering. Positioning of DCX in this signaling pathway opens up additional possibilities of understanding how migrating neurons are controlled...
  10. ncbi request reprint LIS1. let's interact sometimes... (part 1)
    O Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Neuron 28:633-6. 2000
  11. pmc The evolving doublecortin (DCX) superfamily
    Orly Reiner
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    BMC Genomics 7:188. 2006
    ....
  12. ncbi request reprint Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuromolecular Med 8:547-65. 2006
    ....
  13. ncbi request reprint Missense mutations resulting in type 1 lissencephaly
    O Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Cell Mol Life Sci 62:425-34. 2005
    ..Here, we will focus on a particular subset of missense mutations in these two genes and their effect on protein structure and function...
  14. doi request reprint Polarity regulation in migrating neurons in the cortex
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Neurobiol 40:1-14. 2009
    ..We highlight recent interesting findings connecting polarity proteins with neuronal migration events regulated by the microtubule-associated molecular motor, cytoplasmic dynein...
  15. ncbi request reprint LIS1-no more no less
    O Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Mol Psychiatry 7:12-6. 2002
    ..We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions...
  16. ncbi request reprint Cleavage of doublecortin-like kinase by calpain releases an active kinase fragment from a microtubule anchorage domain
    H A Burgess
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:36397-403. 2001
    ..We propose that in neurons cleavage of DCLK by calpain represents a calcium responsive mechanism to regulate localization of the DCLK kinase domain...
  17. ncbi request reprint Interaction between LIS1 and doublecortin, two lissencephaly gene products
    M Caspi
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Mol Genet 9:2205-13. 2000
    ..We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex...
  18. ncbi request reprint LIS1 is a microtubule-associated phosphoprotein
    T Sapir
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Biochem 265:181-8. 1999
    ..In vitro, LIS1 was phosphorylated by protein kinase CKII (casein kinase II), but not many other kinases that were tested. We suggest that LIS1 activity may be regulated by phosphorylation...
  19. pmc Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization
    A Cahana
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 98:6429-34. 2001
    ..This mutation allows us to determine a hierarchy of functions that are sensitive to LIS1 dosage, thus promoting our understanding of the role of LIS1 in the developing cortex...
  20. pmc Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit
    T Sapir
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 16:6977-84. 1997
    ..We postulate that the LIS1-cytoskeletal interaction is important for neuronal migration, a process that is defective in lissencephaly patients...
  21. ncbi request reprint Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1)
    Anat Shmueli
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Neurosci 32:15-26. 2006
    ....
  22. doi request reprint Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex
    Tamar Sapir
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 28:13008-13. 2008
    ..Our results stress the necessity for successful coupling between the polarity pathway and cytoplasmic dynein-dependent activities for proper neuronal migration...
  23. ncbi request reprint LIS1 and platelet-activating factor acetylhydrolase (Ib) catalytic subunits, expression in the mouse oocyte and zygote
    A Cahana
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    FEBS Lett 451:99-102. 1999
    ..These findings suggest a potential role for platelet-activating factor acetylhydrolase (Ib) components in the early mouse embryo...
  24. ncbi request reprint Common and divergent roles for members of the mouse DCX superfamily
    Frédéric M Coquelle
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Cell Cycle 5:976-83. 2006
    ..The sub-specialization of some members due to confined intracellular localization, and protein interactions may explain the success of this superfamily...
  25. ncbi request reprint DCX in PC12 cells: CREB-mediated transcription and neurite outgrowth
    O Shmueli
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Mol Genet 10:1061-70. 2001
    ..Overexpression of a mutation found in a lissencephaly patient (S47R), completely blocks neurite outgrowth. We propose that these functions are important during normal and abnormal brain development...
  26. ncbi request reprint LIS2, gene and pseudogene, homologous to LIS1 (lissencephaly 1), located on the short and long arms of chromosome 2
    O Reiner
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genomics 30:251-6. 1995
    ..Isolated YAC clones and P1 clones mapped by in situ hybridization to two loci on chromosome 2,2p11.2 and 2q13-q14. This hybridization was due to the existence of LIS2 pseudogene LIS2P on the long arm of chromosome 2...
  27. pmc DCX, a new mediator of the JNK pathway
    Amos Gdalyahu
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:823-32. 2004
    ....
  28. ncbi request reprint Expression of chLIS1, a chicken homolog of LIS1
    O Shmueli
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Dev Genes Evol 210:51-4. 2000
    ..Additionally, we describe the pattern of chLIS1 expression in the chicken embryo. The early embryonic expression is highly specific to the developing nervous system, whereas later the expression is more widespread...
