Jonathan Kipnis

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    Jonathan Kipnis
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 101:8180-5. 2004
  2. pmc Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 101:14663-9. 2004
  3. ncbi Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Neurosci 19:1191-8. 2004
  4. ncbi Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 24:6133-43. 2004
  5. ncbi Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains
    Gil M Lewitus
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neuroimmunol 175:31-8. 2006
  6. pmc Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 99:15620-5. 2002
  7. ncbi Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells
    Hila Avidan
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 34:3434-45. 2004
  8. ncbi Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    Yaniv Ziv
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Neurosci 9:268-75. 2006
  9. ncbi Controlled autoimmunity in CNS maintenance and repair: naturally occurring CD4+CD25+ regulatory T-Cells at the crossroads of health and disease
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Neuromolecular Med 7:197-206. 2005
  10. ncbi Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system
    Iftach Shaked
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neuroimmunol 146:84-93. 2004

Collaborators

Detail Information

Publications35

  1. pmc T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    Jonathan Kipnis
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 101:8180-5. 2004
    ..These findings point to critical factors likely to contribute to age- and AIDS-related dementias and might herald the development of a therapeutic vaccination for fighting off cognitive dysfunction and psychiatric conditions...
  2. pmc Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 101:14663-9. 2004
    ..Therefore, therapeutic intervention based on induction of regulatory T cells might have limitations...
  3. ncbi Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Neurosci 19:1191-8. 2004
    ....
  4. ncbi Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 24:6133-43. 2004
    ..g., in neuronal degeneration) or for strengthening it (in autoimmune diseases)...
  5. ncbi Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains
    Gil M Lewitus
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neuroimmunol 175:31-8. 2006
    ....
  6. pmc Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 99:15620-5. 2002
    ..The regulatory T cells might represent an evolutionary compromise between the need to avoid autoimmune diseases and the need for autoimmunity on alert for the purpose of tissue maintenance...
  7. ncbi Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells
    Hila Avidan
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 34:3434-45. 2004
    ..Alzheimer's and other neurodegenerative diseases might be arrested or retarded by vaccination with Cop-1 or related compounds or by treatment with compounds that weaken Treg suppression...
  8. ncbi Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    Yaniv Ziv
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Neurosci 9:268-75. 2006
    ....
  9. ncbi Controlled autoimmunity in CNS maintenance and repair: naturally occurring CD4+CD25+ regulatory T-Cells at the crossroads of health and disease
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Neuromolecular Med 7:197-206. 2005
    ..In line with this notion, the regulatory T-cells are thought to allow autoimmunity to exist in healthy individuals without causing an autoimmune disease. This proposed immune scenario and its implications for therapy are discussed...
  10. ncbi Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system
    Iftach Shaked
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neuroimmunol 146:84-93. 2004
    ..We suggest that such microglial activity, if well controlled, is a crucial step in determining the fate of the neurons in a hostile environment...
  11. ncbi Beneficial effect of orally administered myelin basic protein in EAE-susceptible Lewis rats in a model of acute CNS degeneration
    Alon Monsonego
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Autoimmun 21:131-8. 2003
    ..Oral immunization with MBP can be viewed as a way to control the autoimmunity capable of fighting off the consequences of CNS injury in EAE-susceptible strains...
  12. ncbi Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy
    Michal Schwartz
    Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    J Neuroimmune Pharmacol 1:4-10. 2006
    ....
  13. ncbi Model of acute injury to study neuroprotection
    Michal Schwartz
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 399:41-53. 2007
    ..This approach is collectively termed neuroprotection. In this chapter, we present a view of experimental paradigms used to study neuroprotection...
  14. ncbi Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    J Neuroimmunol 130:78-85. 2002
    ..By identifying the additional cellular component of autoimmune neuroprotection, we may be able to take meaningful steps toward achieving neuroprotection without risk of accompanying autoimmune disease...
  15. ncbi Loss of autoimmune T cells correlates with brain diseases: possible implications for schizophrenia?
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Trends Mol Med 12:107-12. 2006
    ....
  16. ncbi Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases
    Michal Schwartz
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurol Sci 233:163-6. 2005
    ..We also offer an explanation for the commonly observed presence of cells and antibodies directed against self-components in healthy individuals...
  17. pmc How do immune cells support and shape the brain in health, disease, and aging?
    Michal Schwartz
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, Neuroscience Laboratory, CHU de Qu├ębec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec G1V 4G2, Canada, and Neuroimmunology Unit, Center for Excellence in Neuromics, CRCHUM, Universite de Montreal, Montreal, Quebec H4A 2B4, Canada
    J Neurosci 33:17587-96. 2013
    ....
  18. ncbi CD4(+)CD25(-) effector T-cells inhibit hippocampal long-term potentiation in vitro
