Tsviya Olender

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc GeneCards Version 3: the human gene integrator
    Marilyn Safran
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Database (Oxford) 2010:baq020. 2010
  2. ncbi request reprint The canine olfactory subgenome
    Tsviya Olender
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genomics 83:361-72. 2004
  3. pmc Personal receptor repertoires: olfaction as a model
    Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 13:414. 2012
  4. pmc Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments
    Alexandra Sirota-Madi
    The Sackler School of Physics and Astronomy, Tel Aviv University, PO Box 39040, Tel Aviv 69978, Israel
    BMC Genomics 11:710. 2010
  5. pmc Common peptides shed light on evolution of Olfactory Receptors
    Assaf Gottlieb
    School of Physics and Astronomy, Tel Aviv University, Tel Aviv, Israel
    BMC Evol Biol 9:91. 2009
  6. ncbi request reprint The olfactory receptor universe--from whole genome analysis to structure and evolution
    Tsviya Olender
    Department of Molecular Genetics and Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel
    Genet Mol Res 3:545-53. 2004
  7. doi request reprint HORDE: comprehensive resource for olfactory receptor genomics
    Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 1003:23-38. 2013
  8. pmc Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity
    Sebastian M Waszak
    Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 6:e1000988. 2010
  9. pmc High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution
    Yehudit Hasin
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Genet 4:e1000249. 2008
  10. pmc General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations
    Ifat Keydar
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Hum Mutat 34:32-41. 2013

