R Miskin

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint AlphaMUPA mice: a transgenic model for increased life span
    R Miskin
    Department of Biological Chemistry and Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Neurobiol Aging 20:555-64. 1999
  2. ncbi request reprint Enhancement of PAI-1 mRNA in cardiovascular cells after kainate injection is mediated through the sympathetic nervous system
    Ruth Miskin
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Cell Cardiol 38:715-22. 2005
  3. ncbi request reprint Urokinase-type plasminogen activator mRNA is expressed in normal developing teeth and leads to abnormal incisor enamel in alpha MUPA transgenic mice
    Ruth Miskin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Transgenic Res 15:241-54. 2006
  4. ncbi request reprint AlphaMUPA mice: a transgenic model for longevity induced by caloric restriction
    Ruth Miskin
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mech Ageing Dev 126:255-61. 2005
  5. doi request reprint Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant ╬▒MUPA mice
    O Froy
    Robert H Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel
    Int J Obes (Lond) 35:226-35. 2011
  6. ncbi request reprint Long-lived alpha MUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, Hebrew University of Jerusalem, Rehovot 76100, Israel
    Ann N Y Acad Sci 1019:439-42. 2004
  7. ncbi request reprint Plasminogen activator inhibitor-1 mRNA is localized in the ciliary epithelium of the rodent eye
    T Masos
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Invest Ophthalmol Vis Sci 41:1006-11. 2000
  8. ncbi request reprint Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Am J Physiol Endocrinol Metab 291:E1017-24. 2006
  9. doi request reprint Effect of intermittent fasting on circadian rhythms in mice depends on feeding time
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mech Ageing Dev 130:154-60. 2009
  10. ncbi request reprint Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Mech Ageing Dev 126:1262-73. 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint AlphaMUPA mice: a transgenic model for increased life span
    R Miskin
    Department of Biological Chemistry and Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Neurobiol Aging 20:555-64. 1999
    ..Thus alphaMUPA offers a unique transgenic model of inherently reduced eating to investigate the homeostatic state of delayed aging at the systemic and single-cell levels...
  2. ncbi request reprint Enhancement of PAI-1 mRNA in cardiovascular cells after kainate injection is mediated through the sympathetic nervous system
    Ruth Miskin
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Cell Cardiol 38:715-22. 2005
    ..Thus, these findings raise the possibility that glutamate, acting via the SNS, can affect cardiovascular homeostasis and pathology by modulating gene expression in cardiac myocytes and vascular cells...
  3. ncbi request reprint Urokinase-type plasminogen activator mRNA is expressed in normal developing teeth and leads to abnormal incisor enamel in alpha MUPA transgenic mice
    Ruth Miskin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Transgenic Res 15:241-54. 2006
    ..The alphaMUPA tooth phenotype demonstrates a remarkable sensitivity to excessive extracellular proteolysis at the incisor maturation stage of amelogenesis...
  4. ncbi request reprint AlphaMUPA mice: a transgenic model for longevity induced by caloric restriction
    Ruth Miskin
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mech Ageing Dev 126:255-61. 2005
    ....
  5. doi request reprint Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant ╬▒MUPA mice
    O Froy
    Robert H Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel
    Int J Obes (Lond) 35:226-35. 2011
    ..MUPA mice are obesity resistant and they share many similarities with calorically restricted animals. However, extensive metabolic characterization of this unique transgenic model has never been performed...
  6. ncbi request reprint Long-lived alpha MUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, Hebrew University of Jerusalem, Rehovot 76100, Israel
    Ann N Y Acad Sci 1019:439-42. 2004
    ....
  7. ncbi request reprint Plasminogen activator inhibitor-1 mRNA is localized in the ciliary epithelium of the rodent eye
    T Masos
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Invest Ophthalmol Vis Sci 41:1006-11. 2000
    ..To identify in the adult and developing rodent eye cells expressing the gene encoding plasminogen activator inhibitor-1 (PAI-1), an important component of the fibrinolytic system...
  8. ncbi request reprint Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Am J Physiol Endocrinol Metab 291:E1017-24. 2006
    ..Thus we surmise that CR could lead to pronounced and synchronized biological rhythms. Because the biological clock controls mitochondrial, hormonal, and physiological parameters, system synchronicity could lead to extended life span...