    Gil M Lewitus
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Eur J Neurosci 26:1399-406. 2007
    ..The T-cell-mediated inhibition of LTP can be prevented by blockade of gamma-aminobutyric acid (GABA)(A) receptors. These findings provide additional insight into the multiple functions of T-cells in CNS pathologies...
  19. ncbi Therapeutic T cell-based vaccination for neurodegenerative disorders: the role of CD4+CD25+ regulatory T cells
    Michal Schwartz
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Ann N Y Acad Sci 1051:701-8. 2005
    ....
  20. ncbi A common vaccine for fighting neurodegenerative disorders: recharging immunity for homeostasis
    Michal Schwartz
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Trends Pharmacol Sci 25:407-12. 2004
    ..Boosting of relevant T cells by vaccination could thus "recharge" a deteriorating immune system that has to contend with an increasing number of risk factors...
  21. ncbi Therapeutic vaccination for closed head injury
    Jonathan Kipnis
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    J Neurotrauma 20:559-69. 2003
    ..We suggest that a compound such as Cop-1 can be safely developed as a therapeutic vaccine to boost the body's immune repair mechanisms, thereby providing multifactorial protection against the consequences of brain trauma...
  22. ncbi Multiple sclerosis as a by-product of the failure to sustain protective autoimmunity: a paradigm shift
    Michal Schwartz
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Neuroscientist 8:405-13. 2002
    ..The therapeutic implications of the new concept and their experimental findings are discussed...
  23. ncbi Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'
    Michal Schwartz
    Dept of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Trends Immunol 23:530-4. 2002
    ..Downregulation or upregulation of CD4(+)CD25(+) Tr cells might be a way to achieve better protection from neurodegenerative conditions induced by self-destruction or avoid autoimmune inflammatory disease development, respectively...
  24. ncbi A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis
    Yaniv Ziv
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Stroke 38:774-82. 2007
    ..The relative wide therapeutic window, coupled with its efficacy in attenuating further degeneration and enhancing restoration, makes poly-YE a promising immune-based candidate for stroke therapy...
  25. ncbi Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent
    Sharon Bakalash
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    Invest Ophthalmol Vis Sci 43:2648-53. 2002
    ..The current study was conducted to find out whether the ability to resist the IOP-induced loss of RGCs in a rat model is affected by the immune system...
  26. ncbi Dual action of glatiramer acetate (Cop-1) in the treatment of CNS autoimmune and neurodegenerative disorders
    Jonathan Kipnis
    Dept of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Trends Mol Med 8:319-23. 2002
    ....
  27. ncbi Autoimmunity as a special case of immunity: removing threats from within
    Uri Nevo
    School of Physics and Astronomy, Tel Aviv University, 69978 Tel Aviv, Israel
    Trends Mol Med 9:88-93. 2003
    ..Tolerance to self is thus not a lack of response to self, but the ability to tolerate an active defense response to self without developing an autoimmune disease...
  28. doi Adaptive immunity affects learning behavior in mice
    Anna Brynskikh
    Laboratory of NeuroImmune Regulation, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Brain Behav Immun 22:861-9. 2008
    ..These results suggest that throughout lifetime, immune system supports cognitive function and may therefore have far-reaching therapeutic implications for cognitive disorders...
  29. ncbi Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells
    Hagit Cohen
    Ministry of Health Mental Health Center Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Neurobiol 66:552-63. 2006
    ..They might also point the way to development of immune-based therapies for mental disorders, based either on up-regulation of T cells that partially cross-react with self-antigens or on weakening of the activity of regulatory T cells...
  30. ncbi T cell independent mechanism for copolymer-1-induced neuroprotection
    Jianuo Liu
    Laboratory of Neuro Immune Regulation, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Eur J Immunol 37:3143-54. 2007
    ..These findings may facilitate the development of neuroprotective approaches using DC-mediated Cop-1 delivery to diseased nervous tissue...
  31. ncbi Bacterial DNA confers neuroprotection after optic nerve injury by suppressing CD4+CD25+ regulatory T-cell activity
    Thomas V Johnson
    Laboratory of Neuro Immune Regulation, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
    Invest Ophthalmol Vis Sci 48:3441-9. 2007
    ..In this study the ability of bacterial DNA, characterized by unmethylated CpG islands, to downregulate Treg activity and therefore, to confer neuroprotection was investigated...
  32. ncbi Debate: "is increasing neuroinflammation beneficial for neural repair?"
    Keith A Crutcher
    Department of Neurosurgery MSB 4313, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0515, USA
    J Neuroimmune Pharmacol 1:195-211. 2006
  33. pmc Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 56:223-32. 2008
    ..The data, taken together, demonstrate that Cop-1 can modulate innate immunity and, as such, improve disease outcomes in an animal model of HIVE...
  34. ncbi Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype
    Sanjay K Garg
    Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA
    J Immunol 180:3866-73. 2008
    ..However, the context and signaling mechanisms for this dual astrocytic response are unknown. Our results implicate T cells as potential determinants of the context that elicits a protective role for astrocytes in the damaged CNS...
  35. doi Toll-like receptors: roles in neuroprotection?
    Uwe Karsten Hanisch
    Institute of Neuropathology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Trends Neurosci 31:176-82. 2008
    ..This article focuses on the yet less-addressed protective potential of TLR engagement within the CNS...