Detail Information

Publications25

  1. pmc GeneCards Version 3: the human gene integrator
    Marilyn Safran
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Database (Oxford) 2010:baq020. 2010
    ..Finally, we delineate examples of applications and collaborations that have benefited from the GeneCards suite. Database URL: www.genecards.org...
  2. ncbi request reprint The canine olfactory subgenome
    Tsviya Olender
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genomics 83:361-72. 2004
    ..The elucidation of a large portion of the canine olfactory receptor gene superfamily, with some dog-specific attributes, may help us understand the unique chemosensory capacities of this species...
  3. pmc Personal receptor repertoires: olfaction as a model
    Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 13:414. 2012
    ..To this end, we focused on the complete inventory of human olfactory receptor coding regions as a model for personal receptor repertoires...
  4. pmc Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments
    Alexandra Sirota-Madi
    The Sackler School of Physics and Astronomy, Tel Aviv University, PO Box 39040, Tel Aviv 69978, Israel
    BMC Genomics 11:710. 2010
    ..However, no genomic data is available on the Paenibacillus species with pattern-forming and complex social motility. Here we report the de novo genome sequence of this Gram-positive, soil-dwelling, sporulating bacterium...
  5. pmc Common peptides shed light on evolution of Olfactory Receptors
    Assaf Gottlieb
    School of Physics and Astronomy, Tel Aviv University, Tel Aviv, Israel
    BMC Evol Biol 9:91. 2009
    ..Their evolution and their expansion in the vertebrate genomes was the subject of many studies. In this paper we apply a motif-based approach to this problem in order to uncover evolutionary characteristics...
  6. ncbi request reprint The olfactory receptor universe--from whole genome analysis to structure and evolution
    Tsviya Olender
    Department of Molecular Genetics and Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel
    Genet Mol Res 3:545-53. 2004
    ..Such analyses form a basis for a comprehensive sequence-based classification of OR proteins in terms of potential odorant binding specificities...
  7. doi request reprint HORDE: comprehensive resource for olfactory receptor genomics
    Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 1003:23-38. 2013
    ..We also discuss plans for future enhancements and a road map for HORDE to become a better community-based bioinformatics tool. We highlight HORDE's role as a major research tool in the study of an expanding cohort of OR repertoires...
  8. pmc Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity
    Sebastian M Waszak
    Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 6:e1000988. 2010
    ....
  9. pmc High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution
    Yehudit Hasin
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Genet 4:e1000249. 2008
    ..Furthermore, these deletion alleles may be used in future genetic association studies of olfactory inter-individual differences...
  10. pmc General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations
    Ifat Keydar
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Hum Mutat 34:32-41. 2013
    ..This database of genes and their variants should assist in rationalizing the great interindividual variation in human overall olfactory sensitivity (http://genome.weizmann.ac.il/GOSdb)...
  11. pmc In-silico human genomics with GeneCards
    Gil Stelzer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Hum Genomics 5:709-17. 2011
    ....
  12. doi request reprint Human olfaction: from genomic variation to phenotypic diversity
    Yehudit Hasin-Brumshtein
    Department of Molecular Genetics and the Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Genet 25:178-84. 2009
    ..This promises to provide a genome-wide view of human olfaction, resulting in a deeper understanding of personalized odor coding, with the potential to decipher flavor and fragrance preferences...
  13. pmc Ancient genomic architecture for mammalian olfactory receptor clusters
    Ronny Aloni
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genome Biol 7:R88. 2006
    ..Whole-genome sequence alignment nets of five mammals allow their comprehensive comparison, aimed at reconstructing the ancestral olfactory subgenome...
  14. pmc Widespread ectopic expression of olfactory receptor genes
    Ester Feldmesser
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 7:121. 2006
    ..The present study systematically explores the expression patterns of OR genes in a large number of tissues and assesses the potential functional implication of such ectopic expression...
  15. ncbi request reprint GeneCards 2002: towards a complete, object-oriented, human gene compendium
    Marilyn Safran
    Departments of Molecular Genetics Biological Services Bioinformatics Unit Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Bioinformatics 18:1542-3. 2002
    ..In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving, state-of-the-art tools...
  16. pmc Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE
    Marilyn Safran
    Department of Biological Services Bioinformatics Unit, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Nucleic Acids Res 31:142-6. 2003
    ..weizmann.ac.il/HORDE). The synergistic relationships amongst these efforts have positively impacted the quality, quantity and usefulness of the GeneCards gene compendium...
  17. ncbi request reprint USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses
    Avital Adato
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Eur J Hum Genet 10:339-50. 2002
    ....
  18. pmc Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis
    Danit Oz-Levi
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Am J Hum Genet 91:1065-72. 2012
    ..The discovered TECPR2 mutation implicates autophagy, a central intracellular mechanism, in spastic paraparesis...
  19. pmc Update on the olfactory receptor (OR) gene superfamily
    Tsviya Olender
    The Crown Human Genome Center, Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Hum Genomics 3:87-97. 2008
    ..The nomenclature system (based on evolutionary divergence of genes into families and subfamilies of the OR gene superfamily) has been designed similarly to that originally used for the CYP gene superfamily...
  20. ncbi request reprint From subgenome analysis to protein structure
    Orna Man
    The Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Curr Opin Struct Biol 13:353-8. 2003
    ..Comparative studies of gene families throughout the mammalian genome will also help elucidate the functional significance of single nucleotide polymorphisms in coding regions...
  21. doi request reprint Mutations and lethality in simulated prebiotic networks
    Aron Inger
    Department of Molecular Genetics and the Crown Human Genome Center, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Mol Evol 69:568-78. 2009
    ....
  22. doi request reprint Evolutionary grass roots for odor recognition
    Tsviya Olender
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Chem Senses 37:581-4. 2012
    ..It provides a clear relevant example for the impact of genetics on olfaction and is an excellent portrayal of the power of human genomics to decipher olfactory perception...
  23. doi request reprint GeneDecks: paralog hunting and gene-set distillation with GeneCards annotation
    Gil Stelzer
    Departments of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    OMICS 13:477-87. 2009
    ..GeneDecks enables the elucidation of unsuspected putative functional paralogs, and a refined scrutiny of various gene-sets (e.g., from high-throughput experiments) for discovering relevant biological patterns...
  24. pmc Genome analysis of the platypus reveals unique signatures of evolution
    Wesley C Warren
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 453:175-83. 2008
    ..Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation...
  25. ncbi request reprint MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent
    Ronit I Yarden
    Laboratory of Genomic Applications, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Breast Cancer Res Treat 111:497-504. 2008
    ..30; 95% CI 0.69-2.47, P = 0.419). These data suggest that MDM2 SNP309 acts as a modifier of mutant BRCA1/2 mutant alleles in AJ and may accelerate breast and ovarian carcinogenesis in genetically predisposed individuals...