T Lapidot

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells
    Ayelet Dar
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 6:1038-46. 2005
  2. ncbi Mobilizing the older patient with myeloma
    Michele Cottler-Fox
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood Rev 20:43-50. 2006
  3. ncbi Biology of normal and acute myeloid leukemia stem cells
    John E Dick
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Int J Hematol 82:389-96. 2005
  4. ncbi p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts
    Neta Moskovits
    Departments of Molecular Cell Biology and Immunology, The Weizmann Institute of Science, Rehovot, Israel and Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel
    Cancer Res 66:10671-6. 2006
  5. pmc CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules
    Shoham Shivtiel
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 205:2381-95. 2008
  6. ncbi Regulatory cross talks of bone cells, hematopoietic stem cells and the nervous system maintain hematopoiesis
    Orit Kollet
    Immunology Department, Weizmann Institute of Science, Rehovot 76100, Israel
    Inflamm Allergy Drug Targets 11:170-80. 2012
  7. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
  8. ncbi The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
    T Lapidot
    Dept of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Leukemia 16:1992-2003. 2002
  9. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
  10. ncbi The endosteum region keeps human leukemic stem cells alive
    Tsvee Lapidot
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Cell Stem Cell 1:483-4. 2007

Collaborators

Detail Information

Publications55

  1. ncbi Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells
    Ayelet Dar
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 6:1038-46. 2005
    ..Thus, chemokine translocation across the blood-bone marrow barrier allows effective transfer of functional SDF-1 from the periphery to the stem cell niche in the bone marrow during both homeostasis and 'alarm' situations...
  2. ncbi Mobilizing the older patient with myeloma
    Michele Cottler-Fox
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood Rev 20:43-50. 2006
    ....
  3. ncbi Biology of normal and acute myeloid leukemia stem cells
    John E Dick
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Int J Hematol 82:389-96. 2005
    ..Here we review recent studies that have begun, to elucidate the interplay between normal and leukemic human stem cells and their microenvironment...
  4. ncbi p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts
    Neta Moskovits
    Departments of Molecular Cell Biology and Immunology, The Weizmann Institute of Science, Rehovot, Israel and Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel
    Cancer Res 66:10671-6. 2006
    ....
  5. pmc CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules
    Shoham Shivtiel
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 205:2381-95. 2008
    ..Uncoupling environmental and intrinsic defects in chimeric mice, we demonstrated that CD45 regulates progenitor movement and retention by influencing both the hematopoietic and nonhematopoietic compartments...
  6. ncbi Regulatory cross talks of bone cells, hematopoietic stem cells and the nervous system maintain hematopoiesis
    Orit Kollet
    Immunology Department, Weizmann Institute of Science, Rehovot 76100, Israel
    Inflamm Allergy Drug Targets 11:170-80. 2012
    ..Inflammation, DNA damage, cytokine mobilization, microgravity and aging are discussed as specific physiologic and pathologic events entailing dysregulation of the tightly balanced Bone-Brain-Blood triad...
  7. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
    ..This review is focused on mechanisms and key regulators of human stem cell homing to the BM in experimental animal models and clinical transplantation protocols...
  8. ncbi The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
    T Lapidot
    Dept of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Leukemia 16:1992-2003. 2002
    ..In particular, the essential roles of the chemokine SDF-1 and its receptor CXCR4 which mediate and regulate stem cell homing and repopulation will be discussed...
  9. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
    ..Furthermore, the central role of this chemokine in stem cell homing to the bone marrow as well as retention of undifferentiated cells within this tissue will also be discussed...
  10. ncbi The endosteum region keeps human leukemic stem cells alive
    Tsvee Lapidot
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Cell Stem Cell 1:483-4. 2007
  11. ncbi Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions
    T Lapidot
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 938:83-95. 2001
    ..We discuss the pleiotropic roles of SDF-1/CXCR4 interactions in human stem cell migration, development, and repopulation in transplanted immune-deficient mice...
  12. ncbi Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice
    O Kollet
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 97:3283-91. 2001
    ..This study reveals rapid and efficient homing to the murine bone marrow by primitive human CD34(+)CD38(-/low)CXCR4(+) cells that is integrin mediated and depends on activation of the protein kinase C signal transduction pathway by SDF-1...
  13. ncbi The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice
    A Peled
    Departments of Immunology and Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 95:3289-96. 2000
    ..Our results demonstrate that repopulating human stem cells functionally express LFA-1, VLA-4, and VLA-5. Furthermore, this study implies a novel approach to further advance clinical transplantation...
  14. ncbi Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    A Peled
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Science 283:845-8. 1999
    ..Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation...
  15. doi Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors
    O Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Leukemia 27:2006-15. 2013
    ..Our results suggest that daily physiologic Cort oscillations are critical for balanced HSPC proliferation and function involving Notch1 signaling and their supportive BM microenvironment. ..
