B Geiger

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint Exploring the neighborhood: adhesion-coupled cell mechanosensors
    Benjamin Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Cell 110:139-42. 2002
  2. doi request reprint Towards elucidation of functional molecular signatures of the adhesive-migratory phenotype of malignant cells
    Tamar Geiger
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Semin Cancer Biol 20:146-52. 2010
  3. doi request reprint Environmental sensing through focal adhesions
    Benjamin Geiger
    Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Rev Mol Cell Biol 10:21-33. 2009
  4. ncbi request reprint Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk
    B Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Rev Mol Cell Biol 2:793-805. 2001
  5. ncbi request reprint Assembly and mechanosensory function of focal contacts
    B Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 13:584-92. 2001
  6. ncbi request reprint A role for p130Cas in mechanotransduction
    Benjamin Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Cell 127:879-81. 2006
  7. pmc Down-regulation of beta-catenin by activated p53
    E Sadot
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 21:6768-81. 2001
  8. ncbi request reprint Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
    N Q Balaban
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Cell Biol 3:466-72. 2001
  9. ncbi request reprint pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions
    T Volberg
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 114:2279-89. 2001
  10. pmc Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells
    I Simcha
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel, 76100
    Mol Biol Cell 12:1177-88. 2001

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Exploring the neighborhood: adhesion-coupled cell mechanosensors
    Benjamin Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Cell 110:139-42. 2002
    ..Are cells using stretch-activated ion channels to explore the extracellular environment surrounding them, or do they use for that purpose the submembrane protein network that interconnects integrin receptors with the actin cytoskeleton?..
  2. doi request reprint Towards elucidation of functional molecular signatures of the adhesive-migratory phenotype of malignant cells
    Tamar Geiger
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Semin Cancer Biol 20:146-52. 2010
    ..We will primarily focus on the adhesion and migration of cancer cells, and their relationships to the deregulated growth, metastatic dissemination, and anchorage independence associated with malignant transformation...
  3. doi request reprint Environmental sensing through focal adhesions
    Benjamin Geiger
    Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Rev Mol Cell Biol 10:21-33. 2009
    ....
  4. ncbi request reprint Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk
    B Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Rev Mol Cell Biol 2:793-805. 2001
    ..This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces...
  5. ncbi request reprint Assembly and mechanosensory function of focal contacts
    B Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 13:584-92. 2001
    ..The molecular mechanisms underlying these processes are discussed...
  6. ncbi request reprint A role for p130Cas in mechanotransduction
    Benjamin Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Cell 127:879-81. 2006
    ..This change promotes phosphorylation of p130Cas by Src family kinases and the transduction of integrin-mediated signaling...
  7. pmc Down-regulation of beta-catenin by activated p53
    E Sadot
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 21:6768-81. 2001
    ..These findings support the notion that there will be a selective pressure for the loss of wild-type p53 expression in cancers that are driven by excessive accumulation of beta-catenin...
  8. ncbi request reprint Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
    N Q Balaban
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Cell Biol 3:466-72. 2001
    ..The results put clear constraints on the possible molecular mechanisms for the mechanosensory response of focal adhesions to applied force...
  9. ncbi request reprint pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions
    T Volberg
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 114:2279-89. 2001
    ..These findings demonstrate that Src family kinases, and pp60(c-src) in particular, have a central role in regulating protein dynamics at cell-matrix interfaces, both during early stages of interaction and in mature focal contacts...
  10. pmc Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells
    I Simcha
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel, 76100
    Mol Biol Cell 12:1177-88. 2001
    ....
  11. ncbi request reprint Recruitment of beta-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction
    P Goichberg
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 114:1309-19. 2001
    ..These results suggest that increased cadherin-mediated adhesion and translocation of beta-catenin to adherens junctions are involved in activating the early steps of myogenic differentiation...
  12. pmc c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
    G Levkowitz
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 12:3663-74. 1998
    ..These results reveal an endosomal sorting machinery capable of controlling the fate, and, hence, signaling potency, of growth factor receptors...