  9. doi request reprint Effect of intermittent fasting on circadian rhythms in mice depends on feeding time
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mech Ageing Dev 130:154-60. 2009
    ..Taken together, our results show that IF can affect circadian rhythms differently depending on the timing of food availability, and suggest that this regimen induces a metabolic state that affects the suprachiasmatic nuclei (SCN) clock...
  10. ncbi request reprint Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Mech Ageing Dev 126:1262-73. 2005
    ..Collectively, these data are consistent with a model, in which an optimal fine-tuning of SOD2 throughout a long-term regimen of reduced eating could contribute to longevity, at least in the alphaMUPA mice...
  11. doi request reprint The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding
    O Froy
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Neuroscience 155:1152-9. 2008
    ..In summary, herein we reinforce a role for calorie restriction in resetting the SCN clock, and unravel a role for the SCN in determining peripheral rhythms under RF...
  12. ncbi request reprint Mitochondrion-mediated apoptosis is enhanced in long-lived alphaMUPA transgenic mice and calorically restricted wild-type mice
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, Hebrew University of Jerusalem, Rehovot 76100, Israel
    Exp Gerontol 38:955-63. 2003
    ....
  13. ncbi request reprint Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain
    T Masos
    Department of Biochemistry, Weizmann Institute of Science, Rehovot, Israel
    Brain Res Mol Brain Res 35:139-48. 1996
    ..These results support the view of uPA being involved in neuronal functions of the adult brain, specifically in the hippocampal formation and the parietal cortex...
  14. ncbi request reprint A RUNX/AML-binding motif residing in a novel 13-bp DNA palindrome may determine the expression of the proximal promoter of the human uPA gene
    E Kopf
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    J Thromb Haemost 3:2057-64. 2005
    ..The data presented here have implicated, for the first time, RUNX/AML in the regulation of the uPA gene. The significance of the novel palindrome regarding gene regulation through the RUNX motif deserves further investigation...
  15. ncbi request reprint Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA
    Ronit Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Brain Res Mol Brain Res 104:170-5. 2002
    ..Furthermore, because PAI-2 is thought to intracellularly counteract cytotoxic events, our results raise the possibility that PAI-2 can act in the brain as an intracellular neuroprotector against potential plasmin-mediated toxicity...
  16. doi request reprint Relationship between calorie restriction and the biological clock: lessons from long-lived transgenic mice
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Rejuvenation Res 11:467-71. 2008
    ..As CR resets circadian rhythms, and the circadian clock controls many physiological and biochemical systems, we suggest that the biological clock could be an important mediator of longevity in calorically restricted animals...
  17. ncbi request reprint The interrelations among feeding, circadian rhythms and ageing
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Prog Neurobiol 82:142-50. 2007
    ..This surmise is novel, and we provide evidence to support it. Furthermore, we discuss other feeding regimens and their effects on circadian rhythms and/or life span...
  18. ncbi request reprint "Tumor target organs and rate of survival in long-living transgenic mice and their parental wild-type counterparts exposed to the carcinogen dimethylbenz(alpha)anthracene", by Kossoy George, Herzl Ben-Hur, Ruth Miskin and Isthak Zusman. In vivo
    Ruth Miskin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    In Vivo 20:911-2. 2006
  19. pmc Effect of feeding regimens on circadian rhythms: implications for aging and longevity
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Aging (Albany NY) 2:7-27. 2010
    ..This review will summarize recent findings concerning the relationships between feeding regimens, circadian rhythms, and metabolism with implications for ageing attenuation and life span extension...
  20. ncbi request reprint Tumor target organs and rate of survival in long-living transgenic mice and their parental wild-type counterparts exposed to the carcinogen dimethylbenz(a)anthracene
    George Kossoy
    Koret School of Veterinary Medicine, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    In Vivo 20:543-8. 2006
    ..5 +/- 1.3 weeks in WT mice, p <0.01. The lungs, forestomach and skin were target organs for the carcinogenic effect of DMBA. Our observations suggest that aging promotes the rate of spontaneous and induced tumorigenesis...
  21. ncbi request reprint Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma
    Jacob Dan
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Arch Ophthalmol 123:220-4. 2005
    ..To determine the levels of plasminogen activator inhibitor-1 (PAI-1) and total protein in the aqueous humor of patients with glaucoma vs those without glaucoma...
  22. ncbi request reprint Mouse intestinal cryptdins exhibit circadian oscillation
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    FASEB J 19:1920-2. 2005
    ..With the assumption of similar control in humans, our results may imply that defensin expression peaks during the day...