Yoav Gilad

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc Evidence for positive selection and population structure at the human MAO-A gene
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:862-7. 2002
  2. ncbi Population differences in the human functional olfactory repertoire
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, Israel
    Mol Biol Evol 20:307-14. 2003
  3. ncbi Different noses for different people
    Idan Menashe
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 34:143-4. 2003
  4. pmc A framework for exploring functional variability in olfactory receptor genes
    Orna Man
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 2:e682. 2007
  5. ncbi Population differences in haplotype structure within a human olfactory receptor gene cluster
    Idan Menashe
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Hum Mol Genet 11:1381-90. 2002
  6. pmc Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons
    Orna Man
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Protein Sci 13:240-54. 2004
  7. pmc General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations
    Ifat Keydar
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Hum Mutat 34:32-41. 2013
  8. pmc Human specific loss of olfactory receptor genes
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, Leipzig D 04103, Germany
    Proc Natl Acad Sci U S A 100:3324-7. 2003
  9. pmc Absence of the TAP2 human recombination hotspot in chimpanzees
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:e155. 2004
  10. pmc Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E5. 2004

Collaborators

Detail Information

Publications16

  1. pmc Evidence for positive selection and population structure at the human MAO-A gene
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:862-7. 2002
    ....
  2. ncbi Population differences in the human functional olfactory repertoire
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, Israel
    Mol Biol Evol 20:307-14. 2003
    ..Our observations are unlikely to be accounted for by simple demographic models but may be explained by positive selection acting on OR loci in Caucasians...
  3. ncbi Different noses for different people
    Idan Menashe
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 34:143-4. 2003
    ..The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome...
  4. pmc A framework for exploring functional variability in olfactory receptor genes
    Orna Man
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 2:e682. 2007
    ..However, the assumption that overall protein sequence diversity is a good proxy for functional properties is untested...
  5. ncbi Population differences in haplotype structure within a human olfactory receptor gene cluster
    Idan Menashe
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Hum Mol Genet 11:1381-90. 2002
    ..Our data suggests that OR genes may have evolved to create different functional repertoires in distinct human populations...
  6. pmc Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons
    Orna Man
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Protein Sci 13:240-54. 2004
    ..This conclusion is supported by the observation that all but one of the predicted binding site residues correspond to ligand-contact positions in other rhodopsin-like GPCRs...
  7. pmc General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations
    Ifat Keydar
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Hum Mutat 34:32-41. 2013
    ..This database of genes and their variants should assist in rationalizing the great interindividual variation in human overall olfactory sensitivity (http://genome.weizmann.ac.il/GOSdb)...
  8. pmc Human specific loss of olfactory receptor genes
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, Leipzig D 04103, Germany
    Proc Natl Acad Sci U S A 100:3324-7. 2003
    ..As a consequence, the fraction of OR pseudogenes in humans is almost twice as high as in the non-human primates, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes...
  9. pmc Absence of the TAP2 human recombination hotspot in chimpanzees
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:e155. 2004
    ....
  10. pmc Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E5. 2004
    ..Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates...
  11. pmc Natural selection on the olfactory receptor gene family in humans and chimpanzees
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 73:489-501. 2003
    ..These observations are likely due to differences in lifestyle, between humans and great apes, that have led to distinct sensory needs...
  12. pmc A comparison of the human and chimpanzee olfactory receptor gene repertoires
    Yoav Gilad
    Yale University School of Medicine, Department of Genetics, New Haven, Connecticut 06520, USA
    Genome Res 15:224-30. 2005
    ..Thus, although overall there is relaxed constraint on human olfaction relative to chimpanzee, species-specific sensory requirements appear to have shaped the evolution of the functional OR gene repertoires in both species...
  13. ncbi Expression profiling in primates reveals a rapid evolution of human transcription factors
    Yoav Gilad
    Department of Genetics, Yale University, New Haven, Connecticut 06510, USA
    Nature 440:242-5. 2006
    ..Among the gene set with a human-specific increase in expression, there is an excess of transcription factors; the same is not true for genes with increased expression in chimpanzee...
  14. pmc Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray
    Xiaohong Zhang
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Genome Biol 8:R86. 2007
    ..To rectify this, we have developed a DNA microarray that contains probes for most predicted human OR loci and used that array to examine OR gene expression profiles in olfactory epithelium tissues from three individuals...
  15. pmc Using reporter gene assays to identify cis regulatory differences between humans and chimpanzees
    Adrien Chabot
    Department of Human Genetics, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
    Genetics 176:2069-76. 2007
    ..High-throughput application of this approach can provide a map of regulatory element differences between humans and our close evolutionary relatives...
  16. pmc A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathway
    Paola de Candia
    Department of Human Genetics, University of Chicago, Chicago, Illinois, USA
    PLoS ONE 3:e1670. 2008
    ..We concentrated on this gene because of its known role in the regulation of metabolism and in longevity...