  16. pmc MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization
    Yaron Vagima
    Immunology Department, Weizmann Institute of Science, Hertzl Str, Rehovot, Israel
    J Clin Invest 119:492-503. 2009
    ..Our results reveal that the motility, adhesion, homing, and mobilization of human hematopoietic progenitor cells are regulated in a cell-autonomous manner by dynamic and opposite changes in MT1-MMP and RECK expression...
  17. ncbi Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cells
    Tamara Byk
    The Weizmann Institute of Science, Department of Immunology, P O Box 26, Rehovot 76100, Israel
    Stem Cells 23:561-74. 2005
    ....
  18. ncbi Differential effects of CD4+ and CD8+ cells on lymphocyte development from human cord blood cells in murine fetal thymus explants
    A Globerson
    Department of Immunology, The Weizman Institute of Science, Rehovot, Israel
    Exp Hematol 27:282-92. 1999
    ..The presence of CD4+, and not CD8+ cells, interfered with this process. Our results thus imply differential effects of CD4+ and CD8+ cells on thymocytopoiesis...
  19. ncbi CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
    Sigal Tavor
    Immunology Department, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 64:2817-24. 2004
    ..Taken together, our findings demonstrated the importance of the SDF-1/CXCR4 axis in the regulation of in vivo motility and development of human AML stem cells and identified CXCR4 neutralization as a potential treatment for AML...
  20. ncbi CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    Abraham Avigdor
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2981-9. 2004
    ..Taken together, our data suggest a key role for CD44 and HA in SDF-1-dependent transendothelial migration of HSCs/HPCs and their final anchorage within specific niches of the BM...
  21. ncbi Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice
    Ayelet Dar
    Department of Immunology, Weizmann Institute, Rehovot, Israel
    Exp Hematol 34:967-75. 2006
    ..Moreover, the role and the dynamic modulations of this ligand and its receptor in alarm and pathologic conditions will be discussed as well...
  22. ncbi Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation
    Joy Kahn
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2942-9. 2004
    ..Our results suggest CXCR4 overexpression for improved definitive human stem cell motility, retention, and multilineage repopulation, which could be beneficial for in vivo navigation and expansion of hematopoietic progenitors...
  23. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  24. ncbi Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling
    Asaf Spiegel
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2900-7. 2004
    ..Altogether, our data provide new insights into different SDF-1-induced signaling, activation, and consequent motility between normal CD34+ and precursor-B ALL progenitors, which may lead to improved clinical protocols...
  25. ncbi cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors
    Polina Goichberg
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 107:870-9. 2006
    ..Taken together, our data reveal major roles for cAMP-induced PKCzeta activation in signaling governing the motility and development of CD34+ cells...
  26. ncbi Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice
    Sarit Samira
    Immunology Department, Weizmann Institute of Science, Rehovot, Israel
    Stem Cells 22:1085-100. 2004
    ..This study demonstrates the potential of TNF to rapidly augment human T lymphopoiesis in vivo and also provides clinically relevant evidence for this process with adult MPBL progenitors...
  27. ncbi Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation
    Orit Kollet
    Immunology Department, Weizmann Institute of Science, Rehovot, Israel
    Blood 100:2778-86. 2002
    ..Our results suggest dynamic CXCR4 expression on CD34(+) stem and progenitor cells, regulating their motility and repopulation capacities...
  28. pmc HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 112:160-9. 2003
    ..Our results suggest the potential of hematopoietic CD34+/CXCR4+cells to respond to stress signals from nonhematopoietic injured organs as an important mechanism for tissue targeting and repair...
  29. ncbi Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice
    Sigal Tavor
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:2120-7. 2005
    ..Taken together, our data demonstrate that human AML cells constitutively secrete and express SDF-1-dependent cell-surface elastase, which regulates their migration and proliferation...
  30. doi Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells
    A Dar
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Leukemia 25:1286-96. 2011
    ....
  31. doi NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity
    Aviva Lapidot
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochim Biophys Acta 1780:914-20. 2008
    ..g. T140 and AMD3100. This complementary utilization of chemical, biology, and computation analysis provides a powerful approach for designing anti-HIV-1 drugs without interfering with the natural function of CXCL12/CXCR4 binding...
  32. ncbi Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel
    Nat Med 12:657-64. 2006
    ..Our findings indicate involvement of OCLs in selective progenitor recruitment as part of homeostasis and host defense, linking bone remodeling with regulation of hematopoiesis...
  33. ncbi Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation
    Alexandra Zanin-Zhorov
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 175:276-85. 2005
    ..These effects of HSP60 could not be attributed to LPS or LPS-associated lipoprotein contamination. Thus, HSP60 can regulate T cell-mediated inflammation via specific signal transduction and SOCS3 activation...
  34. doi Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system
    Alexander Kalinkovich
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Brain Behav Immun 23:1059-65. 2009
    ....
  35. pmc Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment
    Asaf Spiegel
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 111:4934-43. 2008