  13. ncbi request reprint Galectin-8 functions as a matricellular modulator of cell adhesion
    Y Levy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:31285-95. 2001
    ..Because of its dual effects on the adhesive properties of the cells and its association with fibronectin, galectin-8 might be considered a novel type of matricellular protein...
  14. ncbi request reprint Molecular complexity and dynamics of cell-matrix adhesions
    E Zamir
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 114:3583-90. 2001
    ..These changes are driven by mechanical force generated by the actin- and myosin-containing contractile machinery of the cells, or by external forces applied to the cells, and regulated by matrix rigidity...
  15. ncbi request reprint Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading
    Baruch Zimerman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Cell Motil Cytoskeleton 58:143-59. 2004
    ..The mechanisms underlying the assembly and reorganization of actin-associated focal adhesions and the involvement of mechanical forces in regulating their dynamic properties are discussed...
  16. ncbi request reprint The cytoplasmic domain of adherens-type junctions
    B Geiger
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Cell Motil Cytoskeleton 20:1-6. 1991
  17. ncbi request reprint Adhesion-dependent cell mechanosensitivity
    Alexander D Bershadsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Annu Rev Cell Dev Biol 19:677-95. 2003
    ....
  18. pmc Cell mechanosensitivity controls the anisotropy of focal adhesions
    Alice Nicolas
    Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 101:12520-5. 2004
    ..The growth dynamics is calculated and the predicted sliding of focal adhesions is consistent with several experiments...
  19. ncbi request reprint Temperature-sensitive micrometer-thick layers of hyaluronan grafted on microspheres
    Derk Joester
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    J Am Chem Soc 128:1119-24. 2006
    ..We directly observed a volume contraction of 20% with increasing temperature between 1 and 11 degrees C by wet-mode ESEM...
  20. ncbi request reprint Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system
    E Sadot
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Oncogene 19:1992-2001. 2000
    ....
  21. ncbi request reprint Hierarchical assembly of cell-matrix adhesion complexes
    R Zaidel-Bar
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Biochem Soc Trans 32:416-20. 2004
    ..The formation of these adhesions depends on actomyosin contractility and matrix pliability...
  22. pmc Dynamic study of the transition from hyaluronan- to integrin-mediated adhesion in chondrocytes
    Miriam Cohen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 25:302-11. 2006
    ..These dynamic studies demonstrate that pericellular hyaluronan mediates initial cell-surface adhesion, and regulates the formation of focal adhesions...
  23. ncbi request reprint Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells
    Ronen Zaidel-Bar
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Cell Sci 116:4605-13. 2003
    ..These observations illuminate, for the first time, early stages in focal complex assembly and the dynamic process associated with its transformation into focal adhesion...
  24. doi request reprint An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells
    A Beck
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Diabetologia 54:2845-55. 2011
    ..Pro-inflammatory cytokines induce death of pancreatic beta cells, leading to the development of type 1 diabetes. We sought to identify novel players and the underlying mechanisms involved in this process...
  25. ncbi request reprint Probing molecular processes in live cells by quantitative multidimensional microscopy
    Z Kam
    Dept of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Cell Biol 11:329-34. 2001
    ..Here, we address different aspects of multidimensional microscopy and, in particular, image quantification and the characterization of molecular dynamics, as applied to the study of cell adhesion...
  26. pmc Functional atlas of the integrin adhesome
    Ronen Zaidel-Bar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    Nat Cell Biol 9:858-67. 2007
    ..We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions...
  27. ncbi request reprint Spatial and temporal sequence of events in cell adhesion: from molecular recognition to focal adhesion assembly
    Miriam Cohen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chembiochem 5:1393-9. 2004
    ..The biophysical properties of hyaluronan as well as its ultrastructural organization are analyzed in relation to this proposed function...
  28. ncbi request reprint A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions
    Ronen Zaidel-Bar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 120:137-48. 2007
    ....
  29. ncbi request reprint Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton
    Irena Lavelin
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 280:7178-85. 2005
    ..The overall physiological functions of RC-GAP72 are presently unknown, yet our data suggest that RC-GAP72 plays a role in regulating cell morphology and cytoskeletal organization...