  29. ncbi request reprint Human sphingolipid activator protein-1 and sphingolipid activator protein-2 are encoded by the same gene
    O Reiner
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Mol Neurosci 1:225-33. 1989
    ..The steady-state SAP-1/SAP-2 mRNA levels in Gaucher B cells are higher than in their normal counterparts. There is one human SAP-1/SAP-2 gene that has been cloned and is localized on two approximately 5 kb BamHI fragments...
  30. ncbi request reprint Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration
    O Reiner
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    J Neurosci 15:3730-8. 1995
    ..The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease...
  31. doi request reprint Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration
    Tamar Sapir
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 28:5710-20. 2008
    ..Furthermore, the exact requirements for MARK2 and its kinase activity vary during the course of neuronal migration. Collectively, our results stress the requirements for the different roles of MARK2 during neuronal migration...
  32. ncbi request reprint KIAA0369, doublecortin-like kinase, is expressed during brain development
    H A Burgess
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    J Neurosci Res 58:567-75. 1999
    ....
  33. ncbi request reprint LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties
    Michal Caspi
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 278:38740-8. 2003
    ..Our results implicate that there are probably different biochemical and cellular mechanisms obstructed in each patient yielding the varied lissencephaly phenotypes...
  34. ncbi request reprint Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities
    Harold A Burgess
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:17696-705. 2002
    ..Although this protein isoform was expressed mainly in the adult brain, the phosphorylated form was strongly enriched in embryonic brain and adult olfactory bulb, suggesting a possible role in migrating neurons...
  35. pmc Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity
    Anat Shmueli
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 29:107-19. 2010
    ..Our findings indicate, to the best of our knowledge, for the first time that Ndel1 palmitoylation is a new mean for fine-tuning the activity of the retrograde motor cytoplasmic dynein...
  36. ncbi request reprint Doublecortin supports the development of dendritic arbors in primary hippocampal neurons
    Dror Cohen
    Department of Neurobiology, The Weizmann Institute, Rehovot, Israel
    Dev Neurosci 30:187-99. 2008
    ..These results suggest that DCX supports developing dendrites, in addition to its role in neuronal migration...
  37. ncbi request reprint Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization
    Gabi Gerlitz
    The Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Cell Cycle 4:1632-40. 2005
    ..Our results allow the prediction that mutations within the LisH motif are likely to result in pathogenic consequences in genes associated with genetic diseases...
  38. doi request reprint Neuronal migration and neurodegeneration: 2 sides of the same coin
    Orly Reiner
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Cereb Cortex 19:i42-8. 2009
    ..We propose that the prevalent and early Anosmia found in Alzheimer's patients may be due in part to malfunctioning of the above-mentioned proteins...
  39. ncbi request reprint Migration cues induce chromatin alterations
    Gabi Gerlitz
    The Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Traffic 8:1521-9. 2007
    ..Our studies suggest that dynamic reorganization of the chromatin fiber is an early event in the cellular response to migration cues...
  40. pmc LIS1, CLIP-170's key to the dynein/dynactin pathway
    Frédéric M Coquelle
    Institut Curie, Section de Recherche, CNRS UMR 146, Centre Universitaire d Orsay, 91405 Orsay Cedex, France
    Mol Cell Biol 22:3089-102. 2002
    ..This work suggests that LIS1 is a regulated adapter between CLIP-170 and cytoplasmic dynein at sites involved in cargo-MT loading, and/or in the control of MT dynamics...
  41. ncbi request reprint Pathways of neuronal migration
    Orly Reiner
    Nat Genet 32:341-2. 2002
  42. ncbi request reprint The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications
    Myung Hee Kim
    Department of Molecular Physiology and Biological Physics and Cancer Center, University of Virginia, Charlottesville, VA 22908, USA
    Structure 12:987-98. 2004
    ..The structure explains the molecular basis of a low severity form of lissencephaly...
  43. ncbi request reprint Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse
    Lourdes Valdés-Sánchez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Campus de San Juan, Apartado 18, San Juan, 03550 Alicante, Spain
    Mol Cell Neurosci 35:220-9. 2007
    ..These results demonstrate the presence of functional alterations in the postnatal Lis1/sLis1 cortex and point to abnormalities in GABAA receptor subunit switching processes during postnatal development...
  44. pmc Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1
    Eva M Jimenez-Mateos
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Campus de Cantoblanco, Cantoblanco 28049, Madrid, Spain
    Biochem J 389:333-41. 2005
    ..Clearly, the differential binding of these cytoskeletal proteins could regulate the functions attributed to the LIS1-dynein complex, including those related to extension of the neural processes necessary for neuronal migration...
  45. ncbi request reprint Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression
    Tianzhi Shu
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 49:25-39. 2006
    ..These data provide evidence that DCLK controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis...
  46. ncbi request reprint Cdk5 checks p27kip1 in neuronal migration
    Orly Reiner
    Nat Cell Biol 8:11-3. 2006