    ..Altogether, our data suggest that heparanase modification of the BM microenvironment regulates the retention and proliferation of hematopoietic progenitor cells...
  36. ncbi Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells
    H Gal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Leukemia 20:2147-54. 2006
    ..Identification of additional genes that regulate LSC self-renewal may provide new targets for therapy...
  37. pmc Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...
  38. ncbi The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Annu Rev Immunol 25:51-69. 2007
    ....
  39. ncbi Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling
    Asaf Spiegel
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 8:1123-31. 2007
    ..Our results identify new functions for neurotransmitters and myeloid cytokines in the direct regulation of human and mouse progenitor cell migration and development...
  40. ncbi TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules
    Susanne Franitza
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 32:193-202. 2002
    ..We propose that the effect of TGF-beta1 on the chemotaxis of naive T cells may be important in the locomotion of naive T cells toward SDF-1alpha-rich niches...
  41. ncbi Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
    E E Varfolomeev
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Immunity 9:267-76. 1998
    ..These findings indicate that Caspase 8 plays a necessary and nonredundant role in death induction by several receptors of the TNF/NGF family and serves a vital role in embryonal development...
  42. pmc Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 100:7853-8. 2003
    ..The extensive analysis described here pinpointed genes that might have a direct role in pathogenesis...
  43. ncbi Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells
    Alexander Kalinkovich
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 66:11013-20. 2006
    ..Our findings suggest that functional CXCR4(+) microparticles and SDF-1 are involved in the progression of AML. We propose that their levels are potentially valuable as an additional diagnostic AML variable...
  44. doi Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment
    Asaf Spiegel
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Cell Stem Cell 3:484-92. 2008
    ..Together, interactions between diverse systems create a regulatory "brain-bone-blood triad," contributing an additional dimension to the concept of the hematopoietic stem cell niche...
  45. doi A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells
    Tanja Nicole Hartmann
    The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Leukoc Biol 84:1130-40. 2008
    ..Our findings suggest that although CXCR7 is not an intrinsic signaling receptor for CXCL12 on lymphocytes or CD34(+) cells, its blocking can be useful for therapeutic interference with CXCR4-mediated activation of integrins...
  46. ncbi Caspase-8 serves both apoptotic and nonapoptotic roles
    Tae Bong Kang
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 173:2976-84. 2004
    ..Thus, besides participating in cell death induction by receptors of the TNF/nerve growth factor family, caspase-8, apparently independently of these receptors, also mediates nonapoptotic and perhaps even antiapoptotic activities...
  47. ncbi Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution
    Loretta Gammaitoni
    Department of Oncological Sciences, Institute for Cancer Research and Treatment, Candiolo, Torino, Italy
    Exp Hematol 31:261-70. 2003
    ..So far, this goal has been elusive with adult cells, in which amplification of committed and mature cells, but not of long-term repopulating cells, has been described...
  48. ncbi Correlation between CXCR4 and homing or engraftment of acute myelogenous leukemia
    Giuseppe Monaco
    Cancer Res 64:6832 author reply 6832-3. 2004
  49. ncbi Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells
    Angela Kortesidis
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute, Frome Rd, Adelaide 5000, South Australia, Australia
    Blood 105:3793-801. 2005
    ..These studies indicate that the chemokine, SDF-1, may play a role in the maintenance, survival, and osteogenic capacity of immature BMSSC populations...
  50. doi The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche
    Alexandra Aicher
    Department of Internal Medicine III, J W Goethe University, Frankfurt, Germany
    Circ Res 103:796-803. 2008
    ..Thus, these data show that Dkk-1 is a mobilizer of vasculogenic progenitors but not of inflammatory cells, which could be of great clinical importance to enhance regenerative cell therapy...
  51. ncbi Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory and Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, Australia
    Cancer Res 65:1700-9. 2005
    ..Therefore, we propose that inhibition of the CXCR4-SDF-1alpha axis may provide an effective means of treatment for MM-induced osteolysis...
  52. ncbi Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
    Marjorie Pick
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood 107:3397-406. 2006
    ..Our findings implicate AChE-R in thrombopoietic recovery, suggesting new therapeutic modalities for supporting platelet production...
  53. ncbi Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1
    Amnon Peled
    Hadassah University Hospital, Gene Therapy Institutem, Jerusalem, Israel
    Stem Cells 20:259-66. 2002
    ..These findings suggest a major role for SDF-1-mediated, integrin-dependent BM retention of Ph+CD34+ cells...
  54. ncbi The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts
    Shoshana Peller
    Department of Hematology, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Oncogene 22:4648-55. 2003
    ..However, this apoptotic process is not fully executed because of the exhaustion in caspase 3/7 and thus cells are diverted towards final stages of differentiation...
  55. ncbi Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing
    Vyacheslav Kalchenko
    J Biomed Opt 11:050507. 2006
    ..Thus, in vivo imaging based on NIR lipophilic carbocyanine dyes in combination with advanced optical techniques may serve as a powerful alternative or complementation to other small animal imaging methods...