  30. ncbi request reprint Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells
    Inna Grosheva
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Exp Eye Res 82:945-58. 2006
    ..Inducing such changes in the contractility and actin cytoskeleton of HTM cells in glaucomatous eyes in vivo could produce a therapeutically useful increase in outflow facility...
  31. pmc Initial stages of cell-matrix adhesion can be mediated and modulated by cell-surface hyaluronan
    Ella Zimmerman
    Department of Structural Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Biophys J 82:1848-57. 2002
    ..It may promote it through the establishment of exquisitely stereospecific chemical interactions or inhibit it by virtue of steric exclusion and/or electrostatic repulsion...
  32. pmc HBV infection of cell culture: evidence for multivalent and cooperative attachment
    N Paran
    Departments of Molecular Genetics and Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    EMBO J 20:4443-53. 2001
    ..Furthermore, we provide evidence in support of multivalent HBV attachment with synergistic interplay. Our data depict a mechanistic view of virus attachment and ingestion...
  33. ncbi request reprint Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer
    A Ben-Ze'ev
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Curr Opin Cell Biol 10:629-39. 1998
    ....
  34. ncbi request reprint Preliminary crystallographic study of turkey gizzard vinculin
    O Kogan
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Acta Crystallogr D Biol Crystallogr 56:1055-7. 2000
    ..5 A resolution at the X11 beamline of DESY and belong to the monoclinic space group P2(1). Crystal unit-cell parameters are estimated to be a = 57, b = 351, c = 70 A, alpha = 90, beta = 113, gamma = 90 degrees...
  35. pmc A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein
    T Miron
    Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel
    J Cell Biol 114:255-61. 1991
    ....
  36. ncbi request reprint High-throughput screening of cellular features using high-resolution light-microscopy; application for profiling drug effects on cell adhesion
    Yael Paran
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Struct Biol 158:233-43. 2007
    ..The significance of combining resolution, throughput and multi-parametric analyses for biomedical research and drug discovery is discussed...
  37. pmc p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin
    Shlomit Boguslavsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 104:10882-7. 2007
    ..Cortactin and p120 are shown to directly interact with each other via the cortactin N-terminal region. We propose that the mechanism underlying p120 functions at the leading edge involves its cooperation with cortactin...
  38. doi request reprint Adhesive interactions regulate transcriptional diversity in malignant B cells
    Liat Nadav-Dagan
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cancer Res 8:482-93. 2010
    ..Our findings indicate that B-cell differentiation, as manifested by gene expression profiles, is attenuated by cell adhesion to fibronectin, leading to upregulation of specific genes known to be associated with the pathogenesis of MM...
  39. ncbi request reprint Development and application of automatic high-resolution light microscopy for cell-based screens
    Yael Paran
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Methods Enzymol 414:228-47. 2006
    ....
  40. ncbi request reprint The generation and regulation of functional diversity of malignant plasma cells
    Liat Nadav
    The Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 66:8608-16. 2006
    ..Diverse subpopulations of malignant plasma cells may play distinct roles in the different biological and clinical manifestations of plasma cell dyscrasias, including bone dissemination and selective adhesion to bone marrow compartments...
  41. ncbi request reprint Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize
    Alexander Bershadsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 18:472-81. 2006
    ..Theoretical models have also been used to address the physical mechanisms underlying adhesion-mediated mechanosensing...
  42. ncbi request reprint Allicin inhibits cell polarization, migration and division via its direct effect on microtubules
    Masha Prager-Khoutorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cell Motil Cytoskeleton 64:321-37. 2007
    ..Thus, allicin is a potent microtubule-disrupting reagent interfering with tubulin polymerization by reaction with tubulin SH groups...
  43. pmc Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions
    Eli Zamir
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 3:e1901. 2008
    ..These adhesions are highly variable in their morphology, dynamics, and apparent function, yet their molecular diversity is poorly defined...
  44. pmc Organization and adhesive properties of the hyaluronan pericellular coat of chondrocytes and epithelial cells
    Miriam Cohen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biophys J 85:1996-2005. 2003
    ..We consider the possibility that in A6 cells single hyaluronan molecules, spanning the whole thickness of the pericellular coat, mediate these tight contacts...
