Steffen Jung

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
  2. ncbi request reprint Dendritic cells: a question of upbringing
    Steffen Jung
    The Weizmann Institute of Science, Department of Immunology, Rehovot 76100, Israel
    Immunity 32:502-4. 2010
  3. doi request reprint Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:555-69. 2013
  4. doi request reprint Intestinal lamina propria dendritic cell subsets have different origin and functions
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel 76100
    Immunity 31:502-12. 2009
  5. ncbi request reprint Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages
    Limor Landsman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 179:3488-94. 2007
  6. pmc CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 107:14745-50. 2010
  7. doi request reprint Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
    Ehud Zigmond
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Immunity 37:1076-90. 2012
  8. doi request reprint Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis
    Alexander Mildner
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 121:1016-27. 2013
  9. doi request reprint Defining dendritic cells by conditional and constitutive cell ablation
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Immunol Rev 234:76-89. 2010
  10. doi request reprint Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 41:291-8. 2011

Detail Information

Publications78

  1. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  2. ncbi request reprint Dendritic cells: a question of upbringing
    Steffen Jung
    The Weizmann Institute of Science, Department of Immunology, Rehovot 76100, Israel
    Immunity 32:502-4. 2010
    ..In this issue of Immunity, Siddiqui et al. (2010) describe a population of colitogenic monocyte-derived DCs that propagate intestinal inflammation...
  3. doi request reprint Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:555-69. 2013
    ..Overall, our finding demonstrates that the route of monocyte entry to central nervous system provides an instructional environment to shape their function...
  4. doi request reprint Intestinal lamina propria dendritic cell subsets have different origin and functions
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel 76100
    Immunity 31:502-12. 2009
    ..Our results highlight the critical importance of the lpDC subset balance for robust gut homeostasis...
  5. ncbi request reprint Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages
    Limor Landsman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 179:3488-94. 2007
    ..We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate...
  6. pmc CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 107:14745-50. 2010
    ....
  7. doi request reprint Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
    Ehud Zigmond
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Immunity 37:1076-90. 2012
    ..Collectively, our results highlight cellular dynamics in the inflamed colon and the plasticity of Ly6C(hi) monocytes, marking them as potential targets for inflammatory bowel disease (IBD) therapy...
  8. doi request reprint Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis
    Alexander Mildner
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 121:1016-27. 2013
    ..The results of our study establish a novel role for miRNAs in myeloid cell specification and define miR-142 as a pivotal genetic component in the maintenance of CD4+ DCs...
  9. doi request reprint Defining dendritic cells by conditional and constitutive cell ablation
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Immunol Rev 234:76-89. 2010
    ..In this article, we review recent insight in the functions of classical DC in the mouse, focusing on our own work involving conditional and constitutive cell ablation...
  10. doi request reprint Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 41:291-8. 2011
    ....
  11. pmc Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: roles of T cells and B cells
    Noam Cohen
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 7:e39193. 2012
    ..Thus, a single injection of PS antigen associated with intact BMDC is a more effective vaccine than the soluble PS alone. This model system provides a platform for studying novel aspects of PS-targeted vaccination...
  12. pmc Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Exp Med 204:171-80. 2007
    ..The grafted monocytes give rise to DCs in the intestinal lamina propria and lung, but not to conventional CD11chigh DCs in the spleen, which develop during homeostasis from MDPs without a monocytic intermediate...
  13. pmc Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells
    Anita Sapoznikov
    Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Exp Med 204:1923-33. 2007
    ..Our results establish PDCs as a bona fide DC subset that initiates unique CD4(+) Th cell-dominated primary immune responses...
  14. doi request reprint Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches
    Anita Sapoznikov
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 9:388-95. 2008
    ..Thus, bmDCs are critical for the maintenance of recirculating B cells in the bone marrow...
  15. doi request reprint CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
    Limor Landsman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 113:963-72. 2009
    ....
  16. doi request reprint Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense
    Julia Farache
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Immunol Cell Biol 91:232-9. 2013
    ..In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD)...
  17. doi request reprint Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    Simon Yona
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:79-91. 2013
    ....
  18. doi request reprint In vivo structure/function and expression analysis of the CX3C chemokine fractalkine
    Ki Wook Kim
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 118:e156-67. 2011
    ..Instead, monocyte survival required the full-length membrane-anchored CX3CL1, suggesting differential activities of tethered and shed CX3CL1 entities...
  19. pmc Uterine DCs are crucial for decidua formation during embryo implantation in mice
    Vicki Plaks
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 118:3954-65. 2008
    ..Importantly, our results may aid in understanding the limited implantation success of embryos transferred following in vitro fertilization...
  20. doi request reprint Probing in vivo origins of mononuclear phagocytes by conditional ablation and reconstitution
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 531:71-87. 2009
    ..Here we present methods to investigate the role of MP progenitors, such as monocytes and MPhi/DC precursors (MDPs), in the replenishment of the peripheral MP system...
  21. doi request reprint Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow
    Aya Ludin
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 13:1072-82. 2012
    ..Our study identifies a previously unknown subset of α-SMA(+) activated monocytes and macrophages that maintain HSPCs and protect them from exhaustion during alarm situations...
  22. doi request reprint Origins and tissue-context-dependent fates of blood monocytes
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Immunol Cell Biol 87:30-8. 2009
    ..In particular, we will focus on emerging evidence for monocyte recirculation to the BM and discuss its potential implications in health and disease...
  23. ncbi request reprint Distinct differentiation potential of blood monocyte subsets in the lung
    Limor Landsman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 178:2000-7. 2007
    ..Our results therefore indicate an intrinsic dichotomy in the differentiation potential of the two main blood monocyte subsets...
  24. pmc Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages
    Anat London
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 208:23-39. 2011
    ....
  25. doi request reprint Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome
    Tal Birnberg
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 29:986-97. 2008
    ..Our data identify a critical role of cDCs in the control of steady-state hematopoiesis, revealing a feedback loop that links peripheral cDCs to myelogenesis through soluble growth factors, such as Flt3 ligand...
  26. doi request reprint Defining in vivo dendritic cell functions using CD11c-DTR transgenic mice
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 595:429-42. 2010
    ..Here, we provide basic protocols that describe the use of this prototypic dendritic cell ablation model and highlight pitfalls and strengths of the approach...
  27. ncbi request reprint CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells
    Tami Zaft
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 175:6428-35. 2005
    ..Our results suggest a dual role of CD11chigh dendritic cells as unique APC and cytokine-presenting cells...
  28. pmc Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 6:e1000113. 2009
    ..The hypothesis of the current study is that a specific population of infiltrating monocyte-derived MPhi is functionally distinct from the inflammatory resident microglia and is essential for recovery from SCI...
  29. ncbi request reprint Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markers
    Oleg Butovsky
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Neurosci 35:490-500. 2007
    ..This study emphasizes that microglial plasticity includes their ability to give rise to neural-like cells and shows that cytokines produced by the adaptive immune system are involved in these processes...
  30. doi request reprint Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity
    Dina Preise
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    Cancer Immunol Immunother 58:71-84. 2009
    ..g., immunotherapy) for the enhancement of host antitumor immunity in the treatment of both local and disseminated disease...
  31. doi request reprint Probing in vivo dendritic cell functions by conditional cell ablation
    Anita Sapoznikov
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Immunol Cell Biol 86:409-15. 2008
    ..Here, we summarize the recent progress in this field highlighting pitfalls and prospects of the approach...
  32. pmc Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin
    Elena Appel
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Antimicrob Agents Chemother 54:898-906. 2010
    ..A limitation of this study is that the demonstration was achieved in a constrained setting. Other routes of drug delivery will be investigated for the treatment of pulmonary and extrapulmonary aspergillosis...
  33. doi request reprint Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow
    Idan Milo
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 122:193-208. 2013
    ..Collectively, our results suggest that the BM supports crosspresentation of blood-borne antigens similar to the spleen; uniquely, alongside DCs, other myeloid cells participate in crosspresentation. ..
  34. doi request reprint Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?
    Liat Bar-On
    Department of Immunology, Weizmann Institute of Science, Herzl 1, Rehovot, Israel
    Semin Immunol 23:58-64. 2011
    ..Finally, we discuss potential strategies to translate the recent findings into the management of chronic inflammation in animal models of IBD...
  35. doi request reprint Quantitative analysis of intravenously administered contrast media reveals changes in vascular barrier functions in a murine colitis model
    Tegest Aychek
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 66:235-43. 2011
    ..Thus, the plasma protein leakage from the colonic microvasculature at the focal inflammatory patches could be quantified by MRI, providing a biomarker for assessment of disease progression...
  36. ncbi request reprint Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive
    Noam Cohen
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 180:2409-18. 2008
    ..Resistance induced by the PS4-pulsed bone marrow-derived dendritic cell was specific for pneumococcal CPS serotypes (type 3 or type 4) and was associated with the induction of CPS-specific IgG and IgM Abs...
  37. doi request reprint Monocytes: subsets, origins, fates and functions
    Simon Yona
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Curr Opin Hematol 17:53-9. 2010
    ..Most importantly, recent data suggest that monocyte subsets are also functionally distinct. Here we summarize the recent advances in our understanding of monocyte subsets and their origins, fates and functions...
  38. pmc Microglia, seen from the CX3CR1 angle
    Yochai Wolf
    Department of Immunology, The Weizmann Institute of Science Rehovot, Israel
    Front Cell Neurosci 7:26. 2013
    ....
  39. pmc Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis
    Liat Izhak
    Department of Immunology, Rappaport Institute for Medical Research, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    PLoS ONE 7:e28305. 2012
    ..This further emphasizes the important role of CCL2 as a target for therapy of cancer diseases...
  40. ncbi request reprint Toll-like receptor 4 is needed to restrict the invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine model of acute mastitis
    Erez Gonen
    The Koret School of Veterinary Medicine, Faculty of Agriculture, The Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
    Cell Microbiol 9:2826-38. 2007
    ..Taken together, these results indicate that ECP4 has an invasive potential, which is restricted by alveolar macrophages in response to the LPS/TLR4 signalling...
  41. pmc Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys
    Alexandra Vallon-Eberhard
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Antimicrob Agents Chemother 52:3118-26. 2008
    ..Our results highlight the potential of this family of lipopeptides for the treatment of pulmonary invasive aspergillosis...
  42. ncbi request reprint ATP mediates rapid microglial response to local brain injury in vivo
    Dimitrios Davalos
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 8:752-8. 2005
    ..Thus, extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury...
  43. doi request reprint The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells
    Maria Maryanovich
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Cell Biol 14:535-41. 2012
    ..These results show that the ATM-BID pathway serves as a critical checkpoint for coupling HSC homeostasis and the DNA-damage stress response to enable long-term regenerative capacity...
  44. doi request reprint Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7
    Lior Zangi
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 120:1647-57. 2012
    ..This novel subpopulation of perforin-expressing imDCs was also detected in various lymphoid tissues in normal animals and its frequency was markedly enhanced after GM-CSF administration...
  45. pmc Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation
    Ofer Fainaru
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:969-79. 2004
    ..These data may help elucidate the molecular mechanisms underlying the pathogenesis of allergic airway inflammation in humans...
  46. ncbi request reprint Transepithelial pathogen uptake into the small intestinal lamina propria
    Alexandra Vallon-Eberhard
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 176:2465-9. 2006
    ....
  47. doi request reprint Intestinal macrophages: well educated exceptions from the rule
    Ehud Zigmond
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Trends Immunol 34:162-8. 2013
    ..Manipulation of monocyte fates in the intestine might hold promise for the disease management of inflammatory bowel disorders...
  48. pmc Non-identical twins - microglia and monocyte-derived macrophages in acute injury and autoimmune inflammation
    Steffen Jung
    Department of Immunology, Weizmann Institute of Science Rehovot, Israel
    Front Immunol 3:89. 2012
    ....
  49. ncbi request reprint Good, bad and beautiful--the role of dendritic cells in autoimmunity
    Steffen Jung
    Department of Immunology, The Weizmann Institute of Science, Worsley, Rehovot 76300, Israel
    Autoimmun Rev 3:54-60. 2004
    ..In the light of a number of recent excellent reviews on the topic, this article summarizes the current knowledge obtained from the murine system highlighting hallmark experiments and open questions...
  50. ncbi request reprint Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
    ..These findings raise the potential for novel therapeutic strategies in inflammatory diseases...
  51. pmc Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
    Kazumichi Abe
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:17022-7. 2007
    ..These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation...
  52. pmc In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
    Leonie S van Rijt
    Department of Pulmonary Medicine, Erasmus MC, 3015 GE Rotterdam, Netherlands
    J Exp Med 201:981-91. 2005
    ..These findings identify lung DCs as key proinflammatory cells that are necessary and sufficient for Th2 cell stimulation during ongoing airway inflammation...
  53. pmc Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance
    Stephanie O Harbers
    Departments of Microbiology and Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY, USA
    J Clin Invest 117:1361-9. 2007
    ..Thus, we show that autoreactive antibody can potently enhance the activation of effector T cells in response to cross-presented self antigen, thereby contributing to T cell-mediated autoimmunity...
  54. pmc Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis
    Siegfried Hapfelmeier
    Institute of Microbiology, D BIOL, ETH Zurich, CH 8093 Zurich, Switzerland
    J Exp Med 205:437-50. 2008
    ..These results establish that pathogen sampling by DCs is a discrete, and MyD88-independent, step during the initiation of a mucosal innate immune response to bacterial infection in vivo...
  55. ncbi request reprint Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes
    Eric Muraille
    Groupe Avenir, Institut National de la Sante et de la Recherche Medicale, E 344, Universite de Nice Sophia Antipolis, Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    Eur J Immunol 35:1463-71. 2005
    ....
  56. pmc The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium
    Holly R Chinnery
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, Western Australia
    Invest Ophthalmol Vis Sci 48:1568-74. 2007
    ....
  57. ncbi request reprint Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses
    Dharmesh D Desai
    Department of Medicine and Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 178:6217-26. 2007
    ..Thus, FcgammaRIIB can contribute to peripheral tolerance maintenance by inhibiting DC activation alone or by also limiting processing of exogenously acquired Ag...
  58. ncbi request reprint The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity
    Benoit Vingert
    INSERM U255, Universite Rene Descartes, Unité d Immunologie Biologique, Hôpital Européen Georges Pompidou AP HP, Paris, France
    Eur J Immunol 36:1124-35. 2006
    ..This effect was mainly mediated by CD8+ T cells. STxB therefore appears to be a powerful carrier directly targeting DC in vivo, resulting in a strong and durable CTL response associated with tumor protection...
  59. ncbi request reprint The contribution of dendritic cells to host defenses against Streptococcus pyogenes
    Torsten G Loof
    Infection Immunology Research Group and Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    J Infect Dis 196:1794-803. 2007
    ..Infection with Streptococcus pyogenes remains a significant health care problem. The identification of immune components required for host defenses against S. pyogenes constitutes an important area of research...
  60. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  61. ncbi request reprint Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells
    Katrin Hebel
    German Arthritis Research Center Berlin, Berlin, Germany
    Eur J Immunol 36:2912-9. 2006
    ..Interestingly, we found plasma blasts to express CD11c and to be diphtheria toxin-sensitive in CD11c-diphtheria toxin receptor-transgenic mice, providing a unique tool for future analysis of in vivo aspects of plasma cell biology...
  62. ncbi request reprint A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
    Thorsten Buch
    Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Nat Methods 2:419-26. 2005
    ..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo...
  63. ncbi request reprint CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    Jan Hendrik Niess
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Science 307:254-8. 2005
    ..Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation...
  64. pmc Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes
    Chunfeng Qu
    Dept of Gene and Cell Medicine, Mt Sinai School of Medicine, Box 1496, 1425 Madison Ave, New York, NY 10029, USA
    J Exp Med 200:1231-41. 2004
    ..When these monocyte-derived DCs exit skin to emigrate to LNs, they use not only CCR7 but also CCR8, which was not previously recognized to participate in migration to LNs...
  65. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
    ..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid...
  66. ncbi request reprint Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
    Yuqing Huo
    Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, Health Science Center, Charlottesville, Virginia, USA
    Nat Med 9:61-7. 2003
    ..This role of activated platelets in atherosclerosis is attributed to platelet P-selectin-mediated delivery of platelet-derived proinflammatory factors to monocytes/leukocytes and the vessel wall...
  67. ncbi request reprint Control of microglial neurotoxicity by the fractalkine receptor
    Astrid E Cardona
    Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Neurosci 9:917-24. 2006
    ..Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could increase neuronal vulnerability...
  68. ncbi request reprint Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus
    Shira Fraenkel
    The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 8:715-22. 2007
    ..Thus, it seems that the epigenetic mechanisms that initially bring about monoallelic variable-(diversity)-joining rearrangement continue to be involved in the control of antibody diversity at later stages of B cell development...
  69. ncbi request reprint An essential role for dendritic cells in human and experimental allergic rhinitis
    Alex Kleinjan
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Allergy Clin Immunol 118:1117-25. 2006
    ..In allergic rhinitis (AR) CD4(+) T(H)2 lymphocytes control inflammation by secreting T(H)2 cytokines, but little is known about how these cells are activated to cause disease...
  70. ncbi request reprint CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen
    Michael Neuenhahn
    Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
    Immunity 25:619-30. 2006
    ..Thus, CD8alpha(+) DCs appear to play an important role for efficient bacterial entry into the spleen, which is of relevance for subsequent immune responses...
  71. pmc Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance
    Daniel Engel
    Institute for Molecular Medicine and Experimental Immunology, University Clinic of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Infect Immun 74:6100-7. 2006
    ..These findings demonstrate that some of the abundant DC recruited in UTI contributed innate immune effector functions, which were, however, dispensable in the microenvironment of the bladder...
  72. ncbi request reprint The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system
    DeRen Huang
    Neuroinflammation Research Center, Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
    FASEB J 20:896-905. 2006
    ..These results are the first to define a chemokine that governs NK cell migration to the CNS, and the findings suggest novel therapeutic manipulation of CX3CR1+ NK cells...
  73. pmc Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis
    Oleg Butovsky
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 116:905-15. 2006
    ..The newly formed oligodendrocytes were spatially associated with MG expressing MHC class II proteins and IGF-I. These results point to what we believe to be a novel role for MG in oligodendrogenesis from the endogenous stem cell pool...
  74. ncbi request reprint VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    Myriam Grunewald
    Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell 124:175-89. 2006
    ..Together, the data suggest a model for VEGF-programmed adult neovascularization highlighting the essential paracrine role of recruited myeloid cells and a role for SDF1 in their perivascular retention...
  75. ncbi request reprint A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    Darin K Fogg
    INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France
    Science 311:83-7. 2006
    ..Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS...
  76. ncbi request reprint The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles
    Mrigank Srivastava
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Justus Liebig University, Giessen, Germany
    J Immunol 175:1884-93. 2005
    ....
  77. ncbi request reprint Three pathways to mature macrophages in the early mouse yolk sac
    Julien Y Bertrand
    Institut National de la Santé et de la Recherche Médicale INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France
    Blood 106:3004-11. 2005
    ..Both YS-derived precursors followed a developmental pathway common to adult Mphi and could be qualified as definitive...
  78. ncbi request reprint Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route
    Aurelie Cleret
    Unité Interactions Hôte Pathogène, Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, 38702 La Tronche, France
    J Immunol 178:7994-8001. 2007
    ..Our results demonstrate that LDCs are central to spore transport immediately after infection. The rapid kinetics of pathogen transport may contribute to the clinical features of inhalational anthrax...