Research Topics
Genomes and Genes
Species | Steffen JungSummaryAffiliation: Weizmann Institute of Science Country: Israel Publications
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Detail Information
Publications
Microglia, seen from the CX3CR1 angleYochai Wolf
Department of Immunology, The Weizmann Institute of Science Rehovot, Israel
Front Cell Neurosci 7:26. 2013....- Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cellsAnita Sapoznikov
Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
J Exp Med 204:1923-33. 2007..Our results establish PDCs as a bona fide DC subset that initiates unique CD4(+) Th cell-dominated primary immune responses... 
Dendritic cells: a question of upbringingSteffen Jung
The Weizmann Institute of Science, Department of Immunology, Rehovot 76100, Israel
Immunity 32:502-4. 2010..In this issue of Immunity, Siddiqui et al. (2010) describe a population of colitogenic monocyte-derived DCs that propagate intestinal inflammation...- In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigensSteffen Jung
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
Immunity 17:211-20. 2002..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii... 
Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrowIdan Milo
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Blood 122:193-208. 2013..Collectively, our results suggest that the BM supports crosspresentation of blood-borne antigens similar to the spleen; uniquely, alongside DCs, other myeloid cells participate in crosspresentation. ..- Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexusRavid Shechter
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 38:555-69. 2013..Overall, our finding demonstrates that the route of monocyte entry to central nervous system provides an instructional environment to shape their function... - Intestinal lamina propria dendritic cell subsets have different origin and functionsChen Varol
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel 76100
Immunity 31:502-12. 2009..Our results highlight the critical importance of the lpDC subset balance for robust gut homeostasis... - Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophagesLimor Landsman
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
J Immunol 179:3488-94. 2007..We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate... - CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cellsLiat Bar-On
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 107:14745-50. 2010.... - Monocytes give rise to mucosal, but not splenic, conventional dendritic cellsChen Varol
Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
J Exp Med 204:171-80. 2007..The grafted monocytes give rise to DCs in the intestinal lamina propria and lung, but not to conventional CD11chigh DCs in the spleen, which develop during homeostasis from MDPs without a monocytic intermediate... - CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survivalLimor Landsman
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Blood 113:963-72. 2009.... - Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasisAlexander Mildner
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Blood 121:1016-27. 2013..The results of our study establish a novel role for miRNAs in myeloid cell specification and define miR-142 as a pivotal genetic component in the maintenance of CD4+ DCs... - Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cellsEhud Zigmond
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Immunity 37:1076-90. 2012..Collectively, our results highlight cellular dynamics in the inflamed colon and the plasticity of Ly6C(hi) monocytes, marking them as potential targets for inflammatory bowel disease (IBD) therapy... - Defining dendritic cells by conditional and constitutive cell ablationLiat Bar-On
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Immunol Rev 234:76-89. 2010..In this article, we review recent insight in the functions of classical DC in the mouse, focusing on our own work involving conditional and constitutive cell ablation... - Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivationLiat Bar-On
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Eur J Immunol 41:291-8. 2011.... - Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisSimon Yona
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 38:79-91. 2013.... - Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: roles of T cells and B cellsNoam Cohen
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
PLoS ONE 7:e39193. 2012..Thus, a single injection of PS antigen associated with intact BMDC is a more effective vaccine than the soluble PS alone. This model system provides a platform for studying novel aspects of PS-targeted vaccination... - Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow nichesAnita Sapoznikov
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Immunol 9:388-95. 2008..Thus, bmDCs are critical for the maintenance of recirculating B cells in the bone marrow... - CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cellsTami Zaft
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
J Immunol 175:6428-35. 2005..Our results suggest a dual role of CD11chigh dendritic cells as unique APC and cytokine-presenting cells... - Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defenseJulia Farache
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Immunol Cell Biol 91:232-9. 2013..In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD)... - In vivo structure/function and expression analysis of the CX3C chemokine fractalkineKi Wook Kim
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Blood 118:e156-67. 2011..Instead, monocyte survival required the full-length membrane-anchored CX3CL1, suggesting differential activities of tethered and shed CX3CL1 entities... - Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitisEhud Zigmond
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel The Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
Immunity 40:720-33. 2014..Collectively, our results highlight IL-10 as a critical homeostatic macrophage-conditioning agent in the colon and define intestinal CX3CR1(hi) macrophages as a decisive factor that determines gut health or inflammation... - Origins and tissue-context-dependent fates of blood monocytesChen Varol
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Immunol Cell Biol 87:30-8. 2009..In particular, we will focus on emerging evidence for monocyte recirculation to the BM and discuss its potential implications in health and disease... - Distinct differentiation potential of blood monocyte subsets in the lungLimor Landsman