  45. ncbi request reprint Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow
    Ronen Zaidel-Bar
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 118:3997-4007. 2005
    ....
  46. ncbi request reprint Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys
    Ilana Sabanay
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Exp Eye Res 82:236-46. 2006
    ..The outflow-effective concentration of LAT-B administered intracamerally does not significantly affect the corneal endothelium...
  47. ncbi request reprint Extrajunctional distribution of N-cadherin in cultured human endothelial cells
    D Salomon
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 102:7-17. 1992
    ..Comparison of this pattern with the discrete junctional labeling obtained with the pan-cadherin antibody suggests that different cadherins, co-expressed in the same endothelial cells, may undergo differential surface distribution...
  48. ncbi request reprint Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer
    Christoph Ballestrem
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Cell Sci 119:866-75. 2006
    ..Dynamic FRET-based examination indicated that paxillin phosphorylation occurs in specific areas (hotspots) within focal adhesions, whereas FAK phosphorylation is broadly distributed...
  49. ncbi request reprint Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption
    Jochen Kirchner
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Cell Sci 116:975-86. 2003
    ..Our findings suggest that protein recruitment and growth of focal adhesions are an immediate and direct result of increased contractility induced by microtubule disruption, whereas tyrosine phosphorylation is activated later...
  50. pmc Tumorigenic potential and disease manifestations of malignant B-cell variants differing in their fibronectin adhesiveness
    Liat Nadav
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 36:1524-34. 2008
    ..Disease manifestations of human malignant B-cell variants, isolated based on their differential interactions with fibronectin, were examined in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice...
  51. pmc Surface-induced regulation of podosome organization and dynamics in cultured osteoclasts
    Dafna Geblinger
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Chembiochem 10:158-65. 2009
    ..We conclude that osteoclasts sense the local properties of the underlying substrate and respond to these signals, both locally and globally...
  52. pmc Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown
    Sabina E Winograd-Katz
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 186:423-36. 2009
    ..This study provides a comprehensive information resource on the molecular regulation of multiple cell adhesion features, and sheds light on signaling mechanisms regulating the formation of integrin adhesions...
  53. ncbi request reprint Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling
    Noam Erez
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Exp Cell Res 294:366-78. 2004
    ..We propose that cadherin-mediated signaling is essential for maintaining viability of confluent endothelial cells, and that its perturbation by N-Ac-CHAVC-NH2 drives these cells to apoptosis...
  54. pmc Nano-topography sensing by osteoclasts
    Dafna Geblinger
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 123:1503-10. 2010
    ..The mechanisms whereby the physical properties of the substrate influence osteoclast behavior and their involvement in osteoclast function are discussed...
  55. ncbi request reprint The molecular dynamics of osteoclast adhesions
    Chen Luxenburg
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Eur J Cell Biol 85:203-11. 2006
    ..Studying the nature of the proteins that undergo de-phosphorylation is critical for the understanding of the mechanisms regulating the processes described above...
  56. ncbi request reprint Application of microscope-based FRET to study molecular interactions in focal adhesions of live cells
    Christoph Ballestrem
    Department of Moelcular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 294:321-34. 2005
    ..This is followed by a protocol for fluorescence resonance energy transfer measurements in live cells...
  57. pmc Focal adhesions as mechanosensors: a physical mechanism
    Tom Shemesh
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    Proc Natl Acad Sci U S A 102:12383-8. 2005
    ..We define here specific conditions that can lead to the different regimes of FA assembly, including growth, steady state, and disassembly...
  58. ncbi request reprint Measurement of protein tyrosine phosphorylation in cell adhesion
    Vidhya V Iyer
    Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 294:289-302. 2005
    ..Finally, a quantitative fluorescence microscopic technique using an SH2-containing phosphotyrosine reporter to monitor tyrosine phosphorylation in focal adhesions in live cells is described...
  59. ncbi request reprint Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
    Exp Eye Res 82:935-44. 2006
    ..This suggests that over-expression of the caldesmon gene in the TM may be an effective approach for the gene therapy of glaucoma...
  60. pmc Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands
    Elisabetta Ada Cavalcanti-Adam
    Max Planck Institute for Metals Research, Department of New Materials and Biosystems, Stuttgart, Germany
    Biophys J 92:2964-74. 2007
    ..These findings indicate that a critical RGD density is essential for the establishment of mature and stable integrin adhesions, which, in turn, induce efficient cell spreading and formation of focal adhesions...
  61. ncbi request reprint Heparinoids: integrated control of hemostasis and metastasis
    Liat Nadav
    Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 4:1046-9. 2002
  62. ncbi request reprint Heparanase mediates cell adhesion independent of its enzymatic activity
    Orit Goldshmidt
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    FASEB J 17:1015-25. 2003
    ....
  63. ncbi request reprint Enteropathogenic Escherichia coli induces modification of the focal adhesions of infected host cells
    Yulia Shifrin
    Department of Molecular Genetics and Biotechnology, The Hebrew University, Faculty of Medicine, POB 12272, Jerusalem 91120, Israel
    Cell Microbiol 4:235-43. 2002
    ..These processes are specific and probably play an important role in EPEC virulence...
  64. ncbi request reprint Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts
    Liat Nadav
    Tel Aviv Sourasky Medical Center, Israel
    J Cell Sci 115:2179-87. 2002
    ..Cellular binding and uptake of extracellular heparanase control its activation, clearance rate and storage within the cells...
  65. ncbi request reprint Identification of plant cytoskeleton-interacting proteins by screening for actin stress fiber association in mammalian fibroblasts
    Mohamad Abu-Abied
    The Institute of Plant Sciences, The Volcani Center, Bet Dagan 50250 Israel
    Plant J 48:367-79. 2006
    ..Further evidence for a cytoskeletal function of ERD10 was obtained in planta; GFP-ERD10 was able to protect the actin cytoskeleton from latrunculin-mediated disruption in Nicotiana benthamiana leaves...
  66. ncbi request reprint Tyrphostins which interfere with the actin cytoskeleton do not increase outflow facility
    Tova Volberg
    Exp Eye Res 74:411-6. 2002
  67. doi request reprint Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing
    Marco Arnold
    Department of New Materials and Biosystems, Max Planck Institute for Metals Research, and Department of Biophysical Chemistry, University of Heidelberg, Heisenbergstr 3, D 70569 Stuttgart, Germany
    Nano Lett 8:2063-9. 2008
    ..We propose that differential positional clustering of the integrin transmembrane receptors is used by cells for exploring and interpreting their environment, at high spatial sensitivity...
  68. ncbi request reprint Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases
    Ben Zion Katz
    Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:29115-20. 2003
    ..We propose here a molecular model for the tyrosine phosphorylation-dependent regulation of focal adhesion kinase organization involving Src kinases and an inhibitory phosphorylation of the C-terminal (Tyr-925) tyrosine residue...
  69. ncbi request reprint Supramolecular crafting of cell adhesion
    Hannah Storrie
    Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
    Biomaterials 28:4608-18. 2007
    ..Supramolecular design of artificial bioactive extracellular matrices to tune cell response may prove to be a powerful strategy in regenerative medicine and to study biological processes...
  70. ncbi request reprint Molecular engineering of cellular environments: cell adhesion to nano-digital surfaces
    Joachim P Spatz
    Department of New Materials and Biosystems, Max Planck Institute for Metals Research, Stuttgart, Germany
    Methods Cell Biol 83:89-111. 2007
    ..Detailed consideration is also given to the fact that protein clusters such as those found at focal adhesion sites represent, to a large extent, hierarchically organized cooperativity among various proteins...
  71. ncbi request reprint How do microtubules guide migrating cells?
    J Victor Small
    Nat Rev Mol Cell Biol 3:957-64. 2002
    ..Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility...
  72. pmc Anomalous features of EMT during keratinocyte transformation
    Tamar Geiger
    Department of Biological Chemistry, Institute of Life Science, The Hebrew University, Jerusalem, Israel
    PLoS ONE 3:e1574. 2008
    ..We monitored reduced Rac1-dependent migration also in the cervical cancer cell line SiHa. Therefore we can conclude that up to the stage of tumor formation migratory activity is eliminated...