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
J Immunol 178:2000-7. 2007..Our results therefore indicate an intrinsic dichotomy in the differentiation potential of the two main blood monocyte subsets... - Probing in vivo origins of mononuclear phagocytes by conditional ablation and reconstitutionChen Varol
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Methods Mol Biol 531:71-87. 2009..Here we present methods to investigate the role of MP progenitors, such as monocytes and MPhi/DC precursors (MDPs), in the replenishment of the peripheral MP system... - Uterine DCs are crucial for decidua formation during embryo implantation in miceVicki Plaks
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
J Clin Invest 118:3954-65. 2008..Importantly, our results may aid in understanding the limited implantation success of embryos transferred following in vitro fertilization... - Intestinal macrophages: well educated exceptions from the ruleEhud Zigmond
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Trends Immunol 34:162-8. 2013..Manipulation of monocyte fates in the intestine might hold promise for the disease management of inflammatory bowel disorders... - Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrowAya Ludin
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Nat Immunol 13:1072-82. 2012..Our study identifies a previously unknown subset of α-SMA(+) activated monocytes and macrophages that maintain HSPCs and protect them from exhaustion during alarm situations... - Defining in vivo dendritic cell functions using CD11c-DTR transgenic miceLiat Bar-On
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Methods Mol Biol 595:429-42. 2010..Here, we provide basic protocols that describe the use of this prototypic dendritic cell ablation model and highlight pitfalls and strengths of the approach... - Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndromeTal Birnberg
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 29:986-97. 2008..Our data identify a critical role of cDCs in the control of steady-state hematopoiesis, revealing a feedback loop that links peripheral cDCs to myelogenesis through soluble growth factors, such as Flt3 ligand... - Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophagesAnat London
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
J Exp Med 208:23-39. 2011.... - A close encounter of the third kind: monocyte-derived cellsAlexander Mildner
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Adv Immunol 120:69-103. 2013..Monocytes hence have emerged as a versatile emergency squad that can be rapidly recruited to sites of injury to provide a transient supplement with proinflammatory or resolving activities for local mononuclear phagocytes. .. - Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in miceRavid Shechter
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
PLoS Med 6:e1000113. 2009..The hypothesis of the current study is that a specific population of infiltrating monocyte-derived MPhi is functionally distinct from the inflammatory resident microglia and is essential for recovery from SCI... - Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markersOleg Butovsky
Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
Mol Cell Neurosci 35:490-500. 2007..This study emphasizes that microglial plasticity includes their ability to give rise to neural-like cells and shows that cytokines produced by the adaptive immune system are involved in these processes... - Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunityDina Preise
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
Cancer Immunol Immunother 58:71-84. 2009..g., immunotherapy) for the enhancement of host antitumor immunity in the treatment of both local and disseminated disease... - Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell TypesDiego Adhemar Jaitin
Department of Immunology, Weizmann Institute, Rehovot 76100, Israel
Science 343:776-9. 2014..These data demonstrate single-cell RNA-seq as an effective tool for comprehensive cellular decomposition of complex tissues. .. - Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliinElena Appel
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Antimicrob Agents Chemother 54:898-906. 2010..A limitation of this study is that the demonstration was achieved in a constrained setting. Other routes of drug delivery will be investigated for the treatment of pulmonary and extrapulmonary aspergillosis... - Probing in vivo dendritic cell functions by conditional cell ablationAnita Sapoznikov
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Immunol Cell Biol 86:409-15. 2008..Here, we summarize the recent progress in this field highlighting pitfalls and prospects of the approach... - Monocytes: subsets, origins, fates and functionsSimon Yona
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Curr Opin Hematol 17:53-9. 2010..Most importantly, recent data suggest that monocyte subsets are also functionally distinct. Here we summarize the recent advances in our understanding of monocyte subsets and their origins, fates and functions... - Quantitative analysis of intravenously administered contrast media reveals changes in vascular barrier functions in a murine colitis modelTegest Aychek
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Magn Reson Med 66:235-43. 2011..Thus, the plasma protein leakage from the colonic microvasculature at the focal inflammatory patches could be quantified by MRI, providing a biomarker for assessment of disease progression... - Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?Liat Bar-On
Department of Immunology, Weizmann Institute of Science, Herzl 1, Rehovot, Israel
Semin Immunol 23:58-64. 2011..Finally, we discuss potential strategies to translate the recent findings into the management of chronic inflammation in animal models of IBD... - Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conduciveNoam Cohen
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
J Immunol 180:2409-18. 2008..Resistance induced by the PS4-pulsed bone marrow-derived dendritic cell was specific for pneumococcal CPS serotypes (type 3 or type 4) and was associated with the induction of CPS-specific IgG and IgM Abs... - Development and function of dendritic cell subsetsAlexander Mildner
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 40:642-56. 2014..We will discuss cDC subset ontogeny and transcription factor dependencies, as well as emerging functional specializations within the cDC compartment in lymphoid and nonlymphoid tissues... - Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesisLiat Izhak
Department of Immunology, Rappaport Institute for Medical Research, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
PLoS ONE 7:e28305. 2012..This further emphasizes the important role of CCL2 as a target for therapy of cancer diseases... - Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lysAlexandra Vallon-Eberhard
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Antimicrob Agents Chemother 52:3118-26. 2008..Our results highlight the potential of this family of lipopeptides for the treatment of pulmonary invasive aspergillosis... - ATP mediates rapid microglial response to local brain injury in vivoDimitrios Davalos
Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Neurosci 8:752-8. 2005..Thus, extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury... - Toll-like receptor 4 is needed to restrict the invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine model of acute mastitisErez Gonen
The Koret School of Veterinary Medicine, Faculty of Agriculture, The Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
Cell Microbiol 9:2826-38. 2007..Taken together, these results indicate that ECP4 has an invasive potential, which is restricted by alveolar macrophages in response to the LPS/TLR4 signalling... - Transepithelial pathogen uptake into the small intestinal lamina propriaAlexandra Vallon-Eberhard
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
J Immunol 176:2465-9. 2006.... - Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7Lior Zangi
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Blood 120:1647-57. 2012..This novel subpopulation of perforin-expressing imDCs was also detected in various lymphoid tissues in normal animals and its frequency was markedly enhanced after GM-CSF administration... - The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cellsMaria Maryanovich
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
Nat Cell Biol 14:535-41. 2012..These results show that the ATM-BID pathway serves as a critical checkpoint for coupling HSC homeostasis and the DNA-damage stress response to enable long-term regenerative capacity... - Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammationOfer Fainaru
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
EMBO J 23:969-79. 2004..These data may help elucidate the molecular mechanisms underlying the pathogenesis of allergic airway inflammation in humans... - Blood monocytes consist of two principal subsets with distinct migratory propertiesFrederic Geissmann
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 19:71-82. 2003..These findings raise the potential for novel therapeutic strategies in inflammatory diseases... - Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3Joseph Dicken
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
PLoS ONE 8:e77490. 2013.... - Non-identical twins - microglia and monocyte-derived macrophages in acute injury and autoimmune inflammationSteffen Jung
Department of Immunology, Weizmann Institute of Science Rehovot, Israel
Front Immunol 3:89. 2012.... - Good, bad and beautiful--the role of dendritic cells in autoimmunitySteffen Jung
Department of Immunology, The Weizmann Institute of Science, Worsley, Rehovot 76300, Israel
Autoimmun Rev 3:54-60. 2004..In the light of a number of recent excellent reviews on the topic, this article summarizes the current knowledge obtained from the murine system highlighting hallmark experiments and open questions... - Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cellsKazumichi Abe
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 104:17022-7. 2007..These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation... - A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administrationThorsten Buch
Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
Nat Methods 2:419-26. 2005..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo... - Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenesEric Muraille
Groupe Avenir, Institut National de la Sante et de la Recherche Medicale, E 344, Universite de Nice Sophia Antipolis, Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
Eur J Immunol 35:1463-71. 2005.... - In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthmaLeonie S van Rijt
Department of Pulmonary Medicine, Erasmus MC, 3015 GE Rotterdam, Netherlands
J Exp Med 201:981-91. 2005..These findings identify lung DCs as key proinflammatory cells that are necessary and sufficient for Th2 cell stimulation during ongoing airway inflammation... - Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivityClare L Bennett
Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
J Cell Biol 169:569-76. 2005..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance... - Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitisSiegfried Hapfelmeier
Institute of Microbiology, D BIOL, ETH Zurich, CH 8093 Zurich, Switzerland
J Exp Med 205:437-50. 2008..These results establish that pathogen sampling by DCs is a discrete, and MyD88-independent, step during the initiation of a mucosal innate immune response to bacterial infection in vivo... - The contribution of dendritic cells to host defenses against Streptococcus pyogenesTorsten G Loof
Infection Immunology Research Group and Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
J Infect Dis 196:1794-803. 2007..Infection with Streptococcus pyogenes remains a significant health care problem. The identification of immune components required for host defenses against S. pyogenes constitutes an important area of research... - Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responsesDharmesh D Desai
Department of Medicine and Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Immunol 178:6217-26. 2007..Thus, FcgammaRIIB can contribute to peripheral tolerance maintenance by inhibiting DC activation alone or by also limiting processing of exogenously acquired Ag... - Antibody-enhanced cross-presentation of self antigen breaks T cell toleranceStephanie O Harbers
Departments of Microbiology and Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY, USA
J Clin Invest 117:1361-9. 2007..Thus, we show that autoreactive antibody can potently enhance the activation of effector T cells in response to cross-presented self antigen, thereby contributing to T cell-mediated autoimmunity... - The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epitheliumHolly R Chinnery
School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, Western Australia
Invest Ophthalmol Vis Sci 48:1568-74. 2007.... - Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cellsKatrin Hebel
German Arthritis Research Center Berlin, Berlin, Germany
Eur J Immunol 36:2912-9. 2006..Interestingly, we found plasma blasts to express CD11c and to be diphtheria toxin-sensitive in CD11c-diphtheria toxin receptor-transgenic mice, providing a unique tool for future analysis of in vivo aspects of plasma cell biology... - The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunityBenoit Vingert
INSERM U255, Universite Rene Descartes, Unité d Immunologie Biologique, Hôpital Européen Georges Pompidou AP HP, Paris, France
Eur J Immunol 36:1124-35. 2006..This effect was mainly mediated by CD8+ T cells. STxB therefore appears to be a powerful carrier directly targeting DC in vivo, resulting in a strong and durable CTL response associated with tumor protection... - CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleenMichael Neuenhahn
Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
Immunity 25:619-30. 2006..Thus, CD8alpha(+) DCs appear to play an important role for efficient bacterial entry into the spleen, which is of relevance for subsequent immune responses... - Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein EYuqing Huo
Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, Health Science Center, Charlottesville, Virginia, USA
Nat Med 9:61-7. 2003..This role of activated platelets in atherosclerosis is attributed to platelet P-selectin-mediated delivery of platelet-derived proinflammatory factors to monocytes/leukocytes and the vessel wall... - Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cellsMirjam Kool
Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
J Exp Med 205:869-82. 2008..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid... - Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary routeAurelie Cleret
Unité Interactions Hôte Pathogène, Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, 38702 La Tronche, France
J Immunol 178:7994-8001. 2007..Our results demonstrate that LDCs are central to spore transport immediately after infection. The rapid kinetics of pathogen transport may contribute to the clinical features of inhalational anthrax... - VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cellsMyriam Grunewald
Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Cell 124:175-89. 2006..Together, the data suggest a model for VEGF-programmed adult neovascularization highlighting the essential paracrine role of recruited myeloid cells and a role for SDF1 in their perivascular retention... - Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodesChunfeng Qu
Dept of Gene and Cell Medicine, Mt Sinai School of Medicine, Box 1496, 1425 Madison Ave, New York, NY 10029, USA
J Exp Med 200:1231-41. 2004..When these monocyte-derived DCs exit skin to emigrate to LNs, they use not only CCR7 but also CCR8, which was not previously recognized to participate in migration to LNs... - CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearanceJan Hendrik Niess
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Science 307:254-8. 2005..Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation... - The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous systemDeRen Huang
Neuroinflammation Research Center, Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
FASEB J 20:896-905. 2006..These results are the first to define a chemokine that governs NK cell migration to the CNS, and the findings suggest novel therapeutic manipulation of CX3CR1+ NK cells... - A clonogenic bone marrow progenitor specific for macrophages and dendritic cellsDarin K Fogg
INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France
Science 311:83-7. 2006..Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS... - Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locusShira Fraenkel
The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Nat Immunol 8:715-22. 2007..Thus, it seems that the epigenetic mechanisms that initially bring about monoallelic variable-(diversity)-joining rearrangement continue to be involved in the control of antibody diversity at later stages of B cell development... - Control of microglial neurotoxicity by the fractalkine receptorAstrid E Cardona
Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute, Cleveland, Ohio 44195, USA
Nat Neurosci 9:917-24. 2006..Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could increase neuronal vulnerability... - An essential role for dendritic cells in human and experimental allergic rhinitisAlex Kleinjan
Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
J Allergy Clin Immunol 118:1117-25. 2006..In allergic rhinitis (AR) CD4(+) T(H)2 lymphocytes control inflammation by secreting T(H)2 cytokines, but little is known about how these cells are activated to cause disease... - Three pathways to mature macrophages in the early mouse yolk sacJulien Y Bertrand
Institut National de la Santé et de la Recherche Médicale INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France
Blood 106:3004-11. 2005..Both YS-derived precursors followed a developmental pathway common to adult Mphi and could be qualified as definitive... - Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearanceDaniel Engel
Institute for Molecular Medicine and Experimental Immunology, University Clinic of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Infect Immun 74:6100-7. 2006..These findings demonstrate that some of the abundant DC recruited in UTI contributed innate immune effector functions, which were, however, dispensable in the microenvironment of the bladder... - The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profilesMrigank Srivastava
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Justus Liebig University, Giessen, Germany
J Immunol 175:1884-93. 2005.... - Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosisOleg Butovsky
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
J Clin Invest 116:905-15. 2006..The newly formed oligodendrocytes were spatially associated with MG expressing MHC class II proteins and IGF-I. These results point to what we believe to be a novel role for MG in oligodendrogenesis from the endogenous stem